Fibrobiologics Stock Price, News & Analysis

FibroBiologics (Nasdaq: FBLG) has filed a patent application for a novel method using fibroblasts to improve mitochondrial performance in cells. The company, which holds 160+ patents, is developing this innovative approach to potentially treat chronic conditions driven by mitochondrial dysregulation.

The technology leverages fibroblasts' natural ability to secrete bioactive molecules that influence cellular microenvironments. Through local or systemic fibroblast administration, this method aims to address mitochondrial dysfunction, which is implicated in aging, autoimmune, neurodegenerative, metabolic, and muscular diseases.

The patent filing represents a potential breakthrough in treating chronic diseases by modulating mitochondrial activity, which could fundamentally alter treatment approaches and impact human longevity.

FibroBiologics (Nasdaq: FBLG) and Charles River Laboratories have announced the completion of a master cell bank for CYWC628, a fibroblast-based therapy targeting diabetic foot ulcers. The cell bank, manufactured under FDA Good Manufacturing Practices (cGMP), has passed all required safety testing.

The master cell bank will support upcoming phase I/II clinical trials for diabetic foot ulcers scheduled to begin in 2025. Charles River's cGMP manufacturing facilities will produce both the cell banks and drug product for the trials.

FibroBiologics, a clinical-stage biotech company with 160+ patents issued and pending, focuses on developing therapeutics using fibroblasts and fibroblast-derived materials. Their research spans multiple indications including wound healing, multiple sclerosis, degenerative disc disease, psoriasis, human longevity, and cancer.

FibroBiologics (Nasdaq: FBLG), a clinical-stage biotechnology company focusing on fibroblast-based therapeutics for chronic diseases, has announced two significant upcoming events. The company will host an in-person analyst day on February 12, 2025, at 2:00 p.m. ET at the New York Marriott Marquis.

The analyst day will feature presentations from key management members, including CEO Pete O'Heeron, CSO Hamid Khoja, PhD, and Interim CFO Robert Hoffman. The event will showcase the company's research and development strategy for fibroblast-based therapeutics, followed by a live Q&A session.

Additionally, FibroBiologics will present at the 2025 BIO CEO & Investor Conference in New York on February 11 at 11:15 a.m. ET. The presentation will take place in the Plymouth Room at the New York Marriott Marquis.

FibroBiologics (NASDAQ: FBLG) has closed the second $5 million tranche of its previously announced $25 million Standby Equity Purchase Agreement (SEPA) with Yorkville Advisors. The agreement allows FibroBiologics to sell up to $25 million of common stock over two years, with the first $15 million being advanced in three equal tranches via convertible promissory notes.

The first $5 million tranche was funded upon SEPA entry, and the second $5 million followed the filing of a registration statement. The third $5 million will be funded after registration statement effectiveness and Nasdaq-required shareholder approval. An additional $10 million can be sold subject to Yorkville's consent while the notes remain outstanding.

FibroBiologics (NASDAQ: FBLG) has secured a $25 million financing through a Standby Equity Purchase Agreement (SEPA) with Yorkville Advisors Global's investment fund. The two-year agreement includes an initial $15 million advance in three $5 million tranches via convertible promissory notes, with the first tranche already funded. An additional $10 million in common stock sales is available subject to conditions.

The company plans to use the funds to complete its first-in-human trial for diabetic foot ulcers and IND-enabling studies for its psoriasis program. The remaining capital will support development of human longevity, multiple sclerosis, and cancer indications. FibroBiologics, a clinical-stage biotech company, holds 160+ patents focusing on therapeutics using fibroblasts and fibroblast-derived materials.

FibroBiologics (Nasdaq: FBLG) has filed a patent application for treating splenomegaly using cell-based therapeutics. The application focuses on treating enlarged spleen conditions, which commonly occur in autoimmune disorders, chronic infections, and as a side effect of chemotherapy. The company's approach utilizes fibroblast-based therapies to address immune dysregulation, potentially offering a new treatment method for managing immune system overload and spleen enlargement. This development adds to FibroBiologics' portfolio of 160+ issued and pending patents in chronic disease therapeutics.

FibroBiologics (Nasdaq: FBLG) has filed a patent application for methods using fibroblasts and Tissue Factor-expressing cells to prevent IBMIR-mediated blood clotting in cell therapy treatments. The technology aims to address a major challenge in cell therapy by reducing inflammatory and coagulative responses that can compromise treatment effectiveness and safety. The approach focuses on minimizing complications such as complement activation, immune cell infiltration, and platelet adhesion during intravascular, subcutaneous, and intraperitoneal cell administration. This development could potentially improve the safety and efficacy of cell-based treatments by reducing adverse events and rejection by the body's immune system.

FibroBiologics (NASDAQ: FBLG) reported Q3 2024 financial results and corporate updates. The company plans to initiate a Phase 1/2 clinical trial for its CYWC628 product to treat diabetic foot ulcers in Q2 2025. For the nine months ended September 30, 2024, R&D expenses increased to $3.1M from $1.6M, and G&A expenses rose to $6.9M from $4.8M year-over-year. Net loss widened to $8.1M compared to $6.8M in the same period of 2023. Cash position stood at $7.8M as of September 30, 2024. The company expanded its IP portfolio with multiple patent issuances and joined the Russell 2000® Index.

FibroBiologics (Nasdaq: FBLG) reported promising results from its artificial thymus organoid program. The technology demonstrated that fibroblasts and thymus-derived cell organoids can maintain functionality for over 50 days after transplantation, showing vascularization and generating diverse mature T cells in animal models. The organoids produced fully mature T cells with various differentiation capabilities, including CD4, CD8, T-regulatory, and gamma delta T cells. The artificial thymus also generates T cells with diverse TCR-beta chains for broad antigen recognition, potentially supporting immune function in patients with immune dysregulation or post-chemotherapy conditions.