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Genflow Biosciences PLC Announces Half-year Report

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Genflow Biosciences (LSE:GENF) released its half-year report for the period ending June 30, 2024. Key developments include progress in its longevity programs for MASH and Werner Syndrome, enhanced by the FDA's encouragement to proceed with pilot proof-of-concept studies using 3-D liver organoids from Werner patients. Additionally, Genflow initiated a feasibility study with Exothera S.A. for GMP-compliant production and is selecting CROs for a dog clinical trial of GF-1004.

The company received €777,281 in grants for collaborations on sarcopenia and exosome-mRNA projects and €350,000 from the Wallonia government. Financially, Genflow raised £715,000 in equity financing, bringing cash reserves to £1,139,859, despite higher administration expenses of £1,316,368. The period's operating loss was £524,259. The company remains debt-free and expects future funding to support its R&D activities.

Genflow Biosciences (LSE:GENF) ha pubblicato il suo rapporto semestrale per il periodo conclusosi il 30 giugno 2024. Tra gli sviluppi chiave, ci sono progressi nei suoi programmi di longevità per la Sindrome di MASH e la Sindrome di Werner, migliorati dall'incoraggiamento della FDA a procedere con studi pilota di fattibilità utilizzando organoidi epatici 3-D provenienti da pazienti con la Sindrome di Werner. Inoltre, Genflow ha avviato uno studio di fattibilità con Exothera S.A. per la produzione conforme alle GMP e sta selezionando CRO per un trial clinico su cani del GF-1004.

L'azienda ha ricevuto €777.281 in sovvenzioni per collaborazioni su progetti di sarcopenia e exosome-mRNA e €350.000 dal governo fiammingo. Dal punto di vista finanziario, Genflow ha raccolto £715.000 in finanziamenti azionari, portando le riserve di cassa a £1.139.859, nonostante spese di amministrazione più elevate di £1.316.368. La perdita operativa del periodo è stata di £524.259. L'azienda rimane senza debiti e si aspetta che finanziamenti futuri supportino le sue attività di R&D.

Genflow Biosciences (LSE:GENF) ha publicado su informe semestral para el periodo que finalizó el 30 de junio de 2024. Los desarrollos clave incluyen avances en sus programas de longevidad para el Síndrome de MASH y el Síndrome de Werner, reforzados por el aliento de la FDA para proceder con estudios piloto de prueba de concepto utilizando organoides hepáticos en 3-D de pacientes con el Síndrome de Werner. Además, Genflow inició un estudio de viabilidad con Exothera S.A. para la producción conforme a GMP y está seleccionando CROs para un ensayo clínico en perros de GF-1004.

La empresa recibió €777.281 en subvenciones para colaboraciones en proyectos de sarcopenia y exosome-mRNA, y €350.000 del gobierno de Valonia. Desde el punto de vista financiero, Genflow recaudó £715.000 en financiamiento de capital, elevando las reservas de efectivo a £1.139.859, a pesar de gastos administrativos más altos de £1.316.368. La pérdida operativa del período fue de £524.259. La empresa sigue libre de deudas y espera que la financiación futura apoye sus actividades de I+D.

Genflow Biosciences (LSE:GENF)는 2024년 6월 30일 종료된 반기 보고서를 발표했습니다. 주요 발전 사항으로는 MASH 증후군 및 Werner 증후군의 장수 프로그램에서의 진전이 포함되며, 이는 FDA가 Werner 환자로부터 채취한 3-D 간 오르가노이드를 사용한 파일럿 개념 증명 연구를 진행하도록 권장한 덕분입니다. 또한, Genflow는 Exothera S.A.와 함께 GMP 준수 생산을 위한 타당성 연구를 시작했으며, GF-1004에 대한 개 임상 시험을 위해 CRO를 선정하고 있습니다.

회사는 근감소증 및 엑소좀-mRNA 프로젝트에 대한 협력으로 €777,281의 보조금을 받았고, 왈로니아 정부로부터 €350,000를 지원받았습니다. 재정적으로, Genflow는 £715,000의 자본 조달을 통해 현금 보유액을 £1,139,859로 늘렸지만, 관리비가 £1,316,368로 증가했습니다. 이 기간 동안 운영 손실은 £524,259였습니다. 회사는 부채가 없으며, 향후 자금이 연구 개발 활동을 지원할 것으로 기대하고 있습니다.

Genflow Biosciences (LSE:GENF) a publié son rapport semestriel pour la période se terminant le 30 juin 2024. Les développements clés incluent des progrès dans ses programmes de longévité pour le Syndrome de MASH et le Syndrome de Werner, renforcés par l'encouragement de la FDA à procéder à des études pilotes de preuve de concept utilisant des organoïdes hépatiques en 3-D provenant de patients atteints du syndrome de Werner. De plus, Genflow a lancé une étude de faisabilité avec Exothera S.A. pour une production conforme aux BPF et sélectionne des CRO pour un essai clinique chez les chiens de GF-1004.

L'entreprise a reçu 777.281 € en subventions pour des collaborations sur des projets de sarcopénie et d'exosome-mRNA, ainsi que 350.000 € du gouvernement wallon. Financièrement, Genflow a levé 715.000 £ en financement par actions, portant ses réserves de liquidités à 1.139.859 £, malgré des charges administratives plus élevées de 1.316.368 £. La perte d'exploitation pour la période s'élevait à 524.259 £. L'entreprise reste sans dette et s'attend à ce que le financement futur soutienne ses activités de R&D.

Genflow Biosciences (LSE:GENF) hat seinen Halbjahresbericht für den Zeitraum zum 30. Juni 2024 veröffentlicht. Zu den wichtigsten Entwicklungen gehören Fortschritte in seinen Langlebigkeitsprogrammen für das MASH- und das Werner-Syndrom, unterstützt durch die Ermutigung der FDA, Pilotstudien mit 3-D-Leberorganoiden von Patienten mit dem Werner-Syndrom durchzuführen. Darüber hinaus hat Genflow eine Machbarkeitsstudie mit Exothera S.A. zur GMP-konformen Produktion initiiert und wählt CROs für eine klinische Studie mit Hunden zu GF-1004 aus.

Das Unternehmen erhielt €777.281 an Zuschüssen für Kooperationen zu Sarkopenie- und Exosom-mRNA-Projekten sowie €350.000 von der flämischen Regierung. Finanziell hat Genflow £715.000 in Eigenkapitalfinanzierungen eingeworben, womit die liquide Mittel auf £1.139.859 erhöht wurden, trotz höherer Verwaltungskosten von £1.316.368. Der operative Verlust für den Zeitraum betrug £524.259. Das Unternehmen bleibt schuldenfrei und erwartet, dass zukünftige Finanzierungen seine F&E-Aktivitäten unterstützen.

Positive
  • Received €777,281 in grants for research collaborations.
  • Raised £715,000 through equity financing.
  • Increased cash reserves to £1,139,859.
  • Debt-free status maintained.
Negative
  • Operating loss of £524,259 for the period.
  • Increased administration expenses to £1,316,368.
  • Higher R&D costs at £938,109.

LONDON, UNITED KINGDOM / ACCESSWIRE / September 30, 2024 / Genflow (LSE:GENF) is pleased to announce its half year results for the six-month period ended 30 June 2024.

Chairman's Statement

It is with pleasure that I take this opportunity to update shareholders of Genflow Biosciences Plc ("Genflow" or the "Company") on the Company's performance during the first six months of 2024.

Over the six months to 30 June 2024, the Company has made strides in its principal longevity programs: MASH (Metabolic Dysfunction-Associated Steatohepatitis) and Werner Syndrome.

In June, we updated shareholders on the momentum created with respect to our pre-clinical programs in MASH, and the guidance expected to be received from the FDA in the future. This guidance, which we anticipate receiving in the future, is expected to come through the FDA's Initial Targeted Engagement for Regulatory Advice on CBER Products (INTERACT), as a result of the Company submitting a comprehensive briefing package conducted with our lead drug candidate, GF-1002, for the treatment of MASH. In the meantime, the FDA has encouraged Genflow to proceed with its plans to identify appropriate animal models through pilot proof-of-concept ("POC") studies. Specifically, we have established a functional 3-D organoids of liver using cells from Werner patients. This organoid testing helps reduce the need for animal models in our scientific research. Organoids are miniature, lab-grown versions of human organs or tissues that mimic the structure and function of their real counterparts. By using these organoids, we can model human Werner Syndrome and better test response of our SIRT6 based gene therapy in a more human-relevant environment, rather than relying on unreliable animal models.

Additionally, we have initiated a feasibility study with a Contract Development Manufacturing Organization (CDMO), Exothera S.A, to assess the ability to produce its future MASH clinical lot in accordance with Good Manufacturing Practices (GMP). We are also in the process of selecting Contract Research Organizations (CROs) to conduct our upcoming dog clinical trial, aimed at studying our simplified Nake DNA version of our Centenarian SIRT6 drug candidate, GF-1004. We will provide updates in relation to our veterinary study in due course.

Over the period, we have also been working on two exciting collaborations supported by non-diluting and non-reimbursable research grants from the Government of Wallonia in Belgium, as follows;

· Sarcopeniaresearch program with Revatis SA - focusing on the development of muscle progenitor cells which will be loaded with Genflow's proprietary SIRT6 for the prevention and treatment of sarcopenia, the age-related loss of muscle mass and function. Genflow aims to counteract the detrimental effects of aging on muscle tissue with our sarcopenia program, which holds potential for significantly improving the quality of life for older adults affected by muscle loss and weakness.

· Exosome-mRNA project with EXO Biologics - which aims to deliver a therapeutic product composed of exosomes encapsulating an AAV or mRNA encoding SIRT6. The exosome therapy will be designed to target liver fibrosis (MASH) and Werner Syndrome, potentially leading to groundbreaking treatments for both diseases.

During the period, the Company has received grant funding of totalling €777,281 in respect of these projects, with further financial support committed in the first half of 2025.

In addition, Genflow Biosciences SRL, received €350,000 in April 2024, from the regional government of Wallonia - Belgium Service Public de Wallonie, representing the second tranche of this awarded grant recognised in the previous year, 2023.

Further strengthening the Company's financial position and increasing its institutional investor base, the Company completed a placing and subscription to which raised £715,000 (before expenses) during the period. We were privileged to have Premier Miton, a well-known UK institution, participate in this fundraise.

Financial Overview

As of 30 June 2024, the Group had cash reserves of £1,139,859 (31 December 2023: £683,974) which has been derived from equity fundraising of £663,600 (net of expenses) and the receipt of research and development grants of £664,219 (€777,281) and £299,145 (€350,000) The Company remains debt free.

Administration expenses for 30 June 2024 totalled £1,316,368 (30 June 2023: £815,477), which primarily consisted of research and development costs of £938,109 (30 June 2023: £415,157), legal and professional fees totalling £90,654 (30 June 2023: £103,366) and Directors' fees of £178,656 (30 June 2023: £178,783).

The significant jump in research and development costs for 2024 is in relation to the advancement of testing, which has transitioned to the in vivo stage, which is inherently more costly.

Other Comprehensive Income was charged with a translation gain of £8,652 upon converting the Subsidiary's results for the period to GBP.

Future

On behalf of the Board, I thank you for your continued support. Our commitment to pioneering therapeutic solutions for longevity has been strengthened by the support of our collaborative partners and promising feedback from the FDA during the six-months to 30 June 2024. This encouragement reinforces our commitment to developing effective therapeutic solutions for age-related diseases. We remain focused on our mission to improve healthspan, and I look forward to providing you with further updates as we progress through our work programs, including clinical dog trials.

Tamara Joseph
Chairman

CONSOLIDATED STATEMENT OF FINANCIAL POSITION
AS AT 30 June 2024

Note

Unaudited

6 Months ended

30 June 2024

Audited

12 Months ended

31 December 2023

Unaudited

6 Months ended

30 June 2023

Non-current assets

Property, plant & equipment

3,456

3,394

3,991

Total non-current assets

3,456

3,394

3,991

Current assets

Trade and other receivables

6

207,791

384,285

400,891

Cash and cash equivalents

1,139,859

683,974

1,507,437

Total current assets

1,347,650

1,068,259

1,908,328

Total assets

1,351,106

1,071,653

1,912,319

Current liabilities

Trade and other payables

7

492,761

345,738

194,134

Total current liabilities

492,761

345,738

194,134

Total liabilities

492,761

345,738

194,134

Net Assets

858,345

725,915

1,718,185

Equity

Share capital

8

104,912

87,752

87,752

Share premium

8

4,837,340

4,190,900

4,190,900

Other reserves

9

212,577

219,488

204,592

Retained earnings

(4,296,484)

(3,772,225)

(2,765,059)

Total equity

858,345

725,915

1,718,185

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME
FOR THE SIX MONTHS ENDED 30 JUNE 2024

Notes

Unaudited

6 Months ended

30 June 2024

Audited

12 Months ended

31 December 2023

Unaudited

6 Months ended

30 June 2023

Other operating income

792,109

169,854

194,068

Administrative expenses

4

(1,316,368)

(1,798,559)

(815,477)

Operating loss

(524,259)

(1,628,705)

(621,409)

Finance costs

-

-

(130)

Loss before tax

(524,259)

(1,628,705)

(621,539)

Tax expense

-

-

-

Loss for the period / year attributable to owners of the parent

(524,259)

(1,628,705)

(621,539)

Other Comprehensive loss:

Items that could be reclassified to profit or loss

Exchange differences on translation of foreign operations

(8,652)

(11,853)

(26,749)

Total comprehensive loss for the period / year attributable to owners of the parent

(532,911)

(1,640,558)

(648,288)

Loss per share (pence) from continuing operations attributable to owners of the Parent - Basic & Diluted

5

(0.165)

(0.557)

(0.210)

CONSOLIDATED STATEMENT OF CASH FLOWS
FOR THE SIX MONTHS ENDED 30 JUNE 2024

Unaudited

6 Months ended

30 June 2024

Audited

12 Months ended

31 December 2023

Unaudited

6 months ended

30 June 2023

Cash flows used in operating activities:

Loss after taxation

(524,259)

(1,628,705)

(621,539)

Adjustments for:

Depreciation & amortisation

605

1,034

413

Share based payments

1,741

-

-

Decrease/(increase) in trade and other receivables

168,964

(131,014)

(142,229)

Increase/(decrease) in trade and other payables

154,185

103,228

(107,585)

Foreign exchange

-

-

26,749

Net cash outflow from operating activities

(198,764)

(1,655,457)

(844,191)

Cash flow used in investing activities:

Purchase of property, plant & equipment

(743)

(2,439)

(4,528)

Net cash used in investing activities

(743)

(2,439)

(4,528)

Cash flow from financing activities:

Proceeds from issue of shares

715,000

-

-

Cost of share issue

(51,400)

-

-

Net cash generated from financing activities

663,600

-

-

Net increase/(decrease) in cash and cash equivalents

464,093

(1,657,896)

(848,719)

Cash and cash equivalents at beginning of period / year

683,974

2,356,225

2,356,225

FX on cash

(8,208)

(14,355)

(69)

Cash and cash equivalents at end of period

1,139,859

683,974

1,507,437

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY
FOR THE SIX MONTHS ENDED 30 JUNE 2024

Share capital

Share

premium

Other reserves

Retained earnings/loss

Total

Unaudited- 30 June 2024

At 1 January 2024

87,752

4,190,900

219,488

(3,772,225)

725,915

Loss of the period

-

-

-

(524,259)

(524,259)

Exchange differences on translation of foreign operations

-

-

(8,652)

-

(8,652)

Total comprehensive loss for the period

-

-

(8,652)

(524,259)

(532,911)

Transactions with owners

Issue of share capital

17,160

697,840

-

-

715,000

Costs of issue

-

(51,400)

-

-

(51,400)

Share based payments

-

-

1,741

-

1,741

Total Transactions with owners

17,160

646,440

1,741

-

665,341

At 30 June 2024 (unaudited)

104,912

4,837,340

212,577

(4,296,484)

858,345

Unaudited- 30 June 2023

At 1 January 2023

87,752

4,190,900

231,341

(2,143,520)

2,366,473

Loss of the period

-

-

-

(621,539)

(621,539)

Exchange differences on translation of foreign operations

-

-

(26,749)

-

(26,749)

Total comprehensive loss for the period

-

-

(26,749)

(621,539)

(648,288)

Total Transactions with owners

-

-

-

-

-

At 30 June 2023 (unaudited)

87,752

4,190,900

204,592

(2,765,059)

1,718,185

Audited- 31 December 2023

At 1 January 2023

87,752

4,190,900

231,341

(2,143,520)

2,366,473

Loss for the year

-

-

-

(1,628,705)

(1,628,705)

Exchange differences on translation of foreign operations

-

-

(11,853)

-

(11,853)

Total comprehensive loss for the period

-

-

(11,853)

(1,628,705)

(1,640,558)

Total Transactions with owners

-

-

-

-

-

At 31 December 2023 (audited)

87,752

4,190,900

219,488

(3,772,225)

725,915

1. Reporting Entity

Genflow Biosciences Plc (the "Company") is a company domiciled in the United Kingdom. The consolidated interim financial information as at, and for the six months ended, 30 June 2024 comprise the results of the Company and its subsidiaries (together referred to as the "Group").

The consolidated financial statements of the Group as at, and for the year ended, 31 December 2023 are available upon request from the Company's registered office at 6 Heddon Street, London, W1B 4BT or at genflowbio.com.

2. BASIS OF PREPARATION

The financial information of the Group for the 6 months ended 30 June 2024 was approved and authorised for issue by the Board of the Company on 30 September 2024. The interim results have not been audited. This financial information has been prepared in accordance with the accounting policies that are expected to be applied in the Report and Accounts of the Company for the year ended 31 December 2023 and are consistent with the recognition and measurement requirements of IFRS as adopted by the United Kingdom. The comparative information for the full year ended 31 December 2023 is not the Group's full annual accounts for that period but has been derived from the annual financial statements for that period.

The consolidated financial information incorporates the results of the Group as at 30 June 2024. The corresponding amounts are for the year ended 31 December 2023 and for the 6 month period ended 30 June 2023.

The Group financial information is presented in Pound Sterling and values are rounded to the nearest pound.

The same accounting policies, presentation and methods of computation are followed in the interim consolidated financial information as were applied in the Group's latest annual audited financial statements except for those that relate to new standards and interpretations effective for the first time for periods beginning on (or after) 1 January 2024 and will be adopted in the 2024 annual financial statements.

A number of new standards and amendments became effective on 1 January 2024 and have been adopted by the Group. None of these standards have materially affected the Group.

3. GOING CONCERN

As the Group's assets are not generating revenue, an operating loss has been reported and an operating loss is expected in the 12 months to 30 June 2025. However, the Directors believe that the Group will have sufficient funds to meet its immediate working capital requirements and undertake its targeted operating activities over the next 12 months from the date of approval of these financial statements.

As at 30 June 2024, the Group has cash resources of £1,139,859. The Group received funding during the period to support working capital requirements and to support its scientific research and development work streams. In April 2024, the Company completed a placing and subscription which raised £715,000 (before expenses); and received the second tranche of the grant from the Wallonia Region, totalling €350,000. In May 2024, the Group secured further grant funding of €1.55m, of which €777,273 has been received and the remainder will be received in 2025.

Management plan to use these funds, and future grant funding, to meet the working capital requirements of the Group and to further its research and development activities. In early 2024, management prepared a forecast covering 18-months and believe that current cash reserves plus the receipt of committed grant funding in 2025 will adequately cover the working capital requirements of the Group. Notably, all research and development costs are discretionary and therefore, can be reduced if necessary. However, the Group will need to seek further funding to progress the Group's research workstreams and to progress to the clinical trial phase.

As such, the Directors have a reasonable expectation that the Group has, and will have, future access to adequate resources to continue in operational existence for the foreseeable future and, therefore, continue to adopt the going concern basis in preparing the interim financial statements.

4. EXPENSES BY NATURE

Unaudited

6 Months ended

30 June 2024

£

Audited

12 Months ended

31 December 2023

£

Unaudited

6 Months ended

30 June 2023

£

Directors' fees

178,656

362,312

178,783

Directors' pensions

713

1,093

381

Directors' social security contributions

5,069

14,945

8,245

Fees payable to the Company's auditors for the audit of the Parent Company and group financial statements

5,000

53,285

-

Professional, legal and consulting fees

90,654

215,971

103,366

PR and marketing

48,535

106,819

63,903

Accounting related services

3,780

7,839

8,638

Insurance

19,595

22,476

19,563

Office and administrative expenses

10,777

18,897

5,092

IT and software services

7,377

5,828

1,492

Travel and entertainment

927

23,830

13,255

Research and development costs

938,109

960,314

415,157

Share based payments

1,741

-

-

Depreciation

610

1,034

-

Other expenses

4,825

3,196

(2,398)

Total administrative expenses

1,316,368

1,798,559

815,477

5. LOSS PER SHARE

Unaudited

6 Months ended

30 June 2024

£

Audited

12 Months ended

31 December 2023

£

Unaudited

6 Months ended

30 June 2023

£

Net loss for the year from continued operations attributable to equity shareholders

524,259

1,628,705

621,539

Weighted average number of shares for the period/year

318,085,714

292,506,618

292,506,618

Basic loss per share for continued operations (expressed in pence)

(0.165)

(0.557)

(0.210)

6. TRADE AND OTHER DEBTORS

Trade and other debtors

Unaudited

6 Months ended

30 June 2024

£

Audited

12 Months ended

31 December 2023

£

Unaudited

6 Months ended

30 June 2023

£

VAT receivable

46,011

36,278

48,205

Prepayments

158,748

41,041

22,854

Other receivables

3,032

306,966

329,832

207,791

384,285

400,891

Trade and other receivables are all due within one year. The fair value of all receivables is the same as their carrying values stated above. These assets, excluding prepayments, are the only form of financial asset within the Group, together with cash and cash equivalents. There are no trade receivables therefore an aging analysis has not been provided.

7. TRADE AND OTHER PAYABLES

Unaudited

6 Months ended

30 June 2024

£

Audited

12 Months ended

31 December 2023

£

Unaudited

6 Months ended

30 June 2023

£

Trade payables

442,221

254,695

143,654

Accruals

32,841

60,014

34,012

Other payables

17,699

31,029

16,468

492,761

345,738

194,134

All trade and other payables are due for payment within twelve months. Trade payables are settled within normal commercial terms, usually between 30-60 days.

8. SHARE CAPITAL

Company

Number of shares

Ordinary shares

£

Share premium

£

Total

£

Issued and fully paid

At 1 January 2023

292,506,618

87,752

4,190,900

4,278,652

At 30 December 2023

292,506,618

87,752

4,190,900

4,278,652

Issue of Ordinary Shares

57,200,000

17,160

697,840

715,000

Deduction of cost of capital

-

-

(51,400)

(51,400)

At 30 June 2024

349,706,618

104,912

4,837,340

4,942,252

On 9 Aril 2024, the Company issued and allotted 57,200,000 new Ordinary Shares at a price of 0.0125 pence per share for gross proceeds of £715,000 (excluding expenses).

9. SHARE WARRANT RESERVE

The balance held in the share options reserve relates to the fair value of the share warrants that have been charged to the profit or loss since adoption of IFRS 2 'Share-based payment'.

Warrants:

At 30 June 2024, 2,860,000 warrants over shares were exercisable (31 December 2023: No warrants were exercisable).

2,860,000 warrants were granted during the year (31 December 2023: No warrants granted) pursuant to the terms of a placing of shares.

During the period ended 30 June 2024, no warrants were exercised (year ended 31 December 2023: No warrants were exercised) and no warrants expired in the period (year ended 31 December 2023: No warrants expired).

£1,741 was charge to loss for the year in respect of outstanding warrants (2023: Nil).

10. COMMITMENTS

The commitments stated in the Group's Annual Financial Statements for the year ended 31 December 2023 remain in place.

11. EVENTS AFTER THE REPORTING DATE

There were no events after the reporting period.

Market Abuse Regulation (MAR) Disclosure

The information contained within this announcement is deemed to constitute inside information as stipulated under the Market Abuse Regulation ("MAR") (EU) No. 596/2014, as incorporated into UK law by the European Union (Withdrawal) Act 2018. Upon the publication of this announcement, this inside information is now considered to be in the public domain.

Contacts

Genflow Biosciences

Harbor Access

Dr Eric Leire, CEO

Jonathan Paterson, Investor Relations

+32-477-495-881

+1 475 477 9401

Jonathan.Paterson@Harbor-access.com

Corporate Brokers

Capital Plus Partners Ltd

Keith Swann, +44 0203 821 6169

Jon Critchley, +44 0203 821 6168

About Genflow Biosciences

Founded in 2020, Genflow Biosciences Plc. (LSE:GENF) (OTCQB:GENFF), a biotechnology company headquartered in the UK with R&D facilities in Belgium, is pioneering gene therapies to decelerate the aging process, with the goal of promoting longer and healthier lives while mitigating the financial, emotional, and social impacts of a fast-growing aging global population. Genflow's lead compound, GF-1002, works through the delivery of a centenarian variant of the SIRT6 gene which has yielded promising preclinical results. Scheduled to begin in 2025, Genflow's clinical trial aims to explore the potential benefits of GF-1002 in treating MASH (Metabolic Dysfunction-Associated Steatohepatitis), the most prevalent chronic liver disease for which there is no effective treatments. Please visit www.genflowbio.com and follow the Company on LinkedIn and Twitter/X.

DISCLAIMER

The contents of this announcement have been prepared by, and are the sole responsibility of, the Company.

This announcement may contain forward-looking statements. The forward-looking statements include, but are not limited to, statements regarding the Company's or the Directors' expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statement that refers to projections, forecasts or other characterisations of future events or circumstances, including any underlying assumptions, is a forward-looking statement. The words "anticipate", "believe", "continue", "could", "estimate", "expect", "intend", "may", "might", "plan", "possible", "potential", "predict", "project", "seek", "should", "would" and similar expressions, or in each case their negatives, may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking.

Forward-looking statements include all matters that are not historical facts. Forward-looking statements are based on the current expectations and assumptions regarding the Company, the business, the economy and other future conditions. Because forward-looking statements relate to the future, by their nature, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict. Forward-looking statements are not guarantees of future performance and the Company's actual financial condition, actual results of operations and financial performance, and the development of the industries in which it operates or will operate, may differ materially from those made in or suggested by the forward-looking statements contained in this announcement. In addition, even if the Company's financial condition, results of operations and the development of the industries in which it operates or will operate, are consistent with the forward-looking statements contained in this announcement, those results or developments may not be indicative of financial condition, results of operations or developments in subsequent periods. Important factors that could cause actual results to differ materially from those in the forward-looking statements include regional, national or global, political, economic, social, business, technological, competitive, market and regulatory conditions.

Any forward-looking statement contained in this announcement applies only as of the date of this announcement and is expressly qualified in its entirety by these cautionary statements. Factors or events that could cause the Company's actual plans or results to differ may emerge from time to time, and it is not possible for the Company to predict all of them. The Company expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained in this announcement to reflect any change in its expectations or any change in events, conditions or circumstances on which any forward-looking statement contained in this announcement is based, unless required to do so by applicable law, the Prospectus Regulation Rules, the Listing Rules, the Disclosure Guidance and Transparency Rules of the FCA or the UK Market Abuse Regulation.

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

SOURCE: Genflow Biosciences PLC



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FAQ

What are the key highlights from Genflow Biosciences' half-year report for 2024?

Key highlights include progress in longevity programs, FDA encouragement for pilot studies, €777,281 in grants for research collaborations, and raising £715,000 through equity financing.

How much did Genflow Biosciences raise through equity financing in the first half of 2024?

Genflow Biosciences raised £715,000 through equity financing in the first half of 2024.

What is Genflow Biosciences' cash reserve as of June 30, 2024?

As of June 30, 2024, Genflow Biosciences had cash reserves of £1,139,859.

What were the administration expenses for Genflow Biosciences in the first half of 2024?

The administration expenses for Genflow Biosciences in the first half of 2024 were £1,316,368.

What is the operating loss reported by Genflow Biosciences for the period ending June 30, 2024?

Genflow Biosciences reported an operating loss of £524,259 for the period ending June 30, 2024.

GENFLOW BIOSCIENCES PLC

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