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CytomX Therapeutics, Inc. (Nasdaq: CTMX) is a leading oncology-focused biopharmaceutical company pioneering a novel class of investigational antibody therapeutics with its proprietary Probody® technology platform. Based in South San Francisco, CytomX leverages this platform to develop cancer immunotherapies that target clinically-validated and novel oncological targets. The unique Probody® therapeutics are designed to enhance the tumor-targeting capabilities of antibodies while minimizing toxicity in healthy tissues.
Probody® therapeutics operate by taking advantage of the unique conditions present in the tumor microenvironment, thereby improving both the efficacy and safety profiles of monoclonal antibody treatments, including cancer immunotherapies, antibody-drug conjugates (ADCs), and T-cell-recruiting bispecific antibodies. The company's innovative pipeline includes several promising candidates currently in various stages of development.
Among its recent achievements, CytomX is advancing its lead programs, CX-2051 and CX-801, into Phase 1 clinical studies. CX-2051 is an ADC that targets EpCAM-expressing tumors, including colorectal cancer, while CX-801 aims to overcome limitations associated with interferon-directed therapies. These candidates exemplify the versatility and productivity of CytomX's Probody® platform, promising significant advancements in cancer treatment.
CytomX has established strategic collaborations with industry leaders such as Amgen, Astellas, Bristol Myers Squibb, Regeneron, and Moderna to further enhance its research and development capabilities. As a result, the company is well-positioned to lead in the development of conditionally activated biologics designed for localized action within tumor microenvironments.
Financially, CytomX has made significant strides in cost control and strategic allocation of capital towards lead pipeline programs. In 2023, the company reduced its total operating expenses by $46.8 million, driven by workforce reductions and strategic pipeline prioritization. Research and development expenses decreased by $34.0 million, while general and administrative expenses decreased by $12.8 million.
For more information about CytomX and its innovative approach to cancer treatment, visit their official website at www.cytomx.com and follow them on LinkedIn and Twitter.
CytomX Therapeutics (NASDAQ: CTMX) announced that its CEO, Sean McCarthy, will present at the H.C. Wainwright BioConnect Investor Conference on May 2, 2023, at 11:00 a.m. ET. The presentation will be broadcast live on CytomX's website, allowing investors to attend through a one-on-one meeting format. CytomX, focused on developing innovative conditionally activated biologics for cancer treatment, showcases technologies such as its Probody® platform and has a robust pipeline, including CX-2029, an ADC targeting CD71, and partnerships with leading pharma companies like Bristol Myers Squibb and Amgen. These advancements aim to improve treatment standards in oncology.
CytomX Therapeutics reported its financial results for 2022 and outlined significant advancements in its therapeutic pipeline, including the ongoing Phase 1 study for CX-904, a T-cell engaging bispecific therapy, and anticipated IND filings for CX-2051 and CX-801 later this year. The company highlighted collaborations with Bristol Myers Squibb, Moderna, and Regeneron, aiming to bolster its strategy and funding. Financially, total revenue for 2022 rose to $53.2 million, up from $37.3 million in 2021. However, cash reserves decreased to $194 million at year-end. CytomX is prioritizing ongoing clinical studies and reassessing its CX-2029 program following AbbVie’s decision to terminate its collaboration.
CytomX Therapeutics (Nasdaq: CTMX) announced it will release its full year 2022 financial results on March 27, 2023, after U.S. market close. The company will follow up with a conference call at 5:00 p.m. ET to discuss the results. Investors can access the live webcast on the company’s website and are encouraged to register 10 minutes prior to the call. CytomX is focused on developing conditionally activated biologics for cancer treatment, with a robust pipeline including collaborations with major partners like AbbVie and Bristol Myers Squibb.
SOUTH SAN FRANCISCO, Calif., Feb. 28, 2023 (GLOBE NEWSWIRE) -- CytomX Therapeutics, Inc. (Nasdaq: CTMX) announced CEO Sean McCarthy's participation in March investor conferences. He will speak at the Cowen 43rd Annual Health Care Conference on March 7, 2023, at 9:10 a.m. ET in Boston, MA, and at the Barclays Global Healthcare Conference on March 14, 2023, at 4:05 p.m. ET in Miami, FL. Live webcasts of these events will be available on CytomX's website. CytomX focuses on conditionally activated biologics for cancer treatment, with a diverse pipeline, including collaborations with AbbVie and Bristol Myers Squibb.
CytomX Therapeutics (CTMX) has achieved a significant milestone by progressing its first Probody® TCB clinical candidate in collaboration with Astellas, triggering a $5 million milestone payment. This marks an important step in their multi-target collaboration, where CytomX retains U.S. co-commercialization and economic rights for select programs. The CEO emphasized the potential of localized T-cell engaging therapies to revolutionize cancer treatment. CytomX is advancing a diverse pipeline of seven therapeutic candidates, including T-cell engaging bispecific antibodies and antibody-drug conjugates, further enhancing its position in the oncology market.
CytomX Therapeutics will present at the B. Riley Securities Virtual Annual Oncology Investor Conference on January 19, 2023, at 2:30 p.m. ET. The company's CEO, Sean McCarthy, will lead the presentation, which can be accessed via a live webcast on CytomX’s website, with an archived replay available for 30 days. CytomX specializes in conditionally activated biologics, focusing on innovative cancer treatments, supported by its Probody® technology platform. The company’s pipeline includes seven therapeutic candidates, collaborating with major partners like AbbVie and Amgen. For more information, visit www.cytomx.com.
CytomX Therapeutics (Nasdaq: CTMX) has announced encouraging results from its Phase 2 cohort expansion study of CX-2029, showing a 21% objective response rate in squamous esophageal cancer and a 10% response rate in squamous non-small cell lung cancer (sqNSCLC) among heavily pre-treated patients. The company is collaborating with Moderna to develop mRNA-based therapeutics and anticipates filing two INDs for new wholly owned programs in 2023. CytomX also plans to determine next steps for CX-2029 with AbbVie this year, while continuing research in T-cell bispecifics.