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Jaguar Health, Inc. (NASDAQ: JAGX) is a commercial-stage pharmaceuticals company specializing in the development of novel prescription medicines sustainably derived from natural plant sources in rainforest areas. The company's primary focus is on addressing gastrointestinal (GI) distress in both humans and animals, with an emphasis on chronic debilitating diarrhea and associated symptoms such as urgency, bowel incontinence, and cramping pain.
Jaguar Health operates through several subsidiaries, including Napo Pharmaceuticals, Inc., which develops and commercializes proprietary human GI pharmaceuticals globally. One of its flagship products, Mytesi® (crofelemer), is FDA-approved for symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy. The company’s lead animal prescription drug candidate, Canalevia™, targets forms of diarrhea in dogs, while Equilevia™ supports total gut health in equine athletes.
In addition, Jaguar Health, through its Napo Pharmaceuticals subsidiary, is advancing the development of crofelemer with the ongoing OnTarget study, a pivotal Phase 3 clinical trial aimed at the preventive treatment of chemotherapy-induced overactive bowel (CIOB) in adults with cancer on targeted therapy. Crofelemer has also been designated an Orphan Drug by the FDA and European Medicines Agency for short bowel syndrome (SBS) and microvillus inclusion disease (MVID).
Jaguar Health’s commitment to cancer supportive care is showcased through its preparation to launch Gelclair®, an FDA-approved oral mucositis prescription product, in Q3 2024. This initiative is part of their broader strategy to support cancer patients facing severe treatment side effects.
Beyond GI distress, Jaguar Health has a joint venture called Magdalena Biosciences, in collaboration with Filament Health Corp. This venture focuses on developing plant-based prescription medicines for mental health indications. A recent out-licensing agreement with Magdalena includes a botanical drug candidate for potential schizophrenia and psychoses indications.
Jaguar Health’s financial performance reflects consistent growth, with Q1 2024 revenue at approximately $2.4 million, showing a 20% increase from Q1 2023. Despite operational losses, the company continues to invest in research and development, particularly for rare disease treatments.
For more information, visit Jaguar Health, Napo Pharmaceuticals, Napo Therapeutics, and Magdalena Biosciences. Stay connected with Jaguar Health on LinkedIn, X (formerly Twitter), and Instagram.
Jaguar Health (NASDAQ:JAGX) announced that its subsidiary, Napo Pharmaceuticals, is sponsoring the National Trans Visibility March (NTVM) starting September 28, 2020. In conjunction with this event, Napo will host a virtual workshop on the gastrointestinal (GI) consequences of HIV on September 30, 2020, led by advocate Marissa Miller. Jaguar focuses on plant-based, non-opioid medicines for GI distress, with its product Mytesi approved for treating noninfectious diarrhea in HIV/AIDS patients. The company emphasizes its commitment to health equity and support for marginalized communities.
Jaguar Health (NASDAQ:JAGX) will host its inaugural Diarrhea Dialogues virtual event on October 20, 2020, from 3:00 PM to 4:30 PM EDT. The event focuses on supportive care for cancer patients, specifically addressing debilitating diarrhea caused by cancer therapies. Esteemed oncologists, patient advocates, and Jaguar executives will participate, discussing the significant impact of diarrhea on treatment and quality of life. Additionally, Napo Pharmaceuticals, a subsidiary of Jaguar, is advancing research on Mytesi (crofelemer) for the relief of therapy-related diarrhea.
Jaguar Health, Inc. (NASDAQ:JAGX) will present at the 2020 H.C. Wainwright 22nd Annual Global Investment Conference on September 16 at 3:00 PM ET. Founder and CEO Lisa Conte will lead the presentation, which focuses on the company's innovative, plant-based pharmaceuticals for gastrointestinal distress. Institutional investors can register for the conference here to arrange one-on-one meetings with Jaguar.
Jaguar's Mytesi (crofelemer) is FDA-approved for noninfectious diarrhea relief in adults with HIV/AIDS.
Jaguar Health, Inc. (JAGX) announced a third amendment to its accounts receivable purchase agreement with Oasis Capital, LLC, allowing Oasis to purchase an additional $2,329,662.72 in accounts receivable related to the sales of Mytesi drug product. This financing aims to enhance the company's cash flow without diluting shareholder equity.
The agreement entails a purchase price of $990,106.65 and a transaction fee of $5,000. This follows the success of previous tranches and indicates Jaguar's commitment to a stable cash flow positive business strategy.
Jaguar Health, Inc. (JAGX) announced on September 2, 2020, it has completed transactions boosting its stockholders' equity above $5 million, meeting the Nasdaq Capital Market's initial listing requirement. Previously, the company reported $1,544,000 in equity at the end of June 2020. The transactions involved exchanging shares of preferred stock and issuing common stock, completed on September 1, 2020. These efforts aim to address a prior notification from Nasdaq regarding a breach of listing rules due to insufficient equity.
Jaguar Health, Inc. (NASDAQ:JAGX) provided updates on its investigator-initiated trials of crofelemer (Mytesi), a plant-based FDA-approved medication. Trials include: 1) Chronic Idiopathic Diarrhea, with full enrollment expected by 2020 year-end and results by mid-2021; 2) Functional Diarrhea, starting enrollment in Q4 2020 with results also anticipated in Q4 2021; and 3) Diarrhea in HER2-positive breast cancer patients, nearing enrollment completion with results due mid-2021. Mytesi uniquely treats noninfectious diarrhea in HIV/AIDS patients and aims to address significant healthcare costs associated with chronic diarrhea.
Jaguar Health, Inc. (NASDAQ:JAGX) has submitted the final technical section required by the FDA to seek approval for its oral plant-based drug, Canalevia, aimed at treating chemotherapy-induced diarrhea in dogs. With over 50,000 dogs affected annually, Canalevia would be the first FDA-approved medicine for this condition. The company anticipates conditional approval for both chemotherapy-induced and exercise-induced diarrhea by mid-2021. Jaguar’s subsidiary, Napo Pharmaceuticals, markets Mytesi, another crofelemer-based product for humans.
Jaguar Health (NASDAQ:JAGX) has submitted the final technical section to the FDA for approval of Canalevia, a plant-based drug to treat chemotherapy-induced diarrhea (CID) in dogs. This submission marks a significant step towards potentially becoming the first FDA-approved treatment for over 50,000 affected dogs annually. The filing supports conditional approval under the Minor Use/Minor Species Act. Jaguar also plans to seek approval for treating exercise-induced diarrhea. Canalevia aims to improve comfort and chemotherapy tolerance in dogs.
Jaguar Health (NASDAQ:JAGX) announced an amendment to its accounts receivable purchase agreement with Oasis Capital, LLC. This agreement involves the purchase of additional accounts receivable worth $3,152,545 related to Mytesi drug sales. Oasis will pay $1,339,831.83, with a fee of 5.45% on the total amount. The company aims to secure non-dilutive capital to enhance its cash flow. Mytesi is approved for treating noninfectious diarrhea in HIV/AIDS patients.
Jaguar Health, Inc. (NASDAQ:JAGX) announced a second amendment to its accounts receivable purchase agreement with Oasis Capital for the purchase of additional accounts receivable valued at $3,152,545 related to the sales of Mytesi drug product. Following this amendment, the Company will receive $1,339,831.83 after Oasis charges a 5.45% fee. The financing aims to support Jaguar's strategy to secure non-dilutive capital and work towards becoming a cash flow positive business.
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