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Geron Corp - GERN STOCK NEWS

Welcome to our dedicated page for Geron news (Ticker: GERN), a resource for investors and traders seeking the latest updates and insights on Geron stock.

Overview

Geron Corp (GERN) is a clinical-stage biopharmaceutical company committed to pioneering innovative therapies in the field of oncology. At the heart of its research is the development of first-in-class telomerase inhibitors, which target the underlying cellular mechanism that enables cancer cells to maintain telomere length—a key factor that contributes to their unchecked replication. This advanced approach positions Geron as a focused innovator within the broad landscape of cancer treatment development, emphasizing a precision-driven strategy that seeks to fundamentally alter how hematologic cancers are managed.

Core Business and Therapeutic Focus

The company’s main product candidate, imetelstat, is a potent, specific inhibitor designed to disrupt telomerase activity. This mechanism is central to the survival and proliferation of cancer cells, particularly in hematologic malignancies. By inhibiting telomerase, imetelstat potentially restricts the limitless division of malignant cells, thereby offering a novel therapeutic pathway for conditions such as myelodysplastic syndromes and myelofibrosis. The clinical-stage exploration of imetelstat underscores Geron Corp's commitment to transforming cancer treatment protocols and deepening our understanding of oncology therapy.

Revenue Model and Corporate Strategy

Geron Corp operates with a revenue model rooted in strategic collaborations within the pharmaceutical and biotechnology sectors. The company leverages licensing agreements, milestone-based payments, and royalty structures to support its research and operational endeavors. This multifaceted approach not only diversifies the financial underpinnings of its business strategy but also reinforces its role as an essential contributor to the oncology therapeutic landscape.

Industry Position and Research Emphasis

Within the competitive framework of biopharmaceutical research, Geron distinguishes itself by focusing exclusively on the development of innovative cancer therapies. Its research-driven approach is underscored by rigorous clinical studies and a deep understanding of the molecular biology of cancer. The company is positioned among specialized entities that are exploring targeted treatment options, relying on sophisticated scientific methodologies to bridge the gap between research innovations and practical, clinical applications.

Scientific and Clinical Expertise

Geron Corp marries scientific inquiry with clinical application through its emphasis on personalized and mechanism-based approaches in treating cancer. Its efforts in developing imetelstat represent a blend of cutting-edge research and meticulous clinical evaluation, providing insights into the potential of telomerase inhibition as a therapeutic modality. By prioritizing expert analysis over speculative claims, Geron consistently communicates an evidence-based narrative that underpins its clinical trials and strategic partnerships.

Operational and Strategic Highlights

  • Innovative Mechanism of Action: The focus on telomerase inhibition addresses a fundamental aspect of cancer cell immortality, offering a concrete rationale behind the therapeutic potential of imetelstat.
  • Focused Clinical Applications: With a targeted approach to hematologic malignancies, Geron becomes a key player in the niche area of blood cancer therapies.
  • Strategic Collaborations: Revenue generation through partnerships and licensing highlights the company’s integrated approach to research, development, and commercial strategy.
  • Scientific Rigor: The company’s operations are underpinned by robust clinical research, embodying the principles of precise and evidence-based innovation in oncology.

Conclusion

In summary, Geron Corp represents a paradigm of focused research and development within the biopharmaceutical industry. Its innovative approach to cancer treatment, primarily through the development of a first-in-class telomerase inhibitor, underscores its commitment to addressing complex oncological challenges through scientific precision and clinical expertise. This detailed exploration helps investors, analysts, and industry watchers gain a nuanced understanding of Geron Corp’s operations, setting a clear context for its role in the evolving landscape of cancer therapeutics.

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Geron Corporation (Nasdaq: GERN) has initiated dosing for the first patient in its Phase 3 clinical trial, IMpactMF, studying imetelstat for refractory myelofibrosis (MF), with overall survival as the primary endpoint. This trial, targeting 320 patients, addresses a significant unmet need given the median overall survival of 14-16 months for those unresponsive to JAK inhibitors. Interim results are anticipated in 2024, with final results expected in 2025. Imetelstat is also Fast Track designated by the FDA for certain patient populations, enhancing its development prospects.

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Geron Corporation (Nasdaq: GERN) announced the issuance of non-statutory stock options for 240,000 shares to newly hired employees. These options were granted on March 17, 2021, at an exercise price of $1.81 per share, matching the stock's closing price on that date. The options have a 10-year term and vest over four years, with 12.5% vesting after six months of employment. This grant complies with Nasdaq Listing Rule 5635(c)(4) and is part of Geron's 2018 Inducement Award Plan aimed at attracting new talent.

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Geron Corporation (Nasdaq: GERN) reported its financial results for Q4 and FY 2020, ending with $260 million in cash and marketable securities, expected to last until late 2022. The company is advancing its Phase 3 trials for imetelstat in hematologic malignancies, with IMerge Phase 3 expected to be fully enrolled in H2 2021. However, COVID-19 has caused delays in enrollment. Fiscal 2020 net loss was $75.6 million, with revenues of $253,000. Geron anticipates operating expenses between $108 and $112 million in 2021 while preparing for a potential NDA submission in 2023.

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Geron Corporation (Nasdaq: GERN) will announce its fourth quarter and full year 2020 financial results on March 11, 2021, after market close. A conference call will follow at 4:30 p.m. ET to discuss these results and recent developments. Interested participants can access the call via a pre-registration link. Geron focuses on developing imetelstat, a telomerase inhibitor, currently being tested in two Phase 3 trials: IMerge for lower-risk myelodysplastic syndromes and IMpactMF for refractory myelofibrosis. More details are available on their website.

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Geron Corporation (Nasdaq: GERN) has granted non-statutory stock options totaling 431,600 shares to newly hired employees as part of their employment incentives. The options, issued on February 17, 2021, have an exercise price of $1.99 per share, aligning with Geron's closing stock price on the grant date. The vesting period is set over four years, beginning with 12.5% at six months, followed by equal installments thereafter. This grant adheres to Nasdaq rules and is part of Geron's 2018 Inducement Award Plan.

Geron focuses on developing imetelstat, a telomerase inhibitor, in hematologic malignancies.

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Geron Corporation (Nasdaq: GERN) announced the grant of non-statutory stock options for 120,000 shares of common stock to newly hired employees as an employment inducement. The options were granted on January 20, 2021, with an exercise price of $1.74 per share, matching the closing stock price on the grant date. These options have a 10-year term and vest over four years. This action complies with Nasdaq Listing Rule 5635(c)(4) and aligns with Geron's 2018 Inducement Award Plan. Geron is focused on developing imetelstat, a telomerase inhibitor, in hematologic cancers.

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Geron Corporation (Nasdaq: GERN) announced that CEO John A. Scarlett will present a company overview at the B. Riley Securities Virtual Oncology Investor Conference on January 20 at 3:00 p.m. ET. The presentation will be accessible via a live audio webcast on Geron's website, with a replay available for 30 days post-event.

Geron focuses on developing imetelstat, a first-in-class telomerase inhibitor targeting hematologic myeloid malignancies. For further details, visit www.geron.com.

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Geron Corporation (Nasdaq: GERN) has announced the launch of the IMpactMF Phase 3 clinical trial for imetelstat, a telomerase inhibitor targeting refractory myelofibrosis (MF). This trial aims to enroll approximately 320 patients and assess the drug's ability to extend overall survival and improve symptoms, following promising Phase 2 results. The primary endpoint will focus on overall survival, with secondary endpoints covering various clinical outcomes. The trial incorporates over 150 sites globally, though potential COVID-19-related delays are acknowledged.

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Geron Corporation (Nasdaq: GERN) has achieved fifty percent enrollment in the IMerge Phase 3 clinical trial for imetelstat, targeting lower risk myelodysplastic syndromes (MDS). This milestone is crucial for advancing the trial, which aims to assess transfusion independence and disease-modifying effects of imetelstat. The trial is set to enroll approximately 170 patients, with top-line results expected in the second half of 2022, provided enrollment completes by mid-2021.

Imetelstat is the first telomerase inhibitor in development, offering a potential treatment alternative for MDS patients.

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Geron Corporation (Nasdaq: GERN) announced multiple presentations at the 62nd ASH Annual Meeting, showcasing clinical data on imetelstat, their telomerase inhibitor. Key highlights include:

  • 42% of patients in the IMerge Phase 2 trial achieved over 8-week red blood cell transfusion independence.
  • Imetelstat showed potential disease-modifying activity in patients with relapsed/refractory myelofibrosis (MF), with significant reductions in mutation burden.
  • Upcoming Phase 3 trials, IMerge and IMpactMF, aim to validate imetelstat’s efficacy in lower risk MDS and high-risk MF.
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FAQ

What is the current stock price of Geron (GERN)?

The current stock price of Geron (GERN) is $1.38 as of April 4, 2025.

What is the market cap of Geron (GERN)?

The market cap of Geron (GERN) is approximately 901.2M.

What is Geron Corp's primary focus?

Geron Corp is dedicated to the research and development of innovative cancer therapies, particularly through the use of first-in-class telomerase inhibitors.

How does the company plan to treat cancers?

The company is exploring the use of imetelstat, a potent telomerase inhibitor, to target the cell replication process in hematologic malignancies such as myelodysplastic syndromes and myelofibrosis.

What makes Geron Corp's approach unique?

Geron Corp employs a targeted mechanism-based strategy by inhibiting telomerase, a key enzyme that allows cancer cells limitless replication, thus addressing a fundamental aspect of cancer biology.

How does Geron generate revenue?

The company generates revenue primarily through collaboration agreements, licensing arrangements, milestone payments, and royalties, which support its research and clinical operations.

How is Geron positioned within the oncology research space?

Geron Corp is recognized for its focused research on telomerase inhibition, situating it among specialized entities within the broader oncology and biopharmaceutical sectors.

What therapeutic areas are targeted by imetelstat?

Imetelstat is primarily being developed for hematologic malignancies, with a focus on diseases such as myelodysplastic syndromes and myelofibrosis, where traditional treatment options are limited.
Geron Corp

Nasdaq:GERN

GERN Rankings

GERN Stock Data

901.22M
632.75M
0.1%
78.42%
9.17%
Biotechnology
Pharmaceutical Preparations
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United States
FOSTER CITY