Exact Sciences Announces Fourth Quarter 2024 Results

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Insights

Exact Sciences delivered a strategically significant quarter marked by solid revenue growth and operational improvements, despite booking substantial impairment charges. The 14% growth in Screening revenue to $553 million demonstrates strong market adoption of the company's core Cologuard product, while the flat Precision Oncology segment suggests market maturation requiring innovation-driven growth.

The $838 million impairment charge, primarily related to the Thrive acquisition's R&D assets, reflects adjusted valuations but doesn't impact operational cash flows. More importantly, the company's improving operational efficiency is evident in the $75 million adjusted EBITDA, representing a substantial 300 basis point margin expansion to 11%. The $211 million operating cash flow for 2024 and $1.04 billion cash position provide ample runway for the planned 2025 product launches.

The pipeline developments are particularly compelling. The upcoming launch of Cologuard Plus, with its 40% reduction in false positives, could significantly expand market share in colorectal cancer screening. The Cancerguard test's 62.3% sensitivity at 98.5% specificity for multiple cancers positions the company to potentially reduce cancer mortality by 17% over 10 years. The Oncodetect test's ability to identify residual disease up to 10 months earlier than imaging represents a significant advancement in post-treatment monitoring.

These three planned launches in 2025 could create multiple new revenue streams while deepening the company's competitive moat in cancer diagnostics. The strong cash position and improving operational metrics suggest the company is well-positioned to execute on these launches while maintaining financial flexibility.

02/19/2025 - 04:05 PM

Fourth quarter and 2024 highlights

Total fourth quarter revenue of $713 million, an increase of 10%, or 11% on a core revenue basis, with Screening revenue of $553 million and Precision Oncology revenue of $161 million
Total 2024 revenue of $2.76 billion, an increase of 10%, or 11% on a core revenue basis, with Screening revenue of $2.10 billion and Precision Oncology revenue of $655 million
Plans to launch three new cancer tests in 2025: Cologuard Plus™, next-generation colorectal cancer screening test, Oncodetect™, molecular residual disease test, and Cancerguard™, multi-cancer screening test

MADISON, Wis.--(BUSINESS WIRE)-- Exact Sciences Corp. (Nasdaq: EXAS), a leading provider of cancer screening and diagnostic tests, today announced that the Company generated revenue of $713 million for the fourth quarter of 2024 and $2.76 billion for the full year of 2024, both ended December 31, 2024.

“The Exact Sciences team is off to a good start in 2025, building on the momentum we created in the fourth quarter,” said Kevin Conroy, Chairman and CEO of Exact Sciences. “This year is on track to be the most productive in company history, with continued execution from our core business and the launch of three innovative cancer tests. This will power years of growth and profitability, deepen our leadership in diagnostics, and help eradicate cancer by preventing it, detecting it earlier, and guiding personalized treatment."

Fourth quarter 2024 financial results

For the three-month period ended December 31, 2024, as compared to the same period of 2023 (where applicable):

Total revenue was $713 million, an increase of 10%, or 11% on a core revenue basis
Screening revenue was $553 million, an increase of 14%
Precision Oncology revenue was $161 million, an increase of 0.4%, or 2% on a core revenue basis
Gross margin was 69% and adjusted gross margin was 72%
Impairment charges were $838 million, primarily reflecting changes in external factors related to the in-process research and development asset acquired as part of the Thrive acquisition
Net loss was $865 million, or $4.67 per share, compared to a net loss of $49.8 million, or $0.27 per share
Adjusted EBITDA was $75 million, an increase of $26 million, and adjusted EBITDA margin was 11%, an increase of nearly 300 basis points
Operating cash flow was $47 million and free cash flow was $11 million in the fourth quarter, and full-year 2024 operating cash flow was $211 million and free cash flow was $75 million
Cash, cash equivalents, and marketable securities were $1.04 billion at the end of the quarter

Screening primarily includes laboratory service revenue from Cologuard^® tests and PreventionGenetics. Precision Oncology includes laboratory service revenue from global Oncotype DX^® and therapy selection tests.

Platform and pipeline advancements

In the fourth quarter, Exact Sciences secured favorable Medicare pricing for the Cologuard Plus test, its next-generation colon cancer screening test. The Cologuard Plus test detects cancers and precancerous polyps with even greater sensitivity than the Cologuard test while reducing false positives by nearly 40 percent. This advancement enhances the Company’s screening capabilities and reinforces its commitment to delivering high-quality, non-invasive options for patients. The Company remains on-track to launch Cologuard Plus with Medicare coverage and guideline inclusion in the second quarter of 2025.

In the fourth quarter, the Company shared new evidence from the ASCEND 2 study supporting Cancerguard, its blood-based multi-cancer screening test. The data showed at a 98.5% specificity, overall sensitivity excluding breast and prostate cancer was 62.3%. Sensitivity was 67.1% for the six most aggressive cancers (pancreas, esophagus, liver, lung, stomach, and ovary). This highlights the potential of a multi-omic test to improve early cancer detection. Additionally, Exact Sciences presented new modeling data that estimated adding multi-cancer screening to standard-of-care screening could reduce cancer mortality by 17% over 10 years. These analyses will support the planned launch of Cancerguard™ EX, Exact Sciences’ MCS laboratory-developed test, in the second half of 2025. Exact Sciences will bring this test to patients through its large screening and precision oncology commercial organization and unique ExactNexus™ technology platform.

In January 2025, Exact Sciences presented data in the Journal of Surgical Oncology demonstrating the clinical strength of the Oncodetect test, its molecular residual disease and recurrence monitoring test. Results from a well-designed study of monitored colon cancer patients found those with a positive Oncodetect test were 50 times more likely to recur than those with a negative result. The study further showed Oncodetect identifies residual disease up to 10 months earlier than imaging, the current standard of care. Findings from a second clinical validation study also demonstrated promising performance of Oncodetect as an MRD test. The Company recently submitted results for reimbursement in colorectal cancer and expects to launch the Oncodetect test in the second quarter of 2025.

2025 outlook

The Company announces its full-year 2025 revenue and adjusted EBITDA guidance:

	2024 results	2025 outlook
Total revenue	$2.759 billion	$3.025 - $3.085 billion
Screening	$2.104 billion	$2.350 - $2.390 billion
Precision Oncology	$655 million	$675 - $695 million
Adjusted EBITDA	$323 million	$410 - $440 million

Non-GAAP disclosure

In addition to the Company's financial results determined in accordance with U.S. GAAP, the Company provides non-GAAP measures that it determines to be useful in evaluating its operating performance and liquidity. The Company presents the following non-GAAP measures:

Core revenue — Core revenue is calculated to adjust for recent acquisitions and divestitures, COVID-19 testing revenue and foreign currency exchange rate fluctuations. Revenue from recent acquisitions is adjusted for the 12 months following acquisition when the periods are not comparable. To exclude the impact of change in foreign currency exchange rates from the prior period under comparison, the Company converts the current period non-U.S. dollar denominated revenue using the prior year comparative period exchange rates.

Adjusted EBITDA and adjusted EBITDA margin — The Company defines adjusted EBITDA as net loss adjusted for interest expense, income tax expense or benefit, depreciation expense, amortization of acquired intangible assets, investment income or loss, and certain other items which include significant non-cash items and other charges or benefits resulting from transactions or events that are highly variable, significant in size, and that we do not believe are indicative of ongoing or future business operations. These items are discussed in more detail below in the tables captioned “U.S. GAAP to Non-GAAP Reconciliation”. Adjusted EBITDA margin is calculated as adjusted EBITDA divided by total revenue.

Adjusted gross profit, adjusted research and development expenses, adjusted sales and marketing expenses, adjusted general and administrative expenses, adjusted loss from operations, adjusted net loss before tax, adjusted income tax expense (benefit), adjusted net loss, and adjusted earnings per share — The Company refers to various “adjusted” amounts or measures on an “adjusted” basis, which exclude the impact of amortization of intangible assets and certain charges or benefits resulting from transactions or events that are highly variable, significant in size, and that we do not believe are indicative of ongoing or future business operations. These items are described in more detail below in the tables captioned “U.S. GAAP to Non-GAAP Reconciliation”. The Company also presents certain of these adjusted measures as a percentage of revenue including adjusted gross margin.

Free cash flow — The Company defines free cash flow as net cash used in or provided by operating activities, reduced by purchases of property, plant and equipment. Management uses free cash flow as a liquidity measure.

Management believes that presentation of non-GAAP financial measures provides supplemental information useful to investors in understanding our underlying operating results and trends. Non-GAAP financial information, when taken collectively, may be helpful to investors because it provides consistency and comparability of the Company's operating results across reporting periods. Management uses this non-GAAP financial information to establish budgets, manage the Company's business, and set incentive and compensation arrangements. Free cash flow provides useful information to management and investors since it measures our ability to generate cash from business operations. Non-GAAP financial information is presented for supplemental information purposes only, has limitations as an analytical tool and should not be considered in isolation or as a substitute for financial information presented in accordance with U.S. GAAP. For example, adjusted gross margin and adjusted gross profit exclude the amortization of acquired intangible assets although such measures include the revenue associated with the acquisitions. Additionally, adjusted EBITDA and other adjusted operating result metrics exclude a number of expense items that are included in net loss. As a result, positive adjusted EBITDA, adjusted operating income, or adjusted earnings per share may be achieved while a significant net loss persists. For more information on these non-GAAP financial measures, see the tables captioned “U.S. GAAP to Non-GAAP Reconciliation.” The Company presents certain forward-looking statements about the Company's future financial performance that include non-GAAP measures. These non-GAAP measures include adjustments like stock-based compensation, acquisition and integration costs including gains and losses on contingent consideration, and other significant charges or gains that are difficult to predict for future periods because the nature of the adjustments pertain to events that have not yet occurred. Additionally, management does not forecast many of the excluded items for internal use. Information reconciling forward-looking non-GAAP measures to U.S. GAAP measures is therefore not available without unreasonable effort and is not provided. The occurrence, timing, and amount of any of the items excluded from GAAP to calculate non-GAAP could significantly impact the Company's GAAP results.

Fourth quarter conference call & webcast

Company management will host a conference call and webcast on Wednesday, February 19, 2025, at 5 p.m. ET to discuss fourth quarter and full year 2024 results. The webcast will be available at exactsciences.com. Domestic callers should dial 888-330-2384 and international callers should dial +1-240-789-2701. The access code for both domestic and international callers is 4437608. A replay of the webcast will be available at exactsciences.com. The webcast, conference call, and replay are open to all interested parties.

About the Cologuard and Cologuard Plus tests

Developed in collaboration with Mayo Clinic, the Cologuard and Cologuard Plus tests are non-invasive colorectal cancer (CRC) screening options for the 110 million U.S. adults ages 45 or older who are at average risk for the disease.

The Cologuard test revolutionized CRC screening by detecting specific DNA markers and blood associated with cancer and precancer in stool, allowing patients to use the test at home without special preparation or time off. It is covered by Medicare and included in national screening guidelines from both the American Cancer Society (2018) and the U.S. Preventive Services Task Force (2021). Since its launch in 2014, the Cologuard test has been used to screen for CRC 18 million times.

Building on this success, the FDA-approved Cologuard Plus test raises the performance bar even further and features novel biomarkers, improved laboratory processes, and enhanced sample stability. The Cologuard Plus test is expected to reduce false positives by nearly 40%, to help minimize unnecessary follow-up colonoscopies. Both tests demonstrate Exact Sciences’ commitment to improving CRC screening access and outcomes. Exact Sciences expects to launch the Cologuard Plus test with Medicare coverage and guideline inclusion in 2025.

About the Oncodetect test

Molecular residual disease (MRD) refers to the presence of tumor-specific DNA in the body. These fragments of genetic information, known as circulating tumor DNA (ctDNA), are shed into the bloodstream by tumors, and their presence may indicate that cancer is present . Exact Sciences’ MRD offering leverages our in-house capabilities in whole exome sequencing to offer a tumor-informed MRD test for a personalized approach to detecting and monitoring residual cancer in patients with solid tumors. By identifying somatic genomic alterations in tumor DNA and detecting a subset in ctDNA from blood, the Oncodetect test may enable the detection of ctDNA before, during, and after treatment. This critical information can guide therapy decisions and monitor for cancer recurrence.

About the Cancerguard test

The Cancerguard test, currently in development, is designed to detect multiple cancers in their earliest stages from a single blood draw. Building upon decades of research, Exact Sciences intends to harness the additive sensitivity of multiple biomarker classes to detect more cancers in earlier stages. The Cancerguard test will utilize a streamlined and standardized imaging-based diagnostic pathway, which may result in fewer follow-up procedures. The test is being developed to provide high specificity to help minimize false positives while detecting multiple cancers, including those with the biggest toll on human health. These features describe current development goals. The Cancerguard test has not been cleared or approved by the U.S. Food and Drug Administration or any other national regulatory authority. To learn more, visit http://www.exactsciences.com/cancerguard.

About Exact Sciences’ Precision Oncology portfolio

Exact Sciences’ Precision Oncology portfolio delivers actionable genomic insights to inform prognosis and cancer treatment after a diagnosis. In breast cancer, the Oncotype DX Breast Recurrence Score® test is the only test shown to predict the likelihood of chemotherapy benefit as well as recurrence in invasive breast cancer. The Oncotype DX test is recognized as the standard of care and is included in all major breast cancer treatment guidelines. The OncoExTra™ test applies comprehensive tumor profiling, utilizing whole exome and whole transcriptome sequencing, to aid in therapy selection for patients with advanced, metastatic, refractory, relapsed, or recurrent cancer. With an extensive panel of approximately 20,000 genes and 169 introns, the OncoExTra test is one of the most comprehensive genomic (DNA) and transcriptomic (RNA) panels available today. Exact Sciences enables patients to take a more active role in their cancer care and makes it easy for providers to order tests, interpret results, and personalize medicine by applying real-world evidence and guideline recommendations. To learn more, visit precisiononcology.exactsciences.com.

About PreventionGenetics

Founded in 2004 and located in Marshfield, Wisconsin, PreventionGenetics is a CLIA and ISO 15189:2012 accredited laboratory. PreventionGenetics delivers clinical genetic testing of the highest quality at fair prices with exemplary service to people around the world. PreventionGenetics has 25 PhD geneticists on staff and provides tests for nearly all clinically relevant genes including the powerful and comprehensive germline whole genome sequencing test, PGnome® and whole exome sequencing test, PGxome®. PreventionGenetics was acquired by Exact Sciences in December 2021.

About Exact Sciences Corp.

A leading provider of cancer screening and diagnostic tests, Exact Sciences gives patients and health care professionals the clarity needed to take life-changing action earlier. Building on the success of the Cologuard and Oncotype DX tests, Exact Sciences is investing in its pipeline to develop innovative solutions for use before, during, and after a cancer diagnosis. For more information, visit ExactSciences.com, follow Exact Sciences on X @ExactSciences, or find Exact Sciences on LinkedIn and Facebook.

Forward-Looking Statements

This news release contains forward-looking statements concerning our expectations, anticipations, intentions, beliefs or strategies regarding the future. These forward-looking statements are based on assumptions that we have made as of the date hereof and are subject to known and unknown risks and uncertainties that could cause actual results, conditions and events to differ materially from those anticipated. Therefore, you should not place undue reliance on forward-looking statements. Examples of forward-looking statements include, among others, statements we make regarding expected future operating results; expectations for development or launching of new or improved products and services and their impact on patients; insurance reimbursement potential; our strategies, commercialization efforts, positioning, competition, resources, capabilities and expectations for future events or performance; and the anticipated benefits of our acquisitions, including estimated synergies and other financial impacts.

Important factors that could cause actual results, conditions and events to differ materially from those indicated in the forward-looking statements include, among others, the following: our ability to successfully develop and commercialize new products and services and assess potential market opportunities; our ability to successfully and profitably market our products and services; the acceptance of our products and services by patients and healthcare providers; our reliance upon certain suppliers; our ability to retain and hire key personnel; approval and maintenance of adequate reimbursement rates for our products and services within and outside of the U.S.; the amount and nature of competition for our products and services; the effects of any judicial, executive or legislative action affecting us or the healthcare system; changes in government policies, laws, regulations, and staffing; recommendations, guidelines and quality metrics issued by various organizations regarding cancer screening or our products and services; our ability to obtain and maintain regulatory approvals and comply with applicable regulations; our ability to protect and enforce our intellectual property; our success establishing and maintaining collaborative, licensing, and supplier arrangements; the results of our validation studies and clinical trials, including the risks that the results of future studies and trials may differ materially from the results of previously completed studies and trials; our ability to manage an international business and our expectations regarding our international expansion and opportunities; the potential effects of changing macroeconomic conditions and geopolitical conflict; the possibility that the anticipated benefits from our business acquisitions will not be realized in full or at all or may take longer to realize than expected; the outcome of any potential litigation or legal proceeding; and our ability to raise the capital necessary to support our operations or meet our payment obligations under our indebtedness. The risks included above are not exhaustive. Other important risks and uncertainties are described in the Risk Factors sections of our most recent Annual Report on Form 10-K and any subsequent Quarterly Reports on Form 10-Q, and in our other reports filed with the Securities and Exchange Commission. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

EXACT SCIENCES CORPORATION Selected Unaudited Financial Information Condensed Consolidated Statements of Operations (Amounts in thousands, except per share data)

	Three Months Ended December 31,						Twelve Months Ended December 31,
		2024			2023			2024			2023
Revenue	$	713,424		$	646,885		$	2,758,867		$	2,499,766

Cost of sales		220,831			192,964			840,150			737,564
Gross profit		492,593			453,921			1,918,717			1,762,202

Operating expenses:
Research and development		97,709			115,184			431,210			426,927
Sales and marketing		244,529			216,590			894,125			827,805
General and administrative		191,110			196,388			781,825			800,288
Impairment of long-lived and indefinite-lived assets		838,164			—			869,460			621
Total operating expenses		1,371,512			528,162			2,976,620			2,055,641

Other operating income		2,568			6,400			9,200			78,427
Loss from operations		(876,351	)		(67,841	)		(1,048,703	)		(215,012	)

Other income (expense)
Investment income, net		9,962			25,330			39,558			32,713
Interest expense		(9,577	)		(7,865	)		(27,016	)		(19,447	)
Total other income (expense)		385			17,465			12,542			13,266

Net loss before tax		(875,966	)		(50,376	)		(1,036,161	)		(201,746	)

Income tax benefit (expense)		11,381			610			7,304			(2,403	)

Net loss	$	(864,585	)	$	(49,766	)	$	(1,028,857	)	$	(204,149	)

Net loss per share—basic and diluted	$	(4.67	)	$	(0.27	)	$	(5.59	)	$	(1.13	)

Weighted average common shares outstanding—basic and diluted		185,312			181,114			184,197			180,144

EXACT SCIENCES CORPORATION Selected Unaudited Financial Information Condensed Consolidated Balance Sheets (Amounts in thousands)

	December 31, 2024		December 31, 2023
Assets
Cash and cash equivalents	$	600,889	$	605,378
Marketable securities		437,137		172,266
Accounts receivable, net		248,968		203,623
Inventory		162,383		127,475
Prepaid expenses and other current assets		122,046		85,627
Property, plant and equipment, net		693,673		698,354
Operating lease right-of-use assets		116,952		143,708
Goodwill		2,366,676		2,367,120
Intangible assets, net		1,009,693		1,890,396
Other long-term assets, net		169,722		177,387
Total assets	$	5,928,139	$	6,471,334

Liabilities and stockholders' equity
Convertible notes, net, current portion	$	249,153	$	—
Current liabilities		483,034		514,701
Convertible notes, net, less current portion		2,321,067		2,314,276
Other long-term liabilities		315,503		335,982
Operating lease liabilities, less current portion		157,133		161,070
Total stockholders’ equity		2,402,249		3,145,305
Total liabilities and stockholders’ equity	$	5,928,139	$	6,471,334

EXACT SCIENCES CORPORATION U.S. GAAP to Non-GAAP Reconciliation Core Revenue (Unaudited) (Amounts in thousands)

	GAAP
	Three Months Ended December 31,
		2024		2023	% Change
Screening	$	552,563	$	486,706	14	%
Precision Oncology		160,861		160,179	—	%
Total	$	713,424	$	646,885	10	%

	Non-GAAP
	Three Months Ended December 31,
		2024		2023⁽¹⁾	% Change		Foreign Currency Impact ⁽²⁾		Core Revenue ⁽³⁾		% Change⁽³⁾
Screening	$	552,563	$	486,706	14	%	$	—	$	552,563	14	%
Precision Oncology		160,861		158,096	2	%		1,179		162,040	2	%
Total	$	713,424	$	644,802	11	%	$	1,179	$	714,603	11	%

	GAAP
	Twelve Months Ended December 31,
		2024		2023	% Change
Screening	$	2,103,868	$	1,864,701	13	%
Precision Oncology		654,999		629,110	4	%
COVID-19 Testing		—		5,955	(100	)%
Total	$	2,758,867	$	2,499,766	10	%

	Non-GAAP
	Twelve Months Ended December 31,
		2024⁽¹⁾		2023 ⁽¹⁾	% Change		Foreign Currency Impact ⁽²⁾		Core Revenue⁽³⁾		% Change ⁽³⁾
Screening	$	2,103,868	$	1,864,701	13	%	$	—	$	2,103,868	13	%
Precision Oncology		647,380		620,821	4	%		507		647,887	4	%
Total	$	2,751,248	$	2,485,522	11	%	$	507	$	2,751,755	11	%

(1) Excludes revenue from COVID-19 testing, the divested Oncotype DX Genomic Prostate Score test, and the Resolution Bioscience acquisition.

(2) Foreign currency impact is calculating the change in current period non-U.S. dollar denominated revenue using the prior year comparative period exchange rates.

(3) Excludes revenue from COVID-19 testing, the divested Oncotype DX Genomic Prostate Score test, the impact of foreign currency exchange rate fluctuations, and the Resolution Bioscience acquisition.

EXACT SCIENCES CORPORATION U.S. GAAP to Non-GAAP Reconciliation Adjusted EBITDA (Unaudited) (Amounts in thousands)

	Three Months Ended December 31,						Twelve Months Ended December 31,
		2024			2023			2024			2023
Net loss	$	(864,585	)	$	(49,766	)	$	(1,028,857	)	$	(204,149	)
Interest expense⁽¹⁾		9,577			7,865			27,016			19,447
Income tax (benefit) expense		(11,381	)		(610	)		(7,304	)		2,403
Investment income, net		(9,962	)		(25,330	)		(39,558	)		(32,713	)
Depreciation and amortization		53,147			54,172			214,859			206,608
Stock-based compensation ⁽²⁾		57,787			66,466			254,930			271,218
Acquisition and integration costs ⁽³⁾		(1,664	)		(3,616	)		1,172			(11,762	)
Impairment of long-lived and indefinite-lived assets ⁽⁴⁾		838,164			—			869,460			621
Gain on sale of asset and divestiture related costs ⁽⁵⁾		(2,568	)		(4,311	)		(9,200	)		(74,833	)
Restructuring and business transformation ⁽⁶⁾		6,866			4,837			18,537			5,744
License agreement termination ⁽⁷⁾		—			—			25,843			—
Legal settlement ⁽⁸⁾		—			—			(3,500	)		36,186
Adjusted EBITDA	$	75,381		$	49,707		$	323,398		$	218,770
Adjusted EBITDA margin		11	%		8	%		12	%		9	%

EXACT SCIENCES CORPORATION U.S. GAAP to Non-GAAP Reconciliation U.S. GAAP to Non-GAAP Measures (Unaudited) (Amounts in thousands)

	Three Months Ended December 31, 2024
	Gross Profit			Research & Development Expenses			Sales & Marketing Expenses			General & Administrative Expenses			Loss from Operations			Net Loss Before Tax			Income Tax Benefit (Expense)			Net Loss			Net Loss Per Share
Reported	$	492,593		$	97,709		$	244,529		$	191,110		$	(876,351	)	$	(875,966	)	$	11,381		$	(864,585	)	$	(4.67	)
Reported percent of revenue		69	%		14	%		34	%		27	%
Amortization of acquired intangible assets		20,768			(1,384	)		(1,924	)		(26	)		24,102			24,102			(3,939	)		20,163			0.11
Acquisition and integration costs ⁽³⁾		—			—			—			1,664			(1,664	)		(1,664	)		(12	)		(1,676	)		(0.01	)
Impairment of long-lived and indefinite-lived assets⁽⁴⁾		—			—			—			—			838,164			838,164			(8,398	)		829,766			4.48
Gain on sale of asset and divestiture related costs ⁽⁵⁾		—			—			—			—			(2,568	)		(2,568	)		—			(2,568	)		(0.01	)
Restructuring and business transformation ⁽⁶⁾		—			(114	)		(1,829	)		(4,923	)		6,866			6,866			51			6,917			0.04
Adjusted (non-GAAP)	$	513,361		$	96,211		$	240,776		$	187,825		$	(11,451	)	$	(11,066	)	$	(917	)	$	(11,983	)	$	(0.06	)
Adjusted percent of revenue (non-GAAP)		72	%		13	%		34	%		26	%

EXACT SCIENCES CORPORATION U.S. GAAP to Non-GAAP Reconciliation U.S. GAAP to Non-GAAP Measures (Unaudited) (Amounts in thousands)

	Year Ended December 31, 2024
	Gross Profit			Research & Development Expenses			Sales & Marketing Expenses			General & Administrative Expenses			Loss from Operations			Net Loss Before Tax			Income Tax Benefit (Expense)			Net Loss			Net Loss Per Share
Reported	$	1,918,717		$	431,210		$	894,125		$	781,825		$	(1,048,703	)	$	(1,036,161	)	$	7,304		$	(1,028,857	)	$	(5.59	)
Reported percent of revenue		70	%		16	%		32	%		28	%
Amortization of acquired intangible assets		84,068			(3,293	)		(7,694	)		(103	)		95,158			95,158			(2,106	)		93,052			0.51
Acquisition and integration costs ⁽³⁾		—			—			—			(1,172	)		1,172			1,172			(9	)		1,163			0.01
Impairment of long-lived and indefinite-lived assets ⁽⁴⁾		—			—			—			—			869,460			869,460			(8,398	)		861,062			4.67
Gain on sale of asset and divestiture related costs ⁽⁵⁾		—			—			—			—			(9,200	)		(9,200	)		—			(9,200	)		(0.05	)
Restructuring and business transformation ⁽⁶⁾		200			(6,688	)		(2,051	)		(9,598	)		18,537			18,537			(135	)		18,402			0.10
License agreement termination ⁽⁷⁾		—			(25,843	)		—			—			25,843			25,843			(63	)		25,780			0.14
Legal settlement ⁽⁸⁾		—			—			—			3,500			(3,500	)		(3,500	)		26			(3,474	)		(0.02	)
Adjusted (non-GAAP)	$	2,002,985		$	395,386		$	884,380		$	774,452		$	(51,233	)	$	(38,691	)	$	(3,381	)	$	(42,072	)	$	(0.23	)
Adjusted percent of revenue (non-GAAP)		73	%		14	%		32	%		28	%

EXACT SCIENCES CORPORATION U.S. GAAP to Non-GAAP Reconciliation U.S. GAAP to Non-GAAP Measures (Unaudited) (Amounts in thousands)

	Three Months Ended December 31, 2023
	Gross Profit			Research & Development Expenses			Sales & Marketing Expenses			General & Administrative Expenses			Loss from Operations			Net Loss Before Tax			Income Tax Benefit (Expense)			Net Loss			Net Loss Per Share
Reported	$	453,921		$	115,184		$	216,590		$	196,388		$	(67,841	)	$	(50,376	)	$	610		$	(49,766	)	$	(0.27	)
Reported percent of revenue		70	%		18	%		34	%		30	%
Amortization of acquired intangible assets		21,100			(261	)		(1,924	)		(26	)		23,311			23,311			(571	)		22,740			0.13
Acquisition and integration costs ⁽³⁾		—			—			—			3,616			(3,616	)		(3,616	)		38			(3,578	)		(0.02	)
Gain on sale of asset and divestiture related costs ⁽⁵⁾		—			—			—			(89	)		(4,311	)		(4,311	)		45			(4,266	)		(0.02	)
Restructuring and business transformation ⁽⁶⁾		60			(4,049	)		(282	)		(446	)		4,837			4,837			(51	)		4,786			0.03
Adjusted (non-GAAP)	$	475,081		$	110,874		$	214,384		$	199,443		$	(47,620	)	$	(30,155	)	$	71		$	(30,084	)	$	(0.17	)
Adjusted percent of revenue (non-GAAP)		73	%		17	%		33	%		31	%

EXACT SCIENCES CORPORATION U.S. GAAP to Non-GAAP Reconciliation U.S. GAAP to Non-GAAP Measures (Unaudited) (Amounts in thousands)

	Year Ended December 31, 2023
	Gross Profit			Research & Development Expenses			Sales & Marketing Expenses			General & Administrative Expenses			Loss from Operations			Net Loss Before Tax			Income Tax Benefit (Expense)			Net Loss			Net Loss Per Share
Reported	$	1,762,202		$	426,927		$	827,805		$	800,288		$	(215,012	)	$	(201,746	)	$	(2,403	)	$	(204,149	)	$	(1.13	)
Reported percent of revenue		70	%		17	%		33	%		32	%
Amortization of acquired intangible assets		83,316			(1,047	)		(7,694	)		(103	)		92,160			92,160			(2,542	)		89,618			0.50
Acquisition and integration costs ⁽³⁾		—			(492	)		—			12,254			(11,762	)		(11,762	)		123			(11,639	)		(0.06	)
Impairment of long-lived and indefinite-lived assets ⁽⁴⁾		—			—			—			—			621			621			(7	)		614			—
Gain on sale of asset and divestiture related costs ⁽⁵⁾		—			—			—			(1,594	)		(74,833	)		(74,833	)		46			(74,787	)		(0.42	)
Restructuring and business transformation ⁽⁶⁾		60			(4,772	)		(282	)		(630	)		5,744			5,744			(60	)		5,684			0.03
Legal settlement⁽⁸⁾		—			—			—			(36,186	)		36,186			36,186			(485	)		35,701			0.20
Adjusted (non-GAAP)	$	1,845,578		$	420,616		$	819,829		$	774,029		$	(166,896	)	$	(153,630	)	$	(5,328	)	$	(158,958	)	$	(0.88	)
Adjusted percent of revenue (non-GAAP)		74	%		17	%		33	%		31	%

(1) Interest expense includes net gains recorded of $10.3 million for each of the twelve months ended December 31, 2024 and 2023, from the settlement of convertible notes. The gains represent the difference between (i) the fair value of the consideration transferred and (ii) the sum of the carrying value of the debt at the time of the exchange.

(2) Represents stock-based compensation expense and 401(k) match expense. The Company matches a portion of Exact Sciences employees' contributions annually in the form of the Company's common stock.

(3) Represents acquisition and related integration costs incurred as a result of the Company's business combinations. Acquisition costs represent legal and professional fees incurred to execute the transaction. There were no acquisition costs incurred for the three and twelve months ended December 31, 2024 and there was an insignificant amount incurred for the three and twelve months ended December 31, 2023 related to the acquisition of Resolution Bioscience, Inc. Integration-related costs represent expenses incurred outside regular business operations, specifically relating to the integration of businesses acquired through a business combination. This includes any gain or loss on contingent consideration liabilities, severance and accelerated vesting of stock awards, and professional services. The remeasurement of the contingent consideration liabilities resulted in a gain of $1.0 million and $3.3 million for the three and twelve months ended December 31, 2024, respectively, and a gain of $5.0 million and a gain of $18.0 million for the three and twelve months ended December 31, 2023, respectively. The Company also incurred severance costs and professional service fees which were not significant for the three and twelve months ended December 31, 2024 and 2023. The majority of the professional service fees relate to the integration of information technology systems.

(4) Represents impairment charges on the Company’s long-lived and indefinite-lived assets. For the three months ended December 31, 2024, this primarily includes an impairment charge recorded related to the in-process research and development asset acquired as part of our acquisition of Thrive. For the three and twelve months ended December 31, 2024 this also includes impairment charges recorded on building leases and corresponding leasehold improvements at certain of our domestic facilities. For the three and twelve months ended December 31, 2023, the Company recorded insignificant impairment charges related to building leases that were vacated during the year.

(5) Relates to the sale of the intellectual property and know-how related to the Company's Oncotype DX Genomic Prostate Score test to MDxHealth SA in August 2022 and the subsequent Second Amendment to the Asset Purchase Agreement related to the sale in August 2023. For the three and twelve months ended December 31, 2024, this represents the remeasurement of the associated contingent consideration. For the three months ended December 31, 2023, this represents the remeasurement of the associated contingent consideration and an insignificant amount of legal and professional fees. For the twelve months ended December 31, 2023, this represents a gain of $3.1 million from additional cash and equity consideration received, a $73.3 million contingent consideration gain, and an insignificant amount of legal and professional service fees.

(6) Includes costs associated with the Company's business transformation program intended to consolidate operations, achieve targeted cost reductions, and focus resources on its key strategic priorities. For the three and twelve months ended December 31, 2024, this primarily includes severance costs and accelerated stock-based compensation expense related to the closure of domestic facilities and related consulting services. For the three and twelve months ended December 31, 2023, this primarily includes severance and accelerated stock-based compensation costs associated with the closure of one of the Company's domestic laboratory facilities.

(7) Represents termination related charges incurred due to the termination of the Company's license and sponsored research agreements with The Translational Genomics Research Institute related to its Targeted Digital Sequencing technology, which resulted in the recognition of termination related charges in the second quarter of 2024.

(8) Represents charges incurred in connection with settlements with counterparties related to the Medicare Date of Service Rule Investigation and the Federal Anti-Kickback Statute and False Claims Act qui tam lawsuit.

EXACT SCIENCES CORPORATION U.S. GAAP to Non-GAAP Reconciliation Operating Cash Flow to Free Cash Flow (Unaudited) (Amounts in thousands)

	Three Months Ended December 31,						Twelve Months Ended December 31,
		2024			2023			2024			2023
Net cash provided by operating activities	$	47,063		$	69,549		$	210,536		$	156,119
Net cash provided by (used in) investing activities		(41,872	)		(66,767	)		(442,155	)		49,679
Net cash provided by financing activities		10,499			10,037			231,874			159,766
Effects of exchange rate changes on cash and cash equivalents		(3,721	)		1,947			(3,294	)		1,321
Net increase (decrease) in cash, cash equivalents and restricted cash		11,969			14,766			(3,039	)		366,885
Cash, cash equivalents and restricted cash, beginning of period		594,667			594,909			609,675			242,790
Cash, cash equivalents and restricted cash, end of period	$	606,636		$	609,675		$	606,636		$	609,675

Reconciliation of free cash flow:
Net cash provided by operating activities	$	47,063		$	69,549		$	210,536		$	156,119
Purchases of property, plant and equipment		(36,316	)		(34,922	)		(135,989	)		(124,190	)
Free cash flow	$	10,747		$	34,627		$	74,547		$	31,929

View source version on businesswire.com: https://www.businesswire.com/news/home/20250219858446/en/

Investor Contact:

Derek Leckow

Exact Sciences Corp.

investorrelations@exactsciences.com

608-893-0009

Media Contact:

Steph Spanos

Exact Sciences Corp.

sspanos@exactsciences.com

608-556-4380

Source: Exact Sciences Corp.

FAQ

What was Exact Sciences (EXAS) revenue growth in Q4 2024?

Exact Sciences reported Q4 2024 revenue of $713 million, representing a 10% increase year-over-year, with core revenue growth of 11%.

What caused EXAS's significant net loss in Q4 2024?

The $865 million net loss was primarily due to $838 million in impairment charges related to the in-process research and development asset from the Thrive acquisition.

When will Exact Sciences launch Cologuard Plus and what are its benefits?

Cologuard Plus will launch in Q2 2025 with Medicare coverage. It offers improved cancer and precancerous polyp detection while reducing false positives by nearly 40% compared to the original Cologuard test.

What is the performance data for EXAS's new Cancerguard test?

Cancerguard showed 62.3% overall sensitivity at 98.5% specificity, excluding breast and prostate cancer. For the six most aggressive cancers, sensitivity was 67.1%.

How much cash does Exact Sciences (EXAS) have on hand?

As of Q4 2024, Exact Sciences had $1.04 billion in cash, cash equivalents, and marketable securities.

Exact Sciences Announces Fourth Quarter 2024 Results

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Exact Sciences Announces Fourth Quarter 2024 Results

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What was Exact Sciences (EXAS) revenue growth in Q4 2024?

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