Ceapro Inc. Announces Positive Data from Bioavailability Studies Evaluating CoQ10 Formulations Impregnated with PGX-Processed Carriers
Ceapro (CRPOF) announced positive results from its study on PGX-processed carriers for CoQ10 delivery, demonstrating superior bioavailability. Conducted with the University of Alberta, the study showed that certain formulations increased CoQ10 absorption significantly, achieving up to 3-fold improvement compared to standard formulations. The findings support advancing Ceapro's PGX Technology, aimed at developing first-in-class slow-release products. CEO Gilles Gagnon highlighted the potential for innovative delivery systems in various markets, reinforcing the company's growth strategy and investment decisions for the next phase.
- Demonstrated increased bioavailability of CoQ10 by 2-3 fold compared to existing formulations.
- Results support the decision to scale up PGX Technology for future product development.
- Potential for first-in-class slow-release formulations targeting large market opportunities.
- None.
- Findings from this collaborative project with the University of Alberta using a unique surgical methodology illustrate how PGX-processed carriers can successfully be uniformly loaded with a fat-soluble active ingredient to generate superior bioactive delivery systems
- Superior bioavailability data further confirm potential for the development of first-in-class slow-release formulations
- Strength of data further support investment decision for next scale-up level of the PGX Technology
EDMONTON, Alberta, Oct. 13, 2022 (GLOBE NEWSWIRE) -- Ceapro Inc. (TSX-V: CZO; OTCQX: CRPOF) (“Ceapro” or the “Company”), a growth-stage biotechnology company focused on the development and commercialization of active ingredients for healthcare and cosmetic industries, today announced positive results from its collaborative project led by Dr. Donna Vine, Professor at the Department of Agriculture, Food and Nutritional Science of University of Alberta.
In this study, titled “Pre-clinical Testing of Intestinal Bioavailability of CoQ10-Formulations,” four PGX-processed highly purified carriers, outlined in the table below, were loaded (impregnated) with Coenzyme Q10 (CoQ10) and compared against two positive controls: a food-grade lipid-based formulation (CoQ10 in triolein or oil) and one of the best commercially available dry powder formulation: Cyclodextrin loaded with
| Sample code | Carrier used | CoQ10 load (%w) |
| iYBG | PGX Yeast b-Glucan | 5.80 |
| iAL | PGX Sodium Alginate | 20.2 |
| i(AL+OBG) | PGX (Sodium Alginate + oat b-Glucan) | 15.8 |
| i(AL+YBG) | PGX (Sodium Alginate + yeast b-Glucan) | 22.5 |
In the summary report of the project, Dr. Vine concludes, “This in vivo pilot study shows that following 8 hours, the
“With our recent announcement of the successful development and publication of new chemical conjuguates like PGX Alginate loaded with CoQ10, we are very pleased to have demonstrated in vivo a superior bioavailabilty for these new chemical complexes with CoQ10 even when it is mixed in water formulation where bioavailabilty has always been a challenge for most commercial CoQ10 supplements. Knowing that Ceapro’s PGX-processed carriers can deliver CoQ10 into the tissues, we will advance to the next stage which includes looking for efficacy of these new chemical entities along with a partner involved in the marketing and sales of various forms of delivery systems that can be included in food, drinks, cream formulations, medical supplies like thin films, skin patches and up to nutraceuticals and pharmaceuticals,” said Gilles Gagnon, M.Sc., MBA, President and CEO. “Additionally, we are excited about some data strongly suggesting that we have a slow release formulation when combining i(AL+YBG) with CoQ10 (8-12 hours), which would be a first-in-class product. In summary, these results with alginate and yeast beta glucan as carriers for CoQ10 and possibly other bioactives support our investment decision for the next scale up level of the PGX Technology and the expansion of our pipeline targeting a large market potential.”
About Pressurized Gas eXpanded Liquid Technology (PGX)
Ceapro’s patented Pressurized Gas eXpanded (PGX) technology is a unique and disruptive technology with several key advantages over conventional drying and purification technologies that can be used to process biopolymers into high-value, fine-structured, openporous polymer structures and novel biocomposites. PGX is ideally suited for processing challenging high-molecular-weight, water-soluble biopolymers. It has the ability to make ultra-light, highly porous polymer structures on a continuous basis, which is not possible using today's conventional technologies. PGX was invented by Dr. Feral Temelli from the Department of Agricultural, Food & Nutritional Science of the University of Alberta (U of A) along with Dr. Bernhard Seifried, now Senior Director of Engineering Research and Technology at Ceapro. The license from U of A provides Ceapro with exclusive worldwide rights in all industrial applications.
About Ceapro Inc.
Ceapro Inc. is a Canadian biotechnology company involved in the development of proprietary extraction technology and the application of this technology to the production of extracts and “active ingredients” from oats and other renewable resources. Ceapro adds further value to its extracts by supporting their use in cosmeceutical, nutraceutical, and therapeutics products for humans and animals. The Company has a broad range of expertise in natural product chemistry, microbiology, biochemistry, immunology and process engineering. These skills merge in the fields of active ingredients, biopharmaceuticals and drug-delivery solutions. For more information on Ceapro, please visit the Company’s website at www.ceapro.com.
For more information contact:
Jenene Thomas
JTC Team, LLC
Investor Relations and Corporate Communications Advisor
T (US): +1 (833) 475-8247
E: czo@jtcir.com
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release
FAQ
What were the key findings from Ceapro's CoQ10 study involving PGX-processed carriers?
How does Ceapro plan to utilize the findings from its recent study on CoQ10?
What is the significance of Ceapro's collaboration with the University of Alberta?
What future steps will Ceapro take following the CoQ10 study results?
What is the ticker symbol for Ceapro?
