Cybin Announces Grant of First U.S. Composition of Matter Patent in Support of its CYB005 Phenethylamines Program
Cybin has been granted U.S. patent 12,122,741 by the USPTO for composition of matter claims related to its CYB005 phenethylamines program. The company is investigating these novel molecules at non-hallucinogenic doses for various Central Nervous System disorders. The development includes exploring non-hallucinogenic neuroplastogens and targeted serotonin 5-HT1A and 5-HT2C receptor agonists. This addition brings Cybin's intellectual property portfolio to over 70 granted patents and more than 220 pending patent applications.
Cybin ha ottenuto il brevetto statunitense 12,122,741 dall'USPTO per le rivendicazioni relative alle composizioni di materia del suo programma di fenetilamine CYB005. L'azienda sta studiando queste nuove molecole a dosi non allucinogene per vari disturbi del sistema nervoso centrale. Lo sviluppo comprende l'esplorazione di neuroplastogeni non allucinogeni e agonisti mirati dei recettori della serotonina 5-HT1A e 5-HT2C. Questo aggiornamento porta il portafoglio di proprietà intellettuale di Cybin a oltre 70 brevetti concessi e più di 220 domande di brevetto in attesa.
Cybin ha sido otorgada con la patente estadounidense 12,122,741 por la USPTO en relación con las reclamaciones de composición de materia relacionadas con su programa de feniletilaminas CYB005. La empresa está investigando estas nuevas moléculas en dosis no alucinógenas para diversos trastornos del sistema nervioso central. El desarrollo incluye la exploración de neuroplásticos no alucinógenos y agonistas dirigidos de los receptores de serotonina 5-HT1A y 5-HT2C. Esta adición eleva el portafolio de propiedad intelectual de Cybin a más de 70 patentes otorgadas y más de 220 solicitudes de patente pendientes.
Cybin은 CYB005 페네틸아민 프로그램과 관련된 물질 조성 주장에 대해 USPTO로부터 미국 특허 12,122,741을 부여받았습니다. 이 회사는 다양한 중앙 신경계 장애를 위해 비환각 용량에서 이러한 새로운 분자를 조사하고 있습니다. 개발에는 비환각 신경 가소성 물질과 표적 세로토닌 5-HT1A 및 5-HT2C 수용체의 작용제를 탐색하는 것이 포함됩니다. 이번 추가로 Cybin의 지적 재산권 포트폴리오는 70개 이상의 부여된 특허와 220개 이상의 보류 중인 특허 신청으로 증가했습니다.
Cybin a reçu le brevet américain 12,122,741 de l'USPTO pour des revendications de composition de matière liées à son programme de phényléthylamines CYB005. L'entreprise étudie ces nouvelles molécules à des doses non hallucinogènes pour divers troubles du système nerveux central. Le développement comprend l'exploration de neuroplastogènes non hallucinogènes et d'agonistes ciblés des récepteurs de la sérotonine 5-HT1A et 5-HT2C. Cet ajout porte le portefeuille de propriété intellectuelle de Cybin à plus de 70 brevets accordés et plus de 220 demandes de brevet en attente.
Cybin wurde vom USPTO das US-Patent 12,122,741 für materielle Zusammensetzungsansprüche im Zusammenhang mit ihrem CYB005 Phenethylamine-Programm gewährt. Das Unternehmen untersucht diese neuartigen Moleküle in nicht-halluzinogenen Dosen für verschiedene Störungen des zentralen Nervensystems. Die Entwicklung umfasst die Erforschung von nicht-halluzinogenen Neuroplastogenen und zielgerichteten Serotonin-5-HT1A- und 5-HT2C-Rezeptor-Agonisten. Diese Ergänzung bringt Cybins Portfolio an geistigem Eigentum auf über 70 erteilte Patente und mehr als 220 anhängige Patentanmeldungen.
- Secured new U.S. patent strengthening IP protection for CYB005 program
- Extensive IP portfolio with 70+ granted patents and 220+ pending applications
- Expanding development pipeline beyond clinical tryptamine programs
- None.
Insights
The USPTO grant of composition of matter patent for CYB005 phenethylamines program significantly strengthens Cybin's intellectual property position. This first U.S. patent provides important market exclusivity for their non-hallucinogenic CNS treatment candidates. The patent portfolio's expansion to over 70 granted patents and 220+ pending applications demonstrates robust IP strategy. Composition of matter patents are particularly valuable as they offer the broadest protection for novel chemical compounds, typically lasting 20 years from filing date. This protection is essential for preventing competitors from manufacturing, selling, or using the patented compounds, securing Cybin's market position in the emerging neuropsychiatry space.
The focus on non-hallucinogenic dosing of phenethylamines represents a strategic approach in CNS drug development. The research targeting specific serotonin receptors (5-HT1A and 5-HT2C) shows promise for developing treatments with potentially fewer side effects than traditional psychedelics. Publication in the Journal of Medicinal Chemistry validates the scientific merit of their compound development work. The emphasis on neuroplastogens and targeted receptor agonists suggests a sophisticated understanding of CNS disorder mechanisms, potentially leading to more precise therapeutic interventions with broader market acceptance than hallucinogenic alternatives.
- The Company is evaluating non-hallucinogenic dosing of CYB005 preclinical candidate molecules for the treatment of CNS disorders -
- Cybin’s sector-leading intellectual property portfolio now includes over 70 granted patents and more than 220 patent applications pending -
The Company is investigating novel molecules within the CYB005 program at non-hallucinogenic doses for a range of Central Nervous System (“CNS”) disorders. In addition, the Company is continuing to explore non-hallucinogenic neuroplastogens within its broader discovery pipeline, as well as targeted serotonin 5-HT1A and 5-HT2C receptor agonists.
“The granting of this patent in support of our CYB005 phenethylamines program reinforces our commitment to expanding the breadth of innovative development work beyond our clinical tryptamine programs,” said Doug Drysdale, Chief Executive Officer of Cybin. “Non-hallucinogenic 5-HT receptor agonists have garnered a great deal of attention in recent years, and we are eager to continue exploring their clinical potential in CNS disorders. While our primary focus remains on our clinical-stage psychiatry programs, CYB003 and CYB004, we believe that other programs like CYB005 that target CNS disorders have the potential to address significant unmet medical needs. We remain focused on demonstrating our scientific leadership in the space, while delivering long-term shareholder value.”
The Company previously announced that its research manuscript, entitled “Synthesis and Structure-Activity Relationships of 2,5-dimethoxy-4-substituted phenethylamines and the discovery of CYB210010: A potent, orally bioavailable and long-acting serotonin 5-HT2 receptor agonist,” was published in the Journal of Medicinal Chemistry, a prestigious bi-weekly peer-reviewed publication of the American Chemical Society.
About Cybin
Cybin is a late-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options to address the large unmet need for people who suffer from mental health conditions.
With industry leading proof-of-concept data, Cybin is working to change the mental health treatment landscape through the introduction of intermittent treatments that provide long lasting results. The Company is currently developing CYB003, a proprietary deuterated psilocin program, about to enter Phase 3 studies for the adjunctive treatment of major depressive disorder and CYB004, a proprietary deuterated DMT program in a Phase 2 study for generalized anxiety disorder. The company also has a research pipeline of investigational, 5-HT-receptor focused compounds.
Founded in 2019, Cybin is operational in
Cautionary Notes and Forward-Looking Statements
Certain statements in this news release relating to the Company are forward-looking statements and are prospective in nature. Forward-looking statements are not based on historical facts, but rather on current expectations and projections about future events and are therefore subject to risks and uncertainties which could cause actual results to differ materially from the future results expressed or implied by the forward-looking statements. These statements generally can be identified by the use of forward-looking words such as “may”, “should”, “could”, “intend”, “estimate”, “plan”, “anticipate”, “expect”, “believe” or “continue”, or the negative thereof or similar variations. Forward-looking statements in this news release include statements regarding the Company’s belief that CYB005 has the potential to address significant unmet medical needs; and the Company’s proprietary drug discovery platforms, innovative drug delivery systems, novel formulation approaches and treatment regimens for mental health disorders.
These forward-looking statements are based on reasonable assumptions and estimates of management of the Company at the time such statements were made. Actual future results may differ materially as forward-looking statements involve known and unknown risks, uncertainties, and other factors which may cause the actual results, performance, or achievements of the Company to materially differ from any future results, performance, or achievements expressed or implied by such forward-looking statements. Such factors, among other things, include: implications of the spread of COVID-19 on the Company's operations; fluctuations in general macroeconomic conditions; fluctuations in securities markets; expectations regarding the size of the psychedelics market; the ability of the Company to successfully achieve its business objectives; plans for growth; political, social and environmental uncertainties; employee relations; the presence of laws and regulations that may impose restrictions in the markets where the Company operates; and the risk factors set out in each of the Company's management's discussion and analysis for the three months ended June 30, 2024 and the Company’s annual information form for the year ended March 31, 2024, which are available under the Company's profile on www.sedarplus.ca and with the
Cybin makes no medical, treatment or health benefit claims about Cybin’s proposed products. The
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Investor & Media Contact:
Gabriel Fahel
Chief Legal Officer
Cybin Inc.
1-866-292-4601
irteam@cybin.com – or – media@cybin.com
Source: Cybin Inc.
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