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IGC Pharma Adds Advisor in Artificial Intelligence

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IGC Pharma, Inc. announces the addition of Dr. Pablo Arbelaez, an AI expert, to support the Phase 2 clinical trial of IGC-AD1 targeting agitation in Alzheimer's disease. The trial showed significant reduction in agitation, indicating strong therapeutic potential. Dr. Arbelaez will use AI to analyze disease signatures for personalized medicine, enhancing early detection methods for Alzheimer's disease.
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The engagement of Dr. Pablo Arbelaez, a distinguished AI researcher, by IGC Pharma to enhance the Phase 2 clinical trial of IGC-AD1 is a strategic move that may significantly impact the efficiency and precision of the trial outcomes. The use of AI in analyzing complex patient data can lead to more accurate patient stratification and personalized medicine approaches. This is particularly relevant in a condition like Alzheimer's disease where patient responses to treatments can be highly variable. The potential to reduce false negatives in early diagnosis is a substantial step forward, considering the current challenges in Alzheimer's disease diagnosis and the high percentage of undiagnosed cases.

From a business perspective, the ability to identify patients who are most likely to respond to IGC-AD1 can streamline the clinical trial process and improve the probability of successful outcomes, which is critical for regulatory approval and market acceptance. Furthermore, the use of advanced AI techniques such as deep learning and transformer architectures could set a new standard in the field, potentially leading to intellectual property developments and a competitive edge. The market opportunity for Alzheimer's treatments is significant, given the aging global population and the lack of effective therapies currently available.

IGC Pharma's announcement regarding the addition of Dr. Arbelaez to their advisory team can be seen as a positive signal to investors, indicating the company's commitment to innovation and its potential to disrupt the Alzheimer's treatment market. The interim results showing a significant reduction in agitation among patients is an encouraging development for IGC Pharma's stock. It suggests that IGC-AD1 could address a substantial unmet need within the Alzheimer's disease therapeutic area.

Investors should note the implications of integrating AI into the drug development process, as it may reduce time to market and development costs, which are critical factors in the biotech industry. The focus on precision medicine is in line with current industry trends and successful implementation could lead to strategic partnerships or acquisition interest from larger pharmaceutical companies seeking to expand their neurology portfolios.

The application of AI in clinical trials, as proposed by IGC Pharma, represents a convergence of biotechnology and data science that could revolutionize patient care and treatment efficacy. The use of transformer architectures, a cutting-edge AI technology, for predicting the progression of physiological and psychological variables is an innovative approach. It is important to understand that these architectures have been instrumental in significant breakthroughs in natural language processing and are now being adapted for complex biological data analysis.

For stakeholders, the key takeaway is the potential for AI to not only enhance the predictive power of clinical trials but also to provide a scalable model for future research. The insights gained from AI could lead to a more nuanced understanding of Alzheimer's disease progression and treatment response, which is invaluable for the broader medical community. The data generated could become a cornerstone for future AI-driven healthcare solutions.

POTOMAC, Md.--(BUSINESS WIRE)-- IGC Pharma, Inc. ("IGC Pharma," "IGC" or the "Company") (NYSE American: IGC) today announces the addition of Pablo Arbelaez, Ph.D., an expert in artificial intelligence (“AI”) and one of the world's top researchers. Dr. Arbelaez will support the development of the Phase 2 clinical trial of IGC-AD1, IGC Pharma’s lead therapeutic candidate targeting agitation in Alzheimer’s disease. Recent interim results from the IGC-AD1 Phase 2 trial demonstrated a clinically and statistically significant reduction in agitation compared to placebo in patients with Alzheimer's disease, indicating strong therapeutic potential.

As an Advisor, Dr. Arbelaez aims to utilize AI to analyze variations in disease signatures among patients with a view towards precision and personalized medicine. This will help IGC Pharma identify individuals who are most likely to respond to treatment and accelerate the delivery of treatments to patients. Dr. Arbelaez will advise the Company on the development and training of deep learning algorithms using state-of-the-art transformer architectures. The main goal is to predict the temporal progression of approximately 1,500 physiological and psychological variables for each patient enrolled in the IGC-AD1 Phase 2 clinical trial.

Pablo Arbeláez is a distinguished researcher with over 20 years of experience in Computer Vision and Artificial Intelligence. He obtained his undergraduate degree in Mathematics at Universidad de los Andes and a master’s in applied mathematics from Paris-Dauphine University. He earned a Ph.D. in Applied Mathematics with honors from Paris-Dauphine University in 2005. Between 2007 and 2014, he was a senior research scientist with the Computer Vision Group at the University of California, Berkeley. In 2014, Pablo Arbeláez became a professor in the Department of Biomedical Engineering at Universidad de los Andes. Since 2020, Arbeláez has been the director of the Center for Research and Formation in Artificial Intelligence (CinfonIA) at Universidad de los Andes, the first AI-focused academic center in Latin America, demonstrating his commitment to transformative AI solutions and empowering Latin American talent in the global AI community. He has contributed significantly to fundamental problems in Computer Vision, and his main research focus is on applications of Artificial Intelligence for Social Good.

Ram Mukunda, CEO of IGC Pharma, stated, "We welcome Dr. Pablo Arbelaez to our team of Senior Advisors. His expertise in AI will aid in enhancing early detection methods for Alzheimer's disease and subsequently aiding faster diagnoses, which is essential for effective treatment. According to the Alzheimer's Association, up to 50 percent of people with Alzheimer's or a similar form of dementia do not receive a formal diagnosis. By integrating AI algorithms into the screening process to analyze clinical trials and other data, and with the help of Dr. Arbelaez, the Company aims to reduce the risk of false negatives in the early diagnosis of Alzheimer's disease."

The addition of Dr. Pablo Arbelaez, Ph.D., will continue to support the positive interim results for IGC-AD1 in reducing agitation in Alzheimer's disease. The interim data validate the potential of IGC-AD1 as a transformative therapeutic option with a large market opportunity in the treatment of Alzheimer's disease.

About IGC Pharma Inc. (IGC):

IGC Pharma Inc. ("IGC") is focused on Alzheimer's disease, developing innovative solutions to address this devastating illness. The Company's mission is to transform the landscape of Alzheimer's treatment with a robust pipeline of five promising drug candidates. IGC-AD1 and LMP target the hallmarks of Alzheimer's disease, including neuroinflammation, Aβ plaques, and neurofibrillary tangles. IGC-AD1 is currently undergoing a Phase 2 clinical trial for agitation in dementia associated with Alzheimer's (clinicaltrials.gov, CT05543681). TGR-63 disrupts the progression of Alzheimer's by targeting Aβ plaques. IGC-M3, currently in preclinical development, aims to inhibit the aggregation of Aβ plaques, potentially impacting early-stage Alzheimer's. IGC-1C, also in preclinical stages, targets tau protein and neurofibrillary tangles, representing a forward-thinking approach to Alzheimer's therapy. In addition to its drug development pipeline, IGC Pharma seeks to leverage Artificial Intelligence ("AI") for Alzheimer's research. Their AI projects encompass various areas, including clinical trial optimization and early detection of Alzheimer's.

Forward-Looking Statements:

This press release contains forward-looking statements. These forward-looking statements are based largely on IGC Pharma’s expectations and are subject to several risks and uncertainties, certain of which are beyond IGC Pharma’s control. Actual results could differ materially from these forward-looking statements as a result of, among other factors, the Company’s failure or inability to commercialize one or more of the Company’s products or technologies, including the products or formulations described in this release, or failure to obtain regulatory approval for the products or formulations, where required, or government regulations affecting AI or the AI algorithms not working as intended or producing accurate predictions; general economic conditions that are less favorable than expected; the FDA’s general position regarding cannabis- and hemp-based products; and other factors, many of which are discussed in IGC Pharma’s U.S. Securities and Exchange Commission ("SEC") filings. IGC Pharma incorporates by reference the human trial disclosures and Risk Factors identified in its Annual Report on Form 10-K filed with the SEC on July 7, 2023, and Quarterly Report on Form 10-Q filed with the SEC on February 14, 2024, as if fully incorporated and restated herein. Considering these risks and uncertainties, there can be no assurance that the forward-looking information contained in this release will occur.

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Source: IGC Pharma, Inc.

FAQ

Who is joining IGC Pharma to support the Phase 2 clinical trial of IGC-AD1 targeting agitation in Alzheimer's disease?

Dr. Pablo Arbelaez, an AI expert, is joining IGC Pharma.

What did the recent interim results from the IGC-AD1 Phase 2 trial show?

The trial demonstrated a significant reduction in agitation compared to placebo in patients with Alzheimer's disease.

What will Dr. Arbelaez use AI for in the trial?

Dr. Arbelaez will analyze variations in disease signatures for precision and personalized medicine.

What is the main goal of developing deep learning algorithms in the trial?

The goal is to predict the temporal progression of physiological and psychological variables for each patient.

What is Dr. Arbelaez's background in Computer Vision and Artificial Intelligence?

Dr. Arbelaez has over 20 years of experience in Computer Vision and AI.

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