Disc Medicine Announces Multiple Presentations Across Portfolio at the 66th American Society of Hematology (ASH) Annual Meeting
Disc Medicine (NASDAQ:IRON) has announced multiple presentations at the upcoming 66th American Society of Hematology (ASH) Annual Meeting in San Diego, December 7-10, 2024. The presentations include complete data from the Phase 1b trial of DISC-0974 in anemia of myelofibrosis and updates across their portfolio. The company will present clinical updates on core development programs in EPP, MF, and polycythemia vera, along with translational data from preclinical studies in new indications such as anemia of inflammatory bowel disease and sickle cell disease. Management will host a conference call on December 8 to review the presented data and discuss development plans.
Disc Medicine (NASDAQ:IRON) ha annunciato numerose presentazioni al 66° Congresso Annuale della Società Americana di Ematologia (ASH) che si terrà a San Diego, dal 7 al 10 dicembre 2024. Le presentazioni includono i dati completi del trial di Fase 1b di DISC-0974 nell'anemia dovuta a mielofibrosi e aggiornamenti sul loro portafoglio. L'azienda presenterà aggiornamenti clinici sui programmi di sviluppo principali in EPP, MF e policitemia vera, insieme a dati traslazionali provenienti da studi preclinici in nuove indicazioni come l'anemia da malattia infiammatoria intestinale e la malattia falciforme. La direzione ospiterà una conferenza telefonica l'8 dicembre per rivedere i dati presentati e discutere i piani di sviluppo.
Disc Medicine (NASDAQ:IRON) ha anunciado múltiples presentaciones en la próxima 66ª Reunión Anual de la Sociedad Americana de Hematología (ASH) que se llevará a cabo en San Diego, del 7 al 10 de diciembre de 2024. Las presentaciones incluyen datos completos del ensayo de Fase 1b de DISC-0974 en anemia de mielofibrosis y actualizaciones de su cartera. La compañía presentará actualizaciones clínicas sobre los programas de desarrollo clave en EPP, MF y policitemia vera, junto con datos traslacionales de estudios preclínicos en nuevas indicaciones como anemia de enfermedad inflamatoria intestinal y anemia de células falciformes. La dirección llevará a cabo una conferencia telefónica el 8 de diciembre para revisar los datos presentados y discutir los planes de desarrollo.
Disc Medicine (NASDAQ:IRON)은 2024년 12월 7일부터 10일까지 샌디에고에서 열리는 제66회 미국 혈액학회 (ASH) 연례 회의에서 여러 발표를 진행한다고 발표했습니다. 발표 내용에는 DISC-0974의 1b 단계 시험의 전체 데이터가 포함되어 있으며, 골수 섬유증으로 인한 빈혈에 대한 것이며, 포트폴리오에 대한 업데이트가 포함됩니다. 이 회사는 EPP, MF 및 다혈구증에 대한 핵심 개발 프로그램의 임상 업데이트를 발표하며, 염증성 장 질환과 겸상 적혈구병과 같은 새로운 적응증에 대한 전임상 연구에서의 변환 데이터도 함께 제시할 것입니다. 경영진은 12월 8일에 발표된 데이터를 검토하고 개발 계획에 대해 논의하기 위해 전화 회의를 열 것입니다.
Disc Medicine (NASDAQ:IRON) a annoncé de nombreuses présentations lors du 66e Congrès Annuel de la Société Américaine d'Hématologie (ASH) qui se tiendra à San Diego, du 7 au 10 décembre 2024. Les présentations incluront les données complètes de l'essai de Phase 1b de DISC-0974 dans l'anémie due à la myélofibrose et des mises à jour de leur portefeuille. L'entreprise présentera des mises à jour cliniques sur les programmes de développement clés dans l'EPP, la MF et la polycythémie vera, ainsi que des données translationnelles issues d'études précliniques dans de nouvelles indications telles que l'anémie de la maladie inflammatoire de l'intestin et la drépanocytose. La direction organisera une conférence téléphonique le 8 décembre pour examiner les données présentées et discuter des plans de développement.
Disc Medicine (NASDAQ:IRON) hat mehrere Präsentationen auf dem bevorstehenden 66. Jahresmeeting der American Society of Hematology (ASH) in San Diego, vom 7. bis 10. Dezember 2024, angekündigt. Zu den Präsentationen gehören die kompletten Daten der Phase-1b-Studie zu DISC-0974 bei Anämie durch Myelofibrose sowie Updates zu ihrem Portfolio. Das Unternehmen wird klinische Updates zu den zentralen Entwicklungsprogrammen in EPP, MF und polycythaemia vera präsentieren, zusammen mit translationalen Daten aus präklinischen Studien zu neuen Indikationen wie Anämie bei entzündlichen Darmerkrankungen und Sichelzellenanämie. Das Management wird am 8. Dezember eine Telefonkonferenz abhalten, um die präsentierten Daten zu überprüfen und Entwicklungspläne zu besprechen.
- Multiple clinical program updates across core development portfolio
- Expansion into new potential indications (inflammatory bowel disease and sickle cell disease)
- Complete Phase 1b trial data presentation for DISC-0974
- None.
Insights
This upcoming ASH conference presentation, while providing a comprehensive overview of Disc Medicine's clinical programs, is categorized as not impactful for immediate investor consideration. The abstracts mentioned contain previously presented data, with new analyses reserved for the actual conference.
The company will present updates on multiple programs including:
- DISC-0974 for myelofibrosis anemia
- Bitopertin for erythropoietic protoporphyria
- DISC-3405 for various hematological conditions
While these presentations may be scientifically significant, they represent routine clinical development updates rather than market-moving catalysts. The conference call scheduled for December 8th will provide more detailed information, but this announcement itself doesn't contain new material information that would immediately impact investment decisions.
- Oral presentation of complete data from Phase 1b trial of DISC-0974 in anemia of myelofibrosis (MF)
- Poster presentations across all programs, including updates from ongoing clinical studies and new translational data in preclinical models supporting use in existing and additional indications
- Management will host a conference call during the ASH meeting on Sunday, December 8 at 9:00pm EST / 6:00pm PST
WATERTOWN, Mass., Nov. 05, 2024 (GLOBE NEWSWIRE) -- Disc Medicine, Inc. (NASDAQ:IRON), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel treatments for patients suffering from serious hematologic diseases, today announced that it will present data from multiple programs in its hematology portfolio at the upcoming American Society of Hematology (ASH) Annual Meeting, which will be held in San Diego, CA on December 7-10, 2024.
“We’re delighted to be presenting such a robust set of data at ASH showcasing the significant progress we’ve made across our entire portfolio. At the meeting, we’ll be providing clinical updates on each of our core development programs, setting us up for the next stages of development in EPP, MF and polycythemia vera,” said John Quisel, J.D., Ph.D., President and Chief Executive Officer of Disc. “In addition, we look forward to sharing translational data from preclinical studies in new indications such as anemia of inflammatory bowel disease (DISC-0974) and sickle cell disease (DISC-3405), providing further evidence of the broad potential of Disc’s programs.”
Management will host a call during the ASH meeting to review highlights of the presented data and plans for next steps in development on Sunday, December 8 at 9:00pm EST / 6:00pm PST. Please register for the event on the Events and Presentations page of Disc’s website (https://ir.discmedicine.com/).
Details of Presentations and Abstracts:
The full abstracts are now available through the ASH conference website. Pursuant to Disc Medicine practice, the clinical study abstracts published today contain previously presented data; new data and analyses are reserved for presentation at the conference.
DISC-0974 Oral Presentation:
Abstract Number: 657
Title: A Phase 1b Study of DISC-0974, an Anti-Hemojuvelin Antibody, in Patients with Myelofibrosis and Anemia
Date / Time: Sunday, December 8, 5:00pm PST
Presenting Author: Naseema Gangat, M.B.B.S.
Bitopertin Poster Presentations:
Publication Number: 1089
Title: Results from the AURORA Study: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Bitopertin in Erythropoietic Protoporphyria
Date / Time: Saturday, December 7, 5:30pm – 7:30pm PST
Presenting Author: Amy Dickey, M.D., MSc
Abstract Number: 1093
Title: Results from the BEACON Trial: A Phase 2, Randomized, Open-Label Study of Bitopertin in Erythropoietic Protoporphyria
Date / Time: Sunday, December 8, 5:30pm – 7:30pm PST
Presenting Author: Gayle Ross, M.D.
Abstract Number: 3631
Title: The EPP LIGHT Study: A Survey Describing the Burden of Erythropoietic Protoporphyria and X-Linked Protoporphyria
Date / Time: Sunday, December 8, 6:00pm – 8:00pm PST
Presenting Author: Hetanshi Naik, Ph.D., M.S.
Abstract Number: 2460
Title: Inhibition of Glycine Transporter 1 Reduces Phototoxicity in a Mouse Model of Erythropoietic Protoporphyria (EPP)
Date / Time: Sunday, December 8, 6:00pm – 8:00pm PST
Presenter: Yi Xiang, Ph.D.
DISC-0974 Poster Presentations:
Abstract Number: 3849
Title: Anti-Hemojuvelin Monoclonal Antibody Reverses Anemia and Exerts Disease-Modifying Effects in a Mouse Model of Inflammatory Bowel Disease
Date / Time: Monday, December 9, 6:00pm – 8:00pm PST
Presenting Author: Julia Xu, Ph.D.
Abstract Number: 1752
Title: Anti-Hemojuvelin Monoclonal Antibody Alleviated Anemia Induced By Ruxolitinib Treatment in Mice
Date / Time: Saturday, December 7, 5:30pm – 7:30pm PST
Presenting Author: Julia Xu, Ph.D.
DISC-3405 Poster Presentations:
Abstract Number: 1092
Title: Phase 1 Healthy Volunteer Study of DISC-3405, a Recombinant Humanized Antibody Targeting TMPRSS6
Date / Time: Saturday, December 7, 5:30pm – 7:30pm PST
Presenting Author: Guowen Liu, Ph.D.
Abstract Number: 3863
Title: Pharmacological Inhibition of TMPRSS6 Decreases Hemoglobin Concentration and Red Blood Cell (RBC) Hemolysis in a Mouse Model of Sickle Cell Disease
Date / Time: Monday, December 9, 6:00pm – 8:00pm PST
Presenting Author: Silvia Giannini, Ph.D.
About Disc Medicine
Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, potentially first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. For more information, please visit www.discmedicine.com.
Disc Cautionary Statement Regarding Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, express or implied statements regarding Disc’s expectations with respect to the next stages of its development programs in EPP, MF and polycythemia vera, and with respect to the potential of its development programs in new indications. The use of words such as, but not limited to, “believe,” “expect,” “estimate,” “project,” “intend,” “future,” “potential,” “continue,” “may,” “might,” “plan,” “will,” “should,” “seek,” “anticipate,” or “could” or the negative of these terms and other similar words or expressions that are intended to identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on Disc’s current beliefs, expectations and assumptions regarding the future of Disc’s business, future plans and strategies, clinical results and other future conditions. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.
Disc may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and investors should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements as a result of a number of material risks and uncertainties including but not limited to: the adequacy of Disc’s capital to support its future operations and its ability to successfully initiate and complete clinical trials; the nature, strategy and focus of Disc; the difficulty in predicting the time and cost of development of Disc’s product candidates; Disc’s plans to research, develop and commercialize its current and future product candidates; the timing of initiation of Disc’s planned preclinical studies and clinical trials; the timing of the availability of data from Disc’s clinical trials; Disc’s ability to identify additional product candidates with significant commercial potential and to expand its pipeline in hematological diseases; the timing and anticipated results of Disc’s preclinical studies and clinical trials and the risk that the results of Disc’s preclinical studies and clinical trials may not be predictive of future results in connection with future studies or clinical trials and may not support further development and marketing approval; and the other risks and uncertainties described in Disc’s filings with the Securities and Exchange Commission, including in the “Risk Factors” section of our Annual Report on Form 10-K for the year ended December 31, 2023, and in subsequent Quarterly Reports on Form 10-Q. Any forward-looking statement speaks only as of the date on which it was made. None of Disc, nor its affiliates, advisors or representatives, undertake any obligation to publicly update or revise any forward-looking statement, whether as result of new information, future events or otherwise, except as required by law.
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