Charles River Laboratories Provides Access to Relevant, Well-Characterized Pediatric PDX Collection for Oncology Research

Rhea-AI Summary

Charles River Laboratories offers access to a collection of 400 annotated pediatric cancer models for preclinical cancer research, in line with new regulatory guidelines requiring testing for pediatric indications. This collection will help assess the safety and efficacy of new oncology treatments for children and potentially lead to new treatment options. Charles River has extensive experience in oncology research and is well-equipped to support researchers in navigating these new guidelines.

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• Charles River Laboratories now offers access to a collection of 400 annotated pediatric cancer models for preclinical cancer research, in compliance with new regulatory guidelines. This can positively impact the stock price as it allows Charles River to better assess the safety and efficacy of new oncology treatments specifically for children, potentially leading to new treatment options. The collection is supported by an accompanying dataset consisting of molecular phenotyping and pharmacological characterization, increasing its value for researchers.

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Recently established regulatory guidelines make testing for pediatric indications a necessary step in oncology research and development

WILMINGTON, Mass.--(BUSINESS WIRE)-- Charles River Laboratories International, Inc. (NYSE: CRL) today announced the ability to conduct preclinical cancer research using ITCC-P4’s well-characterized collection of 400 annotated pediatric cancer models. As a global partner, Charles River is offering clients access to this collection. These are critical models for research, as the U.S. Food and Drug Administration’s (FDA) Research to Accelerate Cures and Equity (RACE) for Children Act, requires all oncology drugs to be tested for pediatric indications ahead of approval. Additionally, the EU regulation of the European Medicines Agency (EMA) is being adapted to mirror the FDA’s regulations.

“Globally, 400,000 children and adolescents develop cancer each year, and approximately one in four cannot be cured with currently available therapies,” said Aidan Synnott, Corporate Vice President, Global Discovery Services at Charles River. “The ITCC-P4 collection is comprehensive, relevant, and well-characterized, meaning we can better assess the safety and efficacy of new oncology treatments specifically for children. This will ultimately lead to new treatment options for a critically important patient population.”

The ITCC-P4 repertoire offers access to models that are relevant to pediatric cancer, allowing researchers to appropriately investigate targets of interest, and ultimately increasing translation to preclinical trials. Pediatric tumors have different genomic drivers and phenotypes than adult tumors, requiring unique preclinical models. The ITCC-P4 collection is supported by an accompanying dataset consisting of molecular phenotyping and pharmacological characterization backed-up by expertise from internationally recognized pediatricians. By offering this collection, Charles River is combining decades of oncology research experience with a powerful tool that will better guide critical investigative decisions.

“Charles River worked on 84 percent of the FDA-approved cancer therapies over the last five years, and has delivered 16 oncology candidates to our partners,” added Julia Schüler, DVM, PhD, Research Director and Therapeutic Area Lead, Oncology at Charles River. “We are uniquely positioned to help researchers navigate through these new guidelines and progress their studies.”

Charles River offers a comprehensive portfolio of oncology drug discovery and development services, from model selection to safety assessment and support for biologic therapies. With a global infrastructure and deep scientific bench, Charles River is positioned to support programs from basic science to IND submission.

About Charles River

Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.

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Charles River Investor Contact:

Todd Spencer

Corporate Vice President, Investor Relations

+1- 781-222-6455

todd.spencer@crl.com



Charles River Media Contact:

Amy Cianciaruso

Corporate Vice President & Chief Communications Officer

+1-781-222-6168

amy.cianciaruso@crl.com

Source: Charles River Laboratories International, Inc.

FAQ

What is Charles River Laboratories offering to clients?

Access to a collection of 400 annotated pediatric cancer models for preclinical cancer research.

What are the regulatory guidelines that Charles River is complying with?

The U.S. FDA's Research to Accelerate Cures and Equity (RACE) for Children Act, which requires testing of oncology drugs for pediatric indications, and the EU regulation of the EMA, which is being adapted to mirror the FDA's regulations.

How many children and adolescents develop cancer each year globally?

Approximately 400,000.

What is the significance of the ITCC-P4 collection?

It offers models that are relevant to pediatric cancer, allowing researchers to investigate targets of interest and increase translation to preclinical trials.

What expertise supports the ITCC-P4 collection?

Expertise from internationally recognized pediatricians, with an accompanying dataset consisting of molecular phenotyping and pharmacological characterization.

What is Charles River's experience in oncology research?

They have worked on 84 percent of FDA-approved cancer therapies over the last five years and have delivered 16 oncology candidates to their partners.

What services does Charles River offer in oncology drug discovery and development?

They offer a comprehensive portfolio of services, including model selection, safety assessment, and support for biologic therapies.

What is Charles River's global reach?

They have a global infrastructure and deep scientific bench, positioning them to support programs from basic science to IND submission.