Hoth Therapeutics, Inc. - HOTH STOCK NEWS

On January 28, 2021, Hoth Therapeutics, Inc. (HOTH) announced an extension of its research collaboration with Weill Cornell Medicine for HT-003, a novel treatment for acne. This one-year extension follows positive initial results from prior studies indicating HT-003's therapeutic effects on acne-related signaling pathways. The collaboration aims to further investigate HT-003's mechanism and safety in murine models. Dr. Jonathan Zippin will lead the research, underscoring the commitment to developing effective therapies for dermatological conditions.

Hoth Therapeutics (NASDAQ: HOTH) announced the appointment of Dr. Mario Lacouture to its Scientific Advisory Board on January 27, 2021. Dr. Lacouture, a leader in treating skin toxicities from cancer therapies, will oversee the development of HT-001, a topical treatment aimed at managing skin disorders related to epidermal growth factor receptor inhibitor therapy. CEO Robb Knie expressed optimism about leveraging Dr. Lacouture's expertise to advance the clinical program for HT-001, enhancing Hoth's potential therapeutic offerings.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced promising in vitro findings for HT-003, a potential acne treatment. The research shows that HT-003 significantly inhibits the TLR2 pathway, crucial for acne pathophysiology, and reduces the expression of inflammatory markers in human skin cells. Lead researcher Dr. Jonathan Zippin highlights the drug's potential to benefit patients with various inflammatory skin conditions. Hoth continues to explore HT-003's therapeutic mechanisms through further in vitro studies and animal trials.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced that the FDA granted a Pre-IND meeting regarding HT-001, a topical treatment for rash and skin disorders in cancer patients. The meeting, requested on December 22, 2020, will provide FDA feedback on the drug development program, clinical trial designs, and necessary requirements. Feedback is expected by February 22, 2021. CEO Robb Knie expressed hope that the feedback will help expedite HT-001's transition to clinical trials, emphasizing the importance of these developments for the company's future.

On January 11, 2021, Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced a partnership with Charles River Laboratories to conduct preclinical studies for HT-001, a topical treatment aimed at alleviating rash and skin disorders from EGFR inhibitor cancer therapies. Six preclinical studies are planned, beginning with bioanalytical method development in Q1 2021. The studies aim to fulfill FDA requirements for clinical trial initiation. Hoth's CEO emphasized the collaboration's importance in addressing significant unmet needs in dermatological care.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) has announced a definitive securities purchase agreement for a private placement to institutional investors, expected to generate approximately $5.0 million in gross proceeds. Investors will acquire 2,475,248 shares of Common Stock at $2.02, along with warrants for an additional 1,237,624 shares at an exercise price of $2.25. The placement, facilitated by The Benchmark Company, LLC, is set to close on January 7, 2021, subject to customary conditions. The securities, not registered under the Securities Act, may not be resold in the U.S. without appropriate registration.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) announced a Non-Exclusive Commercial Evaluation License Agreement with the U.S. Army Medical Research and Development Command for a new antibacterial drug, HT-006, targeting serious lung infections like hospital-acquired pneumonia. The drug aims to combat multi-drug resistant bacteria and will benefit from streamlined development through the FDA's program for unmet medical needs. Preclinical studies are set to commence in Q1 2021, leveraging U.S. Army expertise and resources during development.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) has signed a production agreement with Tergus Pharma for GLP and GMP materials related to its cancer treatment drug, HT-001. This follows their request for a Pre-Investigational New Drug meeting with the FDA regarding HT-001, which targets skin disorders associated with EGFR inhibitor therapy. Hoth aims to alleviate dose-limiting skin toxicities, thus enhancing patient outcomes in cancer treatments. CEO Robb Knie expressed optimism for the drug's development and its potential to benefit patients.

Hoth Therapeutics, Inc. (NASDAQ: HOTH) has requested a Pre-Investigational New Drug (IND) meeting with the FDA regarding HT-001, a topical treatment aimed at addressing skin disorders from epidermal growth factor receptor (EGFR) inhibitor therapy. Over 50% of cancer patients on EGFR inhibitors experience dermatological side effects, impacting their treatment. HT-001 seeks to improve these patients' quality of life. Currently in preclinical development, the company plans to discuss clinical trial designs in its upcoming FDA meeting scheduled for Q1 2021.