Hepion Pharmaceuticals to Present CRV431 Preclinical Data at the 2020 Digital International Liver Congress(TM)

Rhea-AI Summary

Hepion Pharmaceuticals (NASDAQ:HEPA) announced it will present a poster on CRV431's antifibrotic activity at the Digital International Liver Congress™ 2020 from August 27-29. Dr. Joseph Kuo will discuss a preclinical study highlighting CRV431's ability to reduce hepatic fibrosis and weight gain in a NASH mouse model. The presentation is scheduled for August 28, 2020, under poster number FRI-239. Hepion aims to develop targeted therapies for liver diseases, with CRV431 showing promise in reducing fibrosis and hepatocellular carcinoma tumor burden.

Positive

• Presentation of CRV431's preclinical data at a major medical congress.
• Demonstration of CRV431's ability to reduce liver fibrosis, indicating potential effectiveness in treating NASH.

Negative

• Uncertainties surrounding the success of clinical trials and regulatory approvals.
• Risks related to substantial competition and need for additional financing.

EDISON, NJ / ACCESSWIRE / August 27, 2020 / Hepion Pharmaceuticals, Inc. (NASDAQ:HEPA) "Hepion", a biopharmaceutical company focused on the development of therapeutic drugs for the treatment of liver disease arising from non-alcoholic steatohepatitis ("NASH"), today announced that it will present a poster on CRV431's antifibrotic activity at the Digital International Liver Congress™ 2020 (EASL), taking place from August 27-29, 2020.

Dr. Joseph Kuo will present a preclinical study evaluating CRV431's ability to reduce hepatic fibrosis and fatty diet-induced body weight gain in a mouse model of NASH.

Presentation Details
CRV431 decreases diet- and chemical-driven fibrosis in livers of mice
Poster presentation number: FRI-239
Authors: Joseph Kuo¹, Erika Cabrera¹, Patrick Mayo², Daren Ure², Robert Foster², and Philippe Gallay^1
1Department of Immunology & Microbiology, The Scripps Research Institute, La Jolla, California, USA. ²Hepion Pharmaceuticals, Edison, New Jersey, USA.
Date: Friday, August 28, 2020

About Hepion Pharmaceuticals
Hepion Pharmaceuticals is a clinical stage biopharmaceutical company focused on the development of targeted therapies for liver disease arising from non-alcoholic steatohepatitis (NASH) and other types of hepatitis. The Company's lead drug candidate, CRV431, reduces liver fibrosis and hepatocellular carcinoma tumor burden in experimental models of NASH. Preclinical studies also have demonstrated antiviral activities towards HBV, HCV, and HDV through several mechanisms. These diverse therapeutic activities result from CRV431's potent inhibition of cyclophilins, which are involved in many disease processes. Currently in clinical phase development, CRV431 shows potential to play an important role in the overall treatment of liver disease - from triggering events through to end-stage disease.

Forward-Looking Statements
Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. These statements may be identified by the use of forward-looking words such as "anticipate," "believe," "forecast," "estimated," and "intend," among others. These forward-looking statements are based on Hepion Pharmaceuticals' current expectations and actual results could differ materially. There are a number of factors that could cause actual events to differ materially from those indicated by such forward-looking statements. These factors include, but are not limited to, substantial competition; our ability to continue as a going concern; our need for additional financing; uncertainties of patent protection and litigation; risks associated with delays, increased costs and funding shortages caused by the COVID-19 pandemic; uncertainties with respect to lengthy and expensive clinical trials, that results of earlier studies and trials may not be predictive of future trial results; uncertainties of government or third party payer reimbursement; limited sales and marketing efforts and dependence upon third parties; and risks related to failure to obtain FDA clearances or approvals and noncompliance with FDA regulations. As with any drug candidates under development, there are significant risks in the development, regulatory approval, and commercialization of new products. There are no guarantees that future clinical trials discussed in this press release will be completed or successful, or that any product will receive regulatory approval for any indication or prove to be commercially successful. Hepion Pharmaceuticals does not undertake an obligation to update or revise any forward-looking statement. Investors should read the risk factors set forth in Hepion Pharmaceuticals' Form 10-K for the year ended December 31, 2019 and other periodic reports filed with the Securities and Exchange Commission.

For further information, please contact:
Stephen Kilmer
Hepion Pharmaceuticals Investor Relations
Direct: (646) 274-3580
skilmer@hepionpharma.com

SOURCE: Hepion Pharmaceuticals, Inc.

View source version on accesswire.com:
https://www.accesswire.com/603559/Hepion-Pharmaceuticals-to-Present-CRV431-Preclinical-Data-at-the-2020-Digital-International-Liver-CongressTM

FAQ

What is CRV431 and its significance for Hepion Pharmaceuticals?

CRV431 is Hepion's lead drug candidate aimed at treating liver disease like NASH. It shows potential in reducing liver fibrosis and tumor burden.

When will Hepion present data on CRV431?

Hepion will present data on CRV431 at the Digital International Liver Congress™ 2020 from August 27-29, with the specific presentation on August 28.

What were the findings of the preclinical study on CRV431?

The preclinical study indicated that CRV431 can reduce hepatic fibrosis and body weight gain in a mouse model of NASH.

What are the risks associated with Hepion Pharmaceuticals and its drug development?

Risks include competition, financing needs, and uncertainties regarding the success and timing of clinical trials and regulatory approvals.