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DURECT Corporation (Nasdaq: DRRX) is a specialized biopharmaceutical company focused on the research, development, and manufacturing of innovative pharmaceutical products. With expertise in drug discovery, delivery, and development, DURECT dedicates its efforts to creating therapies aimed at pain management, acute organ injury, and metabolic diseases. Their proprietary technologies, including oral, transdermal, and injectable depot delivery systems, enhance clinical and commercial attributes such as abuse deterrence, convenience, adherence, efficacy, and safety for both small molecule and biologic drugs.
One of DURECT’s key assets is larsucosterol, an epigenetic modulator currently in Phase 3 clinical trials for the treatment of severe alcohol-associated hepatitis (AH). This promising candidate has received both Fast Track and Breakthrough Therapy designations from the FDA. The company's Phase 2b AHFIRM trial demonstrated significant potential in reducing mortality among AH patients, paving the way for further research and development.
Another noteworthy product is POSIMIR®, an FDA-approved non-opioid analgesic for post-surgical pain management, which utilizes DURECT’s SABER® platform technology. It is exclusively licensed to Innocoll Pharmaceuticals for distribution in the United States.
DURECT also markets ALZET® osmotic pumps, widely used in preclinical research for continuous drug delivery in laboratory animals. A collaboration with Charles River Laboratories aims to further expand the reach of this product line within the pharmaceutical and academic sectors.
Financially, DURECT continues to advance its pipeline with strategic capital management, ensuring the sustainability of its operations while actively seeking regulatory approvals for its drug candidates. Their latest developments include quarterly financial reports, conference calls with stakeholders, and presentations at major medical conferences, showcasing their commitment to transparency and progress.
For more information, visit www.durect.com and follow the company on X (formerly Twitter) at https://x.com/DURECTCorp.
DURECT Corporation (Nasdaq: DRRX) has appointed Dr. Norman Sussman as Chief Medical Officer, effective immediately. Dr. Sussman will guide the clinical development of the company's lead drug candidate, DUR-928, targeting conditions like alcoholic hepatitis (AH) and nonalcoholic steatohepatitis (NASH). With over 30 years in liver disease clinical research, his expertise is expected to enhance DURECT's efforts as it prepares for a pivotal Phase 2b trial in AH. The company aims to transform treatments for acute organ injury and chronic liver diseases with DUR-928, an innovative epigenetic regulator.
DURECT Corporation (Nasdaq: DRRX) will announce its third quarter 2020 financial results on November 2, 2020, at 4:30 PM ET. A conference call will follow, providing key updates on their clinical programs, including DUR-928, an investigational drug targeting acute organ injury and chronic liver diseases. DUR-928 is currently in Phase 2 trials for alcoholic hepatitis and COVID-19 related injuries, and Phase 1 for nonalcoholic steatohepatitis. The company is also advancing POSIMIR, a pain relief solution.
DURECT Corporation (Nasdaq: DRRX) will participate in the ROTH Capital Healthcare Event titled Covid-19 Therapeutics in Development on October 28, 2020. The webinar will cover various therapeutic sessions aimed at treating COVID-19. DURECT’s lead candidate, DUR-928, is in Phase 2 development for treating alcoholic hepatitis and COVID-19 patients with acute liver or kidney injury. Additionally, POSIMIR is being developed for post-surgery pain relief. The press release highlights potential risks in clinical development and FDA approval processes.
DURECT Corporation (Nasdaq: DRRX) announced its participation in the AASLD Liver Meeting Digital Experience 2020, presenting findings from its Phase 1b clinical trial of DUR-928 in nonalcoholic steatohepatitis (NASH) patients. Topline results indicated a 43% reduction in liver fat in patients, showing overall improvement in liver enzymes and lipid profiles. The study demonstrated safety across all dosing regimens. Further safety and efficacy data will be available during the meeting, enhancing understanding of DUR-928 as a potential treatment for liver diseases.
DURECT Corporation (Nasdaq: DRRX) announced participation in a fireside chat on October 5, 2020, from 2:30 p.m. to 3:00 p.m. EDT. Key executives, including President and CEO James E. Brown, CFO Michael H. Arenberg, and EVP of R&D Dr. WeiQi Lin, will join host Ed Arce from H. C. Wainwright. Investors can view the live webcast on DURECT's homepage under the 'Investors' tab or directly here. The company focuses on developing therapies for liver diseases and acute organ injury.
DURECT Corporation (Nasdaq: DRRX) has initiated a Phase 2 trial for DUR-928, targeting hospitalized COVID-19 patients suffering from acute liver or kidney injuries. This randomized, double-blind, placebo-controlled study aims to enroll around 80 patients, assessing safety and efficacy with a primary endpoint focused on survival and absence of organ failure by Day 28. Following promising results from prior trials on alcoholic hepatitis, DURECT is optimistic that DUR-928, combined with standard care, can aid these critical patients.
DURECT Corporation (NASDAQ: DRRX) announced the design of the Phase 2b AHFIRM clinical trial for its lead drug candidate, DUR-928, targeting severe alcoholic hepatitis (AH) patients. The trial will involve approximately 300 patients across three groups: two receiving different doses of DUR-928 and one placebo group. The primary outcome is the 90-day survival rate. Commencing in October, the study aims to validate promising Phase 2a results, with CEO James E. Brown emphasizing the urgent need for effective therapies in severe AH.
DURECT Corporation (Nasdaq: DRRX) will participate in several upcoming virtual investor conferences, including the HC Wainwright 22nd Annual Global Investment Conference on September 14, Cantor Fitzgerald Virtual Global Healthcare Conference on September 15, and Oppenheimer Fall Healthcare Life Sciences & MedTech Summit on September 22. During these events, company representatives will engage in fireside chats discussing the company's advancements in treating acute organ injuries and chronic liver diseases, particularly their lead candidate, DUR-928.
DURECT Corporation (Nasdaq: DRRX) presented pharmacokinetic data from a Phase 2a study of DUR-928 for alcoholic hepatitis at the Digital International Liver Congress 2020. The study included 19 patients and demonstrated that DUR-928 was well tolerated. Key findings revealed a 100% treatment response rate at lower doses and significant reductions in bilirubin and MELD scores at days 7 and 28. DURECT plans to initiate a Phase 2b trial later this year, focusing on survival rates in severe AH patients.
DURECT Corporation (Nasdaq: DRRX) announced participation in a fireside chat hosted by Cantor Fitzgerald on August 27, 2020, at 11:00 a.m. EDT. Key executives will present insights into the company's innovative therapies, particularly DUR-928, for treating acute organ injuries and chronic liver diseases, currently in various development phases. The live event will be accessible via webcast through the DURECT website. The firm remains focused on advancing its therapeutics amid the challenges posed by the ongoing COVID-19 pandemic.
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