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Company Overview
Innate Pharma SA (IPHA) is a clinical-stage biotechnology company that has made significant strides in the field of immuno-oncology by developing innovative therapeutic antibodies. By harnessing the innate immune system, the company addresses unmet medical needs in cancer treatment. Its work in mobilizing natural killer (NK) cells to recognize and eradicate cancer cells places it at a unique intersection of cutting‐edge science and clinical application.
Clinical Pipeline and Technological Innovations
The company has built a diversified pipeline comprising first-in-class clinical stage antibodies and preclinical candidates. Its proprietary platforms, such as the antibody-based NK cell engager therapeutics framework, exemplify its commitment to advancing immunotherapies. This technological edge has allowed Innate Pharma SA to explore a broad range of cancer indications and develop treatments that aim to provide improved outcomes and more targeted therapeutic effects.
Strategic Collaborations and Revenue Model
Revenue for Innate Pharma SA is generated primarily through research agreements, licensing deals, and strategic collaborations with established biopharma companies. These partnerships not only provide financial support but also validate the scientific merit of its approach. Collaborations with industry giants have enabled the company to accelerate clinical development and expand its research capabilities, underlining its credibility within the scientific community.
Innovative Approach and Core Expertise
At the core of Innate Pharma SA’s strategy is an innovative approach that leverages the innate immune system’s natural ability to combat cancer. The company’s deep expertise in natural killer cell biology distinguishes its methods from conventional immunotherapies that primarily target adaptive immune responses. This focused approach has paved the way for the discovery and development of novel checkpoint inhibitors and other therapeutic antibodies which are designed to reinvigorate the immune response against malignancies.
Market Position and Industry Significance
Innate Pharma SA is positioned as a pioneering entity within the immunotherapy sector. Its innovative research and comprehensive pipeline contribute to its reputation as an organization with substantial scientific industrial relevance. By addressing complex cancer biology through innovative solutions, the company plays a critical role in the broader narrative of modern oncology and immunotherapy. The content herein offers an in-depth perspective on how its clinical-stage initiatives and collaborative model set it apart in a competitive landscape.
Research, Development, and Operational Excellence
The company emphasizes a rigorous research and development ethos, meticulously navigating the challenges and complexities of immuno-oncology. Its operational strategy is built on scientific excellence and the clear intent to explore transformative cancer therapies. This approach not only reinforces its research credentials but also ensures that every innovation is subjected to strict scientific scrutiny, thereby upholding high standards of quality and efficacy.
Summary
In summary, Innate Pharma SA is a clinical-stage biotechnology company committed to transforming cancer treatment through its advanced immunotherapies. With a diversified pipeline, robust technological innovations, and strategic partnerships, the company represents a notable presence in the landscape of immuno-oncology. Its work in harnessing the innate immune system through novel therapeutic antibodies continues to influence the evolution of cancer treatment modalities in a meaningful way.
Innate Pharma reported its 2024 financial results with several key developments. The FDA granted Breakthrough Therapy Designation to lacutamab for Sézary syndrome treatment. The company's first patient was dosed in Phase 1 study for IPH4502 (Nectin-4 ADC) in advanced solid tumors, and IPH6501 is being evaluated in B-cell non-Hodgkin's lymphoma.
Financial highlights include a cash position of €91.1 million as of December 31, 2024, with runway extended to mid-2026. Revenue decreased 67.4% to €20.1 million in 2024 (from €61.6 million in 2023). The Institute for Follicular Lymphoma Innovation (IFLI) announced up to $7.9 million investment to support IPH6501 development.
Notable pipeline progress includes positive data from the TELLOMAK Phase 2 study and advancement of the ANKET® platform programs. The company maintains strategic focus on NK-cell engager platform innovation and ADC program acceleration.
Innate Pharma (Nasdaq: IPHA) announced that an abstract for IPH4502, their novel topoisomerase I inhibitor Antibody Drug Conjugate (ADC) targeting Nectin-4, has been selected for presentation at the AACR Annual Meeting 2025 in Chicago.
IPH4502 is currently in Phase 1 clinical trials for advanced solid tumors. The drug has shown preclinical anti-tumor efficacy in models of primary and acquired resistance to enfortumab vedotin, as well as in tumors with low to moderate Nectin-4 expression, suggesting potential applications beyond urothelial carcinoma.
The presentation will take place during a poster session on Tuesday, April 29, 2025. Additionally, CEO Jonathan Dickinson will present an update on Innate's pipeline and strategy at the AACR Oncology Industry Partnering Event on April 24, 2025.
Innate Pharma (Nasdaq: IPHA) has announced its upcoming participation in the Life Sciences Van Lanschot Kempen Conference. The event is scheduled to take place in Amsterdam, Netherlands, from April 1-3, 2025. Members of the company's executive team will be attending this investor conference.
Innate Pharma (Nasdaq: IPHA) has scheduled a conference call and webcast to discuss its full year 2024 financial results on Thursday, March 27, 2025 at 2 p.m. CET / 9 a.m. EDT.
Key executives participating in the call will include Jonathan Dickinson (CEO), Sonia Quaratino (EVP, Chief Medical Officer), Yannis Morel (EVP, Chief Operating Officer), and Frédéric Lombard (SVP, Chief Financial Officer).
The webcast will be accessible through the company's website, with a replay available for 90 days following the event.
Innate Pharma (Nasdaq: IPHA) has announced its participation in the upcoming Leerink Partners 2025 Global Healthcare Conference in Miami, Florida. The event will take place at the W Hotel South Beach from March 10-12, 2025.
The company's executive team will engage in two key activities during the conference: conducting one-on-one meetings with attendees and participating in a fireside chat scheduled for Tuesday, March 11, 2025, from 3:00 to 3:30 pm ET. Both a live webcast and replay of the presentation will be accessible through the Events page in the Investors section of Innate Pharma's website.
Innate Pharma announced that the U.S. FDA has granted Breakthrough Therapy Designation (BTD) to lacutamab for treating adult patients with relapsed or refractory Sézary Syndrome after at least 2 prior systemic therapies including mogamulizumab. The designation is based on Phase 1 and Phase 2 TELLOMAK study results, which showed encouraging efficacy and favorable safety profile in heavily pretreated patients.
The BTD aims to accelerate development and regulatory review of drugs treating serious conditions. This adds to lacutamab's previous Fast Track designation (2019) and PRIME designation by European Medicines Agency (2020). The company is currently aligning with regulatory agencies regarding a confirmatory Phase 3 trial in Cutaneous T Cell Lymphoma and seeking a partnership.
Innate Pharma has announced the dosing of the first patient in its Phase 1 study of IPH4502, a novel antibody-drug conjugate (ADC) targeting Nectin-4, in patients with advanced solid tumors. The study (NCT06781983) will evaluate the safety, tolerability, and preliminary efficacy of IPH4502 as a single agent.
The trial consists of two parts: Part 1 Dose Escalation and Part 2 Dose Optimization, planning to enroll approximately 105 patients. The study targets tumors known to express Nectin-4, including urothelial carcinoma, breast cancer, non-small cell lung cancer, and gastro-intestinal cancer.
IPH4502 is designed with a differentiated topoisomerase I inhibitor payload, potentially offering benefits for patients with tumors resistant to MMAE-ADC. The drug targets tumors with both high and low Nectin-4 expression levels, supporting its development beyond urothelial carcinoma.
Innate Pharma (Nasdaq: IPHA) has announced an upcoming investor and analyst event focused on its Antibody-Drug Conjugate (ADC) strategy, specifically highlighting IPH4502, their lead Nectin-4 antibody-drug candidate program. The hybrid event will take place in New York on February 5, 2025, from 10:00 a.m. to 12:00 p.m. EDT.
The company will present the latest scientific and clinical advancements related to Nectin-4 and its potential in cancer treatment. The event will be accessible both in-person and via webcast, with a replay available on Innate Pharma's website.
Innate Pharma (Euronext Paris: IPH; Nasdaq: IPHA) has released its share and voting rights data as of December 31, 2024. The company reported 83,830,336 ordinary shares, along with 6,494 Preferred Shares 2016 and 7,581 Preferred Shares 2017.
The total number of theoretical voting rights stands at 84,585,576, which includes voting rights attached to AGAP 2016 (130 voting rights for AGAP 2016-1 and 111 for AGAP 2016-2). The total number of exercisable voting rights is 84,567,001, calculated excluding treasury shares. No voting rights are attached to AGAP 2017.
Innate Pharma (Nasdaq: IPHA) announced a new growth strategy based on three key pillars: driving innovation with their proprietary ANKET® NK-cell engager Platform, accelerating development of Antibody-Drug Conjugates (ADCs), and advancing late-stage assets through partnerships.
The company is developing IPH6501, an ANKET® therapy currently in Phase 1/2 study for CD20-expressing non-Hodgkin's Lymphoma, and IPH4502, a topoisomerase I inhibitor ADC targeting Nectin-4 in Phase 1 trials for advanced solid tumors.
For late-stage assets, Innate is seeking partners for lacutamab in advanced T cell lymphomas, while monalizumab, partnered with AstraZeneca, is in Phase 3 PACIFIC-9 trial for non-small cell lung cancer with readouts expected by end of 2026.
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