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Janux Therapeutics Reports Third Quarter 2024 Financial Results and Business Highlights

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Janux Therapeutics reported Q3 2024 financial results and business updates. The company maintains $658.0 million in cash and investments, up from $344.0 million at end-2023. Q3 net loss widened to $28.1 million from $11.6 million year-over-year. R&D expenses increased to $18.6 million, while G&A expenses rose to $17.7 million. Patient enrollment continues for Phase 1 trials of JANX007 in prostate cancer and JANX008 in solid tumors. The company expects to provide JANX007 data updates and expansion cohort dose selection in 2024, with JANX008 updates anticipated in 2025.

Janux Therapeutics ha riportato i risultati finanziari del terzo trimestre del 2024 e aggiornamenti aziendali. L'azienda mantiene 658,0 milioni di dollari in contanti e investimenti, in aumento rispetto ai 344,0 milioni di dollari della fine del 2023. La perdita netta del terzo trimestre è aumentata a 28,1 milioni di dollari, rispetto agli 11,6 milioni di dollari dell'anno precedente. Le spese per la ricerca e sviluppo sono aumentate a 18,6 milioni di dollari, mentre le spese generali e amministrative sono salite a 17,7 milioni di dollari. Continua l'arruolamento dei pazienti per gli studi di Fase 1 di JANX007 per il cancro alla prostata e JANX008 per i tumori solidi. L'azienda prevede di fornire aggiornamenti sui dati di JANX007 e sulla selezione della dose del coorte di espansione nel 2024, mentre gli aggiornamenti su JANX008 sono previsti per il 2025.

Janux Therapeutics reportó los resultados financieros del tercer trimestre de 2024 y actualizaciones empresariales. La compañía mantiene 658,0 millones de dólares en efectivo e inversiones, en comparación con los 344,0 millones de dólares a finales de 2023. La pérdida neta del tercer trimestre se amplió a 28,1 millones de dólares desde 11,6 millones de dólares en el mismo periodo del año anterior. Los gastos de I+D aumentaron a 18,6 millones de dólares, mientras que los gastos generales y administrativos se elevaron a 17,7 millones de dólares. Continúa la inscripción de pacientes para los ensayos de Fase 1 de JANX007 en cáncer de próstata y JANX008 en tumores sólidos. La compañía espera proporcionar actualizaciones de datos de JANX007 y la selección de dosis del grupo de expansión en 2024, con actualizaciones de JANX008 anticipadas para 2025.

Janux Therapeutics는 2024년 3분기 재무 실적 및 사업 업데이트를 보고했습니다. 회사는 2023년 말 3억 4400만 달러에서 증가한 6억 5800만 달러의 현금 및 투자를 보유하고 있습니다. 3분기 순손실은 전년 대비 2810만 달러에서 1160만 달러로 확대되었습니다. 연구 개발 비용은 1860만 달러로 증가했으며, 일반관리(G&A) 비용은 1770만 달러로 상승했습니다. JANX007의 전립선암과 JANX008의 고형종양에 대한 1상 시험에 환자 모집이 계속 진행되고 있습니다. 회사는 2024년 중 JANX007의 데이터 업데이트 및 확장 코호트 용량 선택을 제공할 것으로 예상하며, JANX008 업데이트는 2025년에 예정되어 있습니다.

Janux Therapeutics a publié ses résultats financiers pour le troisième trimestre 2024 ainsi que des mises à jour sur ses activités. L'entreprise dispose de 658,0 millions de dollars en liquidités et investissements, en hausse par rapport à 344,0 millions de dollars à la fin de 2023. La perte nette du troisième trimestre s'est aggravée, passant de 11,6 millions de dollars l'année précédente à 28,1 millions de dollars. Les dépenses de recherche et développement ont augmenté à 18,6 millions de dollars, tandis que les frais généraux et administratifs ont grimpé à 17,7 millions de dollars. L'enrôlement des patients se poursuit pour les essais de Phase 1 de JANX007 dans le cancer de la prostate et JANX008 dans les tumeurs solides. L'entreprise prévoit de fournir des mises à jour sur les données JANX007 et la sélection de doses pour le groupe d'expansion en 2024, avec des mises à jour sur JANX008 attendues pour 2025.

Janux Therapeutics hat die finanziellen Ergebnisse des dritten Quartals 2024 und Unternehmensaktualisierungen veröffentlicht. Das Unternehmen verfügt über 658,0 Millionen Dollar an Bargeld und Investitionen, ein Anstieg von 344,0 Millionen Dollar Ende 2023. Der Nettoverlust im dritten Quartal weitete sich auf 28,1 Millionen Dollar aus, im Vergleich zu 11,6 Millionen Dollar im Vorjahr. Die F&E-Aufwendungen stiegen auf 18,6 Millionen Dollar, während die allgemeinen und administrativen Ausgaben auf 17,7 Millionen Dollar anstiegen. Die Patientenaufnahme für die Phase-1-Studien von JANX007 bei Prostatakrebs und JANX008 bei soliden Tumoren läuft weiter. Das Unternehmen erwartet, 2024 Updates zu JANX007-Daten und die Auswahl der Dosis für die Erweiterungsgruppe bereitzustellen, während Aktualisierungen zu JANX008 für 2025 erwartet werden.

Positive
  • Strong cash position of $658.0 million, significantly increased from $344.0 million at end-2023
  • Two clinical trials actively enrolling patients (JANX007 and JANX008)
  • Pipeline expansion with multiple TRACTr and TRACIr programs in development
Negative
  • Net loss increased to $28.1 million from $11.6 million year-over-year
  • R&D expenses increased 56% to $18.6 million
  • G&A expenses nearly tripled to $17.7 million

Insights

The Q3 results reveal a robust financial position with $658.0 million in cash and investments, nearly doubling from $344.0 million at 2023 year-end. However, operating expenses have increased significantly, with R&D spending up 56.3% to $18.6 million and G&A expenses surging to $17.7 million. The net loss widened to $28.1 million, more than double the previous year's loss of $11.6 million.

The substantial cash position provides an extended runway for clinical development, but investors should note the accelerating burn rate. The $9.5 million stock-based compensation expense in G&A notably impacted the quarter's financials. The company's market cap of $2.88 billion suggests investors are betting heavily on the success of their TRACTr platform technology.

The clinical pipeline progress shows steady advancement in two key programs. JANX007, targeting PSMA for prostate cancer and JANX008, targeting EGFR for multiple solid tumors, are both in Phase 1 trials with active enrollment. The anticipated data update for JANX007 and dose selection for expansion cohorts in 2024 will be important validation points for their proprietary TRACTr platform.

The broad applicability of JANX008 across seven different cancer types demonstrates the platform's versatility. The company's development of additional TRACTr and TRACIr candidates suggests a robust preclinical pipeline, though the mention of "assessing priorities" might indicate potential program prioritization or discontinuation decisions ahead.

  • Enrollment ongoing for PSMA-TRACTr (JANX007) in prostate cancer and EGFR-TRACTr (JANX008) in solid tumors
  • Update on JANX007 data and doses selected for expansion cohorts is anticipated in 2024
  • $658.0 million in cash and cash equivalents and short-term investments at end of third quarter 2024

SAN DIEGO--(BUSINESS WIRE)-- Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms, today reported financial results for the third quarter ended September 30, 2024, and provided a business update.

“Our efforts remain focused on enrolling participants in the PSMA-TRACTr (JANX007) and EGFR-TRACTr (JANX008) clinical trials, and we are encouraged by our continued progress,” said David Campbell, Ph.D., President and CEO of Janux Therapeutics. “We look forward to providing an update on our JANX007 program by year end.”

RECENT BUSINESS HIGHLIGHTS AND FUTURE MILESTONES:

  • The company continues to enroll patients in the first-in-human Phase 1 clinical trials of JANX007 in mCRPC (NCT05519449) and JANX008 in advanced or metastatic solid tumors (NCT05783622). Janux anticipates providing an update on JANX007 data and doses selected for expansion cohorts in 2024. An update on JANX008 data is expected in 2025.

THIRD QUARTER 2024 FINANCIAL RESULTS:

  • Cash and cash equivalents and short-term investments: As of September 30, 2024, Janux reported cash and cash equivalents and short-term investments of $658.0 million compared to $344.0 million at December 31, 2023.
  • Research and development expenses: Research and development expenses for the quarter ended September 30, 2024, were $18.6 million compared to $11.9 million for the comparable period in 2023.
  • General and administrative expenses: General and administrative expenses for the quarter ended September 30, 2024, were $17.7 million compared to $6.4 million for the comparable period in 2023. With respect to the quarter ended September 30, 2024, $9.5 million of the general and administrative expense incurred was due to stock-based compensation expense associated with equity modifications.
  • Net loss: For the quarter ended September 30, 2024, Janux reported a net loss of $28.1 million compared to a net loss of $11.6 million for the comparable period in 2023.

Janux’s TRACTr and TRACIr Pipeline

Janux’s first clinical candidate, JANX007, is a TRACTr that targets PSMA and is being investigated in a Phase 1 clinical trial in adult subjects with metastatic castration-resistant prostate cancer (mCRPC). Janux’s second clinical candidate, JANX008, is a TRACTr that targets EGFR and is being studied in a Phase 1 clinical trial for the treatment of multiple solid cancers including colorectal carcinoma, squamous cell carcinoma of the head and neck, non-small cell lung cancer, renal cell carcinoma, small cell lung cancer, pancreatic ductal adenocarcinoma and triple-negative breast cancer. We are also generating a number of additional TRACTr and TRACIr programs for potential future development, some of which are at development candidate stage or later. We are currently assessing priorities in our preclinical pipeline.

About Janux Therapeutics

Janux is a clinical-stage biopharmaceutical company developing tumor-activated immunotherapies for cancer. Janux’s proprietary technology enabled the development of two distinct bispecific platforms: Tumor Activated T Cell Engagers (TRACTr) and Tumor Activated Immunomodulators (TRACIr). The goal of both platforms is to provide cancer patients with safe and effective therapeutics that direct and guide their immune system to eradicate tumors while minimizing safety concerns. Janux is currently developing a broad pipeline of TRACTr and TRACIr therapeutics directed at several targets to treat solid tumors. Janux has two TRACTr therapeutic candidates in clinical trials, the first targeting PSMA is in development for prostate cancer, and the second targeting EGFR is being developed for colorectal carcinoma, squamous cell carcinoma of the head and neck, non-small cell lung cancer, renal cell carcinoma, small cell lung cancer, pancreatic ductal adenocarcinoma and triple-negative breast cancer. For more information, please visit www.januxrx.com and follow us on LinkedIn.

Forward-Looking Statements

This news release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include statements regarding, among other things, Janux’s ability to bring new treatments to cancer patients in need, expectations regarding the timing, scope and results of Janux’s development activities, including its ongoing and planned preclinical studies and clinical trials, the timing of and plans for regulatory filings, the potential benefits of Janux’s product candidates and platform technologies, expectations regarding the use of Janux’s platform technologies to generate novel product candidates and the strength of Janux’s balance sheet and the adequacy of cash on hand. Factors that may cause actual results to differ materially include the risk that compounds that appear promising in early research do not demonstrate safety and/or efficacy in later preclinical studies or clinical trials, the risk that Janux may not obtain approval to market its product candidates, uncertainties associated with performing clinical trials, regulatory filings and applications, risks associated with reliance on third parties to successfully conduct clinical trials, the risks associated with reliance on outside financing to meet capital requirements, and other risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. You are urged to consider statements that include the words “may,” “will,” “would,” “could,” “should,” “believes,” “estimates,” “projects,” “promise,” “potential,” “expects,” “plans,” “anticipates,” “intends,” “continues,” “designed,” “goal,” or the negative of those words or other comparable words to be uncertain and forward-looking. For a further list and description of the risks and uncertainties Janux faces, please refer to Janux’s periodic and other filings with the Securities and Exchange Commission, which are available at www.sec.gov. Such forward-looking statements are current only as of the date they are made, and Janux assumes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.

Janux Therapeutics, Inc.
Condensed Balance Sheets
(in thousands)

 

 

September 30,
2024

 

 

December 31,
2023

Assets

 

(unaudited)

 

 

 

Current assets:

 

 

 

 

 

Cash and cash equivalents

 

$

26,754

 

 

$

19,205

Short-term investments

 

 

631,277

 

 

 

324,823

Prepaid expenses and other current assets

 

 

8,290

 

 

 

5,213

Total current assets

 

 

666,321

 

 

 

349,241

Restricted cash

 

 

816

 

 

 

816

Property and equipment, net

 

 

5,373

 

 

 

7,003

Operating lease right-of-use assets

 

 

19,686

 

 

 

20,838

Other long-term assets

 

 

2,823

 

 

 

2,509

Total assets

 

$

695,019

 

 

$

380,407

 

 

 

 

 

 

Liabilities and Stockholders’ Equity

 

 

 

 

 

Current liabilities:

 

 

 

 

 

Accounts payable

 

$

2,462

 

 

$

2,424

Accrued expenses

 

 

13,022

 

 

 

7,387

Current portion of deferred revenue

 

 

 

 

 

1,705

Current portion of operating lease liabilities

 

 

1,689

 

 

 

1,517

Total current liabilities

 

 

17,173

 

 

 

13,033

Operating lease liabilities, net of current portion

 

 

21,742

 

 

 

23,025

Total liabilities

 

 

38,915

 

 

 

36,058

Total stockholders’ equity

 

 

656,104

 

 

 

344,349

Total liabilities and stockholders’ equity

 

$

695,019

 

 

$

380,407

Janux Therapeutics, Inc.
Unaudited Condensed Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)

 

 

Three Months Ended
September 30,

 

 

Nine Months Ended
September 30,

 

 

2024

 

 

2023

 

 

2024

 

 

2023

Collaboration revenue

 

$

439

 

 

 

$

2,517

 

 

 

$

10,588

 

 

 

$

5,622

 

Operating expenses:

 

 

 

 

 

 

 

 

 

 

 

Research and development

 

 

18,614

 

 

 

 

11,892

 

 

 

 

47,582

 

 

 

 

42,681

 

General and administrative

 

 

17,667

 

 

 

 

6,438

 

 

 

 

32,831

 

 

 

 

19,783

 

Total operating expenses

 

 

36,281

 

 

 

 

18,330

 

 

 

 

80,413

 

 

 

 

62,464

 

Loss from operations

 

 

(35,842

)

 

 

(15,813

)

 

 

(69,825

)

 

 

(56,842

)

Total other income

 

 

7,783

 

 

 

 

4,245

 

 

 

 

21,047

 

 

 

 

10,307

 

Net loss

 

$

(28,059

)

 

$

(11,568

)

 

$

(48,778

)

 

$

(46,535

)

Other comprehensive gain (loss):

 

 

 

 

 

 

 

 

 

 

 

Unrealized gain (loss) on available-for-sale securities, net

 

 

9,447

 

 

 

 

(115

)

 

 

7,166

 

 

 

 

360

 

Comprehensive loss

 

$

(18,612

)

 

$

(11,683

)

 

$

(41,612

)

 

$

(46,175

)

Net loss per common share, basic and diluted

 

$

(0.51

)

 

$

(0.25

)

 

$

(0.93

)

 

$

(1.08

)

Weighted-average shares of common stock outstanding, basic and diluted

 

 

54,628,670

 

 

 

 

45,708,649

 

 

 

 

52,717,020

 

 

 

 

43,117,403

 

 

Investors:

Andy Meyer

Janux Therapeutics

ameyer@januxrx.com

(202) 215-2579

Media:

Jessica Yingling, Ph.D.

Little Dog Communications Inc.

jessica@litldog.com

(858) 344-8091

Source: Janux Therapeutics

FAQ

What was Janux Therapeutics (JANX) Q3 2024 net loss?

Janux Therapeutics reported a net loss of $28.1 million for Q3 2024, compared to $11.6 million in Q3 2023.

How much cash and investments did JANX have at the end of Q3 2024?

Janux reported $658.0 million in cash, cash equivalents, and short-term investments as of September 30, 2024.

When will JANX provide updates on JANX007 and JANX008 clinical trials?

Janux expects to provide updates on JANX007 data and expansion cohort doses in 2024, while JANX008 data updates are anticipated in 2025.

What are the current clinical trials JANX is conducting?

Janux is conducting Phase 1 trials for JANX007 in metastatic castration-resistant prostate cancer and JANX008 in advanced or metastatic solid tumors.

Janux Therapeutics, Inc.

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SAN DIEGO