Champions Oncology Announces a Partnership with Alloy Therapeutics to Develop Therapeutic Monoclonal Antibodies for Use in ADC Programs

Rhea-AI Summary

Champions Oncology (Nasdaq:CSBR) and Alloy Therapeutics have announced a new partnership aimed at developing therapeutic monoclonal antibodies for use in next-generation Antibody Drug Conjugates (ADCs). The collaboration will leverage Champions' Lumin platform for innovative drug discovery, focusing initially on a target linked to hematologic tumors such as Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM). Champions will retain ownership of the developed therapeutic molecule, while Alloy will receive milestone and royalty payments.

Positive

• Therapeutic partnership with Alloy Therapeutics enhances drug discovery capabilities.
• Focus on unexplored targets linked to significant hematologic tumors could lead to novel treatments.
• Champions retains ownership of the therapeutic molecule, enabling potential long-term revenue through milestones and royalties.

Negative

• None.

HACKENSACK, NJ / ACCESSWIRE / January 4, 2022 / Champions Oncology, Inc. (Nasdaq:CSBR), a leading global technology-enabled biotech that is transforming drug discovery through innovative pharmacology, biomarker, and data platforms, announced today a therapeutic development partnership with Alloy Therapeutics. The partnership will combine novel therapeutic targets identified within Champions' Lumin platform with Alloy's fully-integrated in vivo and in vitro antibody discovery, optimization, and lead development services platform to develop antibodies used in the development of next generation Antibody Drug Conjugates (ADCs).

ADCs engage tumor-specific therapeutic targets at a cell's surface to deliver potent toxic payloads to the tumor, without affecting normal cells. The planned partnership will initiate with a single program focused on a previously unexplored target present in tumor indications such as Acute Myeloid Leukemia (AML), Multiple Myeloma (MM), Chronic Lymphocytic Leukemia (CLL), Lymphoma, and other hematologic tumors. This therapeutic target is the product of Champions' newly expanded data-driven strategy to engage in drug discovery and development. The partnership will also leverage the unique experimental platforms available at Alloy and Champions to ensure rapid and efficient development towards clinical evaluation. Under the terms of this agreement, Champions will wholly own the therapeutic molecule, with milestones and royalty payments owed to Alloy.

Ronnie Morris, MD, President and CEO of Champions Oncology, said: "We have been particularly excited about this specific therapeutic program and partnership with Alloy. The advanced pheno-multiomic integration analytics within our Lumin platform revealed some exciting information about the target at the center of this program. Not only does it look to have strong potential as a classical ADC target, with high tumor-specific expression, but also has with a strong association with underlying biology linked to cancer progression and chemoresistance. This type of dual mechanism targeting with ADCs makes the use of such a platform very powerful. This development partnership with Alloy will ensure that we establish best in class antibodies in a quick timeframe. We're excited to see this therapeutic program enter the pipeline."

Errik Anderson, CEO and Founder of Alloy Therapeutics, said: "We are proud to support antibody discovery in this promising ADC program with far-reaching therapeutic applications, made more powerful by the Lumin advanced analytics and target identification engine. This partnership with Champions represents Alloy's approach to empowering drug developers in the pursuit of important treatments for patients. In 2022 we will increase our discovery services capacity to support a wider range of innovative programs and increase speed to the clinic for our community of partners."

About Champions Oncology

Champions Oncology is a technology-driven research organization that develops innovative therapeutics against cancer targets, offers groundbreaking research software as a service, and provides end-to-end R&D services to biopharma organizations. Champions Oncology is actively engaged in the transformation of drug discovery and development of oncology therapeutics. For more information, please visit www.ChampionsOncology.com.

Website: www.championsoncology.com
Facebook: https://www.facebook.com/championsoncology/
LinkedIn: https://www.linkedin.com/company/champions-oncology-inc-/
Twitter: https://twitter.com/ChampionsOncol1
Instagram:https://www.instagram.com/championsoncology/

Media Contact:

Rachel Bunting, MS, MBA
Sr. Director, Head of Marketing
Marketing@ChampionsOncology.com

About Alloy Therapeutics

Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, Alloy democratizes access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. Alloy's lead offering, the ATX-Gx™ platform, is a human therapeutic antibody discovery platform consisting of a growing suite of proprietary transgenic mice strains. Alloy is a leader in bispecific antibody discovery and engineering services, utilizing its proprietary ATX-CLC common light chain platform integrating novel transgenic mice and phage display. Alloy is headquartered in Boston, MA with labs in Cambridge, UK; Basel, CH; San Francisco, CA; and Athens, GA. As a reflection of Alloy's relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.

Join the Alloy Therapeutics community by visiting alloytx.com, following Alloy on LinkedIn, or scheduling a 15-minute chat with Alloy's Founder and CEO at alloytx.com/ceo.

Media Contact:

Erin Glabets
communications@alloytx.com

SOURCE: Champions Oncology, Inc.

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FAQ

What is Champions Oncology's partnership with Alloy Therapeutics about?

Champions Oncology's partnership with Alloy Therapeutics aims to develop therapeutic monoclonal antibodies for next-generation Antibody Drug Conjugates (ADCs).

What is the focus of the initial program in the CSBR-Alloy partnership?

The initial program focuses on a previously unexplored target present in hematologic tumors like Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM).

When was the partnership between Champions Oncology and Alloy Therapeutics announced?

The partnership was announced on January 4, 2022.

What will Champions Oncology retain under the new partnership?

Champions Oncology will wholly own the therapeutic molecule developed in this partnership.

What benefits does the Lumin platform provide in this partnership?

The Lumin platform offers advanced analytics and target identification to support rapid and efficient drug development.