Welcome to our dedicated page for Hoth Therapeutics news (Ticker: HOTH), a resource for investors and traders seeking the latest updates and insights on Hoth Therapeutics stock.
Hoth Therapeutics, Inc. (NASDAQ: HOTH) is a clinical-stage biopharmaceutical company dedicated to developing innovative therapies for dermatological disorders and other significant medical needs. The company focuses on conditions such as eczema, chronic wounds, psoriasis, asthma, and acne. Utilizing their proprietary BioLexa Platform, Hoth Therapeutics aims to create two topical cream products to treat eczema and reduce post-procedure infections in aesthetic dermatology patients.
Hoth Therapeutics has established numerous license and partnership agreements with prestigious institutions including The George Washington University, The University of Maryland Baltimore, Isoprene Pharmaceuticals, Inc., North Carolina State University, Chelexa Biosciences, Inc., The University of Cincinnati, and Zyla Therapeutics, Inc. Notably, Hoth is co-developing a topical treatment with Zyla Therapeutics for cutaneous lupus erythematosus, an autoimmune disease that severely impacts patient quality of life.
The company’s research collaborations extend to various areas including HT-001, a potential treatment for cancer patients experiencing skin toxicities from Epidermal Growth Factor Receptor Inhibitors (EGFRI). Hoth has recently received FDA clearance to proceed with protocol amendments in its ongoing Phase 2a clinical trials for HT-001, aiming to optimize clinical outcomes.
Hoth Therapeutics has also made strides in Alzheimer's Disease research with its HT-ALZ project, targeting neuroinflammation and cognitive deficits by antagonizing the NK1 receptor. Pre-clinical research has shown promising results in improving cognitive functions among Alzheimer's patients.
In addition to their pipeline, Hoth's subsidiary Merveille.ai has been pivotal in advancing obesity treatment using artificial intelligence. The discovery of a promising new therapeutic candidate for obesity, leveraging large language model technologies, underscores their commitment to innovative health solutions.
Financially, Hoth Therapeutics recently engaged in an agreement to exercise warrants, raising approximately $4.2 million to support its working capital needs. Their strategic partnership with Venable, LLP further strengthens their intellectual property protection, vital for ongoing and future therapeutic developments.
Collaborations with Wise Systems International SRL and integration of the Nvidia BioNeMo AI platform are set to enhance Hoth's drug discovery capabilities, leveraging artificial intelligence for cutting-edge therapeutic advancements.
Hoth Therapeutics (NASDAQ: HOTH) has announced positive data from a first-of-its-kind human patient treatment using HT-001 for epidermal growth factor receptor inhibitor (EGFRI) associated papulopustular eruptions (PPEs). The patient, a 59-year-old female with metastatic breast cancer, experienced significant symptom improvement after just one week of treatment, allowing her to discontinue HT-001 after only seven days. This rapid success highlights HT-001's potential as an effective therapy for EGFRI-associated skin toxicities, which affect up to 90% of cancer patients undergoing EGFRI therapy. A Phase 2a clinical trial is currently underway to further evaluate HT-001's efficacy and safety, with multiple prestigious cancer centers participating in the study.
Hoth Therapeutics (NASDAQ: HOTH) has entered a Master Services Agreement with Aronnax Inc. for its HT-KIT cancer therapeutic. Aronnax will oversee ITR Laboratories in conducting intravenous injection studies to determine the Maximum-Tolerated Dose (MTD) and perform a Dose Range-Finding Phase for HT-KIT.
HT-KIT, an antisense oligonucleotide targeting the proto-oncogene cKIT, has shown promising results in killing human mast cells and reducing KIT expression in GIST and AML cells. It has received Orphan Drug Designation from the FDA for treating mast cell-derived cancers and anaphylaxis.
This study aims to provide Hoth with key metrics for formulating its proposed clinical trial, advancing HT-KIT towards an IND-enabling study.
Hoth Therapeutics (NASDAQ: HOTH) has partnered with LTS Therapy Systems to develop and manufacture the HT-ALZ oral film prototype for Alzheimer's disease treatment. This collaboration follows promising pre-clinical results that demonstrated HT-ALZ's ability to improve cognitive functions and quality of life in subjects with Alzheimer's.
The treatment showed potential to reduce brain inflammation, leading to improved cognitive outcomes. Pre-clinical research indicated HT-ALZ's capacity to enhance memory tasks related to the hippocampus and sensorimotor gating. The prototype development will support a future Investigational New Drug (IND) Application to initiate clinical trials, marking a significant step in Hoth's innovative approach to Alzheimer's treatment.
Hoth Therapeutics (NASDAQ: HOTH) has expanded its First-in-Human Phase 2a clinical trial for HT-001, a treatment for skin toxicities associated with Epidermal Growth Factor Receptor Inhibitors (EGFRi) in cancer patients. The company received approval from three prestigious medical centers: GW University Hospital, UC Irvine, and Northwell Health.
The trial aims to investigate the efficacy, safety, and tolerability of topical HT-001. CEO Robb Knie expressed optimism that the trial will demonstrate successful delivery of their lead therapeutic candidate and provide hope for cancer patients suffering from EGFRi-related skin toxicities. More information about this dose-ranging study is available on clinicaltrials.gov.
Hoth Therapeutics (NASDAQ: HOTH) has entered a joint development agreement with Wise Systems International SRL, using Nvidia's BioNeMo generative AI platform. This collaboration aims to accelerate the drug discovery process by utilizing AI for target identification and lead optimization. The partnership is expected to enhance Hoth's therapeutic pipeline and increase the value of its assets. Key executives from both companies expressed optimism about leveraging AI to bring innovative treatments to patients.
Hoth Therapeutics, Inc. (HOTH) will have its CEO attend the EF Hutton Annual Global Conference in New York, NY. The conference provides networking opportunities and a platform to showcase the company's biopharmaceutical endeavors.
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