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IN8bio, Inc. - INAB STOCK NEWS

Welcome to our dedicated page for IN8bio news (Ticker: INAB), a resource for investors and traders seeking the latest updates and insights on IN8bio stock.

IN8bio, Inc. (Nasdaq: INAB) is a clinical-stage biotechnology company pioneering the development of novel therapies aimed at treating various cancers. Using allogeneic, autologous, and genetically modified gamma-delta T cells, IN8bio is revolutionizing cancer treatment. The company’s mission is to create groundbreaking therapies that harness the power of the body’s immune system to target and destroy cancer cells.

IN8bio's robust portfolio includes several promising product candidates:

  • INB-400: Aimed at treating newly diagnosed glioblastoma (GBM), this product is currently in a Phase 2 clinical trial.
  • INB-100: Designed for patients with high-risk leukemias undergoing hematopoietic stem cell transplantation, this therapy is under Phase 1 clinical trials.
  • INB-200: Another promising candidate targeting GBM, it has shown encouraging preliminary clinical data at the 2024 ASCO Annual Meeting.
  • Additional products, like INB-300 and INB-500, are in various stages of development targeting both solid and liquid tumors.

Recently, IN8bio disclosed significant advancements in the treatment of GBM, utilizing their innovative gamma-delta T cell-based adoptive cellular therapy. A peer-reviewed publication highlighted the strategy and future direction of their novel treatment methods.

Financially, IN8bio extends its cash runway into 2025, bolstered by additional capital from a private placement in December 2023. The company continues to pursue more funding to advance its clinical trials and achieve its milestones.

IN8bio's groundbreaking work has garnered attention in the biotech field, especially for its genetically modified gamma-delta T cells, which are the first to be advanced into clinical trials. The company’s approach shows great potential in improving progression-free survival (PFS) and overall survival (OS) rates for GBM and other cancers.

For investors and stakeholders, IN8bio provides exciting opportunities as it moves towards commercializing its therapies, aiming to address significant unmet medical needs in oncology. For more information, please visit IN8bio.

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IN8bio, Inc. (Nasdaq: INAB) announced a significant milestone with an oral presentation for its Phase 1 study of INB-200 at the 2023 ASCO Annual Meeting on June 2, 2023. This study evaluates the safety and efficacy of INB-200, a treatment targeting glioblastoma multiforme (GBM), a challenging brain cancer. Current treatments provide limited median progression-free survival of 6-7 months and overall survival of 14-16 months. INB-200 utilizes genetically engineered gamma-delta T cells aimed at enhancing cancer cell elimination and potentially prolonging patient survival. The abstract will be publicly accessible on ASCO's website from May 25, 2023. IN8bio also advances its DeltEx platform for developing innovative cancer therapies, currently conducting two Phase 1 trials and planning a Phase 2 trial for newly diagnosed GBM.

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IN8bio, Inc. (Nasdaq: INAB) has achieved FDA orphan drug designation for its genetically modified gamma-delta T cell therapies, INB-400 and INB-410. This designation is notable as it is the first of its kind for these therapies, offering potential 7-year market exclusivity and other benefits. INB-400, an autologous therapy, has been cleared for a Phase 2 trial targeting newly diagnosed glioblastoma multiforme (GBM), with patient enrollment set to begin in the latter half of 2023. With GBM remaining a challenging cancer with limited treatment options, IN8bio's approach combines engineered gamma-delta T cells with standard treatments to enhance tumor elimination. The company anticipates further clinical developments and updates at upcoming medical meetings.

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IN8bio, Inc. (Nasdaq: INAB) announced groundbreaking results from the Phase 1 trial of INB-100 for treating high-risk leukemia patients. As of April 21, 2023, all 7 evaluable patients achieved 100% complete remission (CR) and remain alive, with one patient surviving beyond 3 years. The treatment demonstrated significant gamma-delta T cell expansion, achieving an average of 82.9 times greater expansion at 60 days compared to standard care. Low-grade graft versus host disease was reported, with no dose-limiting toxicities observed. The company recommends Dose Level 2 as the next phase, expanding the trial to enroll more patients. A conference call is scheduled for April 24, 2023, to discuss these clinical updates and future directions.

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IN8bio has announced promising preclinical data for its innovative non-signaling CAR (nsCAR) platform, particularly in the treatment of acute myeloid leukemia (AML) targeting CD33. The recent findings, highlighted at the AACR Annual Meeting 2023, showcase the ability of gamma-delta T cells to distinguish between cancerous and healthy cells, minimizing side effects. The nsCAR platform demonstrated significant efficacy, with a CD19 targeting construct achieving 80% kill rate against leukemia cells while sparing 95% of healthy B cells. The new INB-330 program aims to address challenges in AML treatments due to CD33's presence on both leukemic cells and healthy stem cells. The company is focused on further optimizing CAR constructs for enhanced targeting capabilities, signaling potential advancements in previously difficult-to-treat cancers.

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IN8bio, a clinical-stage biopharmaceutical company, has announced new data on its investigational drug INB-100, an allogeneic gamma-delta T cell therapy for leukemia patients undergoing haploidentical stem cell transplantation. The data, set for presentation at the European Society for Blood and Marrow Transplantation meeting, shows no dose-limiting toxicities, with four patients on the initial dose level achieving durable complete remission (CR). One patient has remained progression-free for nearly three years. The study, which has demonstrated robust immune system reconstitution, is ongoing and focuses on safety, tolerability, and secondary outcomes such as relapse rates.

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IN8bio, Inc. (Nasdaq: INAB) reported strong progress in its gamma-delta T cell therapies during Q4 2022, showcasing significant clinical results. All Cohort 1 leukemia patients maintained durable complete responses, lasting 18 months to 2.7 years in the INB-100 trial. The INB-200 trial demonstrated favorable responses, with patients showing progression-free survival exceeding 1.5 years. The next-generation gamma-delta T cell therapy program, INB-300, presented promising proof-of-concept data. Financially, R&D expenses rose to $14.1 million, and a net loss of $28.5 million was recorded, with cash reserves at $18.2 million as of December 31, 2022.

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IN8bio, a clinical-stage biopharmaceutical company, announced promising preclinical results for its gamma-delta T cell therapy platform, INB-300, which targets malignant cells while preserving healthy tissue. The data highlights its potential utility in 'undruggable' tumor types. Presented at the AACR Annual Meeting 2023, INB-300 aims to distinguish between leukemic and healthy cells, achieving an 80% kill rate in leukemia cells compared to just 5% for healthy B cells. Future studies will focus on additional targets like CD33 for acute myeloid leukemia. Investors are encouraged by the innovative approach aiming to improve treatment outcomes.

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FAQ

What is the current stock price of IN8bio (INAB)?

The current stock price of IN8bio (INAB) is $0.2488 as of December 20, 2024.

What is the market cap of IN8bio (INAB)?

The market cap of IN8bio (INAB) is approximately 18.1M.

What does IN8bio, Inc. do?

IN8bio, Inc. is a biotechnology company focused on developing novel cancer therapies using allogeneic, autologous, and genetically modified gamma-delta T cells.

What are the main products of IN8bio?

IN8bio's main products include INB-400 for glioblastoma, INB-100 for high-risk leukemias, and other candidates like INB-200, INB-300, and INB-500.

What recent advancements has IN8bio made?

IN8bio recently highlighted advancements in GBM treatment using gamma-delta T cell-based adoptive cellular therapy, showing promising clinical data at the 2024 ASCO Annual Meeting.

How is IN8bio funded?

IN8bio’s operations are funded through private placements and capital investments, extending their financial runway into 2025.

What is the significance of IN8bio's gamma-delta T cells?

IN8bio's gamma-delta T cells are the first genetically modified cells advanced into clinical trials, showing potential in improving cancer treatment outcomes.

How can I learn more about IN8bio’s clinical trials?

Details about IN8bio’s clinical trials can be found on their website and clinical trial registries like clinicaltrials.gov.

What is INB-400?

INB-400 is a Phase 2 clinical trial product targeting newly diagnosed glioblastoma, showing promising preliminary data in extending progression-free survival.

Where is IN8bio headquartered?

IN8bio, Inc. is headquartered in New York, NY.

Who can I contact for investor relations?

For investor relations, contact Lee M. Stern at Meru Advisors via email at lstern@meruadvisors.com.

How does IN8bio contribute to cancer research?

IN8bio contributes by developing cutting-edge therapies that leverage the body's immune system to target cancer cells, advancing both scientific and clinical understanding of gamma-delta T cell functions.

IN8bio, Inc.

Nasdaq:INAB

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INAB Stock Data

18.12M
55.10M
21.56%
46.46%
1.38%
Biotechnology
Biological Products, (no Disgnostic Substances)
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United States of America
NEW YORK