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Gain Therapeutics, Inc. - GANX STOCK NEWS

Welcome to our dedicated page for Gain Therapeutics news (Ticker: GANX), a resource for investors and traders seeking the latest updates and insights on Gain Therapeutics stock.

Overview

Gain Therapeutics, Inc. (NASDAQ: GANX) is a clinical-stage biotechnology company that harnesses advanced computational drug discovery and innovative allosteric modulation technologies to develop novel small molecule therapeutics for a spectrum of challenging diseases. Specializing in orphan and neurodegenerative diseases, the company’s research spans inborn errors of metabolism, lysosomal storage disorders, central nervous system disorders, and oncology. By applying technologies such as its proprietary Magellan drug discovery platform and integrating AI-supported structural biology, Gain Therapeutics is able to identify new allosteric binding sites on proteins, offering potential for disease modification where conventional approaches have been limited.

At its core, Gain Therapeutics is committed to addressing high unmet medical needs through the discovery of non-competitive pharmacological chaperones and allosteric small molecule modulators. Its lead clinical program, GT-02287, is designed to restore the function of the lysosomal enzyme glucocerebrosidase (GCase) in Parkinson’s disease patients with or without the GBA1 mutation. The company’s approach involves correcting protein misfolding and dysfunction by targeting allosteric sites that are traditionally difficult to drug, a paradigm shift in difficult-to-treat neurological disorders.

Advanced Drug Discovery Platform

Gain Therapeutics has developed a unique, integrated drug discovery process that combines:

  • Computational Targeting: Leveraging AI, machine-learning tools, and supercomputer-powered physics-based models to screen vast chemical spaces.
  • Magellan Platform: This proprietary platform identifies novel allosteric sites on disease-implicated proteins, underpinning the discovery of small molecule modulators.
  • Innovative Screening: The use of virtual screening capabilities that incorporate on-demand compound libraries allows the company to explore chemical spaces that have been largely untapped by conventional methods.

Pipeline and Clinical Development

The central component of Gain Therapeutics’ development pipeline is its lead drug candidate, GT-02287, currently under clinical evaluation for the treatment of Parkinson’s disease. Designed as a brain-penetrant, orally administered small molecule, GT-02287 has demonstrated the ability to restore enzymatic activity of GCase, reduce neuroinflammatory markers, and improve parameters related to both motor and cognitive function in preclinical models. The company’s research highlights include consistent target engagement and a strong safety and tolerability profile in early studies.

In addition to Parkinson’s disease, Gain Therapeutics is actively pursuing research in other therapeutic areas where allosteric modulation may offer a breakthrough, including rare genetic disorders marked by inborn errors of metabolism and various aspects of oncology. The company’s broad strategy underlines its commitment to unlocking disease-modifying therapeutic approaches in conditions that have historically been challenging to treat.

Market Position and Competitive Landscape

Positioned within the highly competitive biotechnology arena, Gain Therapeutics differentiates itself through its proprietary computational platform and deep scientific expertise. The company’s emphasis on identifying non-traditional allosteric binding sites allows it to explore targets that are not easily addressable by traditional drug discovery techniques. By focusing on high unmet medical needs such as orphan diseases and neurodegenerative disorders, Gain Therapeutics carves out a unique niche in the market.

Its revenue is primarily derived from strategic collaboration and licensing agreements, underscoring a business model that combines public-private partnerships with internally driven therapeutic innovation. This positioning has allowed Gain Therapeutics to build a robust preclinical dossier and a clinical development program that is supported by thought leaders in both the pharmaceutical and neuroscientific fields.

Expertise and Research Strength

The foundation of Gain Therapeutics’ success lies in its team of scientists and clinical experts who bring decades of experience from biotechnology and pharmaceutical industries. Their collaborative approach has fostered an environment where cutting-edge research meets rigorous clinical evaluation. Regular presentations at respected scientific conferences and symposiums provide transparency and reinforce the company’s commitment to advancing a deep understanding of complex disease mechanisms, particularly in the arena of neurodegeneration.

Strategic Focus and Value Proposition

Gain Therapeutics stands out by offering a comprehensive drug discovery strategy that marries advanced computational tools with hands-on experimental validation. Its allosteric modulator programs, exemplified by GT-02287, demonstrate significant potential to offer disease-modifying benefits in conditions like Parkinson’s disease and possibly extend to other tauopathies and metabolic disorders. The integration of AI-enabled structural biology with a rigorous platform for discovering hard-to-target proteins positions the company as an innovator capable of bridging the gap between early therapeutic discovery and clinical application.

Investors and industry analysts will find value in the depth of the company’s research methodology, the strategic focus on high-need therapeutic areas, and the robust expertise behind its clinical and preclinical programs. This multi-faceted approach promotes a comprehensive understanding of disease pathways and underscores Gain Therapeutics’ commitment to developing transformative therapies within challenging and underserved medical sectors.

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Gain Therapeutics, Inc. (GANX) to hold a 2024 Research & Development update on February 22, 2024, focusing on GT-02287 in vivo data for Parkinson's Disease. Key Opinion Leaders to provide insights on unmet medical needs and therapies.
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Gain Therapeutics, Inc. (Nasdaq: GANX) presents preclinical data at the 20th WORLDSymposium™, demonstrating the neuroprotective effects and motor function restoration of its clinical-stage GCase regulator GT-02287 in Parkinson's disease models. The data show a progressive reversal of motor deficit and a reduction of the neurodegeneration biomarker NfL to the level of the control arm. The company is currently conducting a Phase 1 clinical trial of GT-02287 in healthy adults and plans to commence treatment of patients in an extension of that clinical trial in Q3 of this year.
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Gain Therapeutics, Inc. releases a letter to stockholders from its CEO, Matthias Alder, highlighting the progress of the company in 2023 and its strategy for 2024. They focus on the development of their lead drug candidate for Parkinson's disease, GT-02287, and present preclinical data supporting its potential. Additionally, they discuss the upgrade of their computational drug discovery platform, Magellan.
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Gain Therapeutics, Inc. (Nasdaq: GANX) announced new data of GT-02287 in preclinical models of Parkinson’s disease accepted for a platform presentation at the 20th Annual WORLDSymposium™. The presentation will focus on GT-02287, a clinical stage GCase enhancer, displaying neuroprotection and restoring motor function in preclinical models of Parkinson’s disease following delayed administration.
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Gain Therapeutics, Inc. (Nasdaq: GANX) announced CEO Matthias Alder's participation in a fireside chat with John Vandermosten, CFA, Senior Analyst for Zacks Small-Cap Research on December 5, 2023.
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Gain Therapeutics, Inc. (Nasdaq: GANX) announced the publication of preclinical data identifying a novel class of small molecule allosteric regulators with therapeutic potential for galactosidase beta 1 (GLB1)-related lysosomal storage disorders, including GM1 gangliosidosis. The study was published in PLOS ONE and demonstrated the potential of allosteric modulators as a therapeutic option for hard-to-treat genetic diseases where there are no effective approaches for disease modification.
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Gain Therapeutics, Inc. (Nasdaq: GANX) announced that CEO Matthias Alder will participate in a panel at the AI Driven Drug Discovery Summit on December 6, 2023. The event will focus on collaboration in AI-driven drug discovery.
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Gain Therapeutics, Inc. (Gain) (Nasdaq: GANX) closed an underwritten public offering of 2,545,000 shares of common stock and warrants to purchase up to 1,272,500 shares at a combined public offering price of $2.005 per share and accompanying warrant. In a private placement, Gain issued 2,500,088 shares of common stock and warrants to purchase up to 2,500,088 shares at an offering price of $2.00 per share. The gross proceeds from the offerings were approximately $10.1 million, excluding underwriting and placement agent discounts and commissions and other offering-related expenses. Gain intends to use the net proceeds for the development of its lead product candidate GT-02287 for the treatment of neurodegenerative diseases and for general corporate purposes.
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Gain Therapeutics, Inc. (GANX) announced the pricing of an underwritten public offering of 2,213,044 shares of its common stock and warrants to purchase up to an aggregate of 1,106,522 shares of its common stock at a combined public offering price of $2.005 per share and accompanying warrant. The public offering price for each set of two shares of common stock and accompanying warrant to purchase one share of common stock is $4.01 per set of securities, yielding an effective price of $2.00 per share and $0.01 per warrant. The warrants are being sold at the rate of one warrant for every two shares of common stock. The warrants will have an exercise price of $2.75 per share, are exercisable immediately upon issuance, and will expire five years following the date of issuance. In connection with the offering, Gain has granted the underwriters a 30-day option to purchase up to an additional 15% of shares of common stock and/or warrants to purchase shares of common stock at the public offering price, less underwriting discounts and commissions. In a private placement to be completed concurrently with the completion of the public offering, Gain will issue to an accredited investor an aggregate of 2,500,088 shares of common stock (or pre-funded warrants in lieu thereof) and warrants to purchase up to 2,500,088 shares of common stock. The offering price per share and accompanying warrant sold in the private placement is $2.00. The warrants issued in the private placement will be exercisable at an exercise price of $2.75 per share, will be exercisable beginning six months after issuance and will expire five years from the date of issuance. Newbridge Securities Corporation is acting as the sole book-running manager for the public offering and as placement agent for the private placement. Allele Capital Partners, LLC is acting as Financial Advisor to Gain. Gain expects to receive aggregate gross proceeds from the public and private offering, excluding the exercise of the underwriters’ option, if any, of approximately $9.4 million, excluding underwriting and placement agent discounts and commissions and other offering-related expenses. The offerings are expected to close on or before November 28, 2023.
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Gain Therapeutics, Inc. (Nasdaq: GANX) Proposes Public Offering to Fund Neurodegenerative Disease Treatment Development. Gain Therapeutics, Inc. announced a proposed public offering of its common stock and warrants to fund the development of its lead product candidate GT-02287 for the treatment of neurodegenerative diseases, including GBA1 Parkinson’s disease. The offering is subject to market conditions, and the company expects to use the net proceeds for clinical and nonclinical development as well as general corporate purposes.
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FAQ

What is the current stock price of Gain Therapeutics (GANX)?

The current stock price of Gain Therapeutics (GANX) is $1.65 as of April 4, 2025.

What is the market cap of Gain Therapeutics (GANX)?

The market cap of Gain Therapeutics (GANX) is approximately 48.1M.

What is the primary focus of Gain Therapeutics?

Gain Therapeutics is focused on discovering and developing novel allosteric small molecule therapies targeting high unmet medical needs, particularly in neurodegenerative and orphan diseases.

Which therapeutic areas does the company target?

The company targets a range of therapeutic areas including Parkinson's disease, lysosomal storage disorders, metabolic disorders, central nervous system issues, and oncology.

What is GT-02287 and its significance?

GT-02287 is the company’s lead clinical-stage candidate under evaluation for Parkinson's disease. It is designed to restore glucocerebrosidase (GCase) function through allosteric modulation, addressing protein misfolding and neurodegeneration.

How does Gain Therapeutics approach drug discovery?

The company leverages an AI-supported computational platform called Magellan, which identifies novel allosteric binding sites on proteins, combined with high-throughput virtual screening and experimental validation.

What are the primary revenue sources for Gain Therapeutics?

Revenue is primarily generated through collaboration and licensing agreements, allowing the company to partner strategically while advancing its own drug discovery programs.

How is Gain Therapeutics positioned in the competitive biotechnology landscape?

Gain Therapeutics differentiates itself by using innovative computational methods to target previously undruggable protein sites, supported by a team of experienced biotech and pharma experts, which positions it uniquely within the competitive biotech market.

What value does the technology platform bring to their drug development process?

The proprietary Magellan platform and AI-driven strategies enable the rapid identification of allosteric sites on disease-implicated proteins, accelerating the discovery and preclinical validation of novel therapeutics.

Are there any clinical studies associated with the company’s programs?

Yes, the company is actively advancing GT-02287 through clinical development, with early-phase trials indicating a favorable safety profile and promising target engagement in Parkinson’s disease.
Gain Therapeutics, Inc.

Nasdaq:GANX

GANX Rankings

GANX Stock Data

48.07M
26.49M
5.01%
7.64%
1.32%
Biotechnology
Pharmaceutical Preparations
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United States
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