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Werewolf Therapeutics, Inc. (Nasdaq: HOWL) is a groundbreaking biopharmaceutical company specializing in the development of innovative cancer treatments. Leveraging its proprietary PREDATOR™ platform, Werewolf Therapeutics is at the forefront of creating conditionally activated therapeutics designed to stimulate the body’s immune system to combat cancer.
Founded with the mission to address the limitations of conventional proinflammatory immune therapies, Werewolf's core offering includes the pioneering INDUKINE™ molecules. These molecules are engineered to remain inactive in peripheral tissues and activate only within the tumor microenvironment (TME), thereby enhancing both adaptive and innate immunity. This strategic approach aims to significantly reduce systemic toxicity while maximizing therapeutic efficacy.
Among its leading developments, the WTX-124 and WTX-330 stand out. WTX-124, an IL-2 INDUKINE molecule, is currently undergoing a Phase 1/1b clinical trial for patients with advanced or metastatic solid tumors. Recent preliminary data presented at the Society for Immunotherapy of Cancer’s (SITC) 38th Annual Meeting highlight WTX-124’s potential, showing it to be well-tolerated and effective even at higher doses. The study demonstrated proof of mechanism and concept with early evidence of monotherapy antitumor activity.
Moreover, Werewolf is exploring the combination of WTX-124 with pembrolizumab (KEYTRUDA®) to expand its therapeutic reach. Another notable candidate, WTX-330, targets both advanced solid tumors and non-Hodgkin lymphoma using IL-12 INDUKINE molecules.
In addition to its clinical advancements, Werewolf Therapeutics has been actively presenting preclinical data supporting the efficacy of its INDUKINE technology. At recent conferences, the company introduced WTX-518, a novel IL-18 INDUKINE molecule, and reported on the preclinical development of IL-10 INDUKINE molecules for treating inflammatory bowel disease.
With a consistent track record of innovation and a robust pipeline of transformative therapies, Werewolf Therapeutics continues to make significant strides towards providing new hope for cancer patients worldwide.
Werewolf Therapeutics (Nasdaq: HOWL) announced the publication of preclinical data for mWTX-330, an Interleukin-12 INDUKINE molecule, in Cancer Immunology Research. This study demonstrates that mWTX-330 effectively stimulates an anti-tumor immune response by selectively delivering IL-12 to the tumor microenvironment while minimizing systemic toxicity. Key findings include robust immune activation in multiple tumor models and improved T-cell activity without signs of exhaustion. The company is preparing for a Phase 1 clinical trial for WTX-330 in patients with advanced solid tumors or lymphoma resistant to checkpoint inhibitors. The trial aims to evaluate safety and efficacy, marking a significant step in Werewolf's mission to enhance cancer treatments through targeted immune activation.
Werewolf Therapeutics (Nasdaq: HOWL) announced significant advancements in its clinical trials and financial position. The company is preparing to release initial clinical data for its IL-2 INDUKINE WTX-124 monotherapy in Q4 2023, while the first patient has been dosed in the IL-12 INDUKINE WTX-330 trial. Furthermore, it nominated WTX-712 for preclinical development. The financial update shows a cash position of $129.3 million, with guidance extended to cover operations through Q4 2024. Collaboration revenue rose to $7.3 million in Q4 2022, a notable increase from 2021, amidst rising expenses primarily related to R&D.
Werewolf Therapeutics, Inc. (Nasdaq: HOWL) announced the publication of abstracts for poster presentations at the American Association for Cancer Research (AACR) Annual Meeting 2023, scheduled for April 14-19 in Orlando, Florida. Key presentations include:
- Abstract 1829: Generation of IL-21 INDUKINE™ molecules for cancer treatment on April 17, 9:00 a.m. - 12:30 p.m.
- Abstract CT133: Phase 1/1b study of WTX-124, April 17, 1:30 p.m. - 5:00 p.m.
- Abstract CT254: First-in-human study of WTX-330 on April 18, 1:30 p.m. - 5:00 p.m.
Werewolf is focused on conditionally activated therapeutics to enhance the immune response against cancer.
Werewolf Therapeutics, a biopharmaceutical company focused on cancer treatment, announced its upcoming poster presentation at the American Association for Cancer Research (AACR) Annual Meeting 2023, scheduled from April 14-19 in Orlando, Florida. The abstract, numbered 1829, details the generation of IL-21 INDUKINE™ molecules aimed at activating the immune system while minimizing side effects. The presentation will occur on April 17 from 9:00 a.m. to 12:30 p.m. at Poster Section 24, Board Number 1. The company utilizes its proprietary PREDATOR™ platform to develop conditionally activated therapeutics targeting solid tumors, including its lead candidates, WTX-124 and WTX-330.
Werewolf Therapeutics has initiated a Phase 1 clinical trial for WTX-330, a novel Interleukin-12 (IL-12) therapy designed for the treatment of advanced solid tumors and Non-Hodgkin lymphoma. This trial marks the second INDUKINE molecule to enter clinical evaluation from their PREDATOR protein engineering platform. Dosing the first patient highlights Werewolf's commitment to advancing cancer therapies targeting hard-to-treat tumors. WTX-330 aims to minimize off-tumor toxicities while delivering potent treatment directly to the tumor microenvironment, potentially maximizing clinical benefits.
Werewolf Therapeutics, a biopharmaceutical company focused on cancer treatment, announced that Randi Isaacs, M.D., its Chief Medical Officer, will present at the SVB Securities Global Biopharma Conference. The virtual presentation is scheduled for February 16, 2023, at 8:40 AM ET, during the conference which runs from February 14-16. This event highlights the company's innovative PREDATOR™ platform, designed to stimulate the immune system while minimizing peripheral activity. Werewolf's leading candidates, WTX-124 and WTX-330, are conditionally activated molecules aimed at treating various solid tumors. A link to the live webcast and archived presentation will be available following the event.
Werewolf Therapeutics presented preclinical data on mWTX-330, an innovative IL-12 therapy, at the 37th Annual Meeting of the Society for Immunotherapy of Cancer. The findings suggest mWTX-330 promotes significant anti-tumor activity and immune cell activation in the tumor microenvironment. Additionally, the FDA recently cleared the IND application for WTX-330, paving the way for clinical trials. This therapy aims to treat advanced solid tumors and lymphoma, potentially offering improved efficacy and safety over existing IL-12 therapies.
Werewolf Therapeutics (HOWL) announced significant advancements in its clinical pipeline, including the first patient dosed in a Phase 1/1b trial for WTX-124, targeting advanced solid tumors, with preliminary data expected in Q4 2023. The FDA granted IND clearance for WTX-330, aimed at treating relapsed/refractory tumors. The company reported a cash balance of $140.5 million, sufficient to fund operations through at least Q2 2024, alongside $5 million in collaboration revenue. Net loss for Q3 2022 was reduced to $11.9 million from $13.8 million YoY.
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