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Hookipa Pharma - HOOK STOCK NEWS

Welcome to our dedicated page for Hookipa Pharma news (Ticker: HOOK), a resource for investors and traders seeking the latest updates and insights on Hookipa Pharma stock.

Overview

HOOKIPA Pharma Inc. (symbol: HOOK) is a clinical-stage biopharmaceutical company dedicated to developing innovative immunotherapeutics. Using a unique arenavirus platform, the company crafts advanced viral vector technologies that reprogram and stimulate the immune system to combat both infectious diseases and cancer. With a focus on inducing potent pathogen-neutralizing antibodies and CD8+ T cell responses, HOOKIPA leverages a dual-approach in its therapeutic design which includes replication-deficient and attenuated replicating vectors that can be administered repeatedly while retaining their effectiveness.

Core Technology and Therapeutic Platforms

At the heart of HOOKIPA Pharma's innovation is its proprietary arenavirus platform. This technology underpins two major immunotherapeutic modalities: one based on a replication-deficient viral vector known as Vaxwave® and another utilizing an attenuated replicating vector, Therat®. Both platforms are engineered to target dendritic cells in vivo, ensuring a robust activation of the immune system. The design enables systemic treatment of solid tumors—including both primary and metastatic lesions—by inducing a strong cytotoxic T cell response that meets or even exceeds traditional approaches such as adoptive T cell therapy. The approach not only exhibits potential within immune-oncology but also offers prospects in addressing severe infectious diseases.

Pipeline and Clinical Focus

HOOKIPA Pharma has strategically divided its clinical development into two fundamental areas: oncology and infectious diseases. In oncology, the company is advancing programs that target oncoviral cancer antigens and next-generation antigens. One of its key projects, eseba-vec, is in clinical development for treating HPV16-positive head and neck cancers, showcasing the potential of its viral vector technology in generating a tumor-specific immune response. In parallel, HOOKIPA’s partnerships have enabled the development of therapies for major infectious diseases such as hepatitis B and HIV through collaborative programs, which further validate the versatility of the arenavirus platform.

Market Position and Competitive Standing

Operating in the competitive niche of immuno-oncology and infectious disease therapeutics, HOOKIPA Pharma positions itself as an innovator in the use of viral vector technology for immunotherapy. By focusing on "off-the-shelf" solutions that can be administered systemically and repeatedly, the company distinguishes itself in a market where durable and flexible treatment approaches are highly sought after. Unlike traditional approaches that might require complex customization, HOOKIPA’s platform offers a robust alternative with the potential to streamline clinical administration while maintaining efficacy.

Scientific and Clinical Rationale

The company’s approach is grounded in rigorous scientific rationale. By activating dendritic cells, the therapy orchestrates a precise immune response that results in high frequencies of CD8+ T cells specific to tumor antigens. This mirrors, and in some cases exceeds, the immune activation observed in adoptive T cell therapies, thereby providing a quantifiable scientific basis for its clinical strategies. The ability to reprogram the immune system through its viral vector technology not only addresses treatment-resistant cancer forms but also opens new avenues for combatting complex infectious pathogens.

Operational Strategy and Communication

HOOKIPA Pharma maintains a strategy rooted in transparency and consistent communication with its stakeholders. The company disseminates material information through established channels, such as investor relations websites, SEC filings, and public conference calls. This measured communication process reinforces its commitment to trustworthiness and provides assurance regarding its clinical and operational strategies.

Conclusion

In summary, HOOKIPA Pharma Inc. represents a distinctive entity in the biopharmaceutical arena by leveraging a proprietary arenavirus platform to develop next-generation immunotherapeutics. Its dual focus on oncology and infectious diseases, combined with strategic partnerships and a robust clinical development plan, underscores its role as a company with deep technological expertise and a clear scientific rationale. The balanced, evidence-based approach to reprogramming the immune system positions HOOKIPA Pharma as a noteworthy contributor to advances in immunotherapy and a subject of interest for detailed investment research.

Rhea-AI Summary

HOOKIPA Pharma announced updated Phase 2 clinical data for HB-200 combined with pembrolizumab in treating recurrent/metastatic HPV16+ head and neck cancer at the ASCO 2024 Annual Meeting. Out of 35 evaluable patients, results showed a 37% confirmed objective response rate (ORR), 11% complete response (CR) rate, and 69% disease control rate (DCR). Notably, in a subset of 17 patients with a PD-L1 CPS of 20 or higher, the ORR was 53%, CR rate 18%, and DCR 82%. Preliminary progression-free survival (PFS) for this subset was 16.3 months, with a 9-month overall survival (OS) rate of 88%. The treatment was generally well-tolerated, with Grade ≥3 treatment-related adverse events reported in 15% of patients. The pivotal Phase 2/3 trial is set to begin in Q4 2024.

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HOOKIPA Pharma (NASDAQ: HOOK) will host an investor call on June 4, 2024, at 4:15 p.m. ET to discuss promising preliminary results from its Phase 2 clinical trial of HB-200 in combination with pembrolizumab.

The data, presented at the American Society of Clinical Oncology 2024 Annual Meeting, focuses on progression-free survival and overall survival for patients with a Combined Positive Score (CPS) ≥20, targeting human papillomavirus 16 positive head and neck cancer.

The company's proprietary arenavirus platform underpins this new class of immunotherapeutics.

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HOOKIPA Pharma announced positive results from its Phase 1/2 trial of HB-200 for HPV16+ head and neck cancers, to be presented at ASCO 2024. The study, which involved 42 patients, showed an objective response rate (ORR) of 53% and a disease control rate (DCR) of 82% among patients with PD-L1 CPS of 20 or higher. HB-200 combined with pembrolizumab exhibited a favorable safety profile, with no treatment-related deaths and low treatment discontinuation rates. Additional data, including preliminary progression-free survival and overall survival, will be presented on June 4, 2024. Preliminary findings from an investigator-initiated trial for HB-200 with chemotherapy in non-metastatic HPV16+ cancers showed promising results, with an 81% deep response rate. Preclinical data for HB-700, targeting KRAS mutations, demonstrated effective T-cell responses and tumor cell killing in mice.

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HOOKIPA Pharma Inc. reported its first quarter 2024 financial results and business highlights, focusing on its pivotal trial design for HB-200 in combination with pembrolizumab for HPV16+ recurrent or metastatic OPSCC. The company received FDA clearance for its IND application for HB-700 for KRAS mutated cancers. Financially, HOOKIPA saw total revenues of $36.6 million, driven by milestone payments, resulting in a profitable quarter.

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HOOKIPA Pharma announced the final pivotal Phase 2/3 trial design for HB-200 in combination with pembrolizumab. The trial is for the first-line treatment of patients with HPV16+ recurrent or metastatic oropharyngeal squamous cell carcinoma. The Company has aligned with the FDA and anticipates enrolling the first patient in Q4 2024. The data will be presented at ASCO 2024 Annual Meeting, with two additional abstracts accepted. HOOKIPA's CEO expressed confidence in the trial design and potential for accelerated approval based on favorable results.
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HOOKIPA Pharma announced FDA clearance of its Investigational New Drug Application for HB-700, a novel arenaviral therapeutic vaccine for the treatment of KRAS-mutated cancers. The program targets five prevalent KRAS mutations in lung, colorectal, pancreatic, and other cancers, potentially benefiting more patients than single mutation inhibitors. The IND submission resulted in a $10 million milestone payment from Roche, giving HOOKIPA full control of the intellectual property portfolio and collaboration rights for the HB-700 program. Preclinical data will be presented at the ASCO 2024 Annual Meeting, showcasing the company's commitment to advancing oncology treatments.
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HOOKIPA Pharma Inc. grants 250,000 non-statutory options to its Chief Development Officer, Mark Winderlich, under the 2023 Inducement Plan. The options have an exercise price of $0.76 per share, a ten-year term, and vest over four years. This award was granted as an inducement material to Winderlich's acceptance of employment with HOOKIPA in accordance with Nasdaq Listing Rule 5635(c)(4).
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HOOKIPA announces alignment with FDA on pivotal trial design and protocol for HB-200 in combination with pembrolizumab, receiving PRIME designation from EMA. Investor call scheduled to discuss regulatory interactions.
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HOOKIPA Pharma Inc. reports promising Phase 2 data for HB-200 in combination with pembrolizumab for head and neck cancers. They are finalizing IND activities for HB-700 and progressing on infectious disease programs. Financially, they have a strong cash position of $117.5 million at year end 2023.
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HOOKIPA Pharma Inc. (HOOK) CFO to present at Leerink Partners Global Biopharma Conference 2024. The company focuses on immunotherapeutics using its proprietary arenavirus platform.
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FAQ

What is the current stock price of Hookipa Pharma (HOOK)?

The current stock price of Hookipa Pharma (HOOK) is $1.03 as of April 1, 2025.

What is the market cap of Hookipa Pharma (HOOK)?

The market cap of Hookipa Pharma (HOOK) is approximately 12.4M.

What core technology does HOOKIPA Pharma utilize?

HOOKIPA Pharma uses a proprietary arenavirus platform to develop viral vector-based immunotherapies that reprogram the immune system to target cancer and infectious diseases.

Which therapeutic areas are the focus of HOOKIPA Pharma?

The company focuses on oncology and infectious diseases, developing immunotherapeutics that generate potent immune responses against tumors and pathogens.

How does HOOKIPA Pharma differentiate its approach in immunotherapy?

By employing off-the-shelf viral vectors that can be repeatedly administered and by activating dendritic cells in vivo, HOOKIPA’s technology induces strong CD8+ T cell responses, comparable to adoptive T cell therapies.

What is the significance of HOOKIPA Pharma's viral vectors?

The viral vectors, including replication-deficient and attenuated replicating types, are central to the company’s strategy as they trigger robust immune activation and can target both primary and metastatic tumors effectively.

Does HOOKIPA Pharma collaborate with other companies?

Yes, HOOKIPA Pharma engages in partnerships to further develop its infectious disease programs, notably collaborating on treatments for HBV and HIV alongside established industry players.

What distinguishes HOOKIPA Pharma's immunotherapeutic approach?

The company’s method of reprogramming the immune system using its arenavirus technology is designed to induce durable and potent immune responses, offering an innovative alternative to traditional therapies.

How does HOOKIPA Pharma ensure transparent communication with stakeholders?

HOOKIPA Pharma maintains regular and transparent updates through investor relations communications, SEC filings, press releases, and public conference calls, ensuring stakeholders are well-informed.
Hookipa Pharma

Nasdaq:HOOK

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12.42M
9.46M
2%
58.65%
0.55%
Biotechnology
Pharmaceutical Preparations
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