Inozyme Pharma, Inc. - INZY STOCK NEWS

Inozyme Pharma, a biopharmaceutical company focused on rare diseases, announced that CEO Axel Bolte will participate in a fireside chat at the BofA Securities 2021 Virtual Healthcare Conference on May 13 at 11:45 a.m. ET. The event will be available via live webcast on Inozyme’s website, with a replay accessible for 90 days post-event. Inozyme develops innovative therapeutics targeting diseases caused by abnormal mineralization, specifically focusing on ENPP1 and ABCC6 Deficiencies. The company aims to address the underlying causes of these rare genetic conditions.

Inozyme Pharma announced promising preclinical results for its lead candidate, INZ-701, in treating ENPP1 Deficiency. Peer-reviewed findings in the Journal of Bone and Mineral Research revealed that INZ-701 increased plasma levels of pyrophosphate (PPi), improved several disease markers, and reduced mortality in ENPP1-deficient mice. Key results include a dose-dependent increase in PPi levels and prevention of ectopic calcification. Inozyme plans to initiate Phase 1/2 clinical trials for ENPP1 Deficiency in mid-2021, strengthening INZ-701's potential as a therapeutic option.

Inozyme Pharma (Nasdaq: INZY) announced the presentation of preclinical data on INZ-701, targeting ABCC6 Deficiency/Pseudoxanthoma elasticum (PXE), at two upcoming conferences. The first, at the Society for Investigative Dermatology 2021 Virtual Meeting on May 5, focuses on preventing ectopic mineralization in a mouse model. The second presentation is at the European Calcified Tissue Society 2021 Digital Congress on May 7, highlighting INZ-701's efficacy as a recombinant ENPP1-Fc protein. The company is developing therapeutics for rare diseases related to abnormal mineralization.

Inozyme Pharma presented new data revealing the significant disease burden of ENPP1 and ABCC6 Deficiencies at the ACMG annual meeting. The study showcased how these rare genetic diseases impact patients differently across age groups, highlighting severe symptoms such as cardiac issues and skeletal abnormalities. The research included responses from 38 patients across nine countries, emphasizing the need for improved diagnosis and management strategies. Inozyme is preparing to start Phase 1/2 trials for its therapy INZ-701 targeting these disorders in 2021.

Inozyme Pharma (Nasdaq: INZY) announced the presentation of a study on the burden of illness associated with infantile onset ABCC6 and ENPP1 deficiency at the ACMG Annual Clinical Genetics Meeting from April 13-16, 2021. The poster titled 'From the Voice of Patients and Caregivers: Burden of Illness in Infantile Onset ABCC6 and ENPP1 Deficiency' will be displayed starting April 14, 2021. The research focuses on these rare diseases affecting mineralization pathways. The results will be available on Inozyme’s website post-conference.

Inozyme Pharma has announced changes to its Scientific Advisory Board (SAB), welcoming three experts in vascular calcification and renal disease: W Charles O’Neill IV, Jouni Uitto, and Paul B. Yu. David Thompson, former Chief Scientific Officer, joins the SAB as well. The transition follows the departure of three members, aiming to strengthen the company's focus on rare diseases linked to mineralization abnormalities. The new appointees bring valuable expertise that will aid Inozyme in its research and development efforts.

Inozyme Pharma, Inc. (Nasdaq: INZY) received Orphan Drug Designation from the FDA for INZ-701, targeting ABCC6 deficiency. The company plans to initiate Phase 1/2 trials for both ENPP1 and ABCC6 deficiencies in 2021. As of December 31, 2020, cash reserves stood at $159.9 million, projected to fund operations into the second half of 2022. R&D expenses increased significantly to $46.5 million, driven by asset acquisitions and clinical preparations. The net loss reported was $56.4 million, translating to a loss of $5.11 per share.

Inozyme Pharma announces the feature of ENPP1 deficiency on The Balancing Act® to raise awareness about this rare, life-threatening disease with no approved treatments. The episode, airing on March 15 and March 24, 2021, will include personal stories from patients and medical professionals. The ENPP1 gene is vital for regulating mineralization and its deficiency can lead to severe health issues, especially in infants. Inozyme aims to develop therapies for these conditions, emphasizing the need for early diagnosis and proper treatment.

Inozyme Pharma (Nasdaq: INZY) announced the appointment of Dr. Deborah Wenkert as Senior Vice President and Chief Medical Officer, effective February 2, 2021. With over 20 years of experience in pediatric rheumatology and metabolic bone disorders, Dr. Wenkert will lead clinical development programs and scientific communications. She succeeds Dr. Pedro Huertas, who has left the position. Dr. Wenkert has previously held significant roles at PreciThera and Amgen, enhancing her qualifications for the new role as Inozyme advances its clinical trials for rare bone diseases, specifically ENPP1 and ABCC6 deficiencies.