Inhibikase Therapeutics Announces Dosing of First Patient in its Phase 2 '201' Clinical Trial of IkT-148009 to Treat Parkinson's Disease
- Inhibikase Therapeutics has dosed the first patient in its Phase 2 trial for Parkinson's disease treatment
- The trial will assess the safety, tolerability, and pharmacokinetics of IkT-148009
- The trial aims to evaluate the clinical benefit of IkT-148009 for Parkinson's disease and related disorders
- None.
"Dosing of the first patient in our '201' trial completes the first milestone in our revamped Phase 2 program evaluating the clinical benefit of IkT-148009 for the treatment of Parkinson's disease and related disorders," commented Milton H. Werner, Ph.D., President and Chief Executive Officer. "Parkinson's disease remains one of the most prevalent neurodegenerative disorders and affects more than one million people in the
The '201' trial is a 1:1:1:1 randomized, double-blind, twelve-week dosing trial intending to assess the safety, tolerability and steady-state pharmacokinetics of IkT-148009 as primary endpoints. The trial will enroll approximately 120 patients with untreated Parkinson's disease (Hoehn & Yahr < 3.0) who have yet to initiate symptomatic therapy. Patients will be treated at one of three randomized doses, either 50, 100 or 200 mg given once daily, or to a placebo dose. The trial will also measure a hierarchy of fifteen Parkinson's-related disease assessments in the brain and gut as secondary endpoints and use state-of-the-art assessments in skin and spinal fluid to measure the effect of treatment on pathological alpha-synuclein.
Additional information about the trial is available at www.clinicaltrials.gov using the identifier NCT05424276.
About Inhibikase (www.inhibikase.com)
Inhibikase Therapeutics, Inc. (Nasdaq: IKT) is a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders. Inhibikase's multi-therapeutic pipeline has a primary focus on neurodegeneration and its lead program IkT-148009, an Abelson Tyrosine Kinase (c-Abl) inhibitor, targets the treatment of Parkinson's disease inside and outside the brain as well as other diseases that arise from Abelson Tyrosine Kinase. Its multi-therapeutic pipeline is pursuing Parkinson's-related disorders of the brain and GI tract, orphan indications related to Parkinson's disease such as Multiple System Atrophy, and drug delivery technologies for kinase inhibitors such as IkT-001Pro, a prodrug of the anticancer agent imatinib mesylate that the Company believes will provide a better patient experience with fewer on-dosing side-effects. The Company's RAMP™ medicinal chemistry program has identified a number of follow-on compounds to IkT-148009 to be potentially applied to other cognitive and motor function diseases of the brain. Inhibikase is headquartered in
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Contacts:
Company Contact:
Milton H. Werner, Ph.D.
President & CEO
678-392-3419
info@inhibikase.com
Investor Relations:
Alex Lobo
SternIR, Inc.
alex.lobo@sternir.com
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