CPC Launches Industry-First Product for Cell and Gene Therapy Sterile Processing
CPC, a Dover (NYSE: DOV) subsidiary, has launched the MicroCNX® Nano Series aseptic connectors, an innovative solution for cell and gene therapy (CGT) sterile processing. This industry-first product simplifies the connection process by allowing users to click connector halves together to create sterile flow paths, replacing traditional methods like biosafety cabinets and tube welding.
The new connectors are specifically designed for 1/8- and 1/16-inch flow paths, reducing holdup volume by eliminating the need for extra tubing required in traditional tube welding. A key feature is their ability to be frozen to -190°C, supporting cell preservation during storage and transport. The connectors' compact size enables direct integration into freeze cassettes used in CGT product cryopreservation.
CPC, una filiale di Dover (NYSE: DOV), ha lanciato i connettori asettici MicroCNX® Nano Series, una soluzione innovativa per il processamento sterile nella terapia cellulare e genica (CGT). Questo prodotto, primo nel suo genere, semplifica il processo di connessione consentendo agli utenti di unire le metà del connettore con un clic per creare percorsi di flusso sterili, sostituendo metodi tradizionali come le cabine di biosicurezza e la saldatura dei tubi.
I nuovi connettori sono specificamente progettati per percorsi di flusso da 1/8 e 1/16 di pollice, riducendo il volume di ritenzione eliminando la necessità di tubazioni extra richieste nella saldatura tradizionale. Una caratteristica chiave è la loro capacità di essere congelati a -190°C, supportando la preservazione delle cellule durante lo stoccaggio e il trasporto. Le dimensioni compatte dei connettori consentono un'integrazione diretta nei cassette di congelamento utilizzate nella crioconservazione dei prodotti CGT.
CPC, una subsidiaria de Dover (NYSE: DOV), ha lanzado los conectores asépticos MicroCNX® Nano Series, una solución innovadora para el procesamiento estéril en terapia celular y génica (CGT). Este producto, pionero en la industria, simplifica el proceso de conexión permitiendo a los usuarios unir las mitades del conector con un clic para crear caminos de flujo estéril, reemplazando métodos tradicionales como las cabinas de bioseguridad y la soldadura de tubos.
Los nuevos conectores están diseñados específicamente para caminos de flujo de 1/8 y 1/16 de pulgada, reduciendo el volumen de retención al eliminar la necesidad de tuberías adicionales requeridas en la soldadura tradicional. Una característica clave es su capacidad de ser congelados a -190°C, lo que apoya la preservación celular durante el almacenamiento y el transporte. El tamaño compacto de los conectores permite una integración directa en cassette de congelación utilizados en la criopreservación de productos CGT.
CPC는 Dover(NYSE: DOV)의 자회사로, MicroCNX® Nano Series 무균 커넥터를 출시했습니다. 이는 세포 및 유전자 치료(CGT) 용 비위생적 처리에 대한 혁신적인 솔루션입니다. 이 제품은 업계 최초로 커넥터 절반을 클릭하여 결합하여 비위생적 흐름 경로를 형성함으로써 생물 안전 캐비닛 및 튜브 용접과 같은 전통적인 방법을 대체하여 연결 과정을 단순화합니다.
새로운 커넥터는 1/8인치 및 1/16인치 흐름 경로를 위해 특별히 설계되었으며, 전통적인 튜브 용접에서 요구되는 추가 튜빙의 필요성을 없앰으로써 잔여 물량을 줄입니다. 주요 특징 중 하나는 -190°C로 냉동할 수 있는 능력으로, 이는 저장 및 운송 중 세포 보존을 지원합니다. 커넥터의 컴팩트한 크기는 CGT 제품의 동결 보존에 사용되는 동결 캐시세트에 직접 통합될 수 있게 해줍니다.
CPC, une filiale de Dover (NYSE: DOV), a lancé les connecteurs aseptiques MicroCNX® Nano Series, une solution innovante pour le traitement stérile en thérapie cellulaire et génique (CGT). Ce produit, premier de son genre dans l'industrie, simplifie le processus de connexion en permettant aux utilisateurs d'assembler les moitiés du connecteur par un simple clic pour créer des voies de flux stériles, remplaçant ainsi les méthodes traditionnelles telles que les cabines de biosécurité et le soudage des tubes.
Les nouveaux connecteurs sont spécifiquement conçus pour des voies de flux de 1/8 et 1/16 de pouce, réduisant le volume de rétention en éliminant le besoin de tubulures supplémentaires requises lors du soudage traditionnel. Une caractéristique clé est leur capacité à être congelés à -190°C, favorisant la préservation des cellules pendant le stockage et le transport. La taille compacte des connecteurs permet une intégration directe dans des cassettes de congélation utilisées pour la cryoconservation des produits CGT.
CPC, eine Tochtergesellschaft von Dover (NYSE: DOV), hat die MicroCNX® Nano Series aseptischen Verbinder auf den Markt gebracht, eine innovative Lösung für die sterile Verarbeitung in der Zell- und Gentherapie (CGT). Dieses Produkt, das in der Branche seinesgleichen sucht, vereinfacht den Verbindungsprozess, indem es den Nutzern ermöglicht, die Verbindungsstücke mit einem Klick zusammenzufügen, um sterile Fließwege zu schaffen, und ersetzt traditionelle Methoden wie biologisch sichere Kabinen und das Schweißen von Schläuchen.
Die neuen Verbinder sind speziell für Fließwege von 1/8 und 1/16 Zoll konzipiert und reduzieren das Haltevolumen, da die Notwendigkeit für zusätzliches Rohrmaterial, das beim herkömmlichen Schweißen erforderlich ist, entfällt. Ein wesentlicher Vorteil ist ihre Fähigkeit, auf -190°C gefroren zu werden, was die Zellkonservierung während Lagerung und Transport unterstützt. Die kompakte Größe der Verbinder ermöglicht eine direkte Integration in Gefriersysteme, die in der Kryokonservierung von CGT-Produkten verwendet werden.
- Introduction of industry-first product addressing specific CGT processing needs
- Product eliminates need for extra tubing, reducing holdup volume and improving efficiency
- Connectors can withstand extreme temperatures (-190°C) supporting cell preservation
- Technology simplifies sterile processing by replacing cumbersome traditional methods
- None.
Insights
The launch of CPC's MicroCNX® Nano Series connectors marks a pivotal innovation in the rapidly expanding cell and gene therapy manufacturing sector. This development directly addresses a critical bottleneck in CGT production workflows, potentially accelerating manufacturing timelines and reducing costs.
The technical advantages are compelling: The click-together design eliminates the need for cumbersome biosafety cabinets and tube welding, while the reduced holdup volume maximizes the recovery of precious cellular materials - important when dealing with autologous therapies where every cell counts. The connector's cryogenic capabilities (-190°C tolerance) seamlessly integrate with existing freeze storage infrastructure, essential for maintaining cell viability throughout the cold chain.
From a market perspective, this innovation positions Dover's CPC division to capture a larger share of the rapidly growing CGT manufacturing market, projected to reach
The product's ability to maintain sterility while reducing processing complexity could significantly impact manufacturing economics by:
- Decreasing labor requirements and training costs
- Reducing clean room space requirements
- Minimizing product loss during processing
- Accelerating batch processing times
"Cell and gene therapy is advancing quickly, but the industry relies on older, cumbersome techniques like biosafety cabinets or tube welding for sterile processing," said Troy Ostreng, Senior Product Manager for CPC's biopharmaceutical business. "Now, CGT processing assemblies that include the MicroCNX Nano connectors will allow users to easily click together the connector halves to create a sterile flow path. This is a major advancement for CGT applications."
CGT manufacturers currently rely on 1/8- and 1/16-inch flow paths to move cells efficiently, with minimal turbulence, and to help reduce holdup volume, which occurs when liquid is trapped in the tubing and cannot easily be recovered. Tube welding requires extra tubing on either side of the weld, which is a source of holdup volume. The MicroCNX Nano Series does not require extra tubing, and the connectors can be quickly joined outside of a biosafety cabinet.
The MicroCNX Nano connector's small size also allows it to fit directly into the freeze cassettes used in CGT product cryopreservation. The connectors can be frozen to -190°C, which supports cell health during storage and transport.
"We believe small-format aseptic connectors are the future of CGT sterile processing," said Ostreng. "MicroCNX Series products offer a faster, more efficient approach to creating sterile closed systems. "
This new series builds on CPC's pioneering work in creating the industry's smallest aseptic connectors, which are designed specifically to handle CGT's small fluid volumes.
For more information about the performance and versatility of the MicroCNX Series connectors or any of the other innovative connection solutions CPC offers, visit cpcworldwide.com/micro.
About CPC:
CPC (Colder Products Company) is the leader in single-use connection technology, offering a wide variety of connectors for manufacturing in biopharmaceuticals, cell therapy, and gene therapy. The company's innovative, flexible products enable users to easily combine multiple components and systems including process containers, tubing manifolds, transfer lines, bioreactors and other bioprocess equipment. Robust single-use connectors maintain media sterility and integrity while improving production yields, decreasing time to market and reducing costs. The company's well-known AseptiQuik® connectors provide quick and easy sterile connections even in non-sterile environments. Learn more at cpcworldwide.com/bio. Connect with confidence with CPC, an operating company within Dover Corporation.
About Dover:
Dover is a diversified global manufacturer and solutions provider with annual revenue of over
CPC Contact:
Jana Stender
(612) 564-2053
jana.stender@cpcworldwide.com
Dover Media Contact:
Adrian Sakowicz, VP, Communications
(630) 743-5039
asakowicz@dovercorp.com
Dover Investor Contact:
Jack Dickens, VP, Investor Relations
(630) 743-2566
jdickens@dovercorp.com
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SOURCE Dover
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