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Curis Inc. (NASDAQ: CRIS) is a biotechnology company dedicated to the development and commercialization of groundbreaking drug candidates aimed at treating human cancers. Established as a significant player in the biotech sector, Curis is renowned for its focus on immuno-oncology and precision oncology therapeutic areas.
Core Business and Pipeline
Curis's pipeline is robust, featuring a number of promising drug candidates. One of its leading drugs is Emavusertib (CA-4948), an orally available, small molecule IRAK4 inhibitor currently undergoing clinical trials. The trials include the Phase 1/2 TakeAim Lymphoma study, which targets hematologic malignancies such as non-Hodgkin's lymphoma, and the Phase 1/2 TakeAim Leukemia study aimed at acute myeloid leukemia and myelodysplastic syndrome. Emavusertib has already received Orphan Drug Designation from the U.S. Food and Drug Administration.
Curis is also investigating other candidates such as CUDC-907, which focuses on relapsed or refractory diffuse large B-cell lymphoma with alterations in the MYC oncogene, and other small molecule antagonists like CA-170 and CA-327, designed to inhibit pathways such as PD1, VISTA, and TIM3.
Collaborations & Partnerships
Curis has forged a strategic collaboration with Aurigene, granting it exclusive licenses to several promising molecules. This partnership enhances Curis's ability to innovate in the areas of immuno-oncology and precision oncology, specifically with oral small molecule antagonists. Additionally, Curis has licensed its rights to Erivedge® to Genentech, which is commercializing the drug for advanced basal cell carcinoma under the Roche Group.
Recent Achievements and Financial Condition
Curis has recently presented data from multiple clinical studies at prestigious conferences such as the American Society of Hematology (ASH) and the European Hematology Association (EHA), showcasing promising results from its ongoing trials. The company reported a net loss of $47.4 million for the year ended December 31, 2023, but continues to maintain a strong cash position with $56.3 million in cash, cash equivalents, and investments.
Curis's ongoing research and development efforts are backed by substantial funding and strategic partnerships, enabling the company to sustain its operations and advance its pipeline into the year 2025.
For more information, visit Curis's website at www.curis.com.
Curis, Inc. (NASDAQ: CRIS), a biotechnology firm focused on cancer therapeutics, has announced a proposed public offering of its common stock under an existing shelf registration statement. The company plans to grant underwriters a 30-day option to purchase additional shares, up to 15% of the offering size. Proceeds will fund the development of CA-4948 and CI-8993, while also supporting general working capital. Cantor Fitzgerald & Co. and JonesTrading are the joint lead book runners for this offering.
Curis (NASDAQ: CRIS) announced promising preliminary results from its Phase 1 study of CA-4948, an IRAK4 kinase inhibitor targeting acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS). Key findings include marrow blast reductions in all evaluable patients, with no dose-limiting toxicities reported. Out of 7 patients, 6 remain in the study. The results highlight CA-4948's potential, especially for patients who are relapsed or refractory. The company plans to provide further updates on the study in mid-2021.
Curis (NASDAQ: CRIS) announced updated data from its Phase 1 study of CA-4948, an IRAK4 kinase inhibitor for relapsed or refractory non-Hodgkin's lymphoma (NHL). Results indicate that the recommended Phase 2 dose of 300 mg BID demonstrates significant anti-cancer activity with a median tumor reduction of 27% in evaluable patients. The drug is well-tolerated, and preliminary data from biomarkers suggest potential for patient enrichment. A virtual presentation of these findings will occur at the 62nd American Society of Hematology Annual Meeting.
Curis, Inc. (NASDAQ: CRIS) announced a virtual KOL event on December 8, 2020, to discuss the IRAK4 kinase inhibitor CA-4948. This event will share progress from the Phase 1 study in patients with non-Hodgkin lymphoma and new clinical data for acute myeloid leukemia and myelodysplastic syndromes. The presentation will be led by James Dentzer, CEO, alongside Dr. Amit Verma. A live webcast will be available, with a replay accessible for 90 days after the event.
Curis, Inc. (NASDAQ: CRIS) reported its third-quarter 2020 financial results with a net loss of $6.0 million ($0.11 per share), an improvement from a loss of $6.4 million in Q3 2019. Total revenues were $2.7 million, slightly down from $2.9 million a year prior. Key operational highlights include ongoing Phase 1 studies for the IRAK4 inhibitor CA-4948 and the anti-VISTA antibody CI-8993. The company also secured a CRADA with NCI for CA-4948’s development and maintains a cash position of $23.6 million, sufficient for operations through mid-2021.
Curis, a biotechnology company (NASDAQ: CRIS), has entered a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI) to develop CA-4948, an IRAK4 kinase inhibitor for cancer treatment. This collaboration aims to enhance CA-4948's clinical studies and validate Curis's approach to targeted cancer therapeutics. CA-4948 is currently in Phase 1 trials for non-Hodgkin lymphoma and acute myeloid leukemia. The company also plans a combination study with ibrutinib, expected to start in Q4 2020.
Curis, Inc. (NASDAQ: CRIS) announced the acceptance of three abstracts for CA-4948 presentations at the 62nd American Society of Hematology Annual Meeting from December 5-8, 2020. CA-4948 is a first-in-class IRAK4 inhibitor aimed at treating various hematologic malignancies. Data from Phase 1 studies in non-Hodgkin's lymphoma and acute myeloid leukemia are expected by year-end. The company emphasizes progress and will share updated safety and efficacy results during the conference.
Curis, a biotechnology company focused on cancer therapeutics, announced that CEO James Dentzer will present at the H.C. Wainwright & Co. 6th Annual Israel Conference on November 12, 2020, at 12:00 pm ET. A live webcast will be available on Curis' website in the Investors section, with a replay accessible for 90 days post-event.
Curis is advancing multiple cancer treatments, including drugs in collaboration with Aurigene and Genentech. Their pipeline includes CA-4948 for non-Hodgkin lymphoma and acute myeloid leukemia, with ongoing Phase 1 clinical trials.
Curis, Inc. (NASDAQ: CRIS) will report its third quarter 2020 financial results on November 10, 2020, post market close. The management will conduct a conference call at 4:30 p.m. ET on the same day to discuss the results. The call can be accessed via phone or through the Curis website. Curis is known for developing innovative cancer therapeutics and has several key collaborations, including with Aurigene and Genentech for advanced treatment options and ongoing clinical trials.
Curis, Inc. (NASDAQ: CRIS) announced the publication of a research paper in ACS Medicinal Chemistry Letters, detailing CA-4948, an orally bioavailable IRAK4 inhibitor for treating hematologic malignancies. This small molecule demonstrated potent IRAK4 inhibition and showed tumor regression in animal studies without significant toxicity. CA-4948 is currently in Phase 1 trials for non-Hodgkin lymphomas and acute myeloid leukemia. Curis plans to commence a combination study with ibrutinib for non-Hodgkin lymphomas this quarter. Curis emphasizes the need for additional funding to support ongoing operations.
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