CRISPR Therapeutics to Present Preclinical Data at the Society for Immunotherapy of Cancer (SITC) 36th Annual Meeting

Rhea-AI Summary

CRISPR Therapeutics (Nasdaq: CRSP) announced two poster presentations and an oral presentation at the upcoming Society for Immunotherapy of Cancer (SITC) Annual Meeting, scheduled for November 10-14, 2021, in Washington, D.C. The first poster focuses on CRISPR/Cas9 gene-edited CAR-T cells targeting CD33 in acute myeloid leukemia (AML), demonstrating promising preclinical efficacy without long-term toxicity. The joint oral presentation with Nkarta will cover strategies to enhance NK cell efficacy against solid tumors. These presentations highlight CRISPR's commitment to advancing gene-based therapies.

Positive

• Successful preclinical efficacy of CRISPR/Cas9 gene-edited CAR-T cells targeting CD33 against AML.
• Joint presentation with Nkarta demonstrating enhanced NK cell efficacy against solid tumors.
• Upcoming presentations at a prominent industry event indicate strong engagement with the scientific community.

Negative

• None.

ZUG, Switzerland and CAMBRIDGE, Mass., Oct. 01, 2021 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today announced two poster presentations at the Society for Immunotherapy of Cancer (SITC) 36^th Annual Meeting, to be held both virtually and at the Walter E. Washington Convention Center in Washington, D.C., from November 10 to 14, 2021. The Company also announced an oral presentation at the SITC 2021 Pre-Conference Program, The Evolution of Immunotherapy: An Exploration of Immunity Beyond T cells, CAR T in Solid Tumors and Novel Combinations, which will be held from 2:00 p.m. – 6:00 p.m. ET on November 10, 2021.

CRISPR Therapeutics presentation:

Title: CRISPR/Cas9 gene-edited allogeneic CAR-T cells targeting CD33 show high preclinical efficacy against AML without long-term hematopoietic toxicity
Abstract Number and Type: 133, poster
Date and Time: Friday, November 12, 2021, 7:00 a.m. – 8:30 p.m. ET
Location: Walter E. Washington Convention Center, Hall E, or https://www.sitcancer.org/2021/home

Presented jointly with Nkarta:

Title: A combined strategy of CD70 CAR co-expression with membrane-bound IL-15 and CISH knockout results in enhanced NK cytotoxicity and persistence
Abstract Number and Type: 16439, oral
Date and Time: Wednesday, November 10, 2021, 2:40 p.m. ET
Location: Walter E. Washington Convention Center, or https://www.sitcancer.org/2021/program/pre-conference-programs/industryprogram

Title: CISH gene-knockout anti-CD70-CAR NK cells demonstrate potent anti-tumor activity against solid tumor cell lines and provide partial resistance to tumor microenvironment inhibition
Abstract Number and Type: 113, poster
Date and Time: Friday, November 12, 2021, 7:00 a.m. – 8:30 p.m. ET
Location: Walter E. Washington Convention Center, Hall E, or https://www.sitcancer.org/2021/home

About CRISPR Therapeutics
CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom. For more information, please visit www.crisprtx.com.

CRISPR THERAPEUTICS^® word mark and design logo are trademarks and registered trademarks of CRISPR Therapeutics AG. All other trademarks and registered trademarks are the property of their respective owners.

Investor Contact:
Susan Kim
+1-617-307-7503
susan.kim@crisprtx.com

Media Contact:
Rachel Eides
+1-617-315-4493
rachel.eides@crisprtx.com

FAQ

What presentations is CRISPR Therapeutics providing at SITC 2021?

CRISPR Therapeutics will present two poster presentations and one oral presentation at SITC 2021, focusing on CAR-T cells for AML and NK cell strategies against solid tumors.

What is the significance of CRISPR's presentation on CD33 CAR-T cells?

The presentation on CD33 CAR-T cells highlights their high preclinical efficacy against AML without causing long-term hematopoietic toxicity, showcasing potential therapeutic advancements.

When and where will CRISPR's presentations take place?

The presentations will occur at the SITC Annual Meeting in Washington, D.C., from November 10-14, 2021, with specific timings for each session.

How might CRISPR's presentations impact its stock performance?

Successful presentations showcasing innovative therapies could positively influence investor sentiment and stock performance for CRISPR Therapeutics.