I-Mab Announces Poster Presentation of Proprietary CD73 Antibody Uliledlimab at ASCO 2023

Rhea-AI Summary

I-Mab, a clinical-stage biopharmaceutical company, announced a poster presentation for its proprietary CD73 antibody, uliledlimab, at the 2023 ASCO Annual Meeting in Chicago from June 2-6. The presented study features data on uliledlimab in combination with PD-1 therapy for treating non-small-cell lung cancer (NSCLC). The poster, titled 'Uliledlimab and Toripalimab Combination Therapy in Treatment Naïve Advanced NSCLC', will showcase clinical trial results that utilize CD73 as a potential predictive biomarker. I-Mab aims to leverage these findings in advancing its drug development and commercialization strategies.

Uliledlimab's unique mechanism targets the tumor microenvironment, potentially enhancing anti-tumor immune responses when used with checkpoint inhibitors. This strategic presentation could strengthen investor confidence in I-Mab’s innovative pipeline.

Positive

• Presentation of uliledlimab clinical data at a major oncology conference could attract investor interest.
• Uliledlimab shows potential for enhanced anti-tumor activity when combined with PD-1 therapy.

Negative

• None.

GAITHERSBURG, Md. and SHANGHAI, April 26, 2023 /PRNewswire/ -- I-Mab (the "Company") (Nasdaq: IMAB), a clinical-stage biopharmaceutical company committed to the discovery, development, and commercialization of novel biologics, today announced that a poster featuring the latest clinical data of uliledlimab, the Company's proprietary and highly differentiated CD73 antibody, in combination with PD-1 therapy in non-small-cell lung cancer (NSCLC), will be presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place June 2-6 in Chicago, Illinois.

Presentation details:

Abstract Title:	Uliledlimab and Toripalimab Combination Therapy in Treatment Naïve Advanced NSCLC: Phase 1b/2 Clinical Trial Results Using CD73 as a Potential Predictive Biomarker
Abstract Number:	2570
Presenting Author:	Prof. Qing Zhou, Guangdong Provincial People's Hospital
Session:	Developmental Therapeutics – Immunotherapy
Location:	Hall A, McCormick Place Convention Center, Chicago, Illinois
Presentation Date/Time:	June 3, 2023, 8:00 am – 11:00 am E.T.

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About Uliledlimab

Uliledlimab (also known as TJD5) is a differentiated, humanized antibody against CD73, an ecto-enzyme expressed on stromal cells and tumors that converts extracellular adenosine monophosphate (AMP) to adenosine. Adenosine, in turn, binds to adenosine receptors on relevant immune cells and inhibits anti-tumor immune responses in the tumor microenvironment. Uliledlimab is expected to offer clinical benefits by suppressing tumor growth in concert with checkpoint therapies such as PD-(L)1 antibodies. Uliledlimab is effective in anti-tumor activities through a unique intra-dimer binding, leading to differentiated and favorable functional properties, as evident in preclinical studies.

About I-Mab

I-Mab (Nasdaq: IMAB) is a dynamic, global biotech company focused on discovery, development and soon, commercialization of novel or highly differentiated biologics in the therapeutic areas of immuno-oncology and autoimmune diseases. The Company's mission is to bring transformational medicines to patients around the world through innovation. I-Mab's innovative pipeline of more than 10 clinical and pre-clinical stage drug candidates is driven by the Company's Fast-to-Proof-of-Concept and Fast-to-Market development strategies through internal R&D and global partnerships and commercial partnerships. I-Mab has established its global footprint in Shanghai, Beijing, Hangzhou, Lishui and Hong Kong in China, and Maryland and San Diego in the United States.  For more information, please visit http://www.i-mabbiopharma.com and follow I-Mab on LinkedIn, Twitter, and WeChat.

I-Mab Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding data from clinical studies of uliledlimab, the potential implications of clinical data for patients, and I-Mab's advancement of, and anticipated clinical development, regulatory milestones, and commercialization of uliledlimab. Actual results may differ materially from those indicated in the forward-looking statements as a result of various important factors, including but not limited to I-Mab's ability to demonstrate the safety and efficacy of its drug candidates; the clinical results for its drug candidates, which may not support further development or NDA/BLA approval; the content and timing of decisions made by the relevant regulatory authorities regarding regulatory approval of I-Mab's drug candidates; I-Mab's ability to achieve commercial success for its drug candidates, if approved; I-Mab's ability to obtain and maintain protection of intellectual property for its technology and drugs; I-Mab's reliance on third parties to conduct drug development, manufacturing and other services; I-Mab's limited operating history and I-Mab's ability to obtain additional funding for operations and to complete the development and commercialization of its drug candidates; and the impact of the COVID-19 pandemic on the Company's clinical development, commercial and other operations, as well as those risks more fully discussed in the "Risk Factors" section in I-Mab's most recent annual report on Form 20-F, as well as discussions of potential risks, uncertainties, and other important factors in I-Mab's subsequent filings with the US Securities and Exchange Commission. All forward-looking statements are based on information currently available to I-Mab, and I-Mab undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law.

I-Mab Contacts

Richard Yeh	Gigi Feng
Chief Operating Officer, interim Chief Financial Officer	Chief Communications Officer
IR@i-mabbiopharma.com	PR@i-mabbiopharma.com

 

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SOURCE I-Mab

FAQ

What is uliledlimab and why is it important for I-Mab?

Uliledlimab is a proprietary CD73 antibody developed by I-Mab, which may enhance anti-tumor responses when combined with PD-1 therapies, potentially revolutionizing treatments for non-small-cell lung cancer.

When will uliledlimab clinical data be presented?

The clinical data for uliledlimab will be presented at the 2023 ASCO Annual Meeting in Chicago, specifically on June 3, 2023.

What is the significance of presenting at ASCO 2023 for I-Mab?

Presenting at ASCO 2023 allows I-Mab to showcase its innovative research, potentially increasing visibility and interest from investors and the medical community.

What type of cancer is uliledlimab targeting?

Uliledlimab is targeting non-small-cell lung cancer (NSCLC) in combination with PD-1 therapies.

What are I-Mab's future plans for uliledlimab?

I-Mab plans to advance uliledlimab toward further clinical development and potential commercialization based on the outcomes of the presented data.