e-therapeutics Announces Business Updates and Interim Results
e-therapeutics reported interim results and business updates for H1 2024. The company continues advancing its GalOmic pipeline, with ETX-312 progressing through IND-enabling studies for MASH treatment, targeting submission in 2025. The company strengthened its leadership team and infrastructure, partnering with AWS to enhance AI capabilities. Financial highlights include a cash position of £41.0 million as of July 31, 2024, following a £28.9 million fundraise. Operating loss increased to £7.5 million, with R&D expenses at £5.6 million and G&A costs at £2.0 million. The company maintains 39 employees.
e-therapeutics ha riportato risultati preliminari e aggiornamenti aziendali per il primo semestre del 2024. L'azienda continua a far progredire il suo GalOmic pipeline, con l'ETX-312 che avanza attraverso studi abilitanti all'IND per il trattamento MASH, puntando a una presentazione nel 2025. L'azienda ha rafforzato il proprio team di leadership e le infrastrutture, collaborando con AWS per migliorare le capacità di intelligenza artificiale. Tra i punti salienti finanziari si registra una posizione di cassa di 41,0 milioni di sterline al 31 luglio 2024, a seguito di un fundraising di 28,9 milioni di sterline. La perdita operativa è aumentata a 7,5 milioni di sterline, con spese per R&S pari a 5,6 milioni di sterline e costi G&A di 2,0 milioni di sterline. L'azienda conta attualmente 39 dipendenti.
e-therapeutics informó sobre resultados intermedios y actualizaciones comerciales para el primer semestre de 2024. La compañía sigue avanzando en su GalOmic pipeline, con el ETX-312 progresando a través de estudios habilitantes para IND para el tratamiento de MASH, con una presentación prevista para 2025. La empresa ha fortalecido su equipo de liderazgo e infraestructura, asociándose con AWS para mejorar sus capacidades de inteligencia artificial. Los aspectos financieros incluyen una posición de efectivo de 41,0 millones de libras hasta el 31 de julio de 2024, tras una recaudación de fondos de 28,9 millones de libras. La pérdida operativa aumentó a 7,5 millones de libras, con gastos de I+D de 5,6 millones de libras y costos de G&A de 2,0 millones de libras. La empresa mantiene a 39 empleados.
e-therapeutics는 2024년 상반기에 대한 중간 결과 및 사업 업데이트를 보고했습니다. 회사는 MASH 치료를 위한 IND 지원 연구를 진행 중인 GalOmic 파이프라인을 계속 발전시키고 있으며, 2025년 제출을 목표로 하고 있습니다. 회사는 리더십 팀과 인프라를 강화하고 AI 기능 향상을 위해 AWS와 파트너십을 맺었습니다. 재무 하이라이트로는 2024년 7월 31일 기준으로 4,100만 파운드의 현금 보유액이 있으며, 이는 2,890만 파운드의 자금 조달에 따른 것입니다. 운영 손실은 750만 파운드로 증가했으며, R&D 비용은 560만 파운드, G&A 비용은 200만 파운드에 달합니다. 회사는 현재 39명의 직원을 유지하고 있습니다.
e-therapeutics a publié des résultats intermédiaires et des mises à jour commerciales pour le premier semestre 2024. L'entreprise continue de faire avancer son GalOmic pipeline, avec l'ETX-312 progressant à travers des études permettant l'IND pour le traitement du MASH, avec une soumission prévue pour 2025. L'entreprise a renforcé son équipe dirigeante et son infrastructure, s'associant à AWS pour améliorer ses capacités d'intelligence artificielle. Les faits saillants financiers comprennent une position de trésorerie de 41,0 millions de livres au 31 juillet 2024, suite à un financement de 28,9 millions de livres. La perte d'exploitation a augmenté à 7,5 millions de livres, avec des dépenses de R&D de 5,6 millions de livres et des coûts de G&A de 2,0 millions de livres. L'entreprise compte actuellement 39 employés.
e-therapeutics berichtete über Zwischenresultate und Geschäftsaktualisierungen für das erste Halbjahr 2024. Das Unternehmen entwickelt weiterhin seine GalOmic-Pipeline, wobei sich ETX-312 durch IND-ermöglichende Studien zur MASH-Behandlung befindet, mit dem Ziel einer Einreichung im Jahr 2025. Das Unternehmen stärkte sein Führungsteam und die Infrastruktur und ging eine Partnerschaft mit AWS ein, um die KI-Fähigkeiten zu verbessern. Zu den finanziellen Highlights gehört eine Barbestände von 41,0 Millionen Pfund zum 31. Juli 2024, nach einer Mittelbeschaffung von 28,9 Millionen Pfund. Der operative Verlust erhöhte sich auf 7,5 Millionen Pfund, wobei die F&E-Ausgaben bei 5,6 Millionen Pfund und die Verwaltungskosten bei 2,0 Millionen Pfund liegen. Das Unternehmen beschäftigt derzeit 39 Mitarbeiter.
- Strong cash position of £41.0 million following successful £28.9 million fundraise
- Multiple drug candidates advancing through IND-enabling studies
- Strategic partnership with AWS to enhance AI capabilities
- Operating loss increased to £7.5 million from £7.0 million year-over-year
- R&D expenses increased to £5.6 million from £5.3 million
- G&A costs rose to £2.0 million from £1.8 million
LONDON, Oct. 31, 2024 (GLOBE NEWSWIRE) -- e-therapeutics plc, a company integrating computational power and biological data to discover life-transforming RNAi medicines, today announced business updates, including its unaudited interim results for the six months to 31st July 2024.
Ali Mortazavi, CEO, said: “We continue to make strong and rapid progress towards becoming a clinical-stage biotech company, as we advance our pipeline of novel GalOmic therapies, aiming to file our first IND submission in 2025. I am also excited about the ongoing evolution of HepNet. Our investment in AWS infrastructure demonstrates our commitment to integrating cutting-edge technologies across our platform.
To further these efforts, we are thrilled to welcome Dr Lee Clewley as our Vice President of Applied AI and to announce the promotion of Dr Natalie Pursell to Vice President of Early-stage Development.
With a powerful AI-driven platform and a growing GalOmic pipeline, we continue to be well-equipped to transform the landscape of RNAi therapeutics as we advance towards clinical trials.”
GalOmic Pipeline Progress
- ETX-312 for the treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH): ETX-312 continues to progress through IND-enabling studies with an IND submission anticipated during 2025.
- ETX-148 for the treatment of Bleeding Disorders: ETX-148 IND-enabling studies initiated, with an IND submission anticipated during 2026.
- ETX-407 for the treatment of Dry Age-Related Macular Degeneration: ETX-407 continues to progress through the initial phase of IND-enabling studies, following a stage-gated approach to ensure the efficient use of capital.
- ETX-258 for the treatment of Heart Failure: This program has completed preclinical proof-of-concept studies, with selected data due to be presented at the upcoming American Heart Association Conference.
- ETX-394 for the treatment of MASH: Our second MASH program continues to advance through preclinical proof-of-concept studies. ETX-394 targets different disease biology to ETX-312, silencing another novel and differentiated target gene.
HepNet Platform Updates
- Infrastructure Development: We are working with Amazon Web Services (AWS) to accelerate advancement of our Generative AI capabilities, leveraging AWS’ global leadership in AI and cloud infrastructure to enhance the design and scalability of our systems with cutting-edge large-language model (LLM) technologies via AWS Bedrock.
- Application of Latest Artificial Intelligence: We continue to leverage the latest developments in AI to enhance existing processes, including our target-indication assessment workflow that enables us to nominate new programs with confidence in biology, developability, and commercial viability.
Additional Corporate Updates
- Expanding our Leadership Team
- Dr Natalie Pursell was promoted to VP, Early-stage Development. Natalie has served as Head of Preclinical Development at ETX since April 2023, using her extensive knowledge of preclinical research and oligonucleotide therapeutics to drive the progress of our GalOmic pipeline. Prior to this, she held leadership positions at RNA biotech companies such as Dicerna Pharmaceuticals and Moment Biosciences.
- Addition of Dr Lee Clewley to ETX as VP, Head of Applied AI and Informatics. Lee specialises in integrating AI into medicine discovery and delivery processes. Most recently, Lee was Head of Applied AI at GSK, where he led the development of a number of innovative projects designed to accelerate biopharma pipelines.
- Strengthening the Board: Jeremy Punnett was appointed to the Board of Directors in July 2024. Jeremy is a fund manager at M&G Investment Management Ltd and has been involved in numerous private and public investment transactions, including M&G’s most recent investment in ETX.
Financial Highlights
- Cash Position: Cash and cash equivalents were
£41.0 million as of 31 July 2024, including a fundraise of£28.9 million gross in June 2024 (31 January 2024:£20.7 million ). - Operating Loss: Operating loss was
£7.5 million as of 31 July 2024 (H1 2023/24 loss:£7.0 million ). - Research and Development Expenses: R&D expenditure increased to
£5.6 million for H1 2024/25 (H1 2023/24:£5.3 million ), reflecting investment in industry-leading talent and continued advancement of our pipeline. - General and Administrative Expenses: General and administrative costs rose to
£2.0 million (H1 2023/24:£1.8 million ) due to increased spend on human resources to continue the growth of our expert team, alongside further consultancy costs to support operations and progression of our pipeline towards the clinic. - Headcount: Headcount (excluding Non-Executive Directors) was 39 as of 31 July 2024 (31 January 2024: 38).
About e-therapeutics plc
e-therapeutics plc ("ETX") uniquely combines computation and RNAi to discover and develop life-transforming medicines. ETX's proprietary RNAi chemistry platform, GalOmic™, enables generation of specific, potent, and durable siRNA therapeutics for effective silencing of novel gene targets in hepatocytes. The cutting-edge HepNet™ computational platform allows ETX to discover better medicines faster through generation of novel insights and increased automation across all stages of drug development. HepNet™ encompasses an extensive hepatocyte-specific knowledgebase and a suite of advanced AI-driven approaches which enable identification of novel gene targets, rapid target-indication assessment, and predictive in silico siRNA design. The Company has specialist expertise and a robust position in applying computation to biology. Its computational approaches have been extensively validated through generation of data from pipeline programs and successful drug discovery collaborations with biopharma companies, such as Novo Nordisk, Galapagos NV, and iTeos Therapeutics.
Leveraging the combined capabilities of HepNet™ and GalOmic™, ETX is progressing a therapeutic pipeline of highly differentiated RNAi candidates across a variety of therapeutic areas with high unmet need. The Company has generated positive proof-of-concept data on preclinical assets in metabolic dysfunction-associated steatohepatitis (MASH), dry age-related macular degeneration (dry AMD), haemophilia, heart failure, and cardiometabolic disease, further validating its computationally enhanced approach to research and development. ETX is currently progressing its GalOmic™ therapies towards the clinic with its most developed assets, ETX-312 for MASH, ETX-148 for bleeding disorders, and ETX-407 for dry AMD, at the IND-enabling stage.
Press Contact
press@etherapeutics.co.uk
Investor Relations Contact
investorrelations@etherapeutics.co.uk
Unaudited Interim Results for the Six Months to 31st July 2024
| INCOME STATEMENT FOR THE PERIOD ENDED 31 JULY 2024 | |||
6 months ended 31 July 2024 | 6 months ended 31 July 2023 | Year ended 31 January 2024 | |
| (unaudited) | (unaudited) | (audited) | |
| £’000 | £’000 | £’000 | |
| Revenue | - | 160 | 318 |
| Cost of sales | - | - | - |
| Gross profit | - | 160 | 318 |
| Research and development expenditure | (5,554) | (5,324) | (10,247) |
| Administrative expenses | (1,966) | (1,806) | (3,865) |
| Operating loss | (7,520) | (6,970) | (13,794) |
| Interest income | 277 | 343 | 740 |
| Interest expense | (28) | (4) | (27) |
| Loss before tax | (7,271) | (6,631) | (13,081) |
| Taxation | 1,009 | 1,037 | 1,915 |
| Loss for the period/year attributable to equity holders of the Company | (6,262) | (5,594) | (11,166) |
| Loss per share: basic and diluted | (0.89)p | (0.97)p | (1.91)p |
| STATEMENT OF COMPREHENSIVE INCOME FOR THE SIX MONTHS ENDED 31 JULY 2024 | |||
6 months ended 31 July 2024 | 6 months ended 31 July 2023 | Year ended 31 January 2024 | |
| (unaudited) | (unaudited) | (audited) | |
| £’000 | £’000 | £’000 | |
| Loss for the period | (6,262) | (5,594) | (11,166) |
| Other comprehensive income | - | - | - |
| Total comprehensive income for the period/year attributable to equity holders of the Company | (6,262) | (5,594) | (11,166) |
| STATEMENT OF CHANGES IN EQUITY FOR THE PERIOD ENDED 31 JULY 2024 | ||||
| Share capital | Share premium | Retained earnings | Total | |
| £’000 | £’000 | £’000 | £’000 | |
| As at 31 January 2023 | 582 | 112,613 | (80,151) | 33,044 |
| Total comprehensive income for the period | ||||
| Loss for the period | - | - | (5,594) | (5,594) |
| Total comprehensive income for the period | - | - | (5,594) | (5,594) |
| Transactions with owners, recorded directly in equity | ||||
| Issue of ordinary shares | 1 | 21 | - | 22 |
| Equity-settled share-based payment transactions | - | - | 59 | 59 |
| Total contributions by and distribution to owners | 1 | 21 | 59 | 81 |
| As at 31 July 2023 | 583 | 112,634 | (85,686) | 27,531 |
| Total comprehensive income for the period | ||||
| Loss for the period | - | - | (5,572) | (5,572) |
| Total comprehensive income for the period | - | - | (5,572) | (5,572) |
| Transactions with owners, recorded directly in equity | ||||
| Issue of ordinary shares | 1 | 14 | - | 15 |
| Equity-settled share-based payment transactions | - | - | 19 | 19 |
| Total contributions by and distribution to owners | 1 | 14 | 19 | 34 |
| As at 31 January 2024 | 584 | 112,648 | (91,239) | 21,993 |
| Total comprehensive income for the period | ||||
| Loss for the period | - | - | (6,262) | (6,262) |
| Total comprehensive income for the period | - | - | (6,262) | (6,262) |
| Transactions with owners, recorded directly in equity | ||||
| Issue of ordinary shares | 193 | 28,714 | - | 28,907 |
| Equity-settled share-based payment transactions | - | - | 25 | 25 |
| Total contributions by and distribution to owners | 193 | 28,714 | 25 | 28,932 |
| As at 31 July 2024 | 777 | 141,362 | (97,476) | 44,663 |
| STATEMENT OF FINANCIAL POSITION AS AT 31 JULY 2024 | ||||
31 July 2024 | 31 July 2023 | 31 January 2024 | ||
| Note | (unaudited) | (unaudited) | (audited) | |
| £’000 | £’000 | £’000 | ||
| Non-current assets | ||||
| Intangible assets | 658 | 301 | 407 | |
| Property, plant and equipment | 1,103 | 175 | 988 | |
| 1,761 | 476 | 1,395 | ||
Current assets | ||||
| Tax receivable | 2,944 | 2,537 | 1,935 | |
| Trade and other receivables | 512 | 302 | 470 | |
| Prepayments | 419 | 647 | 504 | |
| Cash and cash equivalents | 41,043 | 24,845 | 20,665 | |
| 44,918 | 28,331 | 23,574 | ||
| Total assets | 46,679 | 28,807 | 24,969 | |
Current liabilities | ||||
| Trade and other payables | 1,495 | 1,186 | 2,266 | |
| Lease Liability | 424 | 90 | 393 | |
| Contract liabilities | - | - | - | |
| 1,919 | 1,276 | 2,659 | ||
Non-current liabilities | ||||
| Lease Liability | 97 | - | 317 | |
| Total liabilities | 2,016 | 1,276 | 2,976 | |
| Net assets | 44,663 | 27,531 | 21,993 | |
Equity | ||||
| Share capital | 2 | 777 | 583 | 584 |
| Share premium | 141,362 | 112,634 | 112,648 | |
| Retained earnings | (97,476) | (85,686) | (91,239) | |
| Total equity attributable to equity holders of the Company | 44,663 | 27,531 | 21,993 | |
| CASH FLOW STATEMENT FOR THE PERIOD ENDED 31 JULY 2024 | |||
6 months ended 31 July 2024 | 6 months ended 31 July 2023 | Year ended 31 January 2024 | |
| (unaudited) | (unaudited) | (audited) | |
| £’000 | £’000 | £’000 | |
| Loss for the period/year | (6,262) | (5,594) | (11,166) |
| Adjustments for: | |||
| Depreciation, amortisation and impairment | 266 | 271 | 535 |
| Loss on disposal of fixed assets | - | - | 1 |
| Interest income | (277) | (343) | (740) |
| Interest expense | 28 | 4 | 27 |
| Equity-settled share-based payment expenses | 25 | 59 | 78 |
| Taxation | (1,009) | (1,037) | (1,935) |
| Operating cash flows before movements in working capital | (7,229) | (6,640) | (13,200) |
| (Increase)/Decrease in trade and other receivables | 43 | (137) | (162) |
| Increase/(Decrease) in trade and other payables | (771) | (110) | 965 |
| Tax received | - | - | 1,500 |
| Net cash from operating activities | (7,957) | (6,887) | (10,897) |
Interest received | 277 | 343 | 740 |
| Interest paid | (28) | (4) | (27) |
| Acquisition of property, plant and equipment | (374) | (5) | (247) |
| Acquisition of other intangible assets | (259) | (103) | (234) |
| Movement in short term investments | - | - | - |
| Net cash from investing activities | (384) | 231 | 232 |
Net proceeds from issue of share capital | 28,907 | 22 | 37 |
| Repayment of lease liability | (188) | (210) | (396) |
| Net cash from financing activities | 28,719 | (188) | (359) |
Net decrease in cash and cash equivalents | 20,378 | (6,844) | (11,024) |
| Cash and cash equivalents at the beginning of the period/year | 20,665 | 31,689 | 31,689 |
| Cash and cash equivalents at the end of the period/year | 41,043 | 24,845 | 20,665 |
Notes
1. Basis of Preparation
These unaudited interim financial statements do not comprise statutory accounts as defined within section 434 of the Companies Act 2006. The Company is a public unquoted limited company; and is incorporated and domiciled in the United Kingdom. The address of its registered office is 4 Kingdom Street, Paddington, London, W2 6BD, UK.
Statutory accounts for the year ended 31 January 2024 were approved by the Board of Directors on 5 June 2024 and delivered to the Registrar of Companies. The report of the Auditor on the accounts was unqualified, did not contain an emphasis of matter paragraph and did not contain any statement under section 498 of the Companies Act 2006.
While this interim statement, which is neither audited nor reviewed, has been prepared in accordance with the recognition and measurement criteria of international accounting standards in conformity with the requirements of the Companies Act 2006 this announcement does not in itself contain sufficient information to comply with IFRS. It does not include all the information required for the full annual financial statements and should be read in conjunction with the financial statements as at, and for the year ended, 31 January 2024. It does not comply with International Accounting Standard ("IAS") 34 'Interim Financial Reporting'.
The accounting policies applied in preparing these interim financial statements are the same as those applied in the preparation of the annual financial statements for the year ended 31 January 2024 (as defined therein) other than standards, amendments and interpretations which became effective after 1 February 2024.
New standards, amendments and interpretations not adopted in the current financial year have not been disclosed as they are not expected to have a material impact on the Company’s financial statements.
2. Share Capital
31 July 2024 | 31 July 2023 | 31 January 2024 | |
| (unaudited) | (unaudited) | (audited) | |
| In issue - fully paid | |||
| Ordinary shares of | 777,074,147 | 582,694,162 | 584,335,487 |
Allotted, called up and fully paid | |||
| Ordinary shares of | 777 | 583 | 584 |
During the six-month period to 31 July 2024, 192,666,667 new ordinary shares of 0.1p each were issued following an equity fundraise of
In addition, 71,993 new ordinary shares of 0.1p each were issued at a price of 9.95p each in lieu of fees payable to a non-executive director in accordance with his service agreement.
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