ImmunoPrecise Antibodies Successfully Engineers in silico Antibodies to Elusive Tumor Protein Using Its Patented LENSai Technology

Rhea-AI Summary

ImmunoPrecise Antibodies (IPA) has achieved a significant milestone in antibody engineering using its LENSai technology. The company successfully engineered highly specific antibodies to target a tumor microenvironment protein with previously unknown structure, entirely through computer simulations. This breakthrough demonstrates LENSai's potential to revolutionize drug discovery by:

1. Overcoming the challenge of designing therapeutics without prior structural knowledge
2. Producing antibodies that bind exclusively to the oncology target under specific conditions
3. Avoiding binding to similar proteins on healthy cells, potentially reducing side effects

This achievement could lead to faster, more efficient, and cost-effective development of targeted cancer therapies, addressing the industry's high failure rates and lengthy development timelines.

Positive

• Successfully engineered highly specific antibodies for a challenging oncology target using AI-driven LENSai technology
• Demonstrated ability to design antibodies without prior structural knowledge of the target protein
• Potential to significantly reduce time and cost of drug development compared to traditional methods
• Engineered antibodies show specificity to the target protein while avoiding binding to similar proteins on healthy cells

Negative

• None.

Biotechnology Expert

This breakthrough in in silico antibody engineering using LENSai technology is a game-changer for the biotech industry. By successfully designing antibodies for a tumor microenvironment protein without prior structural information, IPA has demonstrated the power of AI in overcoming major hurdles in drug discovery. This achievement could significantly reduce time and costs associated with antibody development, potentially accelerating the path to market for new cancer therapies.

The ability to create highly specific antibodies that don't bind to similar proteins in healthy tissues addresses a critical challenge in oncology drug development. This specificity could lead to more effective treatments with fewer side effects, a holy grail in cancer therapy. If LENSai can consistently replicate this success, it could revolutionize the $1.3 billion drug development process, potentially bringing more life-saving treatments to patients faster and at lower costs.

Oncology Researcher

The success of LENSai in engineering antibodies for a tumor microenvironment (TME) protein is particularly exciting from an oncology perspective. The TME plays a important role in cancer progression and resistance to therapy, making it a prime target for new treatments. However, its complexity and the harsh conditions within tumors have made it challenging to develop effective therapies.

By creating antibodies that can specifically bind to TME proteins under these conditions, IPA opens up new possibilities for targeted cancer treatments. This approach could lead to therapies that are more effective at penetrating and disrupting the tumor microenvironment, potentially enhancing the body's immune response against cancer. The reduced risk of off-target effects is also significant, as it could mean safer treatments with fewer side effects for patients.

AI and Drug Discovery Analyst

IPA's achievement with LENSai represents a significant leap in AI-driven drug discovery. The ability to engineer antibodies in silico for a protein with unknown structure demonstrates the advanced capabilities of machine learning in predicting protein structures and designing targeted therapeutics. This could dramatically accelerate the drug discovery pipeline, reducing the need for extensive experimental work in the early stages.

The potential impact on the industry is substantial. By potentially cutting down the 10-15 year development cycle and reducing the $1.3 billion average cost of bringing a drug to market, LENSai could enable pharmaceutical companies to pursue a wider range of therapeutic targets. This could lead to a more diverse and robust drug development landscape, potentially resulting in more treatment options for patients across various diseases, not just in oncology.

Engineering antibodies in silico using LENS^ai™ marks a significant milestone toward the complete de novo design of antibodies, aligning with IPA's vision to make groundbreaking and safer therapeutics instantly accessible and affordable.

Key takeaways:

• Highly Specific Binding of Novel Antibodies to a Tumor Microenvironment Protein of Previously Unknown Structure - Verified in Laboratory Setting.
• The Targeted Protein, Residing Within the Harsh Tumor Microenvironment, Represents a Key Challenge in Healthcare and the Treatment of Cancers

VICTORIA, British Columbia--(BUSINESS WIRE)-- ImmunoPrecise Antibodies Ltd. (the “Company” or “IPA”) (NASDAQ: IPA), an AI-driven biotherapeutics company, today announced a groundbreaking achievement: the ability to engineer antibodies entirely through computer simulations using LENS^ai. This marks a significant milestone for the biotechnology industry. Additionally, the antibodies produced by IPA are highly specific to a challenging oncology target located within the Tumor Microenvironment (TME).

This achievement was made possible by the patented LENS^ai technologies, which began from an exceptionally challenging starting point: the target protein had no previously known structural information. Despite this, the LENS^ai platform was able to model the protein's structure and accurately engineer antibodies specifically tailored to bind to it. This is particularly significant because designing effective therapeutics without prior structural knowledge of the target is a major hurdle in drug discovery, often requiring extensive experimentation and resources. LENS^ai's ability to overcome this challenge entirely in silico highlights its advanced capabilities in computational biology and its potential to revolutionize the field of antibody engineering.

The potential therapies were engineered to bind exclusively to the oncology target under specific conditions. Importantly, it was demonstrated that these therapies do not bind to similar proteins known to be present on healthy cells and tissues, which is crucial because such binding typically leads to the negative side effects seen in chemotherapy. These findings highlight LENS^ai's ability to address one of the toughest challenges in optimizing antibodies for oncology.

“This marks a significant milestone for the biotechnology industry, demonstrating LENS^ai's ability to engineer highly specific and validated antibodies for the exceedingly difficult environment around tumors, and doing so entirely on a computer,” said Dr. Jennifer Bath, President and CEO of IPA. “This success, elevated by the fact that important details of the protein being targeted were unknown, represents a major feat in the application of LENS^ai in generating targeted and specific therapies for the potential treatment of cancer. Moreover, our continuous advancements and integrations have significantly enhanced our ability to develop these therapies faster, more efficiently, and at a reduced cost compared to traditional methods.”

Historically, biologic drug discovery has been a risky, time-consuming, and expensive endeavor, with failure rates exceeding 90%. Recent data indicates that it now costs approximately $1.3 billion and takes an average of 10 to 15 years to bring a single new drug to market, with costs potentially rising even higher depending on the complexity of the drug and therapeutic area​. The market has seen major successes like Humira, which has shown potential in the tumor microenvironment and has generated over $20 billion in annual sales. Similarly, Keytruda has demonstrated effectiveness in modulating the tumor microenvironment and has generated over $14 billion annually. However, the time, cost, and risk associated with developing such biologics have historically limited the number of these therapies that can be pursued, creating a bottleneck in the availability of life-saving treatments.

“The successful application of LENS^ai, along with laboratory validation of these novel antibodies, underscores LENS^ai’s potential to accelerate the development of precision-targeted treatments, aimed at more effective cancer therapies with fewer side effects,” stated Dr. Dirk Van Hyfte, MD, PhD, Co-Founder and Head of Innovation at BioStrand, an IPA subsidiary. “What LENS^ai has accomplished today is just one of the reasons we firmly believe in its ability to bring potentially life-changing biologics to patients with the power of our AI.”

About ImmunoPrecise Antibodies Ltd.

The IPA Family is a biotherapeutic research and technology group that leverages systems biology, multi-omics modelling and complex artificial intelligence systems to support its proprietary technologies in bioplatform-based antibody discovery. Services include highly specialized, full-continuum therapeutic biologics discovery, development, and out-licensing to support its business partners in their quest to discover and develop novel biologics against the most challenging targets. ImmunoPrecise Antibodies Ltd. has several subsidiaries in North America and Europe including entities such as Talem Therapeutics LLC, BioStrand BV, ImmunoPrecise Antibodies (Canada) Ltd. and ImmunoPrecise Antibodies (Europe) B.V. (collectively, the “IPA Family”). For further information, visit www.ipatherapeutics.com.

Forward Looking Information

This news release contains forward-looking statements within the meaning of applicable United States securities laws and Canadian securities laws. Forward-looking statements are often identified by the use of words such as “potential”, “plans”, “expects” or “does not expect”, “is expected”, “estimates”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved. Forward-looking information contained in this news release includes, but is not limited to, statements relating to the expected outcome on the market, the life sciences, drug discovery and development, integration and / or success of LENSai, LLMs, RAG, or HYFT technologies, including their benefits, which include accelerating the development of precision-targeted treatments, aimed at more effective cancer therapies with fewer side effects and our belief that we are bringing potentially life-changing biologics to patients with the power of our AI and statements relating to IPA’s expected increased revenue streams and financial growth. In respect of the forward-looking information contained herein, IPA has provided such statements and information in reliance on certain assumptions that management believed to be reasonable at the time, those assumptions include: the continued successful application of LENS^ai technology in engineering highly specific antibodies, including within challenging tumor microenvironments where traditional methods have been less effective; sustained market demand for AI-driven therapeutics that offer more efficient and cost-effective biologic therapies; timely regulatory approval and acceptance of therapies developed using LENS^ai, ensuring market access without significant delays; ongoing advancements and integration in AI and computational methods to enhance the efficiency and accuracy of the LENS^ai platform; the ability of LENS^ai to consistently reduce development time and costs compared to traditional drug discovery methods; and the expectation that these technological advancements will drive increased revenue streams and sustained financial growth for the Company.

Forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements stated herein to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Actual results could differ materially from those currently anticipated due to a number of factors and risks, as discussed in the Company’s Annual Report on Form 20-F for the year ended April 30, 2024 (which may be viewed on the Company’s SEDAR+ profile at www.sedar.com and EDGAR profile at www.sec.gov/edgar). Should one or more of these risks or uncertainties materialize, or should assumptions underlying the forward-looking statements prove incorrect, actual results, performance, or achievements may vary materially from those expressed or implied by the forward-looking statements contained in this news release. Accordingly, readers should not place undue reliance on forward-looking statements contained in this news release. The forward-looking statements contained in this news release are made as of the date of this release and, accordingly, are subject to change after such date. The Company does not assume any obligation to update or revise any forward-looking statements, whether written or oral, that may be made from time to time by us or on our behalf, except as required by applicable law.

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Investor Relations

Kirsten Beduya

Quantum Media Group, LLC

kirsten@quantum-corp.com

Source: ImmunoPrecise Antibodies Ltd.

FAQ

What breakthrough did ImmunoPrecise Antibodies (IPA) achieve using LENSai technology?

IPA successfully engineered highly specific antibodies to target a tumor microenvironment protein with previously unknown structure, entirely through computer simulations using LENSai technology.

How does IPA's LENSai technology potentially improve cancer treatment development?

LENSai can design antibodies without prior structural knowledge of the target, potentially leading to faster, more efficient, and cost-effective development of targeted cancer therapies with fewer side effects.

What is the significance of IPA's antibody engineering achievement for the biotechnology industry?

It demonstrates the potential to revolutionize drug discovery by overcoming challenges in designing therapeutics without prior structural knowledge and producing highly specific antibodies for difficult oncology targets.

How does IPA's LENSai technology address the issue of side effects in cancer treatments?

LENSai engineered antibodies that bind exclusively to the oncology target under specific conditions while avoiding binding to similar proteins on healthy cells, potentially reducing side effects commonly seen in chemotherapy.