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Innate Pharma Highlights Data From Its Innovative Oncology Portfolio Selected for the SITC Annual Meeting 2024

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Innate Pharma announced new preclinical data presentations at the SITC Annual Meeting 2024, featuring two key developments: IPH6501, a tetra-specific NK cell engager targeting CD20 for B cell Non-Hodgkin Lymphoma, and IPH4502, an antibody-drug conjugate (ADC) targeting Nectin-4. The presentations include an oral session on NK Cells and Innate Immunity, chaired by CSO Eric Vivier, and two poster presentations scheduled for November 8-9, 2024, in Houston, Texas. Additionally, related research on the Nectin-4 targeting ADC was presented at the PEGS Europe Summit.

Innate Pharma ha annunciato nuove presentazioni di dati preclinici durante il Congresso Annuale SITC 2024, presentando due sviluppi chiave: IPH6501, un ingaggiante di cellule NK tetra-specifiche che mira al CD20 per il linfoma non-Hodgkin delle cellule B, e IPH4502, un coniugato anticorpo-farmaco (ADC) che targetizza il Nectin-4. Le presentazioni includono una sessione orale sulle cellule NK e l'immunità innata, presieduta dal CSO Eric Vivier, e due presentazioni poster in programma per l'8-9 novembre 2024 a Houston, Texas. Inoltre, ricerche correlate sull'ADC che colpisce il Nectin-4 sono state presentate al PEGS Europe Summit.

Innate Pharma anunció nuevas presentaciones de datos preclínicos en el Congreso Anual SITC 2024, destacando dos desarrollos clave: IPH6501, un engajador de células NK tetra-específico que apunta al CD20 para el linfoma no Hodgkin de células B, y IPH4502, un conjugado anticuerpo-fármaco (ADC) dirigido a Nectin-4. Las presentaciones incluyen una sesión oral sobre células NK e inmunidad innata, presidida por el CSO Eric Vivier, y dos presentaciones en cartel programadas para el 8-9 de noviembre de 2024 en Houston, Texas. Además, se presentó investigación relacionada con el ADC que tiene como objetivo Nectin-4 en la Cumbre PEGS Europa.

Innate PharmaSITC 연례 회의 2024에서 새로운 전임상 데이터 발표를 발표했으며, 여기에는 두 가지 주요 개발 사항이 포함됩니다: B세포 비호지킨 림프종을 위한 CD20을 겨냥한 테트라-특이적 NK 세포 연결체 IPH6501과 Nectin-4를 타겟으로 하는 항체-약물 접합체(ADC) IPH4502. 발표에는 CSO Eric Vivier가 주재하는 NK 세포 및 선천 면역에 대한 구두 세션과 2024년 11월 8-9일 텍사스 휴스턴에서 예정된 두 개의 포스터 발표가 포함됩니다. 또한 Nectin-4를 타겟으로 하는 ADC와 관련된 연구가 PEGS 유럽 정상 회의에서 발표되었습니다.

Innate Pharma a annoncé de nouvelles présentations de données précliniques lors du Congrès Annuel SITC 2024, présentant deux développements clés : IPH6501, un engageur de cellules NK tétra-spécifique ciblant le CD20 pour le lymphome non hodgkinien des cellules B, et IPH4502, un conjugué anticorps-médicament (ADC) ciblant Nectin-4. Les présentations incluent une session orale sur les cellules NK et l'immunité innée, présidée par le CSO Eric Vivier, et deux présentations d'affiches prévues pour les 8 et 9 novembre 2024 à Houston, Texas. De plus, des recherches connexes sur l'ADC ciblant Nectin-4 ont été présentées au Sommet PEGS Europe.

Innate Pharma gab neue präklinische Datenpräsentationen auf dem SITC Jahresmeeting 2024 bekannt, die zwei wesentliche Entwicklungen hervorheben: IPH6501, ein tetra-spezifischer NK-Zell-Engager, der CD20 für Non-Hodgkin-Lymphome der B-Zellen anvisiert, und IPH4502, ein Antikörper-Arzneimittel-Konjugat (ADC), das auf Nectin-4 abzielt. Zu den Präsentationen gehört eine mündliche Sitzung über NK-Zellen und angeborene Immunität, die von CSO Eric Vivier geleitet wird, sowie zwei Poster-Präsentationen, die für den 8.-9. November 2024 in Houston, Texas, geplant sind. Darüber hinaus wurde verwandte Forschung zu dem Nectin-4-zielgerichteten ADC auf dem PEGS Europa Gipfel präsentiert.

Positive
  • Development progress of two innovative cancer therapeutics platforms: NK cell engager and ADC technology
  • Selection of research for presentation at major scientific conference (SITC)
Negative
  • None.

MARSEILLE, France--(BUSINESS WIRE)-- Regulatory News:

Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) (“Innate” or the “Company”) today announced that new preclinical data supporting the clinical development of its proprietary next generation antibody-drug conjugate (ADC) and innovative tetra-specific ANKET® will be presented at the SITC Annual Meeting 2024.

“We are thrilled to share our latest preclinical data at the SITC Annual Meeting, highlighting the potential of IPH6501, our tetra-specific NK cell engager and IPH4502, our innovative ADC targeting Nectin-4. These findings underscore our commitment to advancing next-generation immunotherapies and reflect significant progress in the development of our drug candidates. We look forward to engaging with the scientific community as we continue to push the boundaries of next generation immunotherapies,” commented Pr. Eric Vivier, Chief Scientific Officer of Innate Pharma.

Details of the presentations

Society for Immunotherapy of Cancer (SITC) 39th Annual Meeting | 6-10 November, Houston, Texas and Virtual

  • Harnessing NK Cells in Cancer Therapies
    Session 107d: NK Cells and Innate Immunity
    Presentation Type: Oral Presentation
    Session Date and Time: Friday, Nov. 8, 2024, 3:50-5:25pm CST
    Presentation Time: 4:35pm CST
    Speaker: Eric Vivier, Chief Scientific Officer, Innate Pharma (co-chair of the session)

More information can be found on the JITC website.

Protein & Antibody Engineering Summit (PEGS) Europe | November 5-7, Barcelona, Spain and virtual

In addition, the presentation entitled « A Next-Generation ADC for Nectin-4 Expressing Tumours: Preclinical Characterisation of IPH45, a Novel and Differentiated Exatecan-Based ADC Targeting Nectin-4 » was presented at the PEGS Europe Summit. The presentation is available on the Company website, in the publications section.

About IPH4502

IPH4502 is a novel topoisomerase I inhibitor Antibody Drug Conjugate (ADC) conjugated to exatecan targeting Nectin-4.

Nectin-4 is a cell membrane adhesion protein overexpressed in several solid tumors, including urothelial, breast, lung, ovarian, and pancreatic cancers, with limited expression in normal tissues.

In non-clinical models, IPH4502 is well tolerated and shows anti-tumor efficacy in vitro and in vivo.

In September 2024, the U.S Food and Drug Administration cleared Innate’s investigational new drug (IND) application to initiate a Phase 1 clinical study of IPH4502 in Nectin-4 expressing solid tumor indications.

About IPH6501

IPH6501 is the first Antibody-based NK cell Engager Therapeutic to co-engage activating receptors on NK cells (NKp46 and CD16), IL-2R (but not a subunit) through a variant of human IL-2, and a tumor antigen (CD20) via a single molecule, hence providing proliferation and activation signals targeted to NK cells and promoting their cytotoxic activity against CD20 expressing malignant cells.

IPH6501 has shown better anti-tumor efficacy than approved benchmark antibodies in preclinical tumor models (Demaria, EHA 2023).

IPH6501 is currently being evaluated in a Phase 1/2 multicenter trial (NCT06088654), investigating the safety and tolerability of IPH6501 in patients with Relapsed and/or Refractory CD20-expressing B-cell Non-Hodgkin’s Lymphoma.

About Innate Pharma

Innate Pharma S.A. is a global, clinical-stage biotechnology company developing immunotherapies for cancer patients. Its innovative approach aims to harness the innate immune system through three therapeutic approaches: monoclonal antibodies, multi-specific NK Cell Engagers via its ANKET® (Antibody-based NK cell Engager Therapeutics) proprietary platform and Antibody Drug Conjugates (ADC).

Innate’s portfolio includes lead proprietary program lacutamab, developed in advanced form of cutaneous T cell lymphomas and peripheral T cell lymphomas, monalizumab developed with AstraZeneca in non-small cell lung cancer, several ANKET® drug candidates to address multiple tumor types as well as IPH4502 a differentiated ADC in development in solid tumors.

Innate Pharma is a trusted partner to biopharmaceutical companies such as Sanofi and AstraZeneca, as well as leading research institutions, to accelerate innovation, research and development for the benefit of patients.

Headquartered in Marseille, France with a US office in Rockville, MD, Innate Pharma is listed on Euronext Paris and Nasdaq in the US.

Learn more about Innate Pharma at www.innate-pharma.com and follow us on LinkedIn and X.

Information about Innate Pharma shares

ISIN code
Ticker code
LEI

FR0010331421

Euronext: IPH Nasdaq: IPHA

9695002Y8420ZB8HJE29

Disclaimer on forward-looking information and risk factors

This press release contains certain forward-looking statements, including those within the meaning of applicable securities laws, including the Private Securities Litigation Reform Act of 1995. The use of certain words, including “anticipate,” “believe,” “can,” “could,” “estimate,” “expect,” “may,” “might,” “potential,” “expect” “should,” “will,” or the negative of these and similar expressions, is intended to identify forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. These risks and uncertainties include, among other things, the uncertainties inherent in research and development, including related to safety, progression of and results from its ongoing and planned clinical trials and preclinical studies, review and approvals by regulatory authorities of its product candidates, the Company’s reliance on third parties to manufacture its product candidates, the Company’s commercialization efforts and the Company’s continued ability to raise capital to fund its development. For an additional discussion of risks and uncertainties, which could cause the Company's actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (“Facteurs de Risque") section of the Universal Registration Document filed with the French Financial Markets Authority (“AMF”), which is available on the AMF website http://www.amf-france.org or on Innate Pharma’s website, and public filings and reports filed with the U.S. Securities and Exchange Commission (“SEC”), including the Company’s Annual Report on Form 20-F for the year ended December 31, 2023, and subsequent filings and reports filed with the AMF or SEC, or otherwise made public by the Company. References to the Company’s website and the AMF website are included for information only and the content contained therein, or that can be accessed through them, are not incorporated by reference into, and do not constitute a part of, this press release.

In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by the Company or any other person that the Company will achieve its objectives and plans in any specified time frame or at all. The Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

This press release and the information contained herein do not constitute an offer to sell or a solicitation of an offer to buy or subscribe to shares in Innate Pharma in any country.

For additional information, please contact:

Investors

Innate Pharma

Henry Wheeler

Tel.: +33 (0)4 84 90 32 88

Henry.wheeler@innate-pharma.fr



Media Relations

NewCap

Arthur Rouillé

Tel.: +33 (0)1 44 71 00 15

innate@newcap.eu

Source: Innate Pharma SA

FAQ

What new treatments will Innate Pharma (IPHA) present at SITC 2024?

Innate Pharma will present preclinical data on IPH6501, a tetra-specific NK cell engager targeting CD20, and IPH4502, an ADC targeting Nectin-4.

When and where will Innate Pharma (IPHA) present at SITC 2024?

The presentations will take place November 6-10, 2024, in Houston, Texas, with specific presentations scheduled for November 8-9, 2024.

What is IPH6501 being developed for by Innate Pharma (IPHA)?

IPH6501 is being developed for relapsed or refractory B cell Non-Hodgkin Lymphoma subtypes and post-CAR-T therapy.

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