Welcome to our dedicated page for Crinetics Pharmaceuticals news (Ticker: CRNX), a resource for investors and traders seeking the latest updates and insights on Crinetics Pharmaceuticals stock.
Crinetics Pharmaceuticals, Inc. (NASDAQ: CRNX) is a clinical-stage pharmaceutical company dedicated to the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. Founded with a mission to create impactful treatments, Crinetics focuses on advancing its innovative pipeline of orally delivered small molecule drugs.
The company's leading product candidate, paltusotine, is an investigational somatostatin receptor type 2 (SST2) agonist, currently in Phase 3 development for acromegaly and Phase 2 for carcinoid syndrome associated with neuroendocrine tumors. Paltusotine promises a convenient, once-daily oral treatment alternative to monthly injections, simplifying patient care and improving quality of life.
Moreover, Crinetics is advancing CRN04894 (atumelnant), a first-in-class oral ACTH antagonist in Phase 2 trials for congenital adrenal hyperplasia and ACTH-dependent Cushing's disease. This promising candidate aims to address significant unmet needs in these patient populations by reducing disease drivers and normalizing hormone levels.
Crinetics' in-house drug discovery efforts have resulted in several ongoing programs targeting conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease, thyroid eye disease, diabetes, and obesity. The company's robust pipeline highlights its commitment to developing transformative therapies for patients with rare endocrine disorders.
Recent achievements include a successful private placement of $350 million, strengthening their financial position to support ongoing research and development. The company also reported positive topline results from its Phase 2 study of paltusotine for carcinoid syndrome, as well as from its Phase 3 PATHFNDR-2 study for acromegaly, reinforcing the potential of paltusotine in providing both symptom and biochemical control.
With strategic partnerships, including collaborations with top institutional investors and the National Institutes of Health, Crinetics is well-positioned for future growth. The company remains committed to bringing innovative treatments to market and improving the lives of patients worldwide.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced its participation in the H.C. Wainwright 24th Annual Global Investment Conference from September 12-14, 2022. The company will provide a corporate overview starting at 7:00 a.m. Eastern Time on September 12, 2022. Interested parties can access a webcast available on-demand.
Crinetics is focused on developing therapeutics for rare endocrine diseases, with its lead candidate Paltusotine in advanced clinical stages.
Crinetics Pharmaceuticals (CRNX) presented new data on their investigational compound, paltusotine, at the 35th Brazilian Congress of Endocrinology and Metabolism. The results show that paltusotine effectively lowers and maintains insulin-like growth factor-1 (IGF-1) levels comparable to injected somatostatin receptor ligands (SRLs) for up to 103 weeks. An impressive 88% of trial participants opted to continue treatment, with 89% preferring the oral paltusotine to injected SRLs. The drug demonstrated a safety profile similar to that of injected SRLs, indicating its potential as a long-term therapy for acromegaly.
Crinetics Pharmaceuticals (CRNX) announces that Dr. Monica R. Gadelha will present interim data from the ACROBAT Advance open label extension study at the 35th Brazilian Congress of Endocrinology and Metabolism (CBEM) on September 4, 2022. The presentation highlights paltusotine's long-term safety and maintenance of IGF-1 levels in acromegaly patients transitioning from injectable therapies. Paltusotine is an investigational oral treatment designed to selectively target somatostatin receptor type 2, aiming to improve patient compliance and outcomes.
Crinetics Pharmaceuticals (CRNX) announced that its Phase 3 PATHFNDR program for paltusotine in acromegaly and Phase 2 study for carcinoid syndrome are on schedule for top-line data in 2023. The Phase 1 data for CRN04894 confirmed pharmacologic proof-of-concept for conditions like Cushing’s disease. The company plans to initiate Phase 2 studies for CRN04777 and CRN04894 after protocol finalization with global regulators. In Q2 2022, Crinetics reported a net loss of $42.4 million on revenues of $0.4 million, while cash reserves were $408.5 million, sufficient for operations through 2024.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced on August 10, 2022, the grant of non-qualified stock options for a total of 67,100 shares to nine new non-executive employees. These options, part of the 2021 Employment Inducement Incentive Award Plan, were issued to incentivize hiring as per Nasdaq Listing Rule 5635(c)(4). The exercise price is set at $21.77 per share, matching the stock's fair market value. The options will vest over four years with 25% vesting after one year and the rest in monthly installments, contingent on continued employment.
Crinetics Pharmaceuticals (CRNX) announces Peter J. Trainer, M.D. will present findings from preclinical and Phase 1 studies of CRN04894 at the International Congress of Neuroendocrinology from August 7-10, 2022. CRN04894 is an oral ACTH antagonist targeting Cushing’s disease and congenital adrenal hyperplasia. Results show significant reductions in cortisol levels during the Phase 1 trial, affirming pharmacologic proof-of-concept. The presentation occurs on August 10, 2022, detailing the drug's impact on glucocorticoid secretion.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced the grant of non-qualified stock options for 107,500 shares to six new non-executive employees on July 12, 2022. These options were awarded under the 2021 Employment Inducement Incentive Award Plan to attract new talent, complying with Nasdaq Listing Rule 5635(c)(4). The exercise price is set at $20.33 per share, reflecting the current market value. The options will vest over four years, contingent upon continued employment. Crinetics focuses on developing therapies for rare endocrine diseases, with ongoing clinical trials for key drug candidates.
On June 10, 2022, Crinetics Pharmaceuticals (Nasdaq: CRNX) announced the grant of non-qualified stock options to purchase 138,500 shares to seven new non-executive employees. This action follows the 2021 Employment Inducement Incentive Award Plan, aimed at attracting new talent. The options have an exercise price of $18.59 per share and will vest over four years, contingent upon continued employment. This initiative aligns with Nasdaq regulations designed to incentivize new hires and support the company's growth in developing treatments for rare endocrine diseases.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced the selection of CRN04894 for oral presentation at ENDO 2022. This investigational drug targets conditions like Cushing’s disease and reduces serum cortisol levels and urine free cortisol excretion. Details include an oral session on June 12, 2022, highlighting the inhibition of ACTH-stimulated cortisol secretion. Additionally, results for CRN04777 and a preclinical PTH antagonist will be presented through narrated posters. These events underscore Crinetics' commitment to advancing treatments for rare endocrine diseases.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced participation in a fireside chat at the JMP Securities Life Sciences Conference on June 15-16, 2022, held at the Lotte New York Palace. The chat is scheduled for 3:30 p.m. Eastern Time on June 15. Investors can access the live and archived presentation via the provided webcast link. The company focuses on developing therapies for rare endocrine diseases, with candidates like paltusotine in Phase 3 development for acromegaly.
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