eFFECTOR Therapeutics to Collaborate with the Dana-Farber Cancer Institute on an Investigator-Sponsored Phase 2 Clinical Trial Evaluating Zotatifin as Combination Treatment in ER+ Endometrial Cancer and in Low Grade Serous Ovarian Cancer
eFFECTOR Therapeutics announced a collaboration with the Dana-Farber Cancer Institute for an investigator-sponsored Phase 2 trial. The trial will evaluate zotatifin in combination with abemaciclib and letrozole in patients with estrogen receptor-positive (ER+) endometrial cancer and low grade serous ovarian cancer. Dr. Panagiotis Konstantinopoulos, Director of Translational Research at DFCI, will oversee the study. The trial aims to address the resistance seen in current treatments by targeting eIF4A, thereby improving outcomes. Concurrently, eFFECTOR is progressing zotatifin in ER+ metastatic breast cancer, expecting Phase 2 dosing results in late 2024.
- Collaboration with Dana-Farber Cancer Institute enhances credibility.
- Targeting eIF4A aims to overcome CDK4/6 inhibition resistance.
- Potentially improves treatment efficacy for recurrent endometrial and low grade serous ovarian cancers.
- Phase 2 dose determination for zotatifin in metastatic breast cancer expected in late 2024.
- Combination treatment could be applicable to various malignancies.
- Promising preliminary results of abemaciclib and letrozole combo.
- Patients with recurrent or metastatic ER+ endometrial cancer have current treatment options.
- Resistance to CDK4/6 inhibition remains a critical challenge.
- Long-term success of the proposed combination treatment is uncertain.
- Market reception and stock performance hinge on trial results.
- Clinical trial outcomes are inherently uncertain and risky.
- Potential financial strain from ongoing research and development expenses.
Insights
The collaboration between eFFECTOR Therapeutics and the Dana-Farber Cancer Institute to study zotatifin in combination with abemaciclib and letrozole in patients with ER+ endometrial cancer and low grade serous ovarian cancer is significant. These cancers present major treatment challenges, especially in advanced stages where resistance to existing treatments frequently occurs.
Zotatifin, by targeting eIF4A, has the potential to downregulate proteins responsible for resistance to CDK4/6 inhibitors. If effective, this could enhance treatment efficacy and potentially offer new hope for patients who have limited options. The design of the trial, led by an esteemed oncologist, Dr. Panagiotis Konstantinopoulos, further adds credibility and expertise to the initiative.
However, it's important to note that this is an early-phase trial, so results will take time to materialize. The potential impact on patient outcomes and the broader treatment landscape for these cancers could be substantial, but clinical validation is necessary.
The announcement of this collaboration is a positive indicator for eFFECTOR Therapeutics' strategic direction and future potential. The investigator-sponsored trial (IST) involving zotatifin could lead to promising developments for the company's pipeline. If successful, this could significantly enhance the value of eFFECTOR Therapeutics by positioning it as a leader in cancer treatment innovation.
Financially, the collaboration with a reputable institution like the Dana-Farber Cancer Institute reduces the risk associated with early-stage clinical trials. It also shares the burden of research costs, thus potentially preserving eFFECTOR's financial resources while advancing its R&D efforts. Investors should consider the long-term growth potential and possible market expansion if zotatifin proves effective across multiple cancer types.
However, investors must remain cautious as clinical trials are inherently risky with uncertain outcomes. Positive trial results could lead to significant stock appreciation, but setbacks might negatively impact the stock. Monitoring developments in this trial will be important for assessing the company's future performance.
SOLANA BEACH, Calif. and REDWOOD CITY, Calif., May 20, 2024 (GLOBE NEWSWIRE) -- eFFECTOR Therapeutics, Inc. (NASDAQ: EFTR), a leader in the development of selective translation regulator inhibitors (STRIs) for the treatment of cancer, today announced a collaboration to conduct an investigator-sponsored trial (IST) evaluating zotatifin in combination with abemaciclib and letrozole in patients with estrogen receptor-positive (ER+) endometrial cancer and low grade serous ovarian cancer at the Dana-Farber Cancer Institute (DFCI) under the direction of Panagiotis Konstantinopoulos, M.D., Ph.D., Director of Translational Research and attending oncologist in the Division of Gynecologic Oncology at DFCI, and an Associate Professor of Medicine at Harvard Medical School.
“Endometrial cancer is the most prevalent cancer affecting the female reproductive organs in the United States,” said Dr. Konstantinopoulos. “While early detection offers hope for successful treatment, patients with recurrent or metastatic disease have limited treatment options. Recent studies of the abemaciclib and letrozole combo in ER+ endometrial cancer patients have shown promising activity, however, most patients either fail to respond or eventually develop resistance to CDK4/6 inhibition, a critical aspect of treatment. Similarly, low grade serous ovarian cancer has shown sensitivity to combined treatment with aromatase inhibitors and CDK4/6 inhibition, but responding patients eventually develop disease progression. By targeting eIF4A, which subsequently downregulates the key factors implicated in CDK4/6 inhibition resistance, we believe that integrating zotatifin with abemaciclib and letrozole treatment regimen represents a compelling strategy for combating recurrent endometrial cancer and low grade serous ovarian cancer.”
Doug Warner, M.D., chief medical officer of eFFECTOR Therapeutics added, “We are thrilled to embark on this investigator-sponsored Phase 2 trial in collaboration with Dr. Konstantinopoulos and his team at the DFCI. This trial represents a significant step forward in our collective efforts to address the complexities of endometrial cancer and low grade serous ovarian cancer. By exploring the potential of zotatifin as a combination treatment and its unique mechanism of action, we aim to redefine the treatment landscape and improve outcomes for these patients. With this comprehensive approach which simultaneously targets tumor cell cycle progression while reducing estrogen levels, we hope to overcome resistance mechanisms and enhance treatment efficacy which we believe could be applied in various malignancies beyond breast and endometrial cancers. In parallel, we continue to advance development of zotatifin in ER+ metastatic breast cancer and anticipate determination of the Phase 2 dose (RP2D) of zotatifin in combination with fulvestrant and abemaciclib, in the second half of 2024.”
About Zotatifin
Zotatifin is a potent and sequence-selective small molecule inhibitor of the RNA helicase eIF4A that is designed to suppress the overproduction of cell cycle proteins and oncogenes, including Cyclins D and E, CDKs 4 and 6, ERα, KRAS, HER2, and other RTKs. Zotatifin is currently being evaluated in a Phase 2a expansion cohort in combination with fulvestrant and abemaciclib in ER+ breast cancer. Efficacy data presented at 2023 ASCO and SABCS showed a
About eFFECTOR Therapeutics
eFFECTOR is a clinical-stage biopharmaceutical company pioneering the development of a new class of oncology drugs referred to as STRIs. eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase interacting kinase (MNK). The eIF4F complex is a central node where two of the most frequently mutated signaling pathways in cancer, the PI3K-AKT and RAS-MEK pathways, converge to activate the translation of select mRNA into proteins that are frequent culprits in key disease-driving processes. Each of eFFECTOR’s product candidates is designed to act on a single protein that drives the expression of a network of functionally related proteins, including oncoproteins and immunosuppressive proteins in T cells, that together control tumor growth, survival, and immune evasion. Zotatifin, eFFECTOR’s inhibitor of eIF4A, is currently being evaluated in a Phase 2a expansion cohort in combination with fulvestrant and abemaciclib in ER+ breast cancer and in Phase 2 IST in combination with abemaciclib and letrozole in ER+ endometrial cancer. Tomivosertib, eFFECTOR’s MNK inhibitor, is currently being evaluated in an investigator-sponsored trial in AML. eFFECTOR has a global collaboration with Pfizer to develop inhibitors of a third target, eIF4E.
Forward-Looking Statements
eFFECTOR cautions you that statements contained in this press release regarding matters that are not historical facts are forward-looking statements. The forward-looking statements are based on our current beliefs and expectations and include, but are not limited to: the future clinical development of our product candidates, including expectations on enrollment and the timing of reporting data from ongoing clinical trials; the potential therapeutic benefits of our product candidates; and the timing and potential benefits of the IST evaluating zotatifin in combination with abemaciclib and letrozole in patients with ER+ endometrial cancer and low grade serous ovarian cancer. Actual results may differ from those set forth in this press release due to the risks and uncertainties inherent in our business, including, without limitation: potential delays in the commencement, enrollment and completion of clinical trials, including the IST conducted by DFCI; the success of our clinical trials and preclinical studies for our product candidates is uncertain; we are dependent on DFCI to conduct the IST trial and we may not realize any benefits from the collaboration with DFCI; our dependence on third parties in connection with product manufacturing, research and preclinical and clinical testing; the results of preclinical studies and early clinical trials are not necessarily predictive of future results; regulatory developments in the United States and foreign countries; unexpected adverse side effects or inadequate efficacy of our product candidates that may limit their development, regulatory approval and/or commercialization, or may result in recalls or product liability claims; and other risks described in our prior filings with the Securities and Exchange Commission. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and we undertake no obligation to update such statements to reflect events that occur or circumstances that exist after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.
Contacts:
Investors:
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Managing Director
LifeSci Advisors
917-680-5608
ccalabrese@lifesciadvisors.com
Kevin Gardner
Managing Director
LifeSci Advisors
617-283-2856
kgardner@lifesciadvisors.com
Media:
Michael Fitzhugh
Vice President, Chief of Media Strategy
LifeSci Communications
mfitzhugh@lifescicomms.com
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