Impel Pharmaceuticals Announces First Quarter 2022 Financial Results and Provides Corporate Update

Rhea-AI Summary

Impel Pharmaceuticals (NASDAQ: IMPL) reported a strong Q1 2022 with Trudhesa® achieving 111% growth in total prescriptions compared to Q4 2021. The company generated $1.8 million in net product revenues, an increase from zero in 2021. Research and Development expenses decreased to $3.7 million, while Selling, General and Administrative costs rose significantly to $19.8 million due to commercialization efforts. A $100 million financing agreement with Oaktree Capital extends the cash runway into 2024. The company plans to initiate the INP105 study for Autism Spectrum Disorder in Q2 2022.

Positive

• Trudhesa® prescriptions grew by 111% in Q1 2022 compared to Q4 2021.
• Net product revenues for Q1 2022 reached $1.8 million, showing positive market traction.
• A $100 million financing agreement with Oaktree Capital strengthens the balance sheet and extends the cash runway into 2024.

Negative

• Selling, General and Administrative expenses increased significantly to $19.8 million, indicating high operational costs.
• Net loss for Q1 2022 was $27.0 million, representing a considerable year-on-year increase.

Trudhesa^® Continues Strong Launch Trajectory with Q1 2022 TRx Growth of 111% vs. Q4 2021

Planned initiation of INP105 Proof-of-Concept Study for Autism Spectrum Disorder in 2Q 2022

Financing Agreement with Oaktree Capital Extends Cash Runway into 2024

Impel to Host Investor Conference Call Today at 8:30 A.M. ET

SEATTLE, May 16, 2022 (GLOBE NEWSWIRE) -- Impel Pharmaceuticals (NASDAQ: IMPL), a commercial-stage pharmaceutical company developing transformative therapies for people suffering from diseases with high unmet medical needs, with an initial focus on the central nervous system, today reported financial results for the first quarter ended March 31, 2022 and provided a corporate update.

“We are pleased to see continued strong growth and momentum with Trudhesa^®, supported by favorable market access coverage and positive physician and patient feedback,” said Adrian Adams, Chairman of the Board and Chief Executive Officer of Impel Pharmaceuticals. “Trudhesa has garnered around five percent of new branded acute migraine prescriptions in our Super Target population in only six months since launch, and with 35-45 percent of Trudhesa patients being switched from or added to gepants, we believe Trudhesa is filling a significant unmet need in the post-triptan market.”

Adams continued, “To further support the launch of Trudhesa, we entered into a $100 million royalty and debt agreement with Oaktree Capital in March. This non-dilutive capital strengthened our balance sheet, and based on current projections, extends our cash runway into 2024.”

Recent Corporate Highlights

Trudhesa^® (Dihydroergotamine Mesylate) Nasal Spray (0.725 Mg Per Spray)

• To-date, Trudhesa continues a strong trajectory with approximately 16,750 prescriptions generated since launch, through April 2022 (111 percent growth from December 31, 2021, through March 31, 2022). To-date, based on third-party data, we believe Trudhesa accounts for approximately 4.9 percent of total branded acute migraine prescriptions among Trudhesa prescribers.
• Company recently presented Trudhesa data at the American Academy of Neurology (AAN) annual meeting in April from the pivotal, Phase 3 STOP 301 trial of Trudhesa. Highlights from the data included two post-hoc analyses that suggested rapid, sustained and consistent migraine relief with Trudhesa treatment, and efficacy regardless of prior acute therapies, respectively.
• Company also plans to present additional safety and efficacy data from the pivotal, Phase 3 STOP 301 trial at the upcoming American Headache Society (AHS) Annual Scientific Meeting, taking place June 9-12, 2022 in Denver, Colorado.
  

Clinical Development

• Impel continues to advance its combination product candidate, INP105, an intranasal olanzapine product (a widely used atypical, second-generation antipsychotic) being developed as an acute treatment for agitation in persons with autism spectrum disorder using Impel’s unique Precision Olfactory Delivery (POD^®) technology. Pursuant to discussions with the U.S. Food and Drug Administration (FDA) on the protocol for the Phase 2a proof-of-concept study (the CALM 201 Study), the Company is planning to initiate the trial in the second quarter of 2022.
  

Corporate

• On April 25, the Company announced it changed its name to Impel Pharmaceuticals Inc. to reflect the ongoing corporate and strategic transformation of the Company and the potential use of its proprietary POD^® technology to treat patients suffering from diseases with high unmet needs across multiple disease areas in addition to the central nervous system.
  

Financial Results for First Quarter 2022

• Net Product Revenues: The Company’s net revenues from sales of Trudhesa was $1.8 million for the first quarter 2022. As shipments of Trudhesa were initiated to specialty pharmacies in late September 2021 ahead of the October commercial launch, there were no product revenues for the same period of 2021.
  
  
• Research and Development (R&D) Expenses: R&D expenses were $3.7 million for the first quarter 2022 compared with $4.3 million for the same periods of 2021. The decrease in R&D spending was primarily due to the reduction in Trudhesa clinical expenses as the Phase 3 study was concluded.
  
  
• Selling, General and Administrative (SG&A) Expenses: SG&A expenses were $19.8 million for the first quarter 2022, compared with $5.5 million for the same periods of 2021. The increase in SG&A spending was due primarily to the ramp up in spending to support the commercialization activities of Trudhesa.
  
  
• GAAP Net Loss: Net losses for the first quarter 2022 were $27.0 million or $1.17 per common share. This is compared to net losses of $11.4 million or $15.09 per common share for the same period in 2021.
  
  
• Non-GAAP Net Loss Per Share: Non-GAAP Net Loss Per Share for the first quarter 2022 were $1.17 compared to a Non-GAAP Net Loss Per Share of $0.54 for the same periods in 2021. Non-GAAP Pro Forma Net Loss Per Share gives effect to our reverse stock split, the shares of common stock issued in our April 2021 IPO, shares exchanged for previously issued and outstanding stock warrants of Impel, and the conversion of our convertible preferred stock and our convertible notes into shares of common stock as if such conversions occurred at the beginning of each period presented. Non-GAAP Net Loss Per Share excludes the effect of accretion on our redeemable convertible preferred stock and interest expense on our convertible notes, all of which converted to shares of common stock in our April 2021 IPO. Please refer to the section in this press release titled "Reconciliation of GAAP and Non-GAAP Results" for details.
  
  
• Cash runway into 2024
  As of March 31, 2022, Impel had approximately $130 million in cash and cash equivalents. The Company projects, based on its current operating plan, it has sufficient capital to fund operations into 2024.

Conference Call Information

Impel Pharmaceuticals’ Executive Management will host a live conference call and webcast at 8:30 a.m. ET today to discuss the first quarter 2022 financial results and provide a corporate update. The conference call may be accessed by dialing 877-295-2648 (domestic) or 470-495-9487 (international) and referring to conference ID 2468863. A live webcast of the event will be available on the Investors section of the Impel Pharmaceuticals website at https://investors.impelpharma.com/. A replay of the webcast and accompanying slides will be available on the Impel Pharmaceuticals’ website following the event.

Non-GAAP Financial Measures
We have provided in this press release certain financial information that has not been prepared in accordance with generally accepted accounting principles in the United States (“GAAP”). Our management uses these non-GAAP financial measures internally in analyzing our financial results and believes that use of these non-GAAP financial measures is useful to investors as an additional tool to evaluate ongoing operating results and trends and in comparing our financial results with other companies in our industry, many of which present similar non-GAAP financial measures. Non-GAAP financial measures are not meant to be considered in isolation or as a substitute for comparable financial measures prepared in accordance with GAAP and should be read only in conjunction with our consolidated financial statements prepared in accordance with GAAP. A reconciliation of our historical non-GAAP financial measures to the most directly comparable GAAP measures has been provided in the financial statement tables included in this press release, and investors are encouraged to review these reconciliations.

About Impel Pharmaceuticals
Impel Pharmaceuticals is a commercial-stage pharmaceutical company developing transformative therapies for people suffering from diseases with high unmet medical needs, with an initial focus on diseases of the central nervous system. Impel offers and is developing treatments that pair its proprietary POD^® technology with well-established therapeutics. In addition to Trudhesa^® nasal spray, which is approved in the U.S. for the acute treatment of migraine with or without aura in adults, Impel is also developing INP105 for the acute treatment of agitation and aggression in patients with autism.

About Impel’s Precision Olfactory Delivery (POD^®) Technology:
Impel’s proprietary POD^® technology is able to deliver a range of therapeutic molecules and formulations into the vascular-rich upper nasal space, believed to be a gateway for unlocking the previously unrealized full potential of these molecules. By delivering predictable doses of drug directly to the upper nasal space, Impel’s precision performance technology has the goal of enabling increased and consistent absorption of drug, overriding the high variability associated with other nasal delivery systems, yet without the need for an injection. While an ideal target for drug administration, to date no technology has been able to consistently deliver drugs to the upper nasal space. By utilizing this route of administration, Impel Pharmaceuticals has been able to demonstrate blood concentration levels for its investigational therapies that are comparable to intramuscular (IM) administration and can even reach intravenous (IV)-like systemic levels quickly, which could transform the treatment landscape for central nervous system (CNS) and other disorders. Importantly, the POD technology offers propellant-enabled delivery of dry powder and liquid formulations that eliminates the need for coordination of breathing, allowing for self- or caregiver-administration in a manner that may improve patient outcome, comfort, and potentially, compliance.

About Trudhesa^®
Indication
Trudhesa^® is used to treat an active migraine headache with or without aura in adults. Do not use Trudhesa to prevent migraine when you have no symptoms. It is not known if Trudhesa is safe and effective in children.

Important Safety Information

Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Trudhesa) and strong CYP3A4 inhibitors (such as protease inhibitors and macrolide antibiotics) have been reported rarely. As a result, these medications should not be taken together.

Do not use Trudhesa if you:

• Have any disease affecting your heart, arteries, or blood circulation.
• Are taking certain anti-HIV medications known as protease inhibitors (such as ritonavir or nelfinavir).
• Are taking a macrolide antibiotic such as clarithromycin or erythromycin.
• Are taking certain antifungals such as ketoconazole or itraconazole.
• Have taken certain medications such as triptans or ergot-type medications for the treatment or prevention of migraine within the last 24 hours.
• Have taken any medications that constrict your blood vessels or raise your blood pressure.
• Have severe liver or kidney disease.
• Are allergic to ergotamine or dihydroergotamine.

Before taking Trudhesa, tell your doctor if:

• You have high blood pressure, chest pain, shortness of breath, heart disease; or risk factors for heart disease (such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease or you are postmenopausal, or male over 40); or problems with blood circulation in your arms, legs, fingers, or toes.
• You have or had any disease of the liver or kidney.
• You are taking any prescription or over-the-counter medications, including vitamins or herbal supplements.
• You are pregnant, planning to become pregnant or are nursing, or have ever stopped medication due to an allergy or bad reaction.
• This headache is different from your usual migraine attacks.
  

The use of Trudhesa should not exceed dosing guidelines and should not be used on a daily basis. Serious cardiac (heart) events, including some that have been fatal, have occurred following the use of dihydroergotamine mesylate, particularly with dihydroergotamine for injection, but are extremely rare.

You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, and fatigue after using Trudhesa.
Contact your doctor immediately if you experience:

• Numbness or tingling in your fingers and toes
• Severe tightness, pain, pressure, heaviness, or discomfort in your chest
• Muscle pain or cramps in your arms or legs
• Cold feeling or color changes in one or both legs or feet
• Sudden weakness
• Slurred speech
• Swelling or itching
  

The risk information provided here is not comprehensive. To learn more, talk about Trudhesa with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at www.Trudhesa.com or 1-800-555-DRUG. You can also call 1-833-TRUDHESA (1-833-878-3437) for additional information.

About INP105:
INP105 is an upper nasal formulation of olanzapine administered using Impel’s novel POD^® technology and being developed for the potential treatment of agitation and aggression associated with autism spectrum disorder. The POD^® is a novel, simple-to-use device designed to deliver consistent and predictable doses of drug. INP105 delivers olanzapine to the richly vascularized upper nasal space to offer rapid, consistent, and optimized bioavailability that can be administered by the patient or a caregiver. Olanzapine is the most used treatment for acute agitation, but its use is limited to intramuscular injection and in a hospital setting. INP105 is intended to be a preferred choice for the safe and rapid treatment of acute agitation and because it is designed to be non-invasive, it has the potential to expand the treatment setting beyond the emergency room, such as inpatient treatment or community care facilities and the patient’s home.

Cautionary Note on Forward-Looking Statements
This press release contains “forward-looking” statements within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, including, but not limited to, the potential clinical benefits of Trudhesa^®, the market opportunities of Trudhesa within the migraine market, the speed of uptake and market growth of Trudhesa, and the timing of announcements of clinical results and clinical development activities of Impel’s product candidates. Forward-looking statements can be identified by words such as: “believe,” “may,” “will,” “potentially,” “estimate,” “continue,” “anticipate,” “intend,” “could,” “would,” “project,” “plan,” “expect” or the negative or plural of these words or similar expressions. These statements are subject to numerous risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including but not limited to, Impel’s ability to maintain regulatory approval of Trudhesa, its ability to execute its commercialization strategy for Trudhesa, its ability to develop, manufacture and commercialize its other product candidates including plans for future development of its POD^® devices and plans to address additional indications for which Impel may pursue regulatory approval, whether results of preclinical studies or clinical trials will be indicative of the results of future trials, and the effects of COVID-19 on its clinical programs and business operations. Many of these risks are described in greater detail in Impel’s filings with the Securities and Exchange Commission. Any forward-looking statements in this press release speak only as of the date of this press release. Impel assumes no obligation to update forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.

Impel, POD and the Impel logo are trademarks of Impel Pharmaceuticals Inc. To learn more about Impel Pharmaceuticals, please visit our website at https://impelpharma.com.

Contact:

Investor Relations:
Christina Tartaglia
Stern Investor Relations
Phone: (1) 212-362-1200
Email: christina.tartaglia@sternir.com

Media Relations:
Melyssa Weible
Elixir Health Public Relations
Phone: (1) 201-723-5805
Email: mweible@elixirhealthpr.com

	IMPEL PHARMACEUTICALS INC. Condensed Consolidated Balance Sheet (In thousands, except share and per share data)
			March 31, 2022				December 31, 2021
	Assets
	Current assets:
	Cash and cash equivalents		$	129,837			$	88,212
	Trade receivables, net			3,886				1,352
	Inventory			5,496				2,824
	Prepaid expenses and other current assets			2,965				2,188
	Total current assets			142,184				94,576
	Property and equipment, net			2,847				3,149
	Operating lease right-of-use assets			2,581				—
	Other assets			187				187
	Total assets		$	147,799			$	97,912
	Liabilities and stockholders’ equity
	Current liabilities:
	Accounts payable		$	8,995			$	6,367
	Accrued liabilities			11,967				8,950
	Current portion of deferred royalty obligation			1,569				—
	Current portion of operating lease liability			999				—
	Common stock warrant liability			450				637
	Total current liabilities			23,980				15,954
	Operating lease liability, net of current portion			1,594				—
	Derivative liability			405				—
	Deferred royalty obligation, net of current portion			47,232				—
	Long-term debt			47,106				29,450
	Total liabilities			120,317				45,404
	Commitments and contingencies
	Stockholders’ equity:
	Preferred stock, $0.001 par value; 10,000,000 shares authorized: none issued			—				—
	Common stock, $0.001 par value; 300,000,000 shares authorized; 23,173,297 and 23,037,298 shares issued and outstanding at March 31, 2022 and December 31, 2021, respectively			23				23
	Additional paid-in capital			269,227				267,283
	Accumulated deficit			(241,768	)			(214,798	)
	Total stockholders’ equity			27,482				52,508
	Total liabilities and stockholders’ equity		$	147,799			$	97,912

	Impel Pharmaceuticals Inc. Condensed Consolidated Statement of Operations and Comprehensive Loss (in thousands)
		For the Three Months Ended March 31,
			2022				2021
	Product revenue, net	$	1,759			$	—
	Cost of goods sold		1,033				—
	Gross profit		726				—
	Operating expenses:
	Research and development		3,650				4,346
	Selling, general and administrative		19,799				5,523
	Total operating expenses		23,449				9,869
	Loss from operations		(22,723	)			(9,869	)
	Other income (expense), net :
	Interest income (expense), net		(4,427	)			(298	)
	Other income (expense), net		180				(1,124	)
	Total other income (expense), net		(4,247	)			(1,422	)
	Loss before income taxes		(26,970	)			(11,291	)
	Provision for income taxes		—				—
	Net loss and comprehensive loss	$	(26,970	)		$	(11,291	)
	Accretion on redeemable convertible preferred stock		—				(129	)
	Net loss attributable to common stockholders	$	(26,970	)		$	(11,420	)
	Net loss per share attributable to common stockholders, basic and diluted	$	(1.17	)		$	(15.09	)
	Weighted-average shares used in computing net loss per share attributable to common stockholders, basic and diluted		23,143,773				756,986

	Impel Pharmaceuticals Inc. Earnings Per Share (in thousands, except share and per share amounts)
			For the Three Months Ended March 31,
			2022				2021
	GAAP Basic and Diluted EPS
	Numerator:
	Net loss and comprehensive loss		$	(26,970	)		$	(11,291	)
	Add: Accretion of preferred stock to redemption value			—				(129	)
	Net loss attributable to common shareholders		$	(26,970	)		$	(11,420	)
	Denominator:
	Weighted-average common shares outstanding, basic and diluted			23,143,773				756,986
	Net loss per share attributable to common shareholders, basic and diluted		$	(1.17	)		$	(15.09	)
			For the Three Months Ended March 31,
			2022				2021
	Non-GAAP loss per share information:
	Numerator:
	Historical net loss attributable to common shareholders		$	(26,970	)		$	(11,420	)
	Accretion of preferred stock to redemption value			—				129
	Change in fair value of convertible notes			—				839
	Change in fair value of redeemable convertible preferred stock warrant liabilities			—				55
	Interest expense on convertible notes			—				27
	Non-GAAP pro forma net loss attributable to common stockholders		$	(26,970	)		$	(10,370	)
	Denominator:
	Common shares outstanding:
	Weighted average common shares outstanding			23,143,773				756,986
	Shares issued in IPO			—				5,333,334
	Common shares issued upon conversion of preferred stock			—				12,605,800
	Automatic exchange of Avenue warrant			—				16,518
	Issuance of shares of common stock pursuant to the cash and net exercise of warrants			—				52,974
	Shares issued upon conversion of convertible notes			—				559,585
	Weighted-average number of common shares outstanding used to compute pro forma net loss per share, as adjusted, basic and diluted			23,143,773				19,325,197
	Pro forma net loss per share attributable to common shareholders, basic and diluted		$	(1.17	)		$	(0.54	)

FAQ

What was the revenue for Impel Pharmaceuticals (IMPL) in Q1 2022?

In Q1 2022, Impel Pharmaceuticals reported net product revenues of $1.8 million.

How much did Trudhesa prescriptions grow in Q1 2022?

Trudhesa prescriptions grew by 111% compared to Q4 2021.

What financing agreement did Impel Pharmaceuticals enter into recently?

Impel Pharmaceuticals entered a $100 million financing agreement with Oaktree Capital.

What was the net loss for Impel Pharmaceuticals in Q1 2022?

The net loss for Q1 2022 was $27.0 million.

When does Impel plan to start the INP105 study for Autism Spectrum Disorder?

Impel Pharmaceuticals plans to initiate the INP105 proof-of-concept study in Q2 2022.