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Innovation Pharmaceuticals Inc. (IPIX) is a clinical stage biopharmaceutical company focusing on developing innovative therapies to address various unmet medical needs such as inflammatory diseases, cancer, and infectious diseases. The company recently received patents for Host Defense Protein (HDP) Mimetics and Arylamide Compounds, strengthening its Brilacidin intellectual property rights. Brilacidin, a Host Defense Protein-mimetic drug candidate, shows promise in treating inflammatory diseases of the gastrointestinal tract, viral infections, Ulcerative Proctitis/Ulcerative Proctosigmoiditis, Crohn's Disease, and moderate-to-severe hospitalized cases of COVID-19. Innovation Pharmaceuticals is actively involved in out-licensing its products, with a recent focus on Brilacidin and its potential in fungal diseases. The company is also exploring opportunities to diversify its portfolio through evaluating other investment prospects.
Innovation Pharmaceuticals (OTCQB:IPIX) has announced the publication of research demonstrating the antifungal potential of Brilacidin, a defensin-mimetic drug candidate. In pre-clinical studies, Brilacidin showed synergy with existing antifungal medications against various pathogenic fungi, potentially enhancing treatment efficacy. Notably, it converted caspofungin from fungistatic to fungicidal in cell cultures of Aspergillus fumigatus and displayed significant stand-alone activity against Cryptococcus neoformans, a major pathogen among HIV/AIDS patients. A patent application has also been filed for this promising research.
Innovation Pharmaceuticals (OTCQB: IPIX) announced new in vitro data showing that Brilacidin effectively inhibits various viruses, including alphaviruses and the bunyavirus Rift Valley Fever. This research was presented at the 2022 Military Health System Research Symposium. Brilacidin demonstrated significant antiviral activity across multiple cell lines and was found to have anti-inflammatory properties. The company is also preparing to publish results from a Phase 2 clinical trial of Brilacidin in COVID-19 patients, reinforcing its potential as a broad-spectrum antiviral.
Innovation Pharmaceuticals (OTCQB:IPIX) provided a shareholder update on September 13, 2022, regarding its investment in BT BeaMedical Technologies Ltd. The company reported significant developments, including the initiation of software integration for its surgical laser platform aimed at treating inoperable epilepsy cases and enhancing cancer treatments. BeaMed has begun engaging with regulatory agencies and has formed a distribution partnership with Fortec Medical, accessing over 2700 U.S. hospitals. These advancements are expected to reshape laser-guided surgery.
Innovation Pharmaceuticals (OTCQB:IPIX) announced progress on its Brilacidin program for Oral Mucositis (OM), showing efficacy in Phase 2 trials to reduce severe OM in head and neck cancer patients undergoing chemoradiation. Following a successful End-of-Phase 2 meeting with the FDA, the company is set for Phase 3 trials. A provider-payer analysis indicates a substantial market opportunity, forecasting $188 million in annual sales by 2030 for OM in HNC patients alone, addressing a critical unmet need with no current approved medications for OM treatment.
Innovation Pharmaceuticals (OTCQB:IPIX) announced that new research on Brilacidin's antiviral activity against bunyaviruses and alphaviruses has been accepted for a Poster Presentation at the 2022 Military Health System Research Symposium (MHSRS), scheduled for September 12-15, 2022. Brilacidin is being studied as a broad-spectrum antiviral drug candidate, with previous findings also presented at MHSRS. This research is part of ongoing efforts to develop therapies for infectious diseases, as the company continues to evaluate its clinical trials, including those related to COVID-19.
Innovation Pharmaceuticals (OTCQB:IPIX) announces significant findings regarding its drug Brilacidin, which exhibits broad-spectrum antiviral activity against multiple SARS-CoV-2 variants, including Omicron, Delta, Gamma, and Alpha, as evidenced by recent in vitro tests conducted with the NIH. These promising results demonstrate Brilacidin's ability to inhibit various coronaviruses, supporting its potential as a COVID-19 treatment. The company remains focused on addressing funding opportunities and partnerships to advance Brilacidin's development.
Innovation Pharmaceuticals (OTCQB:IPIX) has acquired a minority stake in Squalus Medical, the developer of the StingRay Laser System, aimed at treating previously inoperable epilepsy and various cancers.
The StingRay System combines innovative fiber optic technology with advanced laser capabilities for precise energy delivery, minimizing damage to surrounding tissues. Squalus will seek FDA 510(k) clearance and a CE Mark in Europe, projecting a significant market opportunity with shorter timelines than pharmaceuticals.
Innovation Pharmaceuticals (OTCQB:IPIX) announced a significant milestone with the publication of a peer-reviewed article in the Journal of Medical Virology, highlighting the dual antiviral mechanism of action of Brilacidin against coronaviruses, including SARS-CoV-2. The study showcases Brilacidin's capacity to prevent viral entry by targeting host cell surfaces and directly attacking viral proteins. The company aims to secure funding for further clinical development. In addition, Scientific Advisor William F. DeGrado received accolades for his work on Brilacidin, including co-awarding the prestigious John Scott Medal.
Innovation Pharmaceuticals (OTCQB:IPIX) reported findings from its Phase 2 COVID-19 study of Brilacidin, showing promising effects in clinical improvement scores and among patients with high biomarker levels. The randomized trial with 120 hospitalized patients revealed no significant differences in primary endpoints compared to placebo, though secondary endpoint analyses indicated beneficial treatment effects. While Brilacidin showed a generally tolerable safety profile, the company focuses on securing government funding and advancing Brilacidin in other disease areas and potential business opportunities.
Innovation Pharmaceuticals (OTCQB:IPIX) announced the completion of its Phase 2 trial of Brilacidin for treating moderate-to-severe COVID-19 in hospitalized patients. The firm is analyzing unblinded data to identify trends and potential improvements in patient outcomes, including biomarker changes noted in compassionate use cases. The Company is also progressing with Brilacidin's development for Inflammatory Bowel Disease and Oral Mucositis. Additionally, Innovation is exploring acquisitions and licensing agreements for new pipeline assets.
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