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Genprex, Inc. (NASDAQ: GNPX) is a pioneering clinical-stage gene therapy company committed to transforming the landscape of cancer and diabetes treatments. The company's mission is to address the unmet medical needs of a growing population of patients worldwide through the development of innovative immunogene therapies. Genprex's flagship product, Reqorsa Immunogene Therapy (quaratusugene ozeplasmid), is at the forefront of its oncology program and is currently being evaluated in three clinical trials targeting non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC).
Oncoprex® Delivery System, Genprex's proprietary platform, encapsulates gene-expressing plasmids using lipid-based nanoparticles. This systemic, non-viral method enables the intravenous delivery of tumor suppressor genes to cancer cells, which then express proteins that were deficient in the tumor. Reqorsa Immunogene Therapy has shown promise by re-establishing pathways for programmed cell death, interrupting cancer cell signaling, and modulating immune responses.
The company's recent achievements include securing new patents and receiving FDA Fast Track and Orphan Drug designations for its clinical programs. Specifically, the Acclaim-2 and Acclaim-3 studies are exploring the potential of Reqorsa in combination with immune checkpoint inhibitors like Keytruda® and Tecentriq®. These trials aim to provide new therapeutic options for patients with advanced-stage lung cancers who have limited treatment alternatives.
In addition to its oncology initiatives, Genprex is advancing a novel gene therapy approach for diabetes. Using an AAV vector, the company delivers Pdx1 and MafA genes directly to the pancreas to transform alpha cells into beta-like cells capable of producing insulin. This method shows promise for both Type 1 and Type 2 diabetes and aims to offer a new lifeline for patients with these conditions.
Genprex collaborates with renowned institutions and industry leaders to further its research and development pipeline. The company's commitment to innovation and patient-centric solutions positions it as a significant player in the gene therapy landscape.
Latest News:
- March 12, 2024 - Genprex announces new patent grants in South Korea for Reqorsa® Immunogene Therapy.
- March 19, 2024 - Genprex enters into agreements for the sale and issuance of shares, expecting gross proceeds of $6.5 million.
- April 2, 2024 - Positive preclinical data for NPRL2 gene therapy presented at AACR Annual Meeting.
- April 3, 2024 - Multiple new trial sites added for Acclaim-3 study in extensive-stage small cell lung cancer.
- April 9, 2024 - Research collaborators present positive preclinical data supporting Reqorsa and NPRL2 therapies.
- May 8, 2024 - Genprex announces the passing of its co-founder and CEO Rodney Varner.
- May 14, 2024 - First patient dosed in Phase 1 of Acclaim-3 clinical study for Reqorsa® and Tecentriq® combination therapy.
Genprex, Inc. (NASDAQ: GNPX) announced the dosing of the first patient in its Acclaim-1 clinical trial, evaluating its lead drug, REQORSA, in combination with Tagrisso for late-stage non-small cell lung cancer (NSCLC) patients. This Phase 1/2 trial aims to improve responses in patients whose disease progressed after Tagrisso treatment. The FDA previously granted Fast Track Designation to REQORSA for this patient population. Positive preclinical data indicate that REQORSA may overcome resistance to Tagrisso.
Genprex, Inc. (NASDAQ: GNPX) announced that President and CEO Rodney Varner will discuss the Company's innovative gene therapies for cancer and diabetes at the upcoming BIO CEO and Investor Conference and Diamond Equity Research Conference. The BIO conference is scheduled for February 14-17, 2022, with on-demand presentations available starting February 11. The Diamond conference will take place on February 24, 2022, at 3 p.m. EST. These events will allow for virtual one-on-one meetings and follow-up questions. For more information, visit www.genprex.com.
Genprex, Inc. (NASDAQ: GNPX) announced promising preclinical findings in a study published in Cancers, demonstrating that its ONCOPREX® Nanoparticle Delivery System effectively restores FAS expression in mouse models of metastatic colorectal cancer. This delivery system showed potential in suppressing tumor growth and increasing survival rates. The company plans to expand its oncology programs, leveraging these results to explore additional therapeutic genes for various cancers. The ONCOPREX system is also pivotal in Genprex's ongoing lung cancer trials.
Genprex, Inc. has announced plans to accelerate the opening of clinical trial sites for the Acclaim-1 trial, which investigates the combination of REQORSA™ and AstraZeneca's Tagrisso® in treating non-small cell lung cancer (NSCLC). Four sites are opening to enroll patients in the Phase 1 portion of the trial, with additional sites anticipated for Phase 2. The trial will evaluate the therapy’s efficacy in patients previously treated with Tagrisso. An interim analysis will be conducted at 25 events, and the Phase 2 primary endpoint is progression-free survival.
Genprex, a clinical-stage gene therapy company (NASDAQ: GNPX), announced its participation in key investor and healthcare conferences in January 2022. CEO Rodney Varner and CMO Mark Berger will lead presentations at events including the HC Wainwright BIOCONNECT, Biotech Showcase, and the Precision Lung Cancer World R&D Summit. The CEO Roadshow presentation is scheduled for January 26, 2022. Genprex focuses on developing gene therapies for cancer and diabetes, utilizing their proprietary ONCOPREX® delivery system. REQORSA™, their lead candidate for lung cancer, has received Fast Track Designation from the FDA.
Genprex, Inc. (NASDAQ: GNPX) has expanded its research pipeline to include small cell lung cancer (SCLC) for its lead drug candidate, REQORSA™. SCLC accounts for 10-15% of the lung cancer market, while non-small cell lung cancer (NSCLC) represents 84%. The Chief Medical Officer noted that REQORSA might be effective due to low TUSC2 protein levels in SCLC. The company aims to address unmet medical needs in cancer treatments, potentially improving patient outcomes significantly.
Genprex, Inc. (NASDAQ: GNPX) announced that the FDA granted a second Fast Track Designation for its lead drug candidate, REQORSA Immunogene Therapy. This designation applies to the drug used in combination with Keytruda for patients with late-stage non-small cell lung cancer (NSCLC). Genprex plans to start the Acclaim-2 clinical trial in early 2022. As of Q3 2021, the Company had a strong cash position of $42 million, positioning it well for clinical development efforts in 2022.
Genprex, Inc. (NASDAQ: GNPX) announced its President and CEO, Rodney Varner, will present at the CEO Roadshow on November 17 at 11 a.m. ET. The webinar will focus on Genprex's innovative gene therapies targeting cancer and diabetes. Attendees will have an opportunity for questions post-presentation. The session will be recorded and accessible on Genprex’s website. Genprex specializes in advanced gene therapy solutions, including its lead product REQORSA™, aimed at treating non-small cell lung cancer.
Genprex, Inc. strengthens its leadership team by appointing Mark S. Berger, M.D. as Chief Medical Officer and Hemant Kumar, Ph.D. as Chief Manufacturing and Technology Officer. These additions come as the company advances its Acclaim-1 and Acclaim-2 clinical trials for REQORSA, a systemic gene therapy targeting non-small cell lung cancer (NSCLC). Both leaders bring extensive experience in oncology and gene therapy, aiming to enhance Genprex's pipeline and clinical strategy. Additionally, they were granted stock options at an exercise price of $2.85.
Genprex, Inc. (NASDAQ: GNPX), a clinical-stage gene therapy company, announced that its President and CEO, Rodney Varner, will present at two upcoming investor conferences in September 2021.
The CEO Roadshow Webinar is scheduled for September 22, 2021, at 11:00 a.m. ET, while the Benzinga Healthcare Small Cap Conference takes place on September 29, 2021, at 1:15 p.m. ET.
These presentations will demonstrate Genprex's innovative therapies for cancer and diabetes and will be available for replay on their website.
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