Monte Rosa Therapeutics Reports First Quarter 2022 Financial Results and Business Updates
Monte Rosa Therapeutics (GLUE) has presented promising preclinical data on MRT-2359, a potential treatment for Myc-driven solid tumors, during the AACR Annual Meeting 2022. The company is set to submit an IND application for MRT-2359 by mid-2022. Additionally, Monte Rosa has initiated a research collaboration with EPFL to enhance AI capabilities in drug discovery. Financially, Q1 2022 showed R&D expenses of $17.9 million, up from $9.3 million in Q1 2021. The net loss for the quarter increased to $23.9 million, and cash reserves stood at $322.5 million as of March 31, 2022.
- Presentation of preclinical data for MRT-2359 indicating its potential in targeting Myc-driven cancers.
- On track to submit IND application for MRT-2359 by mid-2022.
- Collaboration with EPFL to enhance AI-driven drug discovery capabilities.
- Net loss increased to $23.9 million in Q1 2022, up from $12.3 million in Q1 2021.
- R&D expenses increased to $17.9 million in Q1 2022, up from $9.3 million in Q1 2021.
– Presented Preclinical Data at AACR Annual Meeting Supporting Clinical Development of MRT-2359 as Potent and Selective GSPT1-directed Molecular Glue Degrader in Solid Tumors; Company on Track to File Investigational New Drug (IND) Application Mid-year –
– Initiated Research with École Polytechnique Fédérale de Lausanne (EPFL); Collaboration to Broaden Monte Rosa’s AI Capabilities –
BOSTON, May 11, 2022 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (NASDAQ: GLUE), a biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today reported business highlights and financial results for the first quarter, ended March 31, 2022.
“Our first quarter was marked by exciting progress across our pipeline of molecular glue degraders and our proprietary QuEEN™ platform,” said Markus Warmuth, M.D., CEO of Monte Rosa. “Last month, we presented compelling preclinical data underscoring the therapeutic potential of MRT-2359 as a potent inducer of degradation of GSPT1 in Myc-driven solid tumors, and we look forward to submitting our IND for MRT-2359 in mid-2022. We are also thrilled to work with Professor Bruno Correia and the world experts at EPFL to further realize the potential of our proprietary AI engine to identify next-generation molecular glue degraders that can eliminate therapeutically relevant proteins previously considered undruggable.”
FIRST QUARTER 2022 & RECENT HIGHLIGHTS
- Presented preclinical data highlighting potential of GSPT1-directed molecular glue degrader MRT-2359 to target Myc-driven cancers. The data were featured in a poster presentation at the American Association for Cancer Research (AACR) Annual Meeting 2022 in New Orleans. Collectively, the data support the clinical development of MRT-2359 in Myc-driven solid tumors, with an initial focus in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC).
- Initiated research collaboration with Dr. Correia and the Laboratory of Protein Design & Immunoengineering at EPFL. The collaboration integrates Monte Rosa’s AI engine with EPFL’s MaSIF (Molecular Surface Interaction Fingerprinting) technology. This combination will uniquely accelerate Monte Rosa’s ability to identify both novel cereblon-based MGDs and novel E3 ligases to target therapeutically relevant proteins.
UPCOMING MILESTONES & DATA PRESENTATIONS
- Submission of IND application to the U.S. Food and Drug Administration (FDA) for MRT-2359 expected in mid-2022
- Initiation of at least one additional lead optimization program expected in 2022
UPCOMING INVESTOR EVENTS
Monte Rosa will be participating in the following upcoming investor conferences:
- UBS Global Healthcare Conference, May 23-25
- Jefferies Global Healthcare Conference, June 8-10
- Wells Fargo Healthcare Conference, Sept. 7-9
FIRST QUARTER 2022 FINANCIAL RESULTS
Research and Development (R&D) Expenses: R&D expenses for the first quarter of 2022 were
General and Administrative (G&A) Expenses: G&A expenses for the first quarter of 2022 were
Net Loss: Net loss for the first quarter of 2022 was
Cash Position and Financial Guidance: Cash, cash equivalents, restricted cash and marketable securities as of March 31, 2022, were
About Monte Rosa
Monte Rosa Therapeutics is a biotechnology company developing a portfolio of novel molecular glue degrader medicines. These medicines are designed to employ the body’s natural mechanisms to selectively eliminate therapeutically relevant proteins. The company has developed a proprietary protein degradation platform, called QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates), that enables it to rapidly identify protein targets and molecular glue degrader, or MGD, product candidates that are designed to eliminate therapeutically relevant proteins in a highly selective manner. The company’s drug discovery platform combines diverse and proprietary chemical libraries of small molecule protein degraders with in-house proteomics, structural biology, AI/machine learning-based target selection and computational chemistry capabilities to predict and obtain protein degradation profiles. For more information, visit www.monterosatx.com.
Forward-Looking Statements
This communication includes express and implied “forward-looking statements,” including forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward looking statements include all statements that are not historical facts, and in some cases, can be identified by terms such as “may,” “might,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “objective,” “anticipate,” “believe,” “estimate,” “predict,” “potential,” “continue,” “ongoing,” or the negative of these terms, or other comparable terminology intended to identify statements about the future. Forward-looking statements contained in herein include, but are not limited to, statements about our product development activities, including our expectations around MRT-2359 and the ongoing development of our QuEEN™ platform, and the advancement of our pipeline and the various products therein, our expectations of timing for filing our IND for MRT-2359, our ability to initiate and the timing of initiation of additional lead optimization programs, and our expectations regarding our collaboration with EPFL. By their nature, these statements are subject to numerous risks and uncertainties, including the impact that the current COVID-19 pandemic will have on our development activities and operations, as well as those risks and uncertainties set forth in our Annual Report on Form 10-K for the year ended December 31, 2021 filed with the US Securities and Exchange Commission, and any subsequent filings, that could cause actual results, performance or achievement to differ materially and adversely from those anticipated or implied in the statements. You should not rely upon forward looking statements as predictions of future events. Although our management believes that the expectations reflected in our statements are reasonable, we cannot guarantee that the future results, performance or events and circumstances described in the forward-looking statements will be achieved or occur. Recipients are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date such statements are made and should not be construed as statements of fact. We undertake no obligation to publicly update any forward-looking statements, whether as a result of new information, any future presentations or otherwise, except as required by applicable law. Certain information contained in these materials and any statements made orally during any presentation of these materials that relate to the materials or are based on studies, publications, surveys and other data obtained from third-party sources and our own internal estimates and research. While we believe these third-party studies, publications, surveys and other data to be reliable as of the date of these materials, we have not independently verified, and make no representations as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. In addition, no independent source has evaluated the reasonableness or accuracy of our internal estimates or research and no reliance should be made on any information or statements made in these materials relating to or based on such internal estimates and research.
| Consolidated Balance Sheets | ||||||||
| (in thousands, except share and per share amounts) | ||||||||
| (unaudited) | ||||||||
| March 31, | December 31, | |||||||
| 2022 | 2021 | |||||||
| Assets | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 138,305 | $ | 346,071 | ||||
| Marketable securities | 178,858 | — | ||||||
| Prepaid expenses and other current assets | 3,203 | 2,595 | ||||||
| Total current assets | 320,366 | 348,666 | ||||||
| Property and equipment, net | 13,396 | 12,325 | ||||||
| Operating lease right-of-use assets | 6,910 | — | ||||||
| Restricted cash | 5,333 | 5,338 | ||||||
| Total assets | $ | 346,005 | $ | 366,329 | ||||
| Liabilities and stockholders’ equity | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 4,511 | $ | 6,558 | ||||
| Accrued expenses and other current liabilities | 6,455 | 10,080 | ||||||
| Current portion of operating lease liability | 1,524 | — | ||||||
| Total current liabilities | 12,490 | 16,638 | ||||||
| Defined benefit plan liability | 2,183 | 2,176 | ||||||
| Operating lease liability | 5,457 | — | ||||||
| Total liabilities | $ | 20,130 | $ | 18,814 | ||||
| Commitments and contingencies | ||||||||
| Stockholders’ equity | ||||||||
| Common stock, | 5 | 5 | ||||||
| Additional paid-in capital | 473,970 | 471,566 | ||||||
| Accumulated other comprehensive loss | (2,133 | ) | (2,021 | ) | ||||
| Accumulated deficit | (145,967 | ) | (122,035 | ) | ||||
| Total stockholders’ equity | 325,875 | 347,515 | ||||||
| Total liabilities and stockholders’ equity | $ | 346,005 | $ | 366,329 | ||||
| Consolidated Statement of Operations and Comprehensive Loss | ||||||||
| (in thousands, except share and per share amounts) | ||||||||
| (unaudited) | ||||||||
| Three months ended March 31, | ||||||||
| 2022 | 2021 | |||||||
| Operating expenses: | ||||||||
| Research and development | $ | 17,915 | $ | 9,273 | ||||
| General and administrative | 6,387 | 2,231 | ||||||
| Total operating expenses | 24,302 | 11,504 | ||||||
| Loss from operations | (24,302 | ) | (11,504 | ) | ||||
| Other income (expense): | ||||||||
| Interest and other income, net | 149 | 6 | ||||||
| Foreign currency exchange gain, net | 96 | 182 | ||||||
| Gain on disposal of fixed assets | 125 | — | ||||||
| Changes in fair value of preferred stock tranche obligations, net | — | (960 | ) | |||||
| Total other income (expense) | 370 | (772 | ) | |||||
| Net loss | $ | (23,932 | ) | $ | (12,276 | ) | ||
| Provision for pension benefit obligation | 34 | 136 | ||||||
| Unrealized loss on available-for-sale securities | (146 | ) | — | |||||
| Comprehensive loss | $ | (24,044 | ) | $ | (12,140 | ) | ||
| Net loss attributable to common stockholders | $ | (23,932 | ) | $ | (12,276 | ) | ||
| Net loss per share attributable to common stockholders—basic and diluted | $ | (0.51 | ) | $ | (7.18 | ) | ||
| Weighted-average number of shares outstanding used in computing net loss per common share—basic and diluted | 46,595,782 | 1,709,227 | ||||||
Contacts:
Investors
Michael Morabito, Solebury Trout
ir@monterosatx.com
Media
Dan Budwick, 1AB
dan@1abmedia.com
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