Hoth Therapeutics, Inc. - HOTH STOCK NEWS

Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced the successful completion of a pre-IND meeting with the FDA regarding their HT-001 product, aimed at treating skin disorders linked to EGFR inhibitor therapy. Key FDA feedback included approval of the proposed formulation, the appropriateness of the planned indications upon further data, and details on the IND-enabling toxicology program for a phase 2a study. This positive outcome supports Hoth's plans to advance its clinical development for HT-001, a significant milestone for the company in addressing cancer-related dermatological issues.

Hoth Therapeutics (NASDAQ: HOTH) announced plans to expand its HT-003 active pharmaceutical ingredient (API) development to target inflammatory bowel diseases (IBDs) like Crohn's disease and ulcerative colitis. This initiative follows an option agreement with Isoprene Pharmaceuticals to study HT-003's potential as an IBD treatment. Current research shows HT-003 may possess anti-inflammatory properties, which Hoth intends to explore further using ex vivo and in vitro studies. The company aims to address significant patient needs in this area.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced its participation in the Diamond Equity Research Growth Invitational virtual investor conference on February 24, 2021. The event will take place at 9:40 a.m. ET and will include a presentation followed by a Q&A session. Hoth Therapeutics is focused on developing new therapies for unmet medical needs, targeting conditions such as atopic dermatitis and chronic wounds, with ongoing projects related to COVID-19. For more information, visit Hoth's Investor Relations.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced that Scientific Advisory Board member Michael Peter, Ph.D., published a whitepaper in bioRxiv focusing on COVID-19 SARS-CoV-2. The study utilizes computational modeling to analyze protein-protein binding interactions critical for viral entry, particularly regarding mutations in emerging variants. Hoth has previously secured a licensed agreement for peptide therapeutics targeting this interface to aid in COVID-19 treatment, with research guided by Dr. Peter. This work supports the development of therapeutic candidates against SARS-CoV-2 variants.

On February 8, 2021, Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced a partnership with Camargo Pharmaceutical Services. This collaboration aims to prepare and submit an Investigational New Drug (IND) application for their topical product, HT-001, to the U.S. FDA. The IND is anticipated to receive feedback by February 22, 2021, as Hoth conducts GLP toxicology studies. HT-001 targets skin disorders related to epidermal growth factor receptor inhibitors. The company aims to expedite the NDA submission process through a 505(b)(2) development pathway.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) updated shareholders on its therapeutic pipeline targeting dermatological conditions, COVID-19, and supportive care. Key developments include the BioLexa platform set to begin Phase 1b trials in Q1 2021, positive preclinical results for HT-003 targeting acne, and a Pre-IND meeting with the FDA for HT-001 scheduled for February 22, 2021. CEO Robb Knie emphasized the company’s strengthened balance sheet and optimistic outlook for 2021 as a pivotal growth year, aiming to drive shareholder value through continued advancements in its diverse portfolio.

On January 28, 2021, Hoth Therapeutics, Inc. (HOTH) announced an extension of its research collaboration with Weill Cornell Medicine for HT-003, a novel treatment for acne. This one-year extension follows positive initial results from prior studies indicating HT-003's therapeutic effects on acne-related signaling pathways. The collaboration aims to further investigate HT-003's mechanism and safety in murine models. Dr. Jonathan Zippin will lead the research, underscoring the commitment to developing effective therapies for dermatological conditions.

Hoth Therapeutics (NASDAQ: HOTH) announced the appointment of Dr. Mario Lacouture to its Scientific Advisory Board on January 27, 2021. Dr. Lacouture, a leader in treating skin toxicities from cancer therapies, will oversee the development of HT-001, a topical treatment aimed at managing skin disorders related to epidermal growth factor receptor inhibitor therapy. CEO Robb Knie expressed optimism about leveraging Dr. Lacouture's expertise to advance the clinical program for HT-001, enhancing Hoth's potential therapeutic offerings.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced promising in vitro findings for HT-003, a potential acne treatment. The research shows that HT-003 significantly inhibits the TLR2 pathway, crucial for acne pathophysiology, and reduces the expression of inflammatory markers in human skin cells. Lead researcher Dr. Jonathan Zippin highlights the drug's potential to benefit patients with various inflammatory skin conditions. Hoth continues to explore HT-003's therapeutic mechanisms through further in vitro studies and animal trials.