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Inhibikase Therapeutics Announces Pricing of $110 Million Private Placement to Advance IkT-001Pro, an Optimized Prodrug of Imatinib, into a Late-Stage Trial in Pulmonary Arterial Hypertension

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Inhibikase Therapeutics (Nasdaq: IKT) has announced the pricing of a $110 million private placement to advance IkT-001Pro, an optimized prodrug of Imatinib, into a late-stage trial for Pulmonary Arterial Hypertension (PAH). The financing, led by Soleus Capital, involves selling 58,310,000 shares of common stock and pre-funded warrants for 21,985,000 shares, along with accompanying Series A-1 and B-1 warrants. The purchase price is $1.37 per share.

The company plans to use the proceeds to initiate a Phase 2b trial in PAH. The private placement is expected to close on October 21, 2024. Additionally, four new directors will join the company's board, including Roberto Bellini as Independent Chairperson.

Inhibikase Therapeutics (Nasdaq: IKT) ha annunciato la valutazione di un collocamento privato di 110 milioni di dollari per portare IkT-001Pro, un prodrug ottimizzato di Imatinib, in una fase avanzata di sperimentazione per l'Ipertensione Arteriosa Polmonare (PAH). Il finanziamento, guidato da Soleus Capital, prevede la vendita di 58.310.000 azioni di azioni ordinarie e di warrant pre-finanziati per 21.985.000 azioni, insieme ai warrant di Serie A-1 e B-1. Il prezzo d'acquisto è di 1,37 dollari per azione.

La società prevede di utilizzare i proventi per avviare un trial di fase 2b in PAH. Il collocamento privato dovrebbe chiudersi il 21 ottobre 2024. Inoltre, quattro nuovi direttori entreranno a far parte del consiglio di amministrazione della società, inclusi Roberto Bellini come Presidente Indipendente.

Inhibikase Therapeutics (Nasdaq: IKT) ha anunciado la fijación de un colocación privada de 110 millones de dólares para avanzar IkT-001Pro, un prodroga optimizada de Imatinib, a un ensayo en fase avanzada para la Hipertensión Arterial Pulmonar (PAH). El financiamiento, liderado por Soleus Capital, implica la venta de 58.310.000 acciones de acciones ordinarias y warrants prefinanciados para 21.985.000 acciones, junto con los warrants de la Serie A-1 y B-1. El precio de compra es de 1,37 dólares por acción.

La compañía planea utilizar los ingresos para iniciar un ensayo de fase 2b en PAH. Se espera que la colocación privada se cierre el 21 de octubre de 2024. Además, cuatro nuevos directores se unirán a la junta de la compañía, incluyendo a Roberto Bellini como Presidente Independiente.

Inhibikase Therapeutics (Nasdaq: IKT)는 폐동맥 고혈압(PAH)을 위한 최적화된 프로드럭인 IkT-001Pro를 후기 단계 임상 시험으로 진행하기 위해 1억 1천만 달러의 사모펀드 가격을 발표했습니다. 이 자금 조달은 Soleus Capital이 주도하며, 58,310,000주의 보통주와 21,985,000주의 미리 자금이 지원된 워런트를 판매하고, 이에 따른 A-1 및 B-1 시리즈 워런트가 포함됩니다. 매입 가격은 주당 1.37달러입니다.

회사는 수익금을 이용해 PAH에 대한 2b상 임상 시험을 시작할 계획입니다. 이 사모펀드는 2024년 10월 21일에 종료될 것으로 예상됩니다. 또한, 네 명의 새로운 이사가 회사 이사회에 합류할 예정이며, 로베르토 벨리니가 독립 의장으로 임명됩니다.

Inhibikase Therapeutics (Nasdaq: IKT) a annoncé la fixation d'un placement privé de 110 millions de dollars pour faire avancer IkT-001Pro, un prodrug optimisé d'Imatinib, dans un essai de phase avancée pour l'hypertension artérielle pulmonaire (PAH). Le financement, dirigé par Soleus Capital, implique la vente de 58.310.000 actions ordinaires et de warrants préfinancés pour 21.985.000 actions, ainsi que des warrants des séries A-1 et B-1. Le prix d'achat est de 1,37 dollar par action.

La société prévoit d'utiliser les recettes pour initier un essai de phase 2b en PAH. Le placement privé devrait se clôturer le 21 octobre 2024. De plus, quatre nouveaux administrateurs rejoindront le conseil d'administration de l'entreprise, y compris Roberto Bellini en tant que président indépendant.

Inhibikase Therapeutics (Nasdaq: IKT) hat die Preissetzung für eine Private Placement von 110 Millionen US-Dollar bekannt gegeben, um IkT-001Pro, eine optimierte Prodrug von Imatinib, in eine späte Testphase für pulmonale arterielle Hypertonie (PAH) voranzubringen. Die Finanzierung, geleitet von Soleus Capital, umfasst den Verkauf von 58.310.000 Aktien Stammaktien und vorfinanzierten Warrants für 21.985.000 Aktien, zusammen mit den dazugehörigen Serien A-1 und B-1 Warrants. Der Kaufpreis beträgt 1,37 USD pro Aktie.

Das Unternehmen plant, die Erlöse zu verwenden, um eine Phase 2b Studie in PAH einzuleiten. Die Privatplatzierung wird voraussichtlich am 21. Oktober 2024 abgeschlossen sein. Darüber hinaus werden vier neue Direktoren in den Vorstand des Unternehmens eintreten, darunter Roberto Bellini als unabhängiger Vorsitzender.

Positive
  • Secured $110 million in private placement financing
  • Proceeds to fund Phase 2b trial in Pulmonary Arterial Hypertension
  • Participation from notable healthcare-focused investment funds
  • Addition of four new experienced directors to the board
Negative
  • Potential dilution of existing shareholders due to new share issuance
  • Warrants may lead to further dilution if exercised
  • Two current board members resigning

Insights

This $110 million private placement is a significant financial event for Inhibikase Therapeutics, substantially bolstering their cash position. The deal structure, including common stock, pre-funded warrants and two series of warrants, is complex but provides substantial potential upside for investors.

The financing will primarily fund a Phase 2b trial for IkT-001Pro in pulmonary arterial hypertension (PAH), a important step in the drug's development. The involvement of prominent healthcare-focused funds, led by Soleus Capital, lends credibility to the company's prospects.

The board restructuring, bringing in experienced industry executives, could enhance corporate governance and strategic direction. However, the dilutive effect of this financing on existing shareholders is substantial, given the company's previous $9.5 million market cap.

The tiered warrant structure ties additional funding to clinical milestones, aligning investor returns with the company's progress. This could provide up to $275 million in total investment, a transformative amount for a company of this size.

The advancement of IkT-001Pro, an optimized prodrug of imatinib, into a late-stage trial for PAH is a significant development. Imatinib has shown promise in treating PAH, but its use has been by side effects. If IkT-001Pro can maintain efficacy while improving tolerability, it could be a major advancement in PAH treatment.

The Phase 2b trial will be important in determining the drug's potential. PAH is a serious condition with treatment options, representing a substantial market opportunity. The company's focus on Abelson Tyrosine Kinase inhibition is an innovative approach in this field.

The involvement of experienced biotech executives on the board, particularly Roberto Bellini and Amit Munshi, brings valuable expertise in late-stage drug development and commercialization. This could be critical as the company advances its lead candidate through clinical trials and potentially towards market.

-- Aggregate investment of up to approximately $275 Million by healthcare-focused investment funds, led by Soleus Capital --

BOSTON and ATLANTA, Oct. 09, 2024 (GLOBE NEWSWIRE) -- Inhibikase Therapeutics, Inc. (Nasdaq: IKT) (“Inhibikase” or the “Company”), a clinical-stage pharmaceutical company developing protein kinase inhibitor therapeutics to modify the course of cardiopulmonary and neurodegenerative disease through Abelson Tyrosine Kinase inhibition, today announced the pricing of an approximately $110 million private placement financing, before deducting placement agent fees and other offering expenses. The Company intends to use the net proceeds from the private placement to finance the initiation of a Phase 2b trial in pulmonary arterial hypertension (“PAH”) and for general corporate purposes.

The private placement was led by new investor Soleus Capital, with participation from new investors including Sands Capital, Fairmount, Blackstone Multi-Asset Investing, Commodore Capital, Perceptive Advisors, ADAR1 Capital Management, BSQUARED Capital, Nantahala Capital, Stonepine Capital Management and Spruce Street Capital.

In connection with and to be effective immediately prior to the closing of this financing, two current members of the Board of Directors, Ms. Gisele Dion and Dr. Paul Grint, will resign and four new directors will join the Company’s board: Roberto Bellini (former Chief Executive of BELLUS Health Inc. and current Managing Partner of BSQUARED Capital), Amit Munshi (current Chief Executive of Orna Therapeutics and former CEO of Arena Pharmaceuticals), Arvind Kush (current CFO of Candid Therapeutics and former CFO of RayzeBio) and David Canner (Partner at Soleus Capital). In addition, Mr. Bellini will serve as Independent Chairperson of the Board of Directors.

The Company is selling an aggregate of 58,310,000 shares of its common stock and, in lieu of common stock to certain investors, pre-funded warrants to purchase up to an aggregate of 21,985,000 shares of common stock, along with accompanying Series A-1 warrants to purchase an aggregate of 40,139,474 shares of common stock (or, in lieu thereof, additional pre-funded warrants) (the “Series A-1 Warrants”) and accompanying Series B-1 warrants to purchase an aggregate of 73,813,529 shares of common stock (or, in lieu thereof, additional pre-funded warrants) (the “Series B-1 Warrants”). The purchase price for each share of common stock and accompanying warrants is $1.37 (provided, the purchase price for each pre-funded warrant and accompanying warrants is $1.369). The pre-funded warrants have an exercise price of $0.001 per share and are exercisable at any time after their original issuance and will not expire. The accompanying Series A-1 and Series B-1 Warrants will become exercisable  at the earlier of (a) the 75th calendar day following the initial filing of the resale registration statement covering the resale of the shares of common stock issuable upon the exercise of the warrants, if the United States Securities and Exchange Commission (the “SEC”) notifies the Company that it will review the resale registration statement and (b) the 5th business day after the date the Company is notified by the SEC that the resale registration statement will not be subject to further review. Each Series A-1 Warrant will be exercisable for approximately 0.5 shares of common stock and will expire 30 days following the later of (a) the date of the Company’s public announcement of the safety and tolerability of IkT-001Pro for PAH and (b) the Company both obtaining stockholder approval to and filing an amendment to its charter to increase the number of authorized shares of common stock to a number of shares of common stock sufficient to allow for the full exercise of the warrants (the ‘Charter Amendment”). Each Series B-1 Warrant will be exercisable for approximately 0.92 shares of common stock, will become exercisable by an investor once all of such investor’s A-1 Warrants have been exercised and will expire 30 days following the later of (a) the Company’s public announcement of its Phase 2b efficacy readout for IkT-001Pro with respect to PAH and (b) the Charter Amendment. The Series A-1 Warrants have an exercise price of $1.37 per share and the Series B-1 Warrants have an exercise price of $1.49 per share. 

The PIPE is expected to close on October 21, 2024, subject to customary closing conditions.

Jefferies is acting as the lead placement agent for the private placement. Maxim Group LLC is acting as a co-placement agent.

The securities to be issued (including the shares of common stock underlying the pre-funded warrants and warrants) were offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”)and have not been registered under the Securities Act, or any state or other applicable jurisdictions’ securities laws, and may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements of the Securities Act and applicable state or other jurisdictions’ securities laws. As part of the private placement, Inhibikase Therapeutics has agreed to file a registration statement with the SEC registering the resale of the shares of common stock issued in the private placement and the shares of common stock issuable upon the exercise of the pre-funded warrants and accompanying warrants issued in the private placement, no later than 30 days after the closing of the private placement.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction. Any offering of the securities under the resale registration statement will only be made by means of a prospectus.

About Inhibikase

Inhibikase Therapeutics, Inc. (Nasdaq: IKT) is a clinical-stage pharmaceutical company developing Abelson Tyrosine Kinase inhibitor therapeutics for Cardiopulmonary and Neurodegenerative disease. Inhibikase's multi-therapeutic pipeline includes its neurodegenerative disease portfolio led by risvodetinib in Parkinson’s disease, Multiple System Atrophy and other diseases that may arise from alpha-synuclein aggregate formation. Inhibikase’s cardiopulmonary disease portfolio is led by IkT-001Pro, a prodrug of imatinib mesylate, for Pulmonary Arterial Hypertension that will deliver imatinib in a form that the Company believes will provide a better patient experience with fewer on-dosing side-effects. The Company's RAMP™ medicinal chemistry program has identified several follow-on compounds to risvodetinib that could potentially be applied to other cognitive and motor function diseases of the brain. Inhibikase is headquartered in Atlanta, Georgia with offices in Lexington, Massachusetts.

Forward-Looking Statements

This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking terminology such as "believes," "expects," "may," "will," "should," "anticipates," "plans," or similar expressions or the negative of these terms and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based on Inhibikase's current expectations and assumptions. Such statements are subject to certain risks and uncertainties, which could cause Inhibikase's actual results to differ materially from those anticipated by the forward-looking statements. Important factors that could cause actual results to differ materially from those in the forward-looking statements include our ability to enroll and complete clinical trials with risvodetinib or IkT-001Pro that demonstrate a statistically significant clinical benefit to the trial participants and whether results from our animal studies may be replicated in humans, our ability to satisfy customary closing conditions for the offering, and our ability to obtain stockholder approval to increase the number of authorized shares of common stock underlying the Series A-1 Warrants and Series B-1 Warrants, as well as such other factors that are included in our periodic reports on Form 10-K and Form 10-Q that we file with the U.S. Securities and Exchange Commission. Any forward-looking statement in this release speaks only as of the date of this release. Inhibikase undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by any applicable securities laws.

Contacts:

Company Contact:
Milton H. Werner, PhD
President & CEO
678-392-3419
info@inhibikase.com

Investor Relations:
Michael Moyer
617-308-4306
Life Science Advisors
mmoyer@lifesciadvisors.com


FAQ

What is the purpose of Inhibikase Therapeutics' $110 million private placement?

The $110 million private placement is intended to finance the initiation of a Phase 2b trial for IkT-001Pro in Pulmonary Arterial Hypertension (PAH) and for general corporate purposes.

Who led the private placement for Inhibikase Therapeutics (IKT)?

The private placement was led by new investor Soleus Capital, with participation from other healthcare-focused investment funds.

What is the purchase price for each share in Inhibikase Therapeutics' (IKT) private placement?

The purchase price for each share of common stock and accompanying warrants is $1.37.

When is Inhibikase Therapeutics' (IKT) private placement expected to close?

The private placement is expected to close on October 21, 2024, subject to customary closing conditions.

How many new directors will join Inhibikase Therapeutics' (IKT) board following this financing?

Four new directors will join the company's board, including Roberto Bellini as Independent Chairperson.

Inhibikase Therapeutics, Inc.

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