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Gain Therapeutics, Inc. (NASDAQ: GANX) is a pioneering biotechnology company committed to the discovery and development of novel small molecule therapeutics. Specializing in addressing rare genetic diseases, Gain Therapeutics focuses on orphan diseases caused by inborn errors of metabolism. With a strong emphasis on lysosomal storage disorders, central nervous system disorders, metabolic disorders, and oncology, the company's innovative approach aims to provide solutions where there is a high unmet medical need.
At the forefront of Gain Therapeutics' pipeline is GT-02287, a promising clinical-stage product candidate targeting GBA1 Parkinson's disease. Currently in Phase 1 clinical trials, GT-02287 is designed to be a disease-modifying treatment. It functions as an allosteric protein modulator to restore the activity of the lysosomal enzyme glucocerebrosidase (GCase), tackling the underlying cause of disease rather than just alleviating symptoms.
The company's proprietary Magellan™ platform leverages AI-supported structural biology and advanced algorithms to discover novel allosteric binding sites on disease-implicated proteins. This innovative computational technology identifies potential small molecules that can bind to these sites, offering new avenues for therapeutic development. Magellan builds upon Gain’s original SEE-Tx® platform, enhancing it with AI and virtual screening capabilities to explore vast chemical spaces.
Recent achievements highlight Gain Therapeutics' impact on the biotech landscape. Data presented at the 20th WORLDSymposium™ showcased the progressive reversal of motor deficits in preclinical models, alongside a significant reduction of neurodegeneration biomarkers. This underscores the potential of GT-02287 as a best-in-class treatment for neurodegenerative diseases.
Gain Therapeutics collaborates with notable organizations including The Michael J. Fox Foundation for Parkinson’s Research and The Silverstein Foundation for Parkinson’s with GBA. These partnerships provide essential support and validation for the company's mission to transform therapeutic landscapes with innovative treatments.
For more information, visit GainTherapeutics.com and follow their updates on LinkedIn.
Gain Therapeutics, Inc. (GANX) reported a cash position of $43.16 million as of June 30, 2021, significantly up from $7.49 million at the end of 2020. The company continues to advance its developmental programs while expanding its intellectual property portfolio, including two new patents targeting misfolded proteins linked to neurodegenerative diseases. Revenues for Q2 2021 reached $89,000, up from $7,000 in Q2 2020, primarily due to collaboration with Zentalis Pharmaceuticals. However, net losses increased to $3.56 million compared to $543,000 a year earlier.
Gain Therapeutics (Nasdaq: GANX) announced that CEO Eric Richman will present a corporate overview at the BTIG Virtual Biotechnology Conference on August 9-10, 2021. His presentation is scheduled for 11:30 to 11:55 a.m. ET on August 9. Gain Therapeutics specializes in drug discovery targeting protein misfolding associated with neurodegenerative diseases and lysosomal storage disorders. The event expects participation from over 120 management teams and offers thematic panels and one-on-one meetings.
Gain Therapeutics (Nasdaq: GANX) announced the issuance of two PCT patents on June 10, 2021, targeting compounds for misfolded enzymes associated with neurodegenerative and lysosomal storage diseases. The patents include PCT/IB2020/061158, which addresses diseases like Gaucher Disease and Parkinson’s Disease, and PCT/IB2020/061156, focused on conditions linked to GALC alterations. CEO Eric Richman emphasized this as a significant milestone for developing new therapies for these challenging diseases, reinforcing the company's intellectual property and commitment to innovation.
Gain Therapeutics, Inc. (Nasdaq: GANX), a biotechnology firm, will present a corporate overview at the Jefferies Virtual Healthcare Conference from June 1 to June 4, 2021. CEO Eric Richman is set to speak on June 1 at 3:00 PM ET. The session will be accessible via webcast and will be available for replay on the company's website for 30 days post-conference. This annual conference gathers over 400 healthcare companies and 3,000 investors to discuss investment opportunities and trends in healthcare.
Gain Therapeutics, Inc. (Nasdaq: GANX) announced that CEO Eric Richman will present a corporate overview at the 2021 RBC Capital Markets Global Healthcare Virtual Conference on May 19 at 9:10 a.m. ET and at the Oppenheimer Rare & Orphan Disease Summit on May 21 at 8:15 a.m. ET. Both presentations will highlight Gain's innovative drug discovery approach using its SEE-Tx™ platform to target allosteric binding sites, addressing challenging disorders linked to protein misfolding. Webcast links for the events are available on the company’s website.
Gain Therapeutics, Inc. (Nasdaq: GANX) has successfully completed its IPO, raising approximately $46 million in gross proceeds. The company has appointed four independent board members to enhance leadership and signed a collaboration agreement with Zentalis Pharmaceuticals to develop cancer treatments. Positive pre-clinical data was presented at the WorldSymposium™. For Q1 2021, the company reported net loss of $2.45 million with cash reserves of $46.59 million.
Gain Therapeutics, Inc. (NASDAQ: GANX) announced promising pre-clinical data from its GBA1 Parkinson's disease program at the IAPRD World Congress. The data highlights the potential of their Structurally Targeted Allosteric Regulators (STARs), which stabilize and restore activity of mutated GCase, leading to decreased levels of phosphorylated and aggregated α-synuclein. Key candidates GT-02287 and GT-02329 were effective in reversing neurodegeneration in animal models, suggesting a new therapeutic avenue for GBA1-related Parkinson's disease. The research was recognized as one of the top 10 abstracts presented at the conference.
Gain Therapeutics, Inc. (NASDAQ: GANX) announced its CEO, Eric Richman, will present at the B. Riley Securities’ Virtual Neuroscience Conference on April 28-29 at 4:00 p.m. ET. The company focuses on innovative drug discovery using its SEE-Tx™ platform to identify allosteric binding sites for challenging disorders linked to protein misfolding. Since its establishment in 2017, Gain has secured funding from notable organizations, including The Michael J. Fox Foundation and Eurostars-2 program. For more details, visit Gain Therapeutics.
Gain Therapeutics, Inc. (NASDAQ: GANX) announced its STAR candidate for Parkinson's disease has been selected among the 10 Best Abstracts at the IAPRD 2021 World Congress. The poster presentation, led by Roberto Maj, Pharm.D., showcases the potential of the company's structurally targeted allosteric regulators (STARs) to improve motor deficits in an in vivo model of Parkinson's disease. The conference will be held virtually from May 1-4, 2021, and the presentation will remain accessible throughout the event.
Gain Therapeutics, Inc. (NASDAQ: GANX) announced a multi-target collaboration with Zentalis Pharmaceuticals (NASDAQ: ZNTL) to identify new oncology drug targets using its proprietary SEE-Tx computational platform. This technology employs supercomputers to analyze protein structures for novel binding sites, enhancing drug discovery. Gain's CEO highlighted Zentalis' expertise in cancer treatments as a key asset for validating the SEE-Tx platform. This partnership aims to address challenges in cancer treatment through innovative target identification.
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