Welcome to our dedicated page for Inovio Pharmaceuticals news (Ticker: INO), a resource for investors and traders seeking the latest updates and insights on Inovio Pharmaceuticals stock.
Inovio Pharmaceuticals, Inc. (NASDAQ: INO) is a pioneering United States-based biotechnology company dedicated to combating cancers and infectious diseases through DNA medicines. The company's innovative approach harnesses active DNA-based immunotherapies and vaccines to both treat and prevent these conditions.
Inovio's core technology revolves around its DNA plasmids, which are small circular DNA molecules crafted to produce specific proteins to target and fight diseases, delivered via their proprietary CELLECTRA® electroporation devices. This technology enables the body to produce its own disease-fighting proteins and immune responses, without the need for traditional adjuvants or nanoparticles.
The company's flagship candidate, INO-3107, targets Recurrent Respiratory Papillomatosis (RRP), a chronic and rare disease caused by HPV-6 and HPV-11. Inovio has shown significant clinical progress with INO-3107, and after receiving Breakthrough Therapy designation and Orphan Drug designation from both the FDA and the European Commission, it is on track to submit a Biologics License Application (BLA) under the FDA's accelerated approval program. With successful clinical trials demonstrating a robust immune response and a reduction in the need for surgical interventions, INO-3107 stands as a potential game-changer for RRP patients.
In addition to INO-3107, Inovio's expansive product pipeline includes several other promising candidates in various stages of development. These include INO-3112 for HPV-16/18 positive head and neck cancer, INO-4201 as an Ebola vaccine booster, and INO-5401 for glioblastoma, showcasing the versatility and broad applicability of the company's DNA medicine platform.
Inovio has established numerous strategic partnerships and collaborations to enhance its research and development efforts. Key partners include Roche, MedImmune, the University of Pennsylvania, DARPA, Drexel University, NIH, and the U.S. Military HIV Research Program. These collaborations not only bolster Inovio's scientific capabilities but also facilitate the swift advancement of its clinical programs.
Financially, Inovio has maintained a disciplined approach to managing its resources. The company recently projected its cash runway to extend into the second quarter of 2025, following positive feedback from the FDA on the accelerated approval pathway for INO-3107. This financial stability is crucial as Inovio prepares for potential commercialization of its lead candidates.
Inovio's commitment to innovation and its effective strategic execution position it as a formidable player in the biopharmaceutical industry, dedicated to bringing groundbreaking DNA medicine solutions to market. For more information, visit www.inovio.com.
INOVIO (NASDAQ: INO) reported a net loss of $82.1 million, or $0.39 per share, for Q2 2021, compared to a loss of $128.7 million, or $0.83 per share, in Q2 2020. Total revenue slightly increased to $273,000 from $267,000. Operating expenses rose to $83.5 million from $33.4 million, driven primarily by R&D costs associated with manufacturing scale-up for COVID-19 vaccine INO-4800. INOVIO continues advancing its COVID-19 vaccine initiatives, including the INNOVATE Phase 3 trial and the new pan-COVID-19 vaccine INO-4802.
INOVIO (NASDAQ:INO) announced regulatory approval to initiate two clinical trials in China for its COVID-19 DNA vaccine candidate, INO-4800. The trials, sponsored by Advaccine Biopharmaceuticals and Sinovac, will investigate the safety and immunogenicity of a heterologous prime-boost regimen with INO-4800 and Sinovac's CoronaVac. Following successful preclinical results demonstrating strong immune responses, the trials aim to enhance vaccination strategies against emerging COVID-19 variants. If successful, INO-4800 could serve as both a primary and booster vaccine.
INOVIO (NASDAQ: INO) has commenced Phase 2 trials for INO-4700, a DNA vaccine aimed at combating the Middle East Respiratory Syndrome (MERS). This multi-center study, involving around 500 healthy volunteers in Jordan and Lebanon, seeks to assess the safety and immunogenicity of the vaccine. The trial builds on promising results from a previous Phase 1 trial, where 98% of participants developed an immune response. Funded by a $56 million CEPI grant, INOVIO aims to provide a preventive vaccine against MERS, a deadly disease with a high fatality rate.
INOVIO (NASDAQ: INO) will release its second quarter 2021 financial results on August 9, 2021, after market close. A conference call will follow at 4:30 p.m. ET, providing insights into its DNA Medicines Platform and ongoing COVID-19 vaccine developments. The company aims to address financial results and business updates.
Notably, INOVIO's lead candidate VGX-3100 has shown promising results in clearing high-grade cervical lesions in clinical trials, while INO-4800 is currently in Phase 2 trials for COVID-19.
INOVIO (NASDAQ: INO) announced an expansion of its partnership with Advaccine Biopharmaceuticals to conduct a global Phase 3 trial for INO-4800, a DNA vaccine targeting COVID-19. The trial will evaluate the safety and efficacy of a two-dose regimen in adults across Latin America and Asia, with an emphasis on underserved regions. The Phase 3 trial follows promising Phase 2 results showing INO-4800's good tolerance and immunogenicity. The estimated cost of the trial is about $100 million, which will be shared equally with Advaccine.
Geneos Therapeutics announced positive preliminary results from its GT-30 trial, a phase I/II study of personalized vaccine GNOS-PV02 combined with pIL-12 and pembrolizumab for patients with advanced hepatocellular carcinoma (HCC). Out of 10 evaluable patients, the overall response rate was 30%, with 3 achieving partial response and 7 exhibiting disease control. The treatment was generally safe, with no serious adverse events reported. Additionally, interim results from a compassionate use case showed a patient with anaplastic astrocytoma remained recurrence-free for 36 months after treatment.
INOVIO (NASDAQ:INO) announced participation in the Jefferies 2021 Virtual Healthcare Conference on June 1, 2021. Dr. Joseph Kim, President and CEO, will engage in a fireside chat and 1x1 investor meetings at 2:00 PM EDT. INOVIO focuses on developing DNA medicines for infectious diseases, cancer, and HPV-associated conditions, with 15 clinical programs underway. Their proprietary delivery device, CELLECTRA®, allows plasmids to enter cells, generating immune responses without altering individual DNA. INOVIO has conducted over 7,000 applications in clinical trials, showcasing robust efficacy in various programs.
INOVIO (NASDAQ:INO) announced the appointment of Roger D. Dansey, M.D. to its Board of Directors, enhancing its expertise in drug development. Dr. Dansey, currently Chief Medical Officer at Seagen, has extensive experience at Merck, Gilead, and Amgen, where he led notable oncology projects. His expertise will support INOVIO's focus on its late-stage product development programs, including DNA medicines for glioblastoma and COVID-19. This strategic move aims to leverage Dr. Dansey's background to further commercialize INOVIO's innovative treatments.
INOVIO's next-generation Pan-COVID-19 vaccine candidate, INO-4802, has shown strong potential in preclinical studies, inducing robust neutralizing antibodies and T cell responses against several COVID-19 variants, including the original Wuhan strain and the B.1.1.7, B.1.351, and P.1 strains. The dual-track development approach aims to address both pandemic and endemic COVID-19 considerations. Clinical trials for INO-4802 are planned for later this year, enhancing INOVIO's strategy to provide effective cross-variant immunity.
INOVIO (NASDAQ: INO) reported its Q1 2021 financial results with total revenue of $371,000, down from $1.3 million in Q1 2020. The company posted a net loss of $54.4 million, or $0.27 per share, compared to a loss of $32.5 million, or $0.26 per share, in the previous year. INOVIO announced positive Phase 2 trial results for its COVID-19 vaccine candidate, INO-4800, demonstrating safety and immunogenicity across age groups. The company plans a global Phase 3 trial for INO-4800 and continues development of its DNA medicines for HPV-related diseases and cancer.
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