Welcome to our dedicated page for I-MAB American Depositary Shares news (Ticker: IMAB), a resource for investors and traders seeking the latest updates and insights on I-MAB American Depositary Shares stock.
I-Mab American Depositary Shares (Nasdaq: IMAB) represent a leading clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of novel and highly differentiated biologics to treat diseases with unmet medical needs, focusing on cancers and autoimmune disorders. With operations in Rockville, Maryland, and San Diego, California, I-Mab is actively involved in groundbreaking research and innovative drug development.
The company’s pipeline includes several promising candidates:
- Felzartamab (TJ202): A CD38 antibody in Phase III trials for multiple myeloma and autoimmune diseases.
- Eftansomatropin (TJ101): A long-acting human growth hormone that has completed Phase II trials for pediatric growth hormone deficiency.
- Olamkicept (TJ301): An IL-6 blocker in Phase II trials for ulcerative colitis and autoimmune diseases.
- Enoblituzumab: A humanized B7-H3 antibody that has completed Phase I trials for head and neck cancer and other oncology diseases.
- Efineptakin (TJ107): A long-acting recombinant human IL-7 in Phase II trials for glioblastoma multiforme (GBM).
I-Mab's innovative pipeline is driven by its internal R&D strategies, Fast-to-Proof-of-Concept, and Fast-to-Market development, often in collaboration with global partners. Recently, I-Mab announced the divestiture of its Chinese assets and operations, aiming to focus on the U.S. and other international markets. This strategic move included the transfer of its Greater China rights for various assets, potentially generating up to US$80 million based on future milestone achievements.
Notably, the company has entered into a clinical trial collaboration with Bristol Myers Squibb to evaluate givastomig combined with nivolumab and chemotherapy as a first-line treatment for advanced Claudin 18.2-positive gastric and esophageal cancers. I-Mab’s robust development pipeline and strategic global partnerships exemplify its commitment to advancing novel therapies to address critical medical needs.
For the latest updates and detailed information, visit the official website at I-Mab Biopharma.
I-Mab, a clinical-stage biopharmaceutical company, announced a poster presentation for its proprietary CD73 antibody, uliledlimab, at the 2023 ASCO Annual Meeting in Chicago from June 2-6. The presented study features data on uliledlimab in combination with PD-1 therapy for treating non-small-cell lung cancer (NSCLC). The poster, titled 'Uliledlimab and Toripalimab Combination Therapy in Treatment Naïve Advanced NSCLC', will showcase clinical trial results that utilize CD73 as a potential predictive biomarker. I-Mab aims to leverage these findings in advancing its drug development and commercialization strategies.
Uliledlimab's unique mechanism targets the tumor microenvironment, potentially enhancing anti-tumor immune responses when used with checkpoint inhibitors. This strategic presentation could strengthen investor confidence in I-Mab’s innovative pipeline.
I-Mab (NASDAQ: IMAB) announced a favorable arbitration outcome with Tracon Pharmaceuticals on April 25, 2023, concluding a multi-year dispute. The tribunal dismissed Tracon's $200 million damages claim and confirmed the termination of both the TJD5 and BsAb agreements. I-Mab must pay a $9 million termination fee plus interests, while also covering approximately $13.5 million in Tracon's legal costs. This result enables I-Mab to expedite the development of its proprietary CD73 antibody, uliledlimab, and its bi-specific antibodies, potentially unlocking significant value by early 2024. Dr. Andrew Zhu emphasized that this victory safeguards shareholder interests and preserves the future of I-Mab's innovative assets.
I-Mab (Nasdaq: IMAB) has announced the dosing of the first patient in a Phase 3 clinical trial for lemzoparlimab, a CD47 antibody, targeting higher-risk myelodysplastic syndrome (MDS) in China. This trial, a pivotal step in the development of novel therapies for MDS, aims to evaluate the safety and efficacy of lemzoparlimab in combination with azacitidine (AZA) compared to AZA alone. MDS predominantly affects older adults, and current treatments often lead to suboptimal outcomes. Lemzoparlimab represents a potential breakthrough, as it may become the first CD47-targeting therapy approved in China. I-Mab's commitment to addressing the unmet medical needs of MDS patients is underscored by this milestone.
HI-Bio announced positive Phase 2 results for felzartamab, a monoclonal antibody targeting CD38+ plasma cells, aimed at treating Primary Membranous Nephropathy (PMN). Two studies, M-PLACE and NewPLACE, demonstrated significant reductions in pathogenic aPLA2R autoantibodies, which are linked to PMN. In M-PLACE, 31 patients showed a median reduction of 45% in aPLA2R levels as early as one week, with substantial sustainable responses observed. The drug also led to proteinuria remissions in patients resistant to current therapies. HI-Bio plans to advance felzartamab into late-stage development, targeting PMN and other autoimmune diseases. This disease affects over 36,000 patients in the U.S. with no approved treatments currently available.
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