Defence Launches Accum Combined with Actinium-225 to Increase Efficacy and Safety of Radio-Immunoconjugate Cancer Therapies
Defence Therapeutics (DTCFF) has announced a collaboration with Canadian Nuclear Laboratories (CNL) to enhance cancer treatments using a combination of Actinium-225 (Ac-225) and Defence's proprietary Accum® technology. The partnership aims to improve the delivery and efficacy of radio-immunoconjugate therapies.
The collaboration will focus on preclinical studies where CNL will evaluate tumor-targeting antibodies modified with Accum® technology to transport Ac-225. The research will assess biodistribution, therapeutic potency, and safety profiles in rodent models. Accum® technology is designed to enhance the escape of Ac-225-antibody complexes from cellular endosomes, potentially improving their nuclear accumulation while reducing required dosage levels and side effects.
CNL will produce and supply Ac-225 from its Th-229/Ac-225 generator at Chalk River Laboratories. This initiative aligns with the growing radiopharmaceutical market, projected to reach USD 16.87 billion by 2033.
Defence Therapeutics (DTCFF) ha annunciato una collaborazione con Canadian Nuclear Laboratories (CNL) per migliorare i trattamenti contro il cancro utilizzando una combinazione di Actinium-225 (Ac-225) e la tecnologia proprietaria Accum® di Defence. L'obiettivo della partnership è migliorare la somministrazione e l'efficacia delle terapie radio-immunoconjugate.
La collaborazione si concentrerà su studi preclinici in cui CNL valuterà anticorpi mirati ai tumori modificati con la tecnologia Accum® per trasportare Ac-225. La ricerca valuterà la biodistribuzione, la potenza terapeutica e i profili di sicurezza in modelli rodentici. La tecnologia Accum® è progettata per migliorare l'uscita dei complessi Ac-225-anticorpo dagli endosomi cellulari, potenzialmente migliorando la loro accumulazione nucleare riducendo al contempo i livelli di dosaggio richiesti e gli effetti collaterali.
CNL produrrà e fornirà Ac-225 dal suo generatore Th-229/Ac-225 presso i Chalk River Laboratories. Questa iniziativa è in linea con il crescente mercato dei radiofarmaci, previsto raggiungere i 16,87 miliardi di USD entro il 2033.
Defence Therapeutics (DTCFF) ha anunciado una colaboración con Canadian Nuclear Laboratories (CNL) para mejorar los tratamientos contra el cáncer utilizando una combinación de Actinio-225 (Ac-225) y la tecnología Accum® de Defence. La asociación tiene como objetivo mejorar la entrega y la eficacia de las terapias radio-inmunoconjugadas.
La colaboración se centrará en estudios preclínicos donde CNL evaluará anticuerpos dirigidos a tumores modificados con la tecnología Accum® para transportar Ac-225. La investigación evaluará la biodistribución, la potencia terapéutica y los perfiles de seguridad en modelos de roedores. La tecnología Accum® está diseñada para mejorar la salida de los complejos Ac-225-anticuerpo de los endosomas celulares, lo que podría mejorar su acumulación nuclear mientras se reducen los niveles de dosis requeridos y los efectos secundarios.
CNL producirá y suministrará Ac-225 de su generador Th-229/Ac-225 en los Chalk River Laboratories. Esta iniciativa está alineada con el creciente mercado de radiofármacos, que se proyecta alcanzará los 16,87 mil millones de USD para 2033.
Defense Therapeutics (DTCFF)는 Canadian Nuclear Laboratories (CNL)와 협력하여 Actinium-225 (Ac-225)와 Defense의 독점 기술인 Accum®을 결합하여 암 치료를 개선한다고 발표했습니다. 이 파트너십은 방사선 면역접합체 치료의 전달 및 효능을 향상시키는 것을 목표로 합니다.
협력은 CNL이 Ac-225를 운반하기 위해 Accum® 기술로 수정된 종양 표적 항체를 평가하는 전임상 연구에 중점을 둘 것입니다. 연구는 생체 분포, 치료 효능 및 설치류 모델에서의 안전성 프로파일을 평가할 것입니다. Accum® 기술은 Ac-225-항체 복합체가 세포 내 소포에서 탈출하는 것을 향상시키도록 설계되어 있으며, 이는 핵 내 축적을 개선하고 필요한 용량 수준과 부작용을 줄이는 데 기여할 수 있습니다.
CNL은 Chalk River Laboratories의 Th-229/Ac-225 생성기에서 Ac-225를 생산하고 공급할 것입니다. 이 이니셔티브는 2033년까지 168억 7천만 달러에 이를 것으로 예상되는 방사성 의약품 시장의 성장과 일치합니다.
Defence Therapeutics (DTCFF) a annoncé une collaboration avec Canadian Nuclear Laboratories (CNL) pour améliorer les traitements du cancer en utilisant une combinaison d'Actinium-225 (Ac-225) et de la technologie Accum® propriétaire de Defence. L'objectif de ce partenariat est d'améliorer l'administration et l'efficacité des thérapies radio-immunoconjuguées.
La collaboration se concentrera sur des études précliniques où CNL évaluera des anticorps ciblant les tumeurs modifiés avec la technologie Accum® pour transporter Ac-225. La recherche évaluera la biodistribution, la puissance thérapeutique et les profils de sécurité dans des modèles de rongeurs. La technologie Accum® est conçue pour améliorer l'évasion des complexes Ac-225-anticorps des endosomes cellulaires, ce qui pourrait améliorer leur accumulation nucléaire tout en réduisant les niveaux de dosage requis et les effets secondaires.
CNL produira et fournira Ac-225 à partir de son générateur Th-229/Ac-225 aux Chalk River Laboratories. Cette initiative s'inscrit dans la tendance croissante du marché des radio-pharmaceutiques, qui devrait atteindre 16,87 milliards USD d'ici 2033.
Defence Therapeutics (DTCFF) hat eine Zusammenarbeit mit Canadian Nuclear Laboratories (CNL) angekündigt, um die Krebsbehandlungen durch eine Kombination aus Actinium-225 (Ac-225) und der proprietären Accum®-Technologie von Defence zu verbessern. Ziel der Partnerschaft ist es, die Verabreichung und Wirksamkeit von Radioimmunokonjugat-Therapien zu verbessern.
Die Zusammenarbeit konzentriert sich auf präklinische Studien, in denen CNL tumorzielgerichtete Antikörper, die mit der Accum®-Technologie modifiziert wurden, zur Beförderung von Ac-225 bewerten wird. Die Forschung wird die Biodistribution, die therapeutische Potenz und die Sicherheitsprofile in Tiermodellen untersuchen. Die Accum®-Technologie wurde entwickelt, um die Flucht von Ac-225-Antikörper-Komplexen aus zellulären Endosomen zu verbessern, was potenziell deren nukleare Akkumulation erhöht und gleichzeitig die erforderlichen Dosierungsniveaus und Nebenwirkungen reduziert.
CNL wird Ac-225 aus seinem Th-229/Ac-225-Generator in den Chalk River Laboratories produzieren und liefern. Diese Initiative steht im Einklang mit dem wachsenden Markt für Radiopharmazeutika, der bis 2033 voraussichtlich 16,87 Milliarden USD erreichen wird.
- Strategic collaboration with Canada's premier nuclear science facility (CNL)
- Technology potentially reduces required Ac-225 dosage while maintaining efficacy
- Targeting growing radiopharmaceutical market worth USD 16.87B by 2033
- Still in preclinical stage, requiring extensive testing
- No immediate revenue generation from this research collaboration
Montreal, Quebec--(Newsfile Corp. - April 8, 2025) - Defence Therapeutics Inc. (CSE: DTC) (OTCQB: DTCFF) (FSE: DTC) ("Defence" or the "Company"), a Canadian biopharmaceutical company developing advanced cancer therapeutics and drug delivery technologies, is pleased to announce a collaboration with the Canadian Nuclear Laboratories ("CNL"). CNL, Canada's premier nuclear science facility, will conduct preclinical studies combining alpha-particle radiotherapy Actinium-225 ("Ac-225") with Defence's proprietary Accum® delivery technology.
Targeted radiotherapies using Ac-225 have shown great promise in cancer treatment. Ac-225 emits powerful alpha particles that irreparably damage cancer cells' DNA, leading to cell death. Ac-225 is typically attached to cancer-targeting antibodies. However, many of these Ac-225-antibody complexes become trapped in cellular compartments called endosomes, preventing them from reaching the cell's nucleus where they can be most effective. Defence's Accum® technology is designed to enhance the escape of these complexes from endosomes, improving their accumulation in the nucleus. This approach could reduce the required dosage levels of Ac-225, potentially minimizing side effects while maintaining therapeutic efficacy.
The Ac-225 will be produced and supplied by CNL, from its Th-229/Ac-225 generator at Chalk River Laboratories. CNL will evaluate several tumor-targeting antibodies modified with Accum® technology to transport Ac-225. Studies in rodent models will assess the biodistribution, therapeutic potency, and safety profile of these selected radiolabeled antibodies. The research aims to determine how effectively the Accum®-modified antibodies deliver Ac-225 to cancer cells and their impact on tumor growth. This collaboration marks a significant step in Defence's mission to revolutionize cancer treatment through enhanced targeted therapies. By combining CNL's expertise in Ac-225 radioisotope and R&D in Targeted Alpha Therapy with Defence's innovative delivery technology, the project seeks to overcome current limitations in radioisotope-based cancer treatments.
"We believe Accum® will significantly enhance the potency of Ac-225 immunoconjugates by improving therapeutic efficacy and tumor targeting. Our technology's ability to facilitate endosomal escape and increase the presence of therapeutics in cell nuclei enhances the effectiveness of alpha-particles at their primary target. Our team is confident this innovative approach will overcome current limitations in radioisotope delivery for oncology, amplifying anti-cancer effects while reducing off-target toxicity. The synergy between Accum® and CNL's expertise will advance precision oncology, leading to more effective and safer treatments," said Sébastien Plouffe, CEO and Founder of Defence Therapeutics.
As the project progresses, Defence will provide updates on the development of these Accum®-enhanced radioimmunoconjugates. With the global radiopharmaceutical market projected to reach USD 16.87 billion by 2033, Defence is well-positioned to contribute to this rapidly growing field of precision oncology.
https://straitsresearch.com/report/radiopharmaceutical-market
About Defence:
Defence Therapeutics is a publicly-traded clinical-stage biotechnology company developing and engineering the next generation of radio-immuno-conjugate and ADC products using its proprietary platform in addition to novel immune-oncology vaccines. The core of Defence Therapeutics platform is the ACCUM® technology, which enables precision delivery of radio-immuno-conjugates or ADCs in their intact form to target cells, and vaccine antigens. As a result, increased efficacy and potency can be reached against catastrophic illness such as cancer and infectious diseases.
For further information:
Sebastien Plouffe, President, CEO and Director
P: (514) 947-2272
Splouffe@defencetherapeutics.com
www.defencetherapeutics.com
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FAQ
What is the purpose of combining Defence Therapeutics' Accum technology with Actinium-225?
How will CNL evaluate DTCFF's Accum-modified antibodies in the preclinical studies?
What is the market potential for DTCFF's radiopharmaceutical development?
How does Defence Therapeutics' Accum technology improve current Ac-225 cancer treatments?
