Back-to-back Studies Validate geneType Breast Cancer Risk Test

Rhea-AI Summary

Genetic Technologies Limited (NASDAQ: GENE) announced the publication of a new research paper in Cancer Prevention Research, reinforcing the efficacy of its geneType Breast Cancer Risk Assessment Test. This study, utilizing over 200,000 women from the UK Biobank, highlights geneType's superior performance over traditional models like BCRAT over a five-year period. Notably, women classified at ≥3% risk by geneType exhibited a 1.829 times higher incidence of breast cancer. This marks the second peer-reviewed publication in a month, supporting geneType’s role as a crucial risk stratification tool for the general population, and reflects the company’s commitment to clinical validation.

Positive

• Second published peer-reviewed paper on geneType in a month.
• Study based on a large cohort of over 200,000 women from UK Biobank.
• geneType outperformed BCRAT, showing better risk categorization.
• Higher incidence of breast cancer in women classified as at-risk by geneType compared to traditional models.

Negative

• None.

MELBOURNE, Australia, March 13, 2023 (GLOBE NEWSWIRE) -- Genetic Technologies Limited (ASX: GTG; NASDAQ: GENE, “Company”, “GTG”), a global leader in genomics-based tests in health, wellness and serious disease, is pleased to announce the publication of another research paper supporting the utilisation of geneType Breast Cancer Risk Assessment Test in the peer-reviewed journal Cancer Prevention Research.

Highlights:

• 2^nd published peer reviewed paper in the last month supporting the use of geneType, on the back of the ASX release dated February 9, 2023.

• Utilised a prospective cohort of more than 200,000 women from the UK Biobank.
• geneType Breast Cancer Risk Assessment Test demonstrated improved performance compared to a gold-standard model (BCRAT) over a 5-year period.
• The study showed that geneType not only put more women into an increased risk category but also demonstrated women in this category developed breast cancer at a higher incidence.

The paper entitled: Validation of an abridged breast cancer risk prediction model for the general population, reports results from an extensive study undertaken by the GTG Scientific Team in collaboration with Professor John Hopper from the Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne.

This study is the third paper accepted for publication in the last six months that highlights the utility of the geneType Breast Cancer Risk Assessment Test as powerful risk stratification tool available to the general population. GeneType improved discrimination and risk categorization when compared to one of the most well-known models, the Breast Cancer Risk Assessment Tool (BCRAT). Over a five-year period, at-risk women classified ≥3% 5-year risk by geneType had a 1.829 times increased incidence of breast cancer compared to the general population, which was higher than the 1.413 times increased incidence for women classified ≥3% by BCRAT.

Dr Erika Spaeth, GTG’s Director of Clinical & Medical Affairs, also lead author on the paper, noted, “This publication highlights the potential utility of a risk stratification tool able to be used on the general population. There are a significant number of women that are identified as at-increased risk by geneType and these same women ‘fly under the radar’ if traditional clinical models are used.”

GTG’s CEO, Simon Morriss said, “This is another key milestone for the company highlighting our commitment to clinical and scientific validation of the geneType platform. The publication of this study in combination with the Nurses’ Health Study, provides considerable evidence of utility for our discussions with US Payers and, importantly, in gaining additional traction to initiate a pilot study with one or more of these Payers.”

Authorised for release by the board of directors of Genetic Technologies Limited.

About Genetic Technologies Limited

Genetic Technologies Limited (ASX: GTG; Nasdaq: GENE) is a diversified molecular diagnostics company. A global leader in genomics-based tests in health, wellness and serious disease through its geneType and EasyDNA brands. GTG offers cancer predictive testing and assessment tools to help physicians to improve health outcomes for people around the world. The company has a proprietary risk stratification platform that has been developed over the past decade and integrates clinical and genetic risk to deliver actionable outcomes to physicians and individuals. Leading the world in risk prediction in oncology, cardiovascular and metabolic diseases, Genetic Technologies continues to develop risk assessment products. For more information, please visit www.genetype.com

Forward Looking Statements

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FAQ

What is the significance of the latest research publication for Genetic Technologies Limited (ticker: GENE)?

The publication supports the efficacy of geneType Breast Cancer Risk Assessment Test, reinforcing its role in breast cancer risk stratification.

How does geneType's performance compare to traditional breast cancer risk models?

geneType demonstrated improved performance, showing a higher incidence of breast cancer among women classified at risk compared to the traditional BCRAT model.

What were the findings related to the risk categorization of women using geneType?

The study found that women classified at ≥3% risk by geneType had a 1.829 times increased incidence of breast cancer.

How many peer-reviewed publications has Genetic Technologies released about geneType recently?

The company has published two peer-reviewed papers in the last month supporting the geneType test.

What is the source of the data for the recent geneType study?

The study utilized a prospective cohort of more than 200,000 women from the UK Biobank.