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Cyclacel Pharmaceuticals (CYCC) is a clinical-stage biopharmaceutical company pioneering targeted cancer therapies through cell cycle regulation. This resource provides investors and researchers with timely updates on clinical developments, regulatory milestones, and strategic initiatives.
Access comprehensive coverage of CYCC's progress with its CDK and PLK inhibitor pipeline, including fadraciclib and plogosertib development. Stay informed about critical updates across multiple news categories: clinical trial results, regulatory filings, research collaborations, and intellectual property developments.
Our curated news collection enables efficient tracking of the company's precision medicine approach and therapeutic innovations in oncology. Regular updates ensure you never miss pivotal announcements about trial phases, partnership agreements, or scientific presentations.
Bookmark this page for streamlined access to verified CYCC developments. Check back frequently for objective reporting on advancements in targeted cancer treatment research and their implications for hematology/oncology care.
Cyclacel Pharmaceuticals (NASDAQ: CYCC) has announced its Q4 2024 financial results and strategic updates. The company is streamlining operations to focus on developing plogosertib, a PLK 1 inhibitor for advanced cancers, following its acquisition from Cyclacel on March 10, 2025.
Financial highlights include:
- Pro forma cash and equivalents of $7.2M as of Dec 31, 2024
- R&D expenses decreased to $6.7M in 2024 from $19.2M in 2023
- Net loss reduced to $11.2M in 2024 from $22.6M in 2023
- Current cash expected to fund operations into Q2 2025
The liquidation of Cyclacel is expected to increase stockholders' equity by approximately $5.0M and significantly reduce R&D expenses in 2025. The company is developing a new oral formulation of plogosertib with improved bioavailability.
Cyclacel Pharmaceuticals (NASDAQ: CYCC) has secured $1.0 million through a private placement of convertible Series E Preferred Stock to accredited investors, completed on March 21, 2025. Each preferred share is convertible into 110 common shares, subject to stockholder approval per Nasdaq rules.
The company plans to use the net proceeds for working capital and general corporate purposes. Combined with existing cash reserves, this financing is expected to extend Cyclacel's cash runway into the third quarter of 2025. Preferred stockholders will be entitled to participate in any dividends declared on common stock on an as-converted basis.
The securities were issued under Regulation S of the Securities Act and were offered directly to investors without intermediaries. Arc Group and Rimon P.C. served as financial advisor and legal counsel, respectively.
Cyclacel Pharmaceuticals (NASDAQ: CYCC) announced a significant change in control and leadership on February 26, 2025. Datuk Dr. Doris Wong Sing Ee acquired controlling interest through the purchase of convertible preferred stock from former interim CEO David Lazar for $6.3 million.
The transaction involved 1,000,000 shares of Series C and 1,745,262 shares of Series D Convertible Preferred Stock, which were converted into 2,650,000 and 191,978,820 common shares respectively. This resulted in the purchaser owning 70% of Cyclacel's outstanding shares.
Following the transaction, significant leadership changes occurred: David Lazar resigned as interim CEO, Datuk Dr. Doris Wong Sing Ee became CEO and Executive Director, and Kiu Cu Seng was appointed as Executive Director, Secretary and CFO. Additionally, multiple board members resigned or provided notice of resignation, with Chong Kwang Fock joining as an Independent Director.
Cyclacel Pharmaceuticals (NASDAQ: CYCC) has entered into a securities purchase agreement with investor David Lazar, who will invest $3.1 million through the purchase of convertible preferred stock. The deal includes 1,000,000 shares of Series C Preferred Stock at $1.00 per share (convertible to 2.65 common shares each) and 2,100,000 shares of Series D Preferred Stock (convertible to 110 common shares each).
As part of the agreement, significant board changes were announced, with David Lazar appointed as interim CEO, replacing Spiro Rombotis. The company also entered into a Warrant Exchange Agreement to exchange warrants for 24,844,725 common shares plus $1.1 million in cash.
The company must obtain stockholder approval for both the preferred stock conversion and warrant exchange. Cyclacel faces a February 6, 2025 deadline to comply with Nasdaq's minimum stockholders' equity requirement to avoid potential delisting. Management has been directed to reduce operating costs while exploring strategic alternatives.
Cyclacel Pharmaceuticals (NASDAQ: CYCC) announced it is exploring strategic alternatives to preserve cash, including a potential transaction with investor David Lazar of Activist Investing, , subject to existing securityholder consent. The company's Board is reviewing strategies to realize value from assets and has directed management to reduce operating costs.
The company currently does not meet Nasdaq's continued listing requirements and faces potential delisting if compliance is not regained. Without securing a strategic transaction or additional funding, Cyclacel may be forced to cease operations, potentially resulting in stockholders losing part or all of their investment.
Cyclacel Pharmaceuticals announced the closing of a warrant exercise transaction, raising $2.1 million in gross proceeds. The company facilitated the exercise of existing warrants for 4,968,945 shares at a reduced price of $0.415 per share, down from the original $1.36. In exchange, Cyclacel issued new unregistered Series C and D warrants, each for 9,937,890 shares at $0.415 per share. The Series C warrants have a 5.5-year term, while Series D warrants expire in 18 months, both pending stockholder approval. The proceeds will be used for working capital and general corporate purposes.
Cyclacel Pharmaceuticals has entered into an agreement for the exercise of existing warrants to purchase 4,968,945 shares of common stock at a reduced price of $0.415 per share, down from the original $1.36. The company will issue new unregistered Series C and D warrants, each allowing purchase of up to 9,937,890 shares at $0.415 per share. The transaction is expected to generate $2.1 million in gross proceeds, which will be used for working capital and general corporate purposes. H.C. Wainwright & Co. serves as the exclusive placement agent.
Cyclacel Pharmaceuticals reported Q3 2024 financial results, highlighting initial safety and efficacy data from twelve patients in Phase 2 study of fadraciclib. Cash equivalents were $3.0 million as of September 30, 2024, down from $3.4 million at end-2023. Net loss decreased to $2.0 million from $6.0 million year-over-year. R&D expenses reduced to $1.0 million from $5.2 million in Q3 2023. The company faces potential Nasdaq delisting unless it meets minimum stockholders' equity requirement by December 24, 2024. Current cash is expected to fund operations into Q4 2024, with substantial doubt about continuing as a going concern.
Cyclacel Pharmaceuticals presented interim Phase 2 data for fadraciclib (fadra) monotherapy in advanced solid tumor patients with CDKN2A/B abnormalities at the 2024 EORTC-NCI-AACR Symposium. The study enrolled 12 patients in Cohort 8, with various cancer types including pancreatic, melanoma, and others. Out of six evaluable patients, two achieved stable disease: a melanoma patient (125 days treatment) and a squamous cell CUP patient with 11% tumor shrinkage (85+ days, ongoing). The drug showed good tolerability with no Grade 3 or higher adverse events. Two additional patients are ongoing but await first scans.
Cyclacel Pharmaceuticals, Inc. (NASDAQ: CYCC, NASDAQ: CYCCP) has announced that initial safety and efficacy data from its Phase 2 study of oral fadraciclib will be presented at the 2024 AACR-NCI-EORTC 36th Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain (October 23-25, 2024). The data comes from twelve patients with advanced solid tumors enrolled in Cohort 8 of the proof of concept study, who were preselected for CDKN2A and/or CDKN2B abnormalities.
The presentation, titled 'Fadraciclib, an oral CDK2/9 inhibitor, in patients with advanced solid tumors and lymphoma with CDKN2A and/or CDKN2B genetic alterations', will be displayed as a poster on October 23, 2024, from 12:00 p.m. to 7:00 p.m. CEST. This study is part of Cyclacel's efforts in developing innovative cancer medicines.
