Castle Biosciences to Present New Data at EADO Supporting the Clinical Value of the DecisionDx®-Melanoma Test in Guiding Risk-Aligned Management of Patients with Melanoma
Castle Biosciences (CSTL) will present new data at the 11th World Congress of Melanoma and 21st EADO Congress in Athens, Greece (April 3-5, 2025), highlighting the clinical value of their DecisionDx-Melanoma test.
Two key studies will be presented: The first demonstrates the test's ability to stratify survival rates in stage IIB-IIC cutaneous melanoma patients, while the second shows its capability to identify early-stage patients at higher risk of central nervous system metastasis.
Key findings include:
- The test effectively stratified melanoma-specific and overall survival in stage IIB-IIC patients
- Patients with Class 2B (high risk) results showed significantly higher death risk
- DecisionDx-Melanoma was the only significant predictor of CNS metastasis in multivariable analyses
Dr. Brent Moody of Heritage Medical Associates emphasized that the test provides valuable biological insights complementing traditional staging, potentially improving melanoma outcomes through personalized care.
Castle Biosciences (CSTL) presenterà nuovi dati all'11° Congresso Mondiale sul Melanoma e al 21° Congresso EADO ad Atene, Grecia (3-5 aprile 2025), evidenziando il valore clinico del loro test DecisionDx-Melanoma.
Saranno presentati due studi chiave: il primo dimostra la capacità del test di stratificare i tassi di sopravvivenza nei pazienti con melanoma cutaneo di stadio IIB-IIC, mentre il secondo mostra la sua capacità di identificare i pazienti in fase iniziale a maggior rischio di metastasi al sistema nervoso centrale.
I risultati chiave includono:
- Il test ha stratificato efficacemente la sopravvivenza specifica per melanoma e la sopravvivenza generale nei pazienti di stadio IIB-IIC
- I pazienti con risultati di Classe 2B (alto rischio) hanno mostrato un rischio di morte significativamente più elevato
- DecisionDx-Melanoma è stato l'unico predittore significativo di metastasi CNS nelle analisi multivariabili
Il Dr. Brent Moody di Heritage Medical Associates ha sottolineato che il test fornisce preziose informazioni biologiche che completano la stadiazione tradizionale, migliorando potenzialmente gli esiti del melanoma attraverso una cura personalizzata.
Castle Biosciences (CSTL) presentará nuevos datos en el 11° Congreso Mundial de Melanoma y el 21° Congreso de EADO en Atenas, Grecia (3-5 de abril de 2025), destacando el valor clínico de su prueba DecisionDx-Melanoma.
Se presentarán dos estudios clave: el primero demuestra la capacidad de la prueba para estratificar las tasas de supervivencia en pacientes con melanoma cutáneo en estadio IIB-IIC, mientras que el segundo muestra su capacidad para identificar a pacientes en etapas tempranas con mayor riesgo de metástasis en el sistema nervioso central.
Los hallazgos clave incluyen:
- La prueba estratificó eficazmente la supervivencia específica por melanoma y la supervivencia general en pacientes de estadio IIB-IIC
- Los pacientes con resultados de Clase 2B (alto riesgo) mostraron un riesgo de muerte significativamente mayor
- DecisionDx-Melanoma fue el único predictor significativo de metástasis en el SNC en análisis multivariables
El Dr. Brent Moody de Heritage Medical Associates enfatizó que la prueba proporciona valiosos conocimientos biológicos que complementan la estadificación tradicional, mejorando potencialmente los resultados del melanoma a través de una atención personalizada.
Castle Biosciences (CSTL)는 2025년 4월 3일부터 5일까지 그리스 아테네에서 열리는 제11회 세계 흑색종 학회 및 제21회 EADO 학회에서 DecisionDx-Melanoma 검사의 임상 가치를 강조하는 새로운 데이터를 발표할 예정입니다.
두 가지 주요 연구가 발표될 예정입니다: 첫 번째 연구는 검사 결과가 IIB-IIC 단계의 피부 흑색종 환자의 생존율을 stratify하는 능력을 보여주며, 두 번째 연구는 초기 단계 환자 중 중앙 신경계 전이 위험이 높은 환자를 식별하는 능력을 보여줍니다.
주요 발견 사항은 다음과 같습니다:
- 검사가 IIB-IIC 단계 환자의 흑색종 특이적 생존율 및 전체 생존율을 효과적으로 stratify했습니다.
- Class 2B (고위험) 결과를 가진 환자는 사망 위험이 유의미하게 높았습니다.
- DecisionDx-Melanoma는 다변량 분석에서 CNS 전이의 유일한 유의미한 예측 인자였습니다.
Heritage Medical Associates의 Brent Moody 박사는 이 검사가 전통적인 병기와 보완적인 귀중한 생물학적 통찰력을 제공하여 개인 맞춤 치료를 통해 흑색종의 결과를 개선할 수 있다고 강조했습니다.
Castle Biosciences (CSTL) présentera de nouvelles données lors du 11e Congrès Mondial sur le Mélanome et du 21e Congrès de l'EADO à Athènes, en Grèce (3-5 avril 2025), mettant en avant la valeur clinique de leur test DecisionDx-Melanoma.
Deux études clés seront présentées : la première démontre la capacité du test à stratifier les taux de survie chez les patients atteints de mélanome cutané de stade IIB-IIC, tandis que la seconde montre sa capacité à identifier les patients à un stade précoce à risque plus élevé de métastases au système nerveux central.
Les résultats clés incluent:
- Le test a efficacement stratifié la survie spécifique au mélanome et la survie globale chez les patients de stade IIB-IIC
- Les patients avec des résultats de Classe 2B (haut risque) ont montré un risque de décès significativement plus élevé
- DecisionDx-Melanoma était le seul prédicteur significatif de métastases CNS dans les analyses multivariées
Le Dr Brent Moody de Heritage Medical Associates a souligné que le test fournit des informations biologiques précieuses qui complètent le stadification traditionnelle, améliorant potentiellement les résultats du mélanome grâce à des soins personnalisés.
Castle Biosciences (CSTL) wird neue Daten beim 11. Weltkongress über Melanome und beim 21. EADO-Kongress in Athen, Griechenland (3.-5. April 2025), präsentieren und dabei den klinischen Wert ihres DecisionDx-Melanoma-Tests hervorheben.
Es werden zwei wichtige Studien präsentiert: Die erste zeigt die Fähigkeit des Tests, die Überlebensraten bei Patienten mit kutanem Melanom im Stadium IIB-IIC zu stratifizieren, während die zweite die Fähigkeit zeigt, Patienten im Frühstadium mit höherem Risiko für Metastasen im zentralen Nervensystem zu identifizieren.
Wichtige Ergebnisse umfassen:
- Der Test stratifizierte effektiv die melanomspezifische und die allgemeine Überlebensrate bei Patienten im Stadium IIB-IIC
- Patienten mit Ergebnissen der Klasse 2B (hohes Risiko) wiesen ein signifikant höheres Sterberisiko auf
- DecisionDx-Melanoma war der einzige signifikante Prädiktor für CNS-Metastasen in multivariaten Analysen
Dr. Brent Moody von Heritage Medical Associates betonte, dass der Test wertvolle biologische Einblicke bietet, die die traditionelle Stadieneinteilung ergänzen und potenziell die Ergebnisse von Melanomen durch personalisierte Betreuung verbessern können.
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Two posters will share data on the significant risk stratification provided by DecisionDx-Melanoma in a real-world cohort of patients with stage IIB-IIC cutaneous melanoma (CM) to help guide adjuvant therapy, and the role of the test in prompting use of imaging surveillance in early-stage patients at high risk of metastasis to the central nervous system (CNS)
FRIENDSWOOD, Texas, April 01, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, will share data via two poster presentations at the 11th World Congress of Melanoma and 21st European Association of Dermato-Oncology (EADO) Congress, being held April 3-5, 2025, in Athens, Greece. The posters demonstrate the ability of the DecisionDx-Melanoma test to guide more informed, risk-aligned management decisions through the precise risk-stratification of patients with melanoma.
"The findings being presented at EADO demonstrate that DecisionDx-Melanoma provides valuable biological insights that complement traditional staging and may help clinicians tailor surveillance and treatment plans based on a patient's individual predicted risk of metastasis,” said Brent Moody, M.D., dermatologist and Mohs micrographic surgeon at Heritage Medical Associates in Nashville, Tennessee. “By better identifying which patients may benefit from intensified monitoring and adjuvant therapy, the test has the potential to significantly improve melanoma outcomes through more personalized care directed to those who need it most."
Castle will present the following posters at EADO. The corresponding abstracts can be found in the digital Book of Abstracts available for download on the EADO website.
DecisionDx-Melanoma
- Poster P5-30: Improved prognostic guidance with 31-gene expression profiling for patients with stage IIB-IIC cutaneous melanoma: a SEER collaboration
- Abstract: A-314
- Lead Author: Brent Moody, M.D., Heritage Medical Associates
- Key takeaways: In the study, DecisionDx-Melanoma effectively stratified melanoma-specific survival and overall survival in a real-world population of clinically tested patients with stage IIb-IIC CM (p<0.001). As demonstrated by the data, stage IIB-IIC patients with a DecisionDx-Melanoma Class 2B (high risk) result are at a significantly higher risk of death and may benefit from increased management such as adjuvant therapy and surveillance imaging.
- Poster P5-22: The 31-GEP identifies patients with localized cutaneous melanoma at the highest risk of metastasis to the central nervous system
- Abstract: A-270
- Lead Author: Merve Hasanov, M.D., oncologist and director of the division of medical oncology at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio
- Key takeaways: This study demonstrates that the DecisionDx-Melanoma test can identify patients with earlier-stage melanoma who have a higher risk of CNS metastasis within the first three years post-diagnosis and who may benefit from more frequent imaging surveillance designed to identify metastases earlier and potentially improve patient survival. In the study, a Class 2B (high risk) DecisionDx-Melanoma test result was the only significant predictor of CNS metastasis in multivariable analyses that included clinicopathologic-based risk factors considered in the American Joint Committee on Cancer Eight Edition (AJCC8) staging (HR (
95% CI) 9.21 (2.72-31.19); p<0.001).
To learn more about DecisionDx-Melanoma and how the test may help to improve care and outcomes for patients with melanoma, visit Castle’s booth and attend the product theater detailed below:
DecisionDx-Melanoma: Gene Expression Profile Testing to Guide Management Decisions for Patients with Cutaneous Melanoma
- Date and Time: Thursday, April 3, 16:45 – 17:45 local time
- Location: Mitropoulos Hall
- Presenter: John T. Vetto, M.D., FACS, FASA, renowned surgical oncologist and professor of surgery and dermatology at Oregon Health and Science University’s School of Medicine, Portland, Oregon
About DecisionDx®-Melanoma
DecisionDx-Melanoma is a gene expression profile risk stratification test. It is designed to inform two clinical questions in the management of cutaneous melanoma: a patient’s individual risk of sentinel lymph node (SLN) positivity and a patient's personal risk of melanoma recurrence and/or metastasis. By integrating tumor biology with clinical and pathologic factors using a validated proprietary algorithm, DecisionDx-Melanoma is designed to provide a comprehensive and clinically actionable result to guide risk-aligned patient care. DecisionDx-Melanoma has been shown to be associated with improved patient survival and has been studied in more than 10,000 patient samples. DecisionDx-Melanoma’s clinical value is supported by more than 50 peer-reviewed and published studies, providing confidence in disease management plans that incorporate the test’s results. Through Dec. 31, 2024, DecisionDx-Melanoma has been ordered more than 191,000 times for patients diagnosed with cutaneous melanoma. Learn more at www.CastleBiosciences.com.
About Castle Biosciences
Castle Biosciences (Nasdaq: CSTL) is a leading diagnostics company improving health through innovative tests that guide patient care. The Company aims to transform disease management by keeping people first: patients, clinicians, employees and investors.
Castle’s current portfolio consists of tests for skin cancers, Barrett’s esophagus, mental health conditions and uveal melanoma. Additionally, the Company has active research and development programs for tests in other diseases with high clinical need, including its test in development to help guide systemic therapy selection for patients with moderate-to-severe atopic dermatitis seeking biologic treatment. To learn more, please visit www.CastleBiosciences.com and connect with us on LinkedIn, Facebook, X and Instagram.
DecisionDx-Melanoma, DecisionDx-CMSeq, DecisionDx-SCC, MyPath Melanoma, DiffDx-Melanoma, TissueCypher, IDgenetix, DecisionDx-UM, DecisionDx-PRAME and DecisionDx-UMSeq are trademarks of Castle Biosciences, Inc.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the “safe harbor” created by those sections. These forward-looking statements include, but are not limited to, statements concerning: the ability of the DecisionDx-Melanoma test to guide more informed, risk-aligned management decisions through the precise risk-stratification of patients with melanoma; DecisionDx-Melanoma’s value in identifying CM patients who may benefit from enhanced surveillance and management strategies to improve outcomes; and the significant prognostic capabilities of DecisionDx-Melanoma and its ability to (i) enhance risk stratification beyond traditional AJCC8 staging, (ii) equip clinicians with actionable results to enable more precise, personalized treatment decisions and optimize patient management and care and (iii) identify patients with earlier-stage melanoma who have a higher risk of CNS metastasis within the first three years post-diagnosis and who may benefit from more frequent imaging surveillance designed to identify metastases earlier and potentially improve patient survival. The words “believe,” “can” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements that we make. These forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from those in the forward-looking statements, including, without limitation: subsequent study or trial results and findings may contradict earlier study or trial results and findings or may not support the results obtained in these studies, including with respect to the discussion of our tests in this press release; actual application of our tests may not provide the aforementioned benefits to patients; and the risks set forth under the heading “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2024, and in our other filings with the SEC. The forward-looking statements are applicable only as of the date on which they are made, and we do not assume any obligation to update any forward-looking statements, except as may be required by law.
Investor Contact:
Camilla Zuckero
czuckero@castlebiosciences.com
Media Contact:
Allison Marshall
amarshall@castlebiosciences.com
