HALOZYME REPORTS THIRD QUARTER 2023 FINANCIAL AND OPERATING RESULTS
- None.
- None.
Royalty Revenue Increased
Announces Acceleration into 2023 of Remaining
GAAP Diluted EPS of
Maintained Revenue Guidance and Raised 2023 EBITDA Guidance to
"I am delighted that our strong operating performance and expense management throughout the year have resulted in an increase to EBITDA and non-GAAP EPS guidance. Today, we also announced an acceleration into this year of the remaining
Recent Corporate Highlights:
- Announced an acceleration, into this year, of the remaining
under the current approved$250 million share repurchase plan authorized in 2021. The Company intends to execute the$750 million share repurchase by entering into an accelerated share repurchase ("ASR") transaction with a financial Institution, immediately, subject to market conditions.$250 million - In August 2023, the Company announced positive results of a clinical study with its high-volume auto-injector demonstrating SC administration of 10 mL of a representative biologic product co-formulated with our ENHANZE® drug delivery technology in approximately 30 seconds. The results were presented at the 13th annual Partnership Opportunities in Drug Delivery ("PODD") conference in October 2023.
Recent Partner Highlights:
- In November 2023, Halozyme and Acumen entered into a global collaboration and non-exclusive license agreement that provides Acumen access to ENHANZE® technology for a single target. Acumen intends to explore the potential use of ENHANZE for ACU193, Acumen's clinical stage monoclonal antibody candidate to target Amyloid-β Oligomers for the treatment of early Alzheimer's disease.
- In October 2023, Bristol Myers Squibb reported positive topline results from the Phase 3 CheckMate-67T trial evaluating a SC formulation of Opdivo (nivolumab) with ENHANZE® in patients with advanced or metastatic clear cell renal cell carcinoma ("ccRCC") who have received prior systemic therapy. The study met its co-primary pharmacokinetics ("PK") endpoints and a key secondary endpoint.
- In September 2023, Chugai Pharmaceuticals, a member of the Roche Group, announced that it had obtained regulatory approval for Phesgo® from the Ministry of Health, Labour and Welfare ("MHLW") in
Japan . Halozyme is entitled to receive royalties for Phesgo® sales inJapan under its agreement with Roche. - In September 2023, argenx announced the Committee for Medicinal Products for Human Use ("CHMP") of the European Medicines Agency ("EMA") has recommended European Commission ("EC") approval of the SC injectable formulation of efgartigimod as an add on to standard therapy for the treatment of adult patients with generalized myasthenia gravis ("gMG") who are anti-acetylcholine receptor ("AChR") antibody positive. The EC is expected to make a decision on the argenx marketing authorization application within approximately 67 days following the CHMP recommendation.
- In September 2023, Zai Lab limited (argenx commercial partner for
China ) announced the Center for Drug Evaluation ("CDE") of the National Medical Products Administration ("NMPA") granted Breakthrough Therapy Designation for efgartigimod alfa injection (SC injection) (efgartigimod SC) for the treatment of patients with chronic inflammatory demyelinating polyneuropathy ("CIDP"). The Breakthrough Therapy Designation for efgartigimod SC was supported by data from both global and Chinese patients enrolled in the ADHERE study. - In September 2023, Roche informed the Company that there will be a delay in the projected launch timing for Tecentriq® SC in the
U.S. as a result of Roche's need to update chemistry, manufacturing, and controls ("CMC") processes for Tecentriq® SC. Roche expects these updates to be completed in 2023 to support a potential launch of Tecentriq® SC in theU.S. in 2024. There is no expected impact on ex-U.S. filings for Tecentriq® SC. - In August 2023, Roche announced the approval of Tecentriq® SC with ENHANZE® by the Medicines and Healthcare products Regulatory Agency ("MHRA") in
Great Britain , triggering an milestone payment to Halozyme and the right to receive royalties on net product sales.$8.0 million - In August 2023, ViiV initiated a Phase 2b study to evaluate the efficacy, safety, PK and tolerability of VH3810109 (N6LS) administered subcutaneously with ENHANZE® in combination with cabotegravir.
- In August 2023, ViiV achieved a development milestone, which triggered a
milestone payment to Halozyme.$5 million - In July 2023, argenx reported positive data from the ADHERE study evaluating VYVGART® Hytrulo with ENHANZE® in adults with CIDP. The study met its primary endpoint resulting in a
61% reduction in risk of relapse compared to placebo. - In July 2023, Roche announced that the Phase III OCARINA II trial evaluating OCREVUS® (ocrelizumab) with ENHANZE® as a twice a year 10-minute SC injection met its primary and secondary endpoints in patients with relapsing forms of multiple sclerosis ("MS") or primary progressive MS ("RMS" or "PPMS").
Third Quarter 2023 Financial Highlights:
- Revenue was
compared to$216.0 million in the third quarter of 2022. The$209.0 million 3% year-over-year increase was driven by growth in ENHANZE® revenue streams with an increase in royalty revenue and an increase in product sales as a result of an increase in bulk rHuPH20 sales driven by partner demand and continued growth in XYOSTED®, partially offset by in the timing of milestone revenue. Revenue for the quarter included in royalties, an increase of$114.4 million 15% compared to in the prior year period, primarily attributable to increases in revenue of subcutaneous DARZALEX® (daratumumab) and Phesgo®.$99.6 million - Cost of sales was
, compared to$54.8 million in the third quarter of 2022. The increase was driven by growth in proprietary product sales and bulk rHuPH20 demand.$47.3 million - Amortization of intangibles expense was
, compared to$20.3 million in the third quarter of 2022. The decrease was due to a remeasurement period adjustment of our acquired intangible assets recorded in the fourth quarter of 2022, partially offset by an impairment charge of$27.2 million to fully impair the TLANDO® product rights intangible asset as a result of the license agreement termination notice provided to Lipocine in September 2023.$2.5 million - Research and development expense was
, compared to$17.3 million in the third quarter of 2022. Selling, general and administrative expense was$16.7 million , compared to$35.3 million in the third quarter of 2022. The increases were primarily due to an increase in compensation expense.$34.5 million - Operating income was
, compared to operating income of$88.3 million in the third quarter of 2022.$83.3 million - Net Income was
, compared with net income of$81.8 million in the third quarter of 2022.$61.6 million - EBITDA was
, compared with EBITDA of$124.6 million in the third quarter of 2022. Adjusted EBITDA was$109.8 million , compared with Adjusted EBITDA of$114.9 million in the third quarter of 2022.1$110.2 million - Earnings per Share: GAAP diluted earnings per share was
, compared with$0.61 in the third quarter of 2022. Non-GAAP diluted earnings per share was$0.44 , compared with$0.75 in the third quarter of 2022.1$0.74 - Cash, cash equivalents and marketable securities were
on September 30, 2023, compared to$483.3 million on December 31, 2022. The increase was primarily due to the cash provided by operating activities, partially offset by repurchase of common stock for$362.8 million in the first quarter of 2023.$150.0 million
Financial Outlook for 2023
The Company is raising its EBITDA and non-GAAP EPS guidance ranges to reflect strong expense management. For the full year 2023, the Company now expects:
- Total revenue of
to$825 million , representing growth of$845 million 25% to28% over 2022 total revenue primarily driven by continued strength in Wave 2 products, including DARZALEX® SC and Phesgo® utilizing ENHANZE®, as well as full year auto-injector royalty and product contribution. The Company expects revenue from royalties of to$445 million , representing growth of$455 million 23% to26% . - EBITDA of
to$430 million , representing growth of >$445 million 30% over 2022. EBITDA excludes the impact of amortization costs related to the Antares Pharma acquisition.1 - Non-GAAP diluted earnings per share of
to$2.70 , representing growth of$2.80 22% over 20221. The Company's earnings per share guidance does not consider the impact of potential future share repurchases.
Table 1. 2023 Financial Guidance
Guidance Range | Previous Guidance Range | |||
Total Revenue | ||||
Royalty Revenue | ||||
EBITDA | ||||
Non-GAAP Diluted EPS |
Webcast and Conference Call
Halozyme will host its Quarterly Update Conference Call for the third quarter ended September 30, 2023 today, Monday, November 6, 2023 at 1:30 p.m. PT/4:30 p.m. ET. The conference call may be accessed live with pre-registration via link: https://conferencingportals.com/event/xUgmoVIG. The call will also be webcast live through the "Investors" section of Halozyme's corporate website and a recording will be made available following the close of the call. To access the webcast and additional documents related to the call, please visit Halozyme.com.
About Halozyme
Halozyme is a biopharmaceutical company bringing disruptive solutions to significantly improve patient experiences and outcomes for emerging and established therapies. As the innovators of the ENHANZE® technology with the proprietary enzyme rHuPH20, Halozyme's commercially-validated solution is used to facilitate the delivery of injected drugs and fluids in order to reduce the treatment burden to patients. Having touched more than 700,000 patient lives in post-marketing use in seven commercialized products across more than 100 global markets, Halozyme has licensed its ENHANZE® technology to leading pharmaceutical and biotechnology companies including Roche, Takeda, Pfizer, AbbVie, Eli Lilly, Bristol-Myers Squibb, Alexion, argenx, Horizon Therapeutics, ViiV Healthcare, Chugai Pharmaceutical and Acumen Pharmaceuticals.
Halozyme also develops, manufactures and commercializes, for itself or with partners, drug-device combination products using its advanced auto-injector technology that are designed to provide commercial or functional advantages such as improved convenience and tolerability, and enhanced patient comfort and adherence. The Company has a commercial portfolio of proprietary products including XYOSTED® and TLANDO® and partnered commercial products and ongoing product development programs with several pharmaceutical companies including Teva Pharmaceuticals and Idorsia Pharmaceuticals.
Halozyme is headquartered in
For more information visit www.halozyme.com and connect with us on LinkedIn and Twitter.
Note Regarding Use of Non-GAAP Financial Measures
In addition to disclosing financial measures prepared in accordance with
Safe Harbor Statement
In addition to historical information, the statements set forth in this press release include forward-looking statements including, without limitation, statements concerning the Company's financial performance (including the Company's financial outlook for 2023) and expectations for future growth, achieving operational goals, profitability, return on investment, revenues (including royalty, milestone and product sales revenue), EBITDA, non-GAAP diluted earnings-per-share and potential share repurchase under its share repurchase program. Forward-looking statements regarding the Company's ENHANZE® drug delivery technology may include the possible benefits and attributes of ENHANZE®, its potential application to aid in the dispersion and absorption of other injected therapeutic drugs and facilitating more rapid delivery and administration of higher volumes of injectable medications through subcutaneous delivery. Forward-looking statements regarding the Company's business may include potential growth and receipt of royalty and milestone payments driven by our partners' development and commercialization efforts, potential new clinical trial study starts and clinical data, regulatory submissions and product launches, the size and growth prospects of our partners' drug franchises, potential new or expanded collaborations and collaborative targets and regulatory review and potential approvals of new partnered or proprietary products and the Company's development and partnership potential of a high volume auto-injector. These forward-looking statements are typically, but not always, identified through use of the words "believe," "enable," "may," "will," "could," "intends," "estimate," "anticipate," "plan," "predict," "probable," "potential," "possible," "should," "continue," and other words of similar meaning and involve risk and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. Actual results could differ materially from the expectations contained in these forward-looking statements as a result of several factors, including unexpected levels of revenues, expenditures and costs, unexpected delays in the execution of the Company's share repurchase program, unexpected results or delays in the growth of the Company's business, or in the development, regulatory review or commercialization of the Company's partnered or proprietary products (including its high volume auto-injector), regulatory approval requirements, unexpected adverse events or patient outcomes and competitive conditions. These and other factors that may result in differences are discussed in greater detail in the Company's most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission. Except as required by law, the Company undertakes no duty to update forward-looking statements to reflect events after the date of this release.
Contacts:
Tram Bui
VP, Investor Relations and Corporate Communications
609-359-3016
tbui@halozyme.com
Dawn Schottlandt
Argot Partners
212-600-1902
Halozyme@argotpartners.com
Footnotes:
1. Reconciliations between GAAP reported and non-GAAP financial information and adjusted guidance measures are provided at the end.
Halozyme Therapeutics, Inc Consolidated Statements of Operations (Unaudited) (In thousands, except per share amounts) | ||||||||
Three Months Ended September 30, | Nine Months Ended September 30, | |||||||
2023 | 2022 | 2023 | 2022 | |||||
Revenues: | ||||||||
Royalties | $ 114,433 | $ 99,551 | $ 325,813 | $ 254,496 | ||||
Product sales, net | 86,569 | 61,427 | 221,252 | 129,867 | ||||
Revenues under collaborative agreements | 15,031 | 47,998 | 52,149 | 94,257 | ||||
Total revenues | 216,033 | 208,976 | 599,214 | 478,620 | ||||
Operating expenses: | ||||||||
Cost of sales | 54,823 | 47,319 | 140,063 | 97,184 | ||||
Amortization of intangibles | 20,341 | 27,193 | 56,011 | 38,596 | ||||
Research and development | 17,321 | 16,705 | 55,027 | 44,041 | ||||
Selling, general and administrative | 35,269 | 34,467 | 111,574 | 105,777 | ||||
Total operating expenses | 127,754 | 125,684 | 362,675 | 285,598 | ||||
Operating income | 88,279 | 83,292 | 236,539 | 193,022 | ||||
Other income (expense): | ||||||||
Investment and other (expense) income, net | 4,786 | 641 | 10,957 | 194 | ||||
Inducement expense related to convertible note | — | (2,712) | — | (2,712) | ||||
Contingent liability fair value measurement gain | 13,200 | — | 13,200 | — | ||||
Interest expense | (4,505) | (7,514) | (13,542) | (12,377) | ||||
Net income before income taxes | 101,760 | 73,707 | 247,154 | 178,127 | ||||
Income tax expense | 19,923 | 12,073 | 50,948 | 33,700 | ||||
Net income | $ 81,837 | $ 61,634 | $ 196,206 | $ 144,427 | ||||
Net income per share: | ||||||||
Basic | $ 0.62 | $ 0.45 | $ 1.48 | $ 1.05 | ||||
Diluted | $ 0.61 | $ 0.44 | $ 1.45 | $ 1.02 | ||||
Shares used in computing net income per share: | ||||||||
Basic | 131,965 | 136,527 | 132,896 | 137,370 | ||||
Diluted | 134,083 | 139,387 | 135,233 | 141,019 |
Halozyme Therapeutics, Inc Consolidated Balance Sheets (Unaudited) (In thousands) | ||||
September 30, | December 31, | |||
ASSETS | ||||
Current assets: | ||||
Cash and cash equivalents | $ 274,227 | $ 234,195 | ||
Marketable securities, available-for-sale | 209,055 | 128,599 | ||
Accounts receivable, net and contract assets | 217,325 | 231,072 | ||
Inventories, net | 128,921 | 100,123 | ||
Prepaid expenses and other current assets | 49,478 | 45,024 | ||
Total current assets | 879,006 | 739,013 | ||
Property and equipment, net | 74,669 | 75,570 | ||
Prepaid expenses and other assets | 18,115 | 26,301 | ||
Goodwill | 416,821 | 409,049 | ||
Intangible assets, net | 490,641 | 546,652 | ||
Deferred tax assets, net | 13,410 | 44,426 | ||
Restricted cash | — | 500 | ||
Total assets | $ 1,892,662 | $ 1,841,511 | ||
LIABILITIES AND STOCKHOLDERS' EQUITY | ||||
Current liabilities: | ||||
Accounts payable | $ 19,318 | $ 17,693 | ||
Accrued expenses | 95,200 | 96,516 | ||
Deferred revenue, current portion | 667 | 3,246 | ||
Current portion of long-term debt, net | — | 13,334 | ||
Total current liabilities | 115,185 | 130,789 | ||
Deferred revenue, net of current portion | 2,253 | 2,253 | ||
Long-term debt, net | 1,497,621 | 1,492,766 | ||
Other long-term liabilities | 28,422 | 30,433 | ||
Contingent liability | — | 15,472 | ||
Total liabilities | 1,643,481 | 1,671,713 | ||
Stockholders' equity: | ||||
Common stock | 132 | 135 | ||
Additional paid-in capital | 25,537 | 27,368 | ||
Accumulated other comprehensive loss | 1,227 | (922) | ||
Retained earnings (accumulated deficit) | 222,285 | 143,217 | ||
Total stockholders' equity | 249,181 | 169,798 | ||
Total liabilities and stockholders' equity | $ 1,892,662 | $ 1,841,511 |
Halozyme Therapeutics, Inc GAAP to Non-GAAP Reconciliations Net Income and Diluted EPS (Unaudited) (In thousands, except per share amounts) | ||||
Three Months Ended September 30, | ||||
2023 | 2022 | |||
GAAP Net Income | $ 81,837 | $ 61,634 | ||
Adjustments: | ||||
Inducement expense related to convertible notes | — | 2,712 | ||
Share-based compensation | 9,367 | 6,797 | ||
Amortization of debt discount | 1,824 | 3,932 | ||
Amortization of intangible assets | 17,834 | 27,193 | ||
Transaction costs for business combinations(1) | — | 439 | ||
Amortization of inventory step-up at fair value(2) | 493 | 5,830 | ||
TLANDO Related Adjustments: | ||||
Gain on changes in fair value of contingent liability(3) | (13,200) | — | ||
Inventory write-off(3) | 3,509 | 825 | ||
Impairment charge of TLANDO product rights intangible assets(3) | 2,507 | |||
Income tax effect of above adjustments(4) | (3,649) | (6,034) | ||
Non-GAAP Net Income | $ 100,522 | $ 103,328 | ||
GAAP Diluted EPS | $ 0.61 | $ 0.44 | ||
Adjustments: | ||||
Inducement expense related to convertible notes | — | 0.02 | ||
Share-based compensation | 0.07 | 0.05 | ||
Amortization of debt discount | 0.01 | 0.03 | ||
Amortization of intangible assets | 0.13 | 0.20 | ||
Transaction costs for business combinations(1) | — | — | ||
Amortization of inventory step-up at fair value(2) | — | 0.04 | ||
TLANDO Related Adjustments: | ||||
Gain on changes in fair value of contingent liability(3) | (0.10) | — | ||
Inventory write-off(3) | 0.03 | 0.01 | ||
Impairment charge of TLANDO product rights intangible assets(3) | 0.02 | — | ||
Income tax effect of above adjustments(4) | (0.03) | (0.04) | ||
Non-GAAP Diluted EPS | $ 0.75 | $ 0.74 | ||
GAAP & Non-GAAP Diluted Shares | 134,083 | 139,387 |
Dollar amounts, as presented, are rounded. Consequently, totals may not add up. | |
(1) | Amount represents incremental costs including legal fees, accounting fees and advisory fees incurred for the Antares acquisition. |
(2) | Amounts relate to amortization of the inventory step-up associated with purchase accounting for the Antares acquisition. |
(3) | Amounts relate to fair value gain on contingent liability, inventory write-off and impairment of TLANDO product rights intangible assets due to the termination of the TLANDO license agreement in September 2023. |
(4) | Adjustments relate to taxes for the reconciling items, as well as excess benefits or tax deficiencies from stock-based compensation, and the quarterly impact of other discrete items. |
Halozyme Therapeutics, Inc GAAP to Non-GAAP Reconciliations Diluted EPS | ||||||
Twelve Months December 31, | 2023 Guidance | Percentage | ||||
GAAP Diluted EPS | $ 1.44 | |||||
Adjustments: | ||||||
Inducement expense related to convertible notes | 0.02 | |||||
Share-based compensation | 0.17 | |||||
Amortization of debt discount | 0.06 | |||||
Amortization of intangible assets | 0.31 | |||||
Transaction costs for business combinations(1) | 0.16 | |||||
Severance and share-based compensation acceleration expense(2) | 0.16 | |||||
Amortization of inventory step-up at fair value(3) | 0.06 | |||||
Realized loss from marketable securities(4) | 0.01 | |||||
Income tax effect of above adjustments(5) | (0.17) | |||||
Non-GAAP Diluted EPS | $ 2.21 |
Dollar amounts, as presented, are rounded. Consequently, totals may not add up. | |
(1) | Amount represents incremental costs including legal fees, accounting fees and advisory fees incurred for the Antares acquisition. |
(2) | Amount represents severance cost and acceleration of unvested equity awards as part of the Antares merger agreement. |
(3) | Amount related to amortization of the inventory step-up associated with purchase accounting for the Antares acquisition. |
(4) | Amount represents realized loss from the sale of our marketable securities to finance the acquisition of Antares. |
(5) | Adjustments relate to taxes for the reconciling items, as well as excess benefits or tax deficiencies from stock-based compensation, and the quarterly impact of other discrete items. |
Halozyme Therapeutics, Inc GAAP to Non-GAAP Reconciliations EBITDA (Unaudited) (In thousands) | ||||
Three Months Ended September 30, | ||||
2023 | 2022 | |||
GAAP Net Income | $ 81,837 | $ 61,634 | ||
Adjustments: | ||||
Investment and other income | (4,786) | (641) | ||
Interest expense | 4,505 | 7,514 | ||
Income tax expense | 19,923 | 12,073 | ||
Depreciation and amortization | 23,078 | 29,203 | ||
EBITDA | 124,557 | 109,783 | ||
Adjustments: | ||||
Gain on changes in fair value of contingent liability | (13,200) | — | ||
Inventory write-off | 3,509 | — | ||
Transaction costs for business combinations | — | 439 | ||
Adjusted EBITDA | $ 114,866 | $ 110,222 |
Halozyme Therapeutics, Inc GAAP to Non-GAAP Reconciliations EBITDA (Unaudited) (In millions) | ||||||
Twelve Months | 2023 Guidance | Percentage | ||||
GAAP Net Income | $ 202 | |||||
Adjustments: | ||||||
Investment and other income | (1) | |||||
Interest expense | 17 | |||||
Income tax expense | 47 | |||||
Depreciation and amortization | 50 | |||||
EBITDA | 315 | |||||
Adjustments: | ||||||
Severance and share-based compensation acceleration expense | 23 | |||||
Transaction costs for business combinations | 22 | |||||
Gain on changes in fair value of contingent liability | (13) | |||||
Inventory write-off | 3 | |||||
Adjusted EBITDA | $ 360 | |||||
Dollar amounts, as presented, are rounded. Consequently, totals may not add up. |
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SOURCE Halozyme Therapeutics, Inc.
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