Innovation Pharmaceuticals Brilacidin Antifungal Research Published in Nature Communications
Innovation Pharmaceuticals (OTCQB: IPIX) announced the publication of research on Brilacidin in Nature Communications, highlighting its potential in treating fungal infections. The study demonstrated that Brilacidin can enhance the effectiveness of existing antifungal treatments, such as caspofungin, against multiple pathogenic fungi. So far, Brilacidin has shown activity against 14 of the 19 priority fungal pathogens identified by the WHO, with ongoing research in collaboration with NIH/NIAID. The company also welcomed Dr. Gustavo H. Goldman as a Scientific Advisor. His expertise in fungal genetics aims to guide the study of Brilacidin's antifungal properties. The research emphasizes the urgent need for new antifungal agents due to growing drug resistance and limited options in current treatments.
- Publication of Brilacidin research in a prestigious journal enhances visibility and credibility.
- Demonstrated activity of Brilacidin against 14 out of 19 WHO priority fungal pathogens.
- Research collaboration with NIH/NIAID suggests strong institutional support.
- Appointment of Dr. Goldman as Scientific Advisor strengthens research capabilities.
- None.
WAKEFIELD, MA, April 17, 2023 (GLOBE NEWSWIRE) -- via NewMediaWire -- Innovation Pharmaceuticals (OTCQB:IPIX) (“the Company”), a clinical stage biopharmaceutical company, today announced publication of Brilacidin antifungal research in Nature Communications, a leading peer-reviewed scientific journal. The paper, discussing combinations of Brilacidin and other antifungal drugs toward improving treatment outcomes in fungal infections, is available at the link below:
dos Reis, T.F., de Castro, P.A., Bastos, R.W. et al. A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. Nat Commun 14, 2052 (2023). https://doi.org/10.1038/s41467-023-37573-y
To date, Brilacidin has demonstrated varying degrees of antifungal activity, both in vitro and in vivo, in 14 of 19 “priority” fungal pathogens identified by the World Health Organization, with research ongoing in collaboration with NIH/NIAID-affiliated researchers and other academic groups.
“There is a critical need for new antifungal agents,” commented Gustavo H. Goldman, Professor of Molecular Biology, at the University of São Paulo (USP), Brazil, and a Chief Editor for Frontiers in Fungal Biology. “The clinical utility of currently available antifungal treatments is limited due to emerging drug resistance, toxicity, fungistatic and not fungicidal properties, as well as drug interaction concerns. Brilacidin’s ability to potentiate marketed antifungals, such as caspofungin, in multiple human pathogenic fungi, while showing strong stand-alone potency against the hard-to-treat fungal pathogen, C. neoformans, clearly supports Brilacidin’s potential to be developed as a novel antifungal. Myself, along with team members, are looking forward to exploring Brilacidin’s direct antifungal activity and possible favorable modulation of the host response following infection.”
Dr. Goldman, a co-author of the Nature Communications paper, has now agreed to join the Company as a Scientific Advisor, helping guide the study of Brilacidin in the area of mycology and fungal diseases. He is an expert in fungal genetics and antifungal resistance and his laboratory at USP focuses on the molecular biology of human fungal pathogens. Among his scientific achievements, Dr. Goldman has authored over 300 publications, is a member of the Brazilian Academy of Sciences, and a fellow of the American Academy of Microbiology and European Confederation of Medical Mycology.
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About Innovation Pharmaceuticals
Innovation Pharmaceuticals Inc. (IPIX) is a clinical stage biopharmaceutical company developing a portfolio of innovative therapies addressing multiple areas of unmet medical need, including inflammatory diseases, cancer, and infectious diseases. The Company is also active in evaluating other potential investment opportunities that can add value and diversify its portfolio.
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