GE HealthCare announces FDA approval of Flyrcado (flurpiridaz F 18) injection PET radiotracer for enhanced diagnosis of coronary artery disease

Rhea-AI Summary

GE HealthCare (Nasdaq: GEHC) announced FDA approval of Flyrcado (flurpiridaz F 18) injection, a novel PET radiotracer for detecting coronary artery disease (CAD). Flyrcado offers higher diagnostic efficacy compared to SPECT MPI, the current standard in nuclear cardiology. With a 109-minute half-life, it allows for off-site production and wider distribution, potentially expanding access to PET myocardial perfusion imaging (MPI).

Key advantages include:

• First practical opportunity to combine exercise stress testing with cardiac PET imaging for CAD
• Improved diagnostic accuracy for difficult-to-image patients
• Ability to rescan patients during the same session if needed

Flyrcado is expected to be available in initial U.S. markets in early 2025, with expanding availability thereafter.

Positive

• FDA approval of Flyrcado, a novel PET radiotracer for CAD detection
• Higher diagnostic efficacy compared to current SPECT MPI standard
• Longer half-life (109 minutes) enables wider distribution and access
• Potential to expand clinician and patient access to PET MPI
• Ability to combine exercise stress testing with cardiac PET imaging
• Improved diagnostic accuracy for difficult-to-image patients
• Planned market launch in early 2025

Negative

• None.

Insights

Medical Research Analyst

The FDA approval of Flyrcado (flurpiridaz F 18) injection represents a significant advancement in cardiac imaging for coronary artery disease (CAD). This PET radiotracer offers superior diagnostic efficacy compared to the current standard SPECT MPI, potentially improving detection and management of CAD, the leading cause of death in the U.S.

Key advantages of Flyrcado include:

• Longer half-life (109 minutes) enabling wider distribution and practical combination with exercise stress testing
• Ready-to-use unit dose, expanding access to PET MPI
• Improved imaging for challenging patients (high BMI, women)
• Potential for same-session rescans if needed

The approval could lead to a shift in cardiac imaging practices, potentially increasing the adoption of PET MPI over SPECT. This may result in more accurate diagnoses and better patient outcomes. For GE HealthCare, Flyrcado represents a significant addition to their molecular imaging portfolio, potentially driving growth in their Pharmaceutical Diagnostics segment.

Financial Analyst

The FDA approval of Flyrcado is a positive development for GE HealthCare (GEHC), potentially driving significant revenue growth in its Pharmaceutical Diagnostics (PDx) segment. Key financial implications include:

• Market Opportunity: With ~6 million MPI procedures annually in the U.S., Flyrcado has a substantial addressable market
• Revenue Potential: As a novel, superior product, Flyrcado could command premium pricing
• Market Expansion: The product's advantages may drive overall market growth for cardiac PET imaging
• Competitive Position: Flyrcado strengthens GEHC's position in the molecular imaging market
• Royalty Obligations: While GEHC has exclusive global commercialization rights, royalties to Lantheus may impact margins

The planned 2025 launch allows time for market preparation and potential inclusion in clinical guidelines. Investors should monitor the initial rollout and adoption rates as indicators of long-term commercial success. This approval aligns with GEHC's strategy to innovate in high-value diagnostic areas, potentially enhancing shareholder value.

• GE HealthCare’s FDA-approved flurpiridaz F 18 PET radiotracer, Flyrcado, delivers higher diagnostic efficacy in patients with known or suspected coronary artery disease (CAD), compared to SPECT MPI, the predominant procedure used in nuclear cardiology today
• With a half-life over ten times longer than currently approved cardiac PET radiotracers, Flyrcado brings the first practical opportunity to combine exercise stress testing with cardiac PET imaging for CAD
• Available as a unit dose - or ready-to-use, Flyrcado has the potential to expand clinician and patient access to PET myocardial perfusion imaging (MPI)

ARLINGTON HEIGHTS, Ill.--(BUSINESS WIRE)-- GE HealthCare (Nasdaq: GEHC) today announced that the U.S. Food and Drug Administration (FDA) has granted approval of Flyrcado™ (flurpiridaz F 18) injection, a first of its kind positron emission tomography myocardial perfusion imaging (PET MPI) agent, for the detection of coronary artery disease (CAD). Indicated for patients with known or suspected CAD, Flyrcado delivers higher diagnostic efficacy compared to single-photon emission computed tomography (SPECT) MPI, the predominant procedure used in nuclear cardiology today. Flyrcado, which can be manufactured in an offsite pharmacy and delivered as a ready-to-use unit dose, has the potential to expand clinician and patient access to PET MPI, including improving diagnostic accuracy in difficult-to-image patients such as those with a high body mass index (BMI) and women¹.

Healthcare professionals reviewing myocardial perfusion PET images. (Photo: Business Wire)

With a half-life of 109-minutes—significantly longer than existing PET MPI tracers—Flyrcado removes the need for on-site tracer production and generator maintenance and enables distribution to a wide network of hospitals and imaging centers. This longer half-life also means Flyrcado brings the first practical opportunity to combine exercise stress testing with cardiac PET imaging for CAD, enabling the most robust protocol for evaluating ischemia in patients. Furthermore, clinicians would have the ability to rescan a patient during the same imaging session in the event of technical difficulties, rather than rescheduling an additional scan.

Dr. Jamshid Maddahi, MD, FACC, MASNC, principal investigator of the Flyrcado clinical trials, clinical professor of medicine (cardiology) and molecular and medical pharmacology (nuclear medicine) at UCLA School of Medicine and director of the Biomedical Imaging Institute, said, “Flyrcado is the most exciting development in the field of nuclear cardiology over the past few decades. Although PET MPI as a modality enables high diagnostic accuracy as compared to SPECT MPI², only a minority of annual PET scans in the US are PET MPI because of limited access to the currently available PET tracers—which may be addressed with the introduction of Flyrcado. I am excited for this new radiotracer and its potential impact, as a game changer, for diagnosing the disease with the highest mortality rate in the world.”

CAD is the most common form of heart disease and remains the leading cause of death for men and women in the U.S.³, with 695,000 deaths recorded in 2021⁴. During the multicenter international AURORA Phase III trial, flurpiridaz F 18 was compared with both invasive coronary angiography as a standard of truth to determine diagnostic efficacy in detecting CAD, as well as with SPECT MPI. Around six million MPI procedures are undertaken each year in the U.S.⁵ to show blood flow through the heart muscle, and evaluate the presence, extent and degree of myocardial ischemia or infarction.

Dr. Mouaz Al-Mallah, MD, MSc, MASNC, immediate Past President of the American Society of Nuclear Cardiology (ASNC) and Director of Cardiac PET at Houston Methodist Hospital, said “Given the desirable properties of flurpiridaz F 18, both in terms of myocardial uptake and fluorine-18 imaging characteristics, Flyrcado represents a favorable combination of imaging agent pharmacology and convenience to imaging institutions and patients. There are new frontiers for cardiac PET that this tracer can achieve; it can be ordered as a unit dose, and it offers the flexibility to perform exercise stress testing. We expect new imaging centers to be able to offer cardiac PET to their patients, making it more convenient to access PET MPI and providing a meaningful impact for clinicians and their patients.”

Kevin O’Neill, CEO of the Pharmaceutical Diagnostics (PDx) segment of GE HealthCare, said, “As the first and only FDA-approved F 18 PET MPI radiotracer for CAD detection, Flyrcado can make a real difference to clinicians and their patients. This is another example of GE HealthCare’s commitment to innovating and investing to shape the future of molecular imaging, increasing diagnostic confidence and addressing unmet patient needs.”

Flyrcado is one of three F 18 imaging agents in GE HealthCare’s portfolio of FDA-approved molecular imaging PET products, joining radiopharmaceutical PET imaging agents Cerianna™ (fluoroestradiol F 18) injection, used to detect estrogen receptor positive lesions as an adjunct to biopsy in patients with metastatic and recurrent breast cancer, and Vizamyl™ (flutemetamol F 18) injection which is a PET tracer for imaging of the brain to estimate beta amyloid neuritic plaque density in adult patients who are being evaluated for Alzheimer’s disease or other causes of cognitive decline.

GE HealthCare acquired exclusive global commercialization rights for flurpiridaz F 18 from Lantheus in 2017 and has led the funding and development of the product through to approval. Lantheus collaborated on the development and will also collaborate on commercialization through a joint steering committee. Lantheus is entitled to royalties based on commercial sales milestones.

Flyrcado will be available in initial U.S. markets in early 2025 with expanding availability thereafter.

As a leading global medical technology and pharmaceutical diagnostics innovator, GE HealthCare provides both molecular imaging equipment and proprietary radiopharmaceuticals used across cardiology, neurology and oncology. The PDx segment is a global leader in imaging agents used to support over 120 million patient procedures per year globally, equivalent to four patient procedures every second.

About GE HealthCare Technologies Inc.

GE HealthCare is a leading global medical technology, pharmaceutical diagnostics, and digital solutions innovator, dedicated to providing integrated solutions, services, and data analytics to make hospitals more efficient, clinicians more effective, therapies more precise, and patients healthier and happier. Serving patients and providers for more than 125 years, GE HealthCare is advancing personalized, connected, and compassionate care, while simplifying the patient’s journey across the care pathway. Together our Imaging, Ultrasound, Patient Care Solutions, and Pharmaceutical Diagnostics businesses help improve patient care from diagnosis, to therapy, to monitoring. We are a $19.6 billion business with approximately 51,000 colleagues working to create a world where healthcare has no limits.

Follow us on LinkedIn, X , Facebook, Instagram, and Insights for the latest news, or visit our website https://www.gehealthcare.com/ for more information.

https://www.gehealthcare.com/products/molecular-imaging-agents/flyrcado

INDICATIONS AND USAGE OF FLYRCADO™:

FLYRCADO™ (flurpiridaz F 18) injection, for intravenous use important safety information

IMPORTANT SAFETY INFORMATION

Indications and Usage

FLYRCADO is a radioactive diagnostic drug indicated for positron emission tomography (PET) myocardial perfusion imaging (MPI) under rest or stress (pharmacologic or exercise) in adult patients with known or suspected coronary artery disease (CAD) to evaluate for myocardial ischemia and infarction.

Contraindications

None

Warnings and Precautions

• Risk associated with exercise or pharmacologic stress: Patients evaluated with exercise or pharmacologic stress may experience serious adverse reactions such as myocardial infarction, arrhythmia, hypotension, bronchoconstriction, stroke, and seizure. Perform stress testing in the setting where cardiac resuscitation equipment and trained staff are readily available. When pharmacologic stress is selected as an alternative to exercise, perform the procedure in accordance with the pharmacologic stress agent’s prescribing information.
• Radiation risks: FLYRCADO contributes to a patient’s overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk of cancer. Ensure safe handling to minimize radiation exposure to patients and health care providers. Advise patients to hydrate before and after administration and to void.

Adverse Reactions

• Most common adverse reactions occurring during FLYRCADO PET MPI under rest and stress (pharmacologic or exercise) (incidence ≥ 2%) are dyspnea, headache, angina pectoris, chest pain, fatigue, ST segment changes, flushing, nausea, abdominal pain, dizziness, and arrhythmia.

Use in Specific Populations

• Pregnancy

There are no data on use of flurpiridaz F 18 in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes. If considering FLYRCADO administration to a pregnant woman, inform the patient about the potential for adverse pregnancy outcomes based on the radiation dose from flurpiridaz F 18 and the gestational timing of exposure.

FLYRCADO contains ethanol (a maximum daily dose of 337 mg anhydrous ethanol). If considering FLYRCADO administration to a pregnant woman, inform the patient about the potential for adverse pregnancy outcomes associated with ethanol exposure during pregnancy.

• Lactation

Temporarily discontinue breastfeeding. A lactating woman should pump and discard breastmilk for at least 8 hours after FLYRCADO administration.

• Pediatric Use

Safety and effectiveness of FLYRCADO in pediatric patients have not been established.

To report SUSPECTED ADVERSE REACTIONS, contact GE HealthCare at 800-654-0118 (option 2 then option 1) or by email at GPV.drugsafety@gehealthcare.com or FDA at 800-FDA-1088 or www.fda.gov/medwatch

For full prescribing information, click here. For important safety information, please click here.

INDICATIONS AND USAGE OF CERIANNA™:

INDICATIONS AND USAGE

CERIANNA is indicated for use with positron emission tomography (PET) imaging for the detection of estrogen receptor (ER)-positive lesions as an adjunct to biopsy in patients with recurrent or metastatic breast cancer.

Limitations of Use

Tissue biopsy should be used to confirm recurrence of breast cancer and to verify ER status by pathology. CERIANNA is not useful for imaging other receptors, such as human epidermal growth factor receptor 2 (HER2) and the progesterone receptor (PR).

CONTRAINDICATIONS

None.

ADVERSE REACTIONS

In Clinical Trials (n=1207) the most common adverse reactions seen occurred at a rate < 1% were injection-site pain and dysgeusia.

To report SUSPECTED ADVERSE REACTIONS, contact GE HealthCare Company at 800.654.0118 (option 2 then option 1) or by email at GPV.drugsafety@gehealthcare.com or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

For full Prescribing Information click here.

INDICATIONS AND USAGE OF VIZAMYL™:

PRODUCT INDICATIONS AND USE

VIZAMYL™ (Flutemetamol F 18) injection is indicated for positron-emission tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer’s disease (AD) or other causes of cognitive decline. A negative scan indicates sparse to no neuritic plaques, inconsistent with a diagnosis of AD at the time of image acquisition. A negative scan result reduces the likelihood that a patient’s cognitive impairment is due to AD. A positive scan indicates moderate to frequent amyloid neuritic plaques. This amount of amyloid neuritic plaque has been shown to be present in patients with AD but may also be present in patients with other neurologic conditions as well as in older people with normal cognition. Vizamyl is an adjunct to other diagnostic evaluations.

Limitations: A positive scan does not establish a diagnosis of AD or other cognitive disorder. The safety and effectiveness of Vizamyl have not been established for predicting the development of dementia or other neurologic conditions or for monitoring responses to therapies.

Important Safety Information About VIZAMYL™ (Flutemetamol F 18) injection

CONTRAINDICATIONS

• Known hypersensitivity to Vizamyl or any excipient, including polysorbate 80

ADVERSE REACTIONS

• The most commonly reported adverse reactions in clinical trials were flushing (2%), increased blood pressure (2%), headache (1%), nausea and dizziness (1%)

For full prescribing information, including additional important safety information, please click here.

¹ Maddahi J, Agostini D, Bateman TM, Bax JJ, Beanlands RSB, BermanDS, Dorbala S, Garcia EV, Feldman J, Heller GV, Knuuti JM, Martinez-Clark P, Pelletier-Galarneau M, Shepple B, Tamaki N, Tranquart F, Udelson JE. Flurpiridaz F-18 PET Myocardial Perfusion Imaging in Patients with Suspected Coronary Artery Disease. J AmColl Cardiol. 2023; 82:1598–1610

² Schindler, T. H., Bateman, T. M., Berman, D. S., Chareonthaitawee, P., De Blanche, L. E., Dilsizian, V., Dorbala, S., Gropler, R. J., Shaw, L., Soman, P., Winchester, D. E., Verberne, H., Ahuja, S., Beanlands, R. S., Di Carli, M. F., Murthy, V. L., Ruddy, T. D., & Schwartz, R. G. (2020). Appropriate use criteria for PET myocardial perfusion imaging. Journal of Nuclear Medicine, 61(8), 1221-1265. https://doi.org/10.2967/jnumed.120.246280

³ Friede A, O’Carroll PW, Thralls RB, Reid JA. CDC WONDER on the web. Proc AMIA Annu Fall Symp. 1996:408–412.

⁴ Tsao CW, Aday AW, Almarzooq ZI, et al. Heart disease and stroke statistics—2023 update: A report from the American Heart Association. Circulation. 2023;147: e93–e621. https://doi.org/10.1161/CIR.0000000000001123.

⁵ Miller, R. J. H., Bednarski, B. P., Pieszko, K., Kwiecinski, J., Williams, M. C., Shanbhag, A., Liang, J. X., Huang, C., Sharir, T., Hauser, M. T., Dorbala, S., Di Carli, M. F., Fish, M. B., Ruddy, T. D., Bateman, T. M., Einstein, A. J., Kaufmann, P. A., Miller, E. J., Sinusas, A. J., Acampa, W., Han, D., Dey, D., Berman, D. S., & Slomka, P. J. (2024). Clinical phenotypes among patients with normal cardiac perfusion using unsupervised learning: A retrospective observational study. EBioMedicine, 99, 104930. https://doi.org/10.1016/j.ebiom.2023.104930

View source version on businesswire.com: https://www.businesswire.com/news/home/20240927874133/en/

GE HealthCare Media Contact:

Emmy Elguizaoui

+1 (978) 243-7503

Emmy.Elguizaoui@gehealthcare.com

Source: GE HealthCare Technologies Inc.

FAQ

What is Flyrcado and what has the FDA approved it for?

Flyrcado (flurpiridaz F 18) is a PET radiotracer that the FDA has approved for the detection of coronary artery disease (CAD) in patients with known or suspected CAD.

How does Flyrcado compare to current imaging methods for CAD?

Flyrcado offers higher diagnostic efficacy compared to SPECT MPI, which is currently the predominant procedure used in nuclear cardiology for detecting CAD.

What are the key advantages of Flyrcado (GEHC) for CAD diagnosis?

Flyrcado has a longer half-life, allows for exercise stress testing with PET imaging, improves diagnostic accuracy for difficult-to-image patients, and can be manufactured off-site and delivered as a ready-to-use unit dose.

When will Flyrcado be available in the US market?

GE HealthCare plans to make Flyrcado available in initial U.S. markets in early 2025, with expanding availability thereafter.

How might Flyrcado impact access to PET myocardial perfusion imaging?

Flyrcado's longer half-life and ability to be produced off-site have the potential to expand clinician and patient access to PET myocardial perfusion imaging, including in areas without on-site production capabilities.