HemoShear Therapeutics Advancing Several Novel Compounds for Horizon Therapeutics plc Gout Discovery Pipeline

Rhea-AI Summary

HemoShear Therapeutics has received a milestone payment for advancing its gout treatment candidates in collaboration with Horizon Therapeutics (Nasdaq: HZNP). This payment is the fourth earned under their exclusive drug discovery agreement initiated in January 2019. The partnership combines Horizon's expertise in gout with HemoShear's REVEAL-Tx™ platform, potentially leading to over $500 million in future milestone payments and royalties. Gout affects over nine million people in the U.S., necessitating aggressive management to prevent severe pain and joint damage.

Positive

• HemoShear received a milestone payment, indicating progress in gout treatment development.
• The collaboration with Horizon has generated multiple potential first-in-class gout drug candidates.
• The partnership could yield over $500 million in milestone payments plus royalties.

Negative

• None.

CHARLOTTESVILLE, Va., Sept. 21, 2021 /PRNewswire/ -- HemoShear Therapeutics, Inc., a privately held clinical stage biotechnology company, has earned a milestone payment for the advancement of potential lead product candidates for the treatment of gout under its collaboration with Horizon Therapeutics plc (Nasdaq: HZNP). This milestone marks the fourth payment that HemoShear has earned, following previous payments for the identification and validation of two novel gout drug targets in accordance with the Horizon exclusive drug discovery agreement established in January 2019.

"Horizon has been a great partner throughout this collaboration," said Brian Wamhoff, PhD, chief operating officer of HemoShear. "By combining Horizon's expertise in gout with HemoShear's REVEAL-Tx^TM drug discovery platform, we are managing a research program that has generated new insights into the disease process, identified novel gout targets and generated several first-in-class modulators of these targets."

Under the terms of the agreement, HemoShear received an upfront payment and R&D funding, and Horizon received exclusive access to HemoShear's proprietary disease modeling platform, to discover new therapeutics for gout. Successful development and commercialization of multiple therapies by Horizon will make HemoShear eligible to receive milestone payments of potentially more than $500 million plus royalties. Further financial terms were not disclosed.  

Gout is a chronic, progressive inflammatory form of arthritis affecting more than nine million people in the United States that is caused by excess uric acid in the body and needs to be managed aggressively. If uric acid levels in the blood remain elevated, crystals can form and deposit in the joints, which can lead to severe pain, tenderness, stiffness, swelling and joint damage. In addition to the joint damage, urate crystals can also deposit in other organs of the body, and if left unmanaged, gout can lead to significant tissue damage. Uncontrolled gout occurs when people living with gout continue to have high levels of uric acid and gout symptoms despite the use of standard oral urate-lowering therapies.

About HemoShear Therapeutics

HemoShear Therapeutics, Inc. is a privately held clinical stage company developing treatments for rare metabolic disorders with significant unmet patient need. HemoShear's drug discovery platform, REVEAL-Tx™, enables the Company's scientists to create best-in-class, biologically relevant human disease models to uncover the underlying mechanisms of disease, translate those discoveries into drug targets, and select candidates that may treat patients successfully. In addition to the Company's proprietary rare disease programs, HemoShear has exclusive partnerships to identify novel therapeutic approaches in nonalcoholic steatohepatitis (NASH) and an undisclosed rare liver disease with Takeda, and in gout with Horizon Therapeutics. For more information visit www.HemoShear.com

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SOURCE HemoShear Therapeutics

FAQ

What milestone payment did HemoShear Therapeutics receive from Horizon Therapeutics?

HemoShear Therapeutics received a milestone payment for advancing its gout treatment candidates under its collaboration with Horizon Therapeutics.

What is the significance of the collaboration between HemoShear and Horizon Therapeutics?

The collaboration focuses on discovering new therapeutics for gout, potentially generating over $500 million in milestone payments for HemoShear.

How many milestone payments has HemoShear Therapeutics earned from Horizon Therapeutics?

HemoShear Therapeutics has earned four milestone payments from Horizon Therapeutics to date.

Why is gout a significant health issue in the United States?

Gout affects over nine million people in the U.S. and requires aggressive management to prevent severe pain and joint damage.