Ginkgo Bioworks integrates Callisto for difficult-to-automate NGS processes in their high-throughput lab
Ginkgo Bioworks (NYSE: DNA) has integrated the Callisto™ Sample Prep System into their routine Illumina sequencing workflow. The system, developed by Volta Labs, addresses the automation challenges in DNA clean-up processes, particularly for high-throughput labs handling thousands of samples.
The Callisto system features an App Store concept that enables access to multiple sequencing technologies and chemistries on a single platform, helping maintain low operating costs. A notable addition is the Size Selection app, which allows short-read labs using Illumina, Element Biosciences, and Ultima Genomics platforms to purify and select optimal fragment sizes for sequencing.
The system's advanced electrowetting, magnetic, and acoustic capabilities, along with its proprietary VoltaNode™ technology, enable precise liquid separation, efficient DNA elution from beads, and flexible batch processing.
Ginkgo Bioworks (NYSE: DNA) ha integrato il sistema di preparazione campioni Callisto™ nel loro flusso di lavoro di sequenziamento Illumina. Il sistema, sviluppato da Volta Labs, affronta le sfide di automazione nei processi di pulizia del DNA, in particolare per i laboratori ad alta capacità che gestiscono migliaia di campioni.
Il sistema Callisto presenta un concetto di App Store che consente l'accesso a diverse tecnologie e chimiche di sequenziamento su un'unica piattaforma, contribuendo a mantenere bassi i costi operativi. Un'aggiunta notevole è l'app Size Selection, che consente ai laboratori di lettura breve che utilizzano le piattaforme Illumina, Element Biosciences e Ultima Genomics di purificare e selezionare le dimensioni ottimali dei frammenti per il sequenziamento.
Le avanzate capacità di elettroinzuppamento, magnetiche e acustiche del sistema, insieme alla sua tecnologia proprietaria VoltaNode™, consentono una separazione precisa dei liquidi, un'efficiente eluzione del DNA dalle sfere e una flessibile elaborazione in lotti.
Ginkgo Bioworks (NYSE: DNA) ha integrado el sistema de preparación de muestras Callisto™ en su flujo de trabajo de secuenciación Illumina. El sistema, desarrollado por Volta Labs, aborda los desafíos de automatización en los procesos de limpieza de ADN, especialmente para laboratorios de alto rendimiento que manejan miles de muestras.
El sistema Callisto presenta un concepto de App Store que permite el acceso a múltiples tecnologías y químicas de secuenciación en una sola plataforma, ayudando a mantener bajos los costos operativos. Una adición notable es la aplicación Size Selection, que permite a los laboratorios de lectura corta que utilizan las plataformas Illumina, Element Biosciences y Ultima Genomics purificar y seleccionar los tamaños óptimos de fragmentos para la secuenciación.
Las avanzadas capacidades de electrohumectación, magnéticas y acústicas del sistema, junto con su tecnología propietaria VoltaNode™, permiten una separación precisa de líquidos, una eficiente elución de ADN de las perlas y un procesamiento flexible por lotes.
징코 바이오웍스 (NYSE: DNA)는 Callisto™ 샘플 준비 시스템을 일루미나 시퀀싱 작업 흐름에 통합했습니다. 이 시스템은 Volta Labs에서 개발했으며, 특히 수천 개의 샘플을 처리하는 고처리량 실험실의 DNA 정화 과정에서 자동화 문제를 해결합니다.
Callisto 시스템은 단일 플랫폼에서 여러 시퀀싱 기술과 화학 물질에 접근할 수 있는 앱 스토어 개념을 특징으로 하여 운영 비용을 낮추는 데 도움을 줍니다. 주목할 만한 추가 기능은 Size Selection 앱으로, 이는 Illumina, Element Biosciences 및 Ultima Genomics 플랫폼을 사용하는 짧은 읽기 실험실이 시퀀싱을 위한 최적의 조각 크기를 정화하고 선택할 수 있게 해줍니다.
시스템의 고급 전기 습윤, 자기 및 음향 기능과 독점 기술인 VoltaNode™는 정확한 액체 분리, 비드에서의 효율적인 DNA 엘루션 및 유연한 배치 처리를 가능하게 합니다.
Ginkgo Bioworks (NYSE: DNA) a intégré le système de préparation d'échantillons Callisto™ dans son flux de travail de séquençage Illumina. Le système, développé par Volta Labs, répond aux défis d'automatisation dans les processus de nettoyage de l'ADN, en particulier pour les laboratoires à haut débit traitant des milliers d'échantillons.
Le système Callisto dispose d'un concept de boutique d'applications qui permet d'accéder à plusieurs technologies et chimies de séquençage sur une seule plateforme, contribuant à maintenir des coûts d'exploitation bas. Une addition notable est l'application Size Selection, qui permet aux laboratoires à lecture courte utilisant les plateformes Illumina, Element Biosciences et Ultima Genomics de purifier et de sélectionner les tailles de fragments optimales pour le séquençage.
Les capacités avancées d'électrowetting, magnétiques et acoustiques du système, ainsi que sa technologie propriétaire VoltaNode™, permettent une séparation précise des liquides, une élution efficace de l'ADN des billes et un traitement flexible par lots.
Ginkgo Bioworks (NYSE: DNA) hat das Callisto™ Probenvorbereitungssystem in ihren routinemäßigen Illumina-Sequenzierungsworkflow integriert. Das System, das von Volta Labs entwickelt wurde, adressiert die Automatisierungsherausforderungen in den DNA-Reinigungsprozessen, insbesondere für Hochdurchsatzlabore, die Tausende von Proben bearbeiten.
Das Callisto-System bietet ein App-Store-Konzept, das den Zugriff auf mehrere Sequenzierungstechnologien und -chemikalien auf einer einzigen Plattform ermöglicht, wodurch die Betriebskosten niedrig gehalten werden. Eine bemerkenswerte Ergänzung ist die Size Selection-App, die es kurzen Leselaboren, die Illumina-, Element Biosciences- und Ultima Genomics-Plattformen verwenden, ermöglicht, optimale Fragmentgrößen für die Sequenzierung zu reinigen und auszuwählen.
Die fortschrittlichen elektrowettenden, magnetischen und akustischen Fähigkeiten des Systems sowie die proprietäre VoltaNode™-Technologie ermöglichen eine präzise Flüssigkeitstrennung, eine effiziente DNA-Elution von Perlen und eine flexible Batchverarbeitung.
- Integration of Callisto system expected to improve operational efficiency in DNA sequencing workflow
- App Store concept helps maintain low operating costs through multiple sequencing technologies access
- System provides complete walk-away automation capability for high-throughput processing
- None.
Insights
The integration of Volta Labs' Callisto™ Sample Prep System into Ginkgo Bioworks' operations marks a strategic enhancement of their automated genomics capabilities, with several key implications for operational efficiency and market competitiveness:
Operational Impact: The system's ability to handle thousands of individual samples with varying batch sizes addresses a critical bottleneck in NGS workflows. Traditional liquid handling technologies have struggled with DNA clean-up automation, making this integration particularly significant for scaling operations. The walk-away automation capability could substantially reduce labor costs and human error in sample preparation.
Strategic Advantages: The App Store concept for accessing multiple sequencing technologies on a single platform represents a shift toward more flexible and cost-effective lab operations. This approach allows Ginkgo to:
- Adapt quickly to different sequencing requirements without additional capital investment
- Maintain lower operating costs through standardized processes
- Scale operations more efficiently with varying demand
Market Implications: This integration demonstrates Ginkgo's commitment to optimizing their foundry operations, which is important for maintaining their competitive edge in synthetic biology. The partnership with Volta Labs also suggests a strategic focus on reducing operational costs while increasing throughput capacity - essential factors for improving margins in the capital-intensive biotech sector.
The addition of size selection capabilities through the Volta Apps menu further enhances the platform's utility, particularly for short-read sequencing applications across multiple platforms (Illumina, Element Biosciences, and Ultima Genomics). This multi-platform compatibility positions Ginkgo to maintain technological flexibility while optimizing their sequencing workflows.
"I like the Apps and the App Store concept on Callisto. It allows us to keep our operating costs low and access multiple sequencing technologies and chemistries on the same platform," said Alex Plocik, Senior Director of Genomics at Ginkgo Bioworks. "In our short-read sequencing workflow, we often pool thousands of individual samples into tens of sample pools for bead clean ups with varying batch size from day to day. The Callisto system is perfect for this use case while providing a complete walk away experience."
"Ginkgo has been a valued partner for Volta Labs since inception," said Udayan Umapathi, founder and CEO of Volta Labs. "Their team has played an instrumental role in refining our solution for high throughput labs. I am excited about the short-term integration of Callisto into their Illumina workflows and the long-term potential to expand into many applications."
Size selection is one of the newest apps to be released in the Volta Apps menu. This app allows all short-read labs performing sequencing on Illumina, Element Biosciences and Ultima Genomics platforms to purify and select optimal fragment sizes for sequencing. Despite significant advancements in sequencing, something as primitive as DNA clean-up is challenging to automate on traditional liquid handling technologies. Callisto's advanced electrowetting, magnetic and acoustic capabilities enable very precise and clean separation of liquids, efficient elution of DNA from beads, and batch-level flexibility enabled by proprietary VoltaNode™ technology. Kits are now available to order for all customers interested in using the Double-Sided Size Selection app on Callisto.
About Volta Labs
Volta Labs is a genomics applications company that has developed a cutting-edge digital fluidics platform to maximize performance and scalability of sample preparation in genomics while providing unparalleled consistency. Volta is transforming the way biological research and analyses are performed, allowing scientists to focus on what they do best -- pushing the boundaries of biology.
About Ginkgo Bioworks
Ginkgo Bioworks is the leading horizontal platform for cell programming, providing flexible, end-to-end services that solve challenges for organizations across diverse markets, from food and agriculture to pharmaceuticals to industrial and specialty chemicals. Ginkgo Biosecurity is building and deploying the next-generation infrastructure and technologies that global leaders need to predict, detect, and respond to a wide variety of biological threats. For more information, visit ginkgobioworks.com and ginkgobiosecurity.com, read our blog, or follow us on social media channels such as X (@Ginkgo and @Ginkgo_Biosec), Instagram (@GinkgoBioworks), Threads (@GinkgoBioworks) or LinkedIn.
Media Contacts:
Volta Labs
kmiller@voltalabs.co
Ginkgo Bioworks
press@ginkgobioworks.com
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SOURCE Volta Labs Inc.
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